StarFunc result for job id Q96JI7

User Input

>input (2443 residues)
MAAEEGVASAASAGGSWGTAAMGRVLPMLLVPVPAEAMGQLGSRAQLRTQPEALGSLTAA
GSLQVLSLTPGSRGGGRCCLEGPFWHFLWEDSRNSSTPTEKPKLLALGENYELLIYEFNL
KDGRCDATILYSCSREALQKLIDDQDISISLLSLRILSFHNNTSLLFINKCVILHIIFPE
RDAAIRVLNCFTLPLPAQAVDMIIDTQLCRGILFVLSSLGWIYIFDVVDGTYVAHVDLAL
HKEDMCNEQQQEPAKISSFTSLKVSQDLDVAVIVSSSNSAVALNLNLYFRQHPGHLLCER
ILEDLPIQGPKGVDEDDPVNSAYNMKLAKFSFQIDRSWKAQLSSLNETIKNSKLEVSCCA
PWFQDILHLESPESGNHSTSVQSWAFIPQDIMHGQYNVLQKDHAKTSDPGRSWKIMHISE
QEEPIELKCVSVTGFTALFTWEVERMGYTITLWDLETQGMQCFSLGTKCIPVDSSGDQQL
CFVLTENGLSLILFGLTQEEFLNRLMIHGSASTVDTLCHLNGWGRCSIPIHALEAGIENR
QLDTVNFFLKSKENLFNPSSKSSVSDQFDHLSSHLYLRNVEELIPALDLLCSAIRESYSE
PQSKHFSEQLLNLTLSFLNNQIKELFIHTEELDEHLQKGVNILTSYINELRTFMIKFPWK
LTDAIDEYDVHENVPKVKESNIWKKLSFEEVIASAILNNKIPEAQTFFRIDSHSAQKLEE
LIGIGLNLVFDNLKKNNIKEASELLKNMGFDVKGQLLKICFYTTNKNIRDFLVEILKEKN
YFSEKEKRTIDFVHQVEKLYLGHFQENMQIQSFPRYWIKEQDFFKHKSVLDSFLKYDCKD
EFNKQDHRIVLNWALWWDQLTQESILLPRISPEEYKSYSPEALWRYLTARHDWLNIILWI
GEFQTQHSYASLQQNKWPLLTVDVINQNTSCNNYMRNEILDKLARNGVFLASELEDFECF
LLRLSRIGGVIQDTLPVQNYKTKEGWDFHSQFILYCLEHSLQHLLYVYLDCYKLSPENCP
FLEKKELHEAHPWFEFLVQCRQVASNLTDPKLIFQASLANAQILIPTNQASVSSMLLEGH
TLLALATTMYSPGGVSQVVQNEENENCLKKVDPQLLKMALTPYPKLKTALFPQCTPPSVL
PSDITIYHLIQSLSPFDPSRLFGWQSANTLAIGDAWSHLPHFSSPDLVNKYAIVERLNFA
YYLHNGRPSFAFGTFLVQELIKSKTPKQLIQQVGNEAYVIGLSSFHIPSIGAACVCFLEL
LGLDSLKLRVDMKVANIILSYKCRNEDAQYSFIRESVAEKLSKLADGEKTTTEELLVLLE
EGTWNSIQQQEIKRLSSESSSQWALVVQFCRLHNMKLSISYLRECAKANDWLQFIIHSQL
HNYHPAEVKSLIQYFSPVIQDHLRLAFENLPSVPTSKMDSDQVCNKCPQELQGSKQEMTD
LFEILLQCSEEPDSWHWLLVEAVKQQAPILSVLASCLQGASAISCLCVWIITSVEDNVAT
EAMGHIQDSTEDHTWNLEDLSVIWRTLLTRQKSKTLIRGFQLFFKDSPLLLVMEMYELCM
FFRNYKEAEAKLLEFQKSLETLNTAATKVHPVIPAMWLEDQVCFLLKLMLQQCKTQYELG
KLLQLFVEREHLFSDGPDVKKLCILCQILKDTSIAINHTIITSYSIENLQHECRSILERL
QTDGQFALARRVAELAELPVDNLVIKEITQEMQTLKHIEQWSLKQARIDFWKKCHENFKK
NSISSKAASSFFSTQAHVACEHPTGWSSMEERHLLLTLAGHWLAQEDVVPLDKLEELEKQ
IWLCRITQHTLGRNQEETEPRFSRQISTSGELSFDSLASEFSFSKLAALNTSKYLELNSL
PSKETCENRLDWKEQESLNFLIGRLLDDGCVHEASRVCRYFHFYNPDVALVLHCRALASG
EASMEDLHPEIHALLQSAELLEEEAPDIPLRRVHSTSSLDSQKFVTVPSSNEVVTNLEVL
TSKCLHGKNYCRQVLCLYDLAKELGCSYTDVAAQDGEAMLRKILASQQPDRCKRAQAFIS
TQGLKPDTVAELVAEEVTRELLTSSQGTGHKQMFNPTEESQTFLQLTTLCQDRTLVGMKL
LDKISSVPHGELSCTTELLILAHHCFTLTCHMEGIIRVLQAAHMLTDNHLAPSEEYGLVV
RLLTGIGRYNEMTYIFDLLHKKHYFEVLMRKKLDPSGTLKTALLDYIKRCRPGDSEKHNM
IALCFSMCREIGENHEAAARIQLKLIESQPWEDSLKDGHQLKQLLLKALTLMLDAAESYA
KDSCVRQAQHCQRLTKLITLQIHFLNTGQNTMLINLGRHKLMDCILALPRFYQASIVAEA
YDFVPDWAEILYQQVILKGDFNYLEEFKQQRLLKSSIFEEISKKYKQHQPTDMVMENLKK
LLTYCEDVYLYYKLAYEHKFYEIVNVLLKDPQTGCCLKDMLAG

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q3UHA3	0.319	0.321	0.000	2430	0.764	0.768	Q3UHA3.pdb.gz	SPTCS_MOUSE Spatacsin OS=Mus musculus OX=10090 GN=Spg11 PE=1 SV=3
2	AFDB:Q96JI7	1.000	1.000	0.000	2443	1.000	1.000	Q96JI7.pdb.gz	SPTCS_HUMAN Spatacsin OS=Homo sapiens OX=9606 GN=SPG11 PE=1 SV=3
3	AFDB:F1R072	0.230	0.332	3.839E-89	1612	0.302	0.457	F1R072.pdb.gz
4	AFDB:D4HMK9	0.180	0.302	2.644E-59	1248	0.208	0.406	D4HMK9.pdb.gz	D4HMK9_DANRE Spatacsin isoform 2 OS=Danio rerio OX=7955 GN=spg11 PE=2 SV=1
5	PDB:7qpgR	0.064	0.068	2.027E-11	2208	0.114	0.126	7qpgR.pdb.gz
6	AFDB:P11442	0.095	0.132	1.099E-8	1675	0.092	0.134	P11442.pdb.gz	CLH1_RAT Clathrin heavy chain 1 OS=Rattus norvegicus OX=10116 GN=Cltc PE=1 SV=3
7	PDB:1xi4A	0.093	0.133	2.256E-7	1630	0.090	0.136	1xi4A.pdb.gz
8	PDB:7wooD	0.108	0.170	5.908E-6	1398	0.064	0.112	7wooD.pdb.gz
9	PDB:6n8sA	0.074	0.203	7.671E-6	834	0.014	0.042	6n8sA.pdb.gz
10	PDB:7mq8LM	0.068	0.076	1.351E-5	2005	0.108	0.132	7mq8LM.pdb.gz	Nucleolar maturation of the human small subunit processome.
11	PDB:7mq8LS	0.077	0.356	1.351E-5	453	0.011	0.060	7mq8LS.pdb.gz	Nucleolar maturation of the human small subunit processome.
12	PDB:7mq8LR	0.077	0.178	1.680E-5	773	0.025	0.080	7mq8LR.pdb.gz	Nucleolar maturation of the human small subunit processome.
13	PDB:5a9qA	0.107	0.212	2.181E-5	1097	0.054	0.119	5a9qA.pdb.gz
14	PDB:7d5sB2	0.089	0.231	2.832E-5	851	0.024	0.069	7d5sB2.pdb.gz	Cryo-EM structure of 90S preribosome with inactive Utp24 (state A2)
15	PDB:7wooC	0.107	0.183	2.832E-5	1325	0.063	0.116	7wooC.pdb.gz
16	AFDB:B1WC72	0.061	0.156	4.119E-5	677	0.028	0.100	B1WC72.pdb.gz	B1WC72_RAT Rpgr protein OS=Rattus norvegicus OX=10116 GN=Rpgr PE=1 SV=1
17	AFDB:Q9LFE2	0.073	0.129	1.278E-4	876	0.031	0.087	Q9LFE2.pdb.gz	TOZ_ARATH Protein TORMOZ EMBRYO DEFECTIVE OS=Arabidopsis thaliana OX=3702 GN=TOZ PE=1 SV=1
18	AFDB:Q9P3W2	0.078	0.407	1.456E-4	364	0.016	0.110	Q9P3W2.pdb.gz	HSV2_SCHPO SVP1-like protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=hsv2 PE=3 SV=1
19	AFDB:Q8N157	0.068	0.126	1.589E-4	1196	0.021	0.043	Q8N157.pdb.gz	AHI1_HUMAN Jouberin OS=Homo sapiens OX=9606 GN=AHI1 PE=1 SV=1
20	AFDB:Q57VP9	0.063	0.059	3.795E-4	2653	0.068	0.063	Q57VP9.pdb.gz	Q57VP9_TRYB2 EF-hand domain-containing protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.29O4.100 PE=4 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	C4B7M2	0.0	4657	2265	0.921	0.994	C4B7M2_HUMAN SPG11 vesicle trafficking associated, spatacsin OS=Homo sapiens OX=9606 GN=SPG11 PE=1 SV=1
2	C4B7M4	0.0	5053	2443	1.000	1.000	C4B7M4_HUMAN Spatacsin OS=Homo sapiens OX=9606 GN=SPG11 PE=2 SV=1
3	D3Z9Z3	0.0	2808	2315	0.583	0.616	D3Z9Z3_RAT SPG11 vesicle trafficking associated, spatacsin OS=Rattus norvegicus OX=10116 GN=Spg11 PE=4 SV=2
4	D4HMK8	0.0	1682	2379	0.409	0.420	D4HMK8_DANRE Spatacsin isoform 1 OS=Danio rerio OX=7955 GN=spg11 PE=2 SV=1
5	H0YN34	0.0	1600	779	0.316	0.992	H0YN34_HUMAN SPG11 vesicle trafficking associated, spatacsin OS=Homo sapiens OX=9606 GN=SPG11 PE=1 SV=1
6	Q3UHA3	0.0	3770	2430	0.765	0.770	SPTCS_MOUSE Spatacsin OS=Mus musculus OX=10090 GN=Spg11 PE=1 SV=3
7	Q96JI7	0.0	5054	2443	1.000	1.000	SPTCS_HUMAN Spatacsin OS=Homo sapiens OX=9606 GN=SPG11 PE=1 SV=3
8	D4HMK9	2.80e-135	461	1248	0.125	0.245	D4HMK9_DANRE Spatacsin isoform 2 OS=Danio rerio OX=7955 GN=spg11 PE=2 SV=1
9	F4JW20	9.23e-19	97.1	3184	0.041	0.031	F4JW20_ARATH Spatacsin carboxy-terminus protein OS=Arabidopsis thaliana OX=3702 GN=At4g39420 PE=1 SV=1
10	A0A8I6AI75	1.1	37.0	1157	0.014	0.029	A0A8I6AI75_RAT DNA helicase OS=Rattus norvegicus OX=10116 GN=Wrn PE=1 SV=1
11	F1LTH9	1.4	37.0	1400	0.014	0.024	F1LTH9_RAT DNA helicase OS=Rattus norvegicus OX=10116 GN=Wrn PE=1 SV=3
12	P9WN71	8.0	33.9	466	0.008	0.043	G6PD1_MYCTU Glucose-6-phosphate 1-dehydrogenase 1 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=zwf1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF14649 Spatacsin_C	3.2e-106	366.4	Spatacsin C-terminus

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000261866

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000297562	0.967	AP-5 complex subunit zeta-1
2	9606.ENSP00000251119	0.964	Zinc finger FYVE domain-containing protein 26
3	9606.ENSP00000481750	0.912	AP-5 complex subunit sigma-1
4	9606.ENSP00000454303	0.908	AP-5 complex subunit beta-1
5	9606.ENSP00000261558	0.848	AP-5 complex subunit mu-1
6	9606.ENSP00000416673	0.837	Protein PAT1 homolog 2
7	9606.ENSP00000264276	0.780	Alsin
8	9606.ENSP00000268704	0.773	Paraplegin
9	9606.ENSP00000480893	0.769	Spastin
10	9606.ENSP00000204566	0.749	Maspardin
11	9606.ENSP00000224140	0.714	Probable helicase senataxin
12	9606.ENSP00000346839	0.703	Fibronectin type III domain containing
13	9606.ENSP00000318016	0.690	WASH complex subunit 5
14	9606.ENSP00000346112	0.679	Solute carrier family 12 member 6
15	9606.ENSP00000417175	0.671	Vesicle-associated membrane protein-associated protein B/C
16	9606.ENSP00000438346	0.666	Receptor expression-enhancing protein 1
17	9606.ENSP00000219368	0.663	Fatty acid 2-hydroxylase
18	9606.ENSP00000261842	0.661	AP-4 complex subunit epsilon-1
19	9606.ENSP00000230124	0.660	Polyphosphoinositide phosphatase
20	9606.ENSP00000407509	0.653	Neuropathy target esterase

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0019901	1.000	protein kinase binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.996	cellular process
GO:0007033	0.981	vacuole organization
GO:0008152	0.977	metabolic process
GO:0030705	0.975	cytoskeleton-dependent intracellular transport
GO:0080171	0.954	lytic vacuole organization
GO:0007017	0.950	microtubule-based process
GO:0044237	0.949	cellular metabolic process
GO:0099111	0.945	microtubule-based transport
GO:0010970	0.940	transport along microtubule
GO:0008088	0.924	axo-dendritic transport
GO:0007040	0.892	lysosome organization
GO:0051640	0.860	organelle localization
GO:0061919	0.800	process utilizing autophagic mechanism
GO:0044248	0.742	cellular catabolic process
GO:0006914	0.713	autophagy
GO:0051648	0.685	vesicle localization
GO:0065007	0.673	biological regulation
GO:0097479	0.630	synaptic vesicle localization
GO:0050789	0.547	regulation of biological process
GO:0007154	0.468	cell communication
GO:0023052	0.398	signaling
GO:0050794	0.371	regulation of cellular process
GO:0016236	0.366	macroautophagy

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0016020	1.000	membrane
GO:0005829	0.996	cytosol
GO:0031981	0.996	nuclear lumen
GO:0043232	0.994	intracellular non-membrane-bounded organelle
GO:0071944	0.991	cell periphery
GO:0005886	0.984	plasma membrane
GO:0031090	0.970	organelle membrane
GO:0012505	0.931	endomembrane system
GO:0098588	0.898	bounding membrane of organelle
GO:0005730	0.817	nucleolus
GO:0000323	0.721	lytic vacuole
GO:0030054	0.709	cell junction
GO:0005764	0.698	lysosome
GO:0005774	0.692	vacuolar membrane
GO:0098852	0.659	lytic vacuole membrane
GO:0005765	0.631	lysosomal membrane
GO:0045202	0.585	synapse
GO:0005654	0.542	nucleoplasm
GO:0031410	0.471	cytoplasmic vesicle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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