StarFunc result for job id Q96K58

User Input

>input (619 residues)
MEVEAAEARSPAPGYKRSGRRYKCVSCTKTFPNAPRAARHAATHGPADCSEEVAEVKPKP
ETEAKAEEASGEKVSGSAAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRR
FMQPVCLRVHLASHAGELPFRCAHCPKAYGALSKLKIHQRGHTGERPYACADCGKSFADP
SVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLT
CHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQR
AHEGVKPYHCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSG
QRPFRCEECGRAFAERASLTKHSRVHSGERPFHCNACGKSFVVSSSLRKHERTHRSSEAA
GVPPAQELVVGLALPVGVAGESSAAPAAGAGLGDPPAGLLGLPPESGGVMATQWQVVGMT
VEHVECQDAGVREAPGPLEGAGEAGGEEADEKPPQFVCRECKETFSTMTLLRRHERSHPE
LRPFPCTQCGKSFSDRAGLRKHSRTHSSVRPYTCPHCPKAFLSASDLRKHERTHPVPMGT
PTPLEPLVALLGMPEEGPA

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q8K2R5	0.511	0.511	4.907E-100	619	0.919	0.919	Q8K2R5.pdb.gz	ZN668_MOUSE Zinc finger protein 668 OS=Mus musculus OX=10090 GN=Znf668 PE=2 SV=1
2	AFDB:E9Q981	0.454	0.443	3.957E-49	636	0.318	0.310	E9Q981.pdb.gz	E9Q981_MOUSE Zinc finger protein 976 OS=Mus musculus OX=10090 GN=Zfp976 PE=4 SV=1
3	AFDB:P51814	0.474	0.368	6.333E-49	821	0.317	0.239	P51814.pdb.gz	ZNF41_HUMAN Zinc finger protein 41 OS=Homo sapiens OX=9606 GN=ZNF41 PE=1 SV=2
4	AFDB:A0A0U1RQ46	0.441	0.447	1.014E-48	609	0.321	0.327	A0A0U1RQ46.pdb.gz	A0A0U1RQ46_MOUSE Zinc finger protein 950 OS=Mus musculus OX=10090 GN=Zfp950 PE=4 SV=1
5	AFDB:E9QAG8	0.413	0.468	1.014E-48	526	0.292	0.344	E9QAG8.pdb.gz	ZN431_MOUSE Zinc finger protein 431 OS=Mus musculus OX=10090 GN=Znf431 PE=1 SV=1
6	AFDB:Q3KP31	0.346	0.368	2.308E-48	576	0.325	0.349	Q3KP31.pdb.gz	ZN791_HUMAN Zinc finger protein 791 OS=Homo sapiens OX=9606 GN=ZNF791 PE=1 SV=1
7	AFDB:Q6ECI4	0.504	0.447	5.575E-48	717	0.326	0.282	Q6ECI4.pdb.gz	ZN470_HUMAN Zinc finger protein 470 OS=Homo sapiens OX=9606 GN=ZNF470 PE=2 SV=3
8	AFDB:Q9R164	0.446	0.398	7.933E-48	701	0.331	0.292	Q9R164.pdb.gz	Q9R164_MOUSE Zinc finger protein 111 OS=Mus musculus OX=10090 GN=Zfp111 PE=2 SV=1
9	AFDB:Q5TYW1	0.456	0.285	1.270E-47	1059	0.331	0.194	Q5TYW1.pdb.gz	ZN658_HUMAN Zinc finger protein 658 OS=Homo sapiens OX=9606 GN=ZNF658 PE=1 SV=2
10	AFDB:Q9UEG4	0.433	0.322	4.627E-47	869	0.339	0.242	Q9UEG4.pdb.gz	ZN629_HUMAN Zinc finger protein 629 OS=Homo sapiens OX=9606 GN=ZNF629 PE=1 SV=2
11	PDB:3w5kB	0.082	0.262	4.255E-5	110	0.069	0.391	3w5kB.pdb.gz	Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin beta.
12	PDB:6o9lQ	0.050	0.059	4.598E-1	430	0.099	0.142	6o9lQ.pdb.gz	Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
13	PDB:7ena4	0.079	0.094	4.598E-1	457	0.061	0.083	7ena4.pdb.gz	Structures of the human Mediator and Mediator-bound preinitiation complex.
14	PDB:7o4iW	0.060	0.102	9.873E-1	312	0.061	0.122	7o4iW.pdb.gz	Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening.
15	PDB:5c8dE	0.060	0.102	1.047	280	0.050	0.111	5c8dE.pdb.gz	Structural basis for gene regulation by a B12-dependent photoreceptor.
16	PDB:7uhyC	0.065	0.067	1.325	578	0.063	0.067	7uhyC.pdb.gz	Structure of the nutrient-sensing hub GATOR2.
17	PDB:5aj0Ap	0.043	0.167	1.405	91	0.023	0.154	5aj0Ap.pdb.gz	Structural Snapshots of Actively Translating Human Ribosomes
18	PDB:7k041	0.065	0.077	1.490	487	0.061	0.078	7k041.pdb.gz	Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair.
19	PDB:7evoC	0.072	0.092	1.777	422	0.040	0.059	7evoC.pdb.gz	Structural Insights into Branch Site Proofreading by Human Spliceosome.
20	PDB:7dvqM	0.036	0.096	2.120	191	0.055	0.178	7dvqM.pdb.gz	Structure of the activated human minor spliceosome.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q8K2R5	0.0	1153	619	0.919	0.919	ZN668_MOUSE Zinc finger protein 668 OS=Mus musculus OX=10090 GN=Znf668 PE=2 SV=1
2	Q96K58	0.0	1243	619	1.000	1.000	ZN668_HUMAN Zinc finger protein 668 OS=Homo sapiens OX=9606 GN=ZNF668 PE=1 SV=4
3	Q8TAQ5	9.29e-124	383	688	0.344	0.310	ZN420_HUMAN Zinc finger protein 420 OS=Homo sapiens OX=9606 GN=ZNF420 PE=1 SV=1
4	A0A0U1RQ46	1.35e-123	380	609	0.323	0.328	A0A0U1RQ46_MOUSE Zinc finger protein 950 OS=Mus musculus OX=10090 GN=Zfp950 PE=4 SV=1
5	Q9P2J8	5.42e-123	386	865	0.344	0.246	ZN624_HUMAN Zinc finger protein 624 OS=Homo sapiens OX=9606 GN=ZNF624 PE=1 SV=3
6	Q8BLA2	6.57e-123	377	578	0.344	0.369	Q8BLA2_MOUSE C2H2-type domain-containing protein OS=Mus musculus OX=10090 GN=Zfp420 PE=2 SV=1
7	Q7TMN8	6.94e-123	377	578	0.344	0.369	Q7TMN8_MOUSE Zfp420 protein OS=Mus musculus OX=10090 GN=Zfp420 PE=1 SV=1
8	P51523	1.23e-120	376	738	0.354	0.297	ZNF84_HUMAN Zinc finger protein 84 OS=Homo sapiens OX=9606 GN=ZNF84 PE=1 SV=2
9	A0A087WSF4	2.15e-120	372	635	0.323	0.315	A0A087WSF4_MOUSE Zinc finger protein 976 OS=Mus musculus OX=10090 GN=Zfp976 PE=4 SV=1
10	E9Q981	2.15e-120	372	636	0.323	0.314	E9Q981_MOUSE Zinc finger protein 976 OS=Mus musculus OX=10090 GN=Zfp976 PE=4 SV=1
11	Q99PJ6	1.57e-119	374	736	0.312	0.262	Q99PJ6_RAT RCG38839 OS=Rattus norvegicus OX=10116 GN=Zfp709 PE=2 SV=1
12	Q5TYW1	1.60e-119	382	1059	0.334	0.195	ZN658_HUMAN Zinc finger protein 658 OS=Homo sapiens OX=9606 GN=ZNF658 PE=1 SV=2
13	Q8IYB9	4.32e-119	370	648	0.307	0.293	ZN595_HUMAN Zinc finger protein 595 OS=Homo sapiens OX=9606 GN=ZNF595 PE=1 SV=2
14	Q14587	1.35e-118	377	947	0.354	0.231	ZN268_HUMAN Zinc finger protein 268 OS=Homo sapiens OX=9606 GN=ZNF268 PE=1 SV=2
15	Q6ZN57	1.76e-116	357	461	0.247	0.332	ZFP2_HUMAN Zinc finger protein ZFP2 OS=Homo sapiens OX=9606 GN=ZFP2 PE=1 SV=1
16	P17038	3.50e-116	367	809	0.344	0.263	ZNF43_HUMAN Zinc finger protein 43 OS=Homo sapiens OX=9606 GN=ZNF43 PE=2 SV=4
17	Q9UJW7	9.88e-116	366	825	0.326	0.245	ZN229_HUMAN Zinc finger protein 229 OS=Homo sapiens OX=9606 GN=ZNF229 PE=1 SV=4
18	Q5MCW4	1.59e-115	362	686	0.305	0.276	ZN569_HUMAN Zinc finger protein 569 OS=Homo sapiens OX=9606 GN=ZNF569 PE=1 SV=1
19	E9QAG8	3.10e-115	355	526	0.291	0.342	ZN431_MOUSE Zinc finger protein 431 OS=Mus musculus OX=10090 GN=Znf431 PE=1 SV=1
20	Q86WZ6	5.12e-115	363	799	0.328	0.254	ZN227_HUMAN Zinc finger protein 227 OS=Homo sapiens OX=9606 GN=ZNF227 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16204 BDHCT_assoc	13	16.9	BDHCT-box associated domain on Bloom syndrome protein
2	PF07975 C1_4	1.6	20.4	TFIIH C1-like domain
3	PF20026 DUF6434	1.1e+02	14.3	Domain of unknown function (DUF6434)
4	PF07754 HVO_2753_ZBP	43	15.3	Small zinc finger protein HVO_2753-like, Zn-binding pocket
5	PF01155 HypA	2.3e+02	13.2	Hydrogenase/urease nickel incorporation, metallochaperone, hypA
6	PF14149 YhfH	4e+02	12.4	YhfH-like protein
7	PF01428 zf-AN1	0.3	22.6	AN1-like Zinc finger
8	PF00096 zf-C2H2	2.2e-70	240.5	Zinc finger, C2H2 type
9	PF16622 zf-C2H2_11	0.0013	29.8	zinc-finger C2H2-type
10	PF13894 zf-C2H2_4	5.9e-53	183.9	C2H2-type zinc finger
11	PF13912 zf-C2H2_6	3.5e-12	57.3	C2H2-type zinc finger
12	PF12171 zf-C2H2_jaz	1.3e-26	103.5	Zinc-finger double-stranded RNA-binding
13	PF13913 zf-C2HC_2	47	15.3	zinc-finger of a C2HC-type
14	PF13465 zf-H2C2_2	7.2e-87	293.5	Zinc-finger double domain
15	PF13909 zf-H2C2_5	4.9e+02	11.9	C2H2-type zinc-finger domain
16	PF08790 zf-LYAR	0.093	23.9	LYAR-type C2HC zinc finger
17	PF12874 zf-met	0.0041	28.7	Zinc-finger of C2H2 type
18	PF18439 zf_UBZ	1.1e-08	45.8	Ubiquitin-Binding Zinc Finger
19	PF17032 zinc_ribbon_15	2.5	20.2	zinc-ribbon family
20	PF09723 Zn-ribbon_8	9.2e-05	33.8	Zinc ribbon domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000442573

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000340330	0.791	Histone acetyltransferase KAT5
2	9606.ENSP00000358071	0.768	SEC23-interacting protein
3	9606.ENSP00000296292	0.694	Protein RFT1 homolog
4	9606.ENSP00000352021	0.675	Nucleolar protein 12
5	9606.ENSP00000265000	0.634	N-acetylgalactosaminyltransferase 7
6	9606.ENSP00000444850	0.609	General vesicular transport factor p115
7	9606.ENSP00000482282	0.603	Uncharacterized protein C8orf31
8	9606.ENSP00000300811	0.600	Zinc finger protein 428
9	9606.ENSP00000310042	0.563	Zinc finger protein 622
10	9606.ENSP00000348527	0.543	Centromere protein L
11	9606.ENSP00000262109	0.526	Glutamate-rich protein 1
12	9606.ENSP00000355812	0.520	FGFR1 oncogene partner
13	9606.ENSP00000296930	0.519	Nucleophosmin
14	9606.ENSP00000369519	0.515	S-methyl-5'-thioadenosine phosphorylase

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.998	protein binding
GO:0097159	0.909	organic cyclic compound binding
GO:1901363	0.908	heterocyclic compound binding
GO:0003676	0.891	nucleic acid binding
GO:1990837	0.438	sequence-specific double-stranded DNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050789	0.998	regulation of biological process
GO:0050794	0.989	regulation of cellular process
GO:0019222	0.950	regulation of metabolic process
GO:0080090	0.933	regulation of primary metabolic process
GO:0031323	0.896	regulation of cellular metabolic process
GO:0048519	0.866	negative regulation of biological process
GO:0051171	0.866	regulation of nitrogen compound metabolic process
GO:0048523	0.862	negative regulation of cellular process
GO:0060255	0.858	regulation of macromolecule metabolic process
GO:0051252	0.844	regulation of RNA metabolic process
GO:0031326	0.838	regulation of cellular biosynthetic process
GO:0009892	0.837	negative regulation of metabolic process
GO:0010556	0.837	regulation of macromolecule biosynthetic process
GO:0006355	0.826	regulation of DNA-templated transcription
GO:0009987	0.816	cellular process
GO:0031324	0.752	negative regulation of cellular metabolic process
GO:0006357	0.717	regulation of transcription by RNA polymerase II
GO:0051172	0.615	negative regulation of nitrogen compound metabolic process
GO:0010605	0.533	negative regulation of macromolecule metabolic process
GO:0048518	0.532	positive regulation of biological process
GO:0071704	0.457	organic substance metabolic process
GO:0044238	0.419	primary metabolic process
GO:0044237	0.419	cellular metabolic process
GO:0048522	0.398	positive regulation of cellular process
GO:0043170	0.395	macromolecule metabolic process
GO:0006807	0.384	nitrogen compound metabolic process
GO:0010558	0.302	negative regulation of macromolecule biosynthetic process
GO:0031327	0.301	negative regulation of cellular biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005634	0.999	nucleus
GO:0005654	0.991	nucleoplasm
GO:0005829	0.901	cytosol
GO:0043228	0.774	non-membrane-bounded organelle
GO:0043232	0.726	intracellular non-membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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