StarFunc result for job id Q96LT7

User Input

>input (481 residues)
MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEIT
FLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTE
LSFYLPLHRVCVDRLTHIIRKGRIWMHKERQENVQKIILEGTERMEDQGQSIIPMLTGEV
IPVMELLSSMKSHSVPEEIDIADTVLNDDDIGDSCHEGFLLNAISSHLQTCGCSVVVGSS
AEKVNKIVRTLCLFLTPAERKCSRLCEAESSFKYESGLFVQGLLKDSTGSFVLPFRQVMY
APYPTTHIDVDVNTVKQMPPCHEHIYNQRRYMRSELTAFWRATSEEDMAQDTIIYTDESF
TPDLNIFQDVLHRDTLVKAFLDQVFQLKPGLSLRSTFLAQFLLVLHRKALTLIKYIEDDT
QKGKKPFKSLRNLKIDLDLTAEGDLNIIMALAEKIKPGLHSFIFGRPFYTSVQERDVLMT
F

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A2R8Y5K2	0.961	0.940	1.647E-77	492	1.000	0.978	A0A2R8Y5K2.pdb.gz	A0A2R8Y5K2_HUMAN C9orf72-SMCR8 complex subunit OS=Homo sapiens OX=9606 GN=C9orf72 PE=1 SV=1
2	AFDB:Q6TLH8	0.941	0.979	2.052E-67	462	0.730	0.760	Q6TLH8.pdb.gz	Q6TLH8_DANRE Guanine nucleotide exchange C9orf72 homolog OS=Danio rerio OX=7955 GN=C9orf72 PE=1 SV=1
3	PDB:7o2wA	0.811	0.928	9.863E-51	418	0.869	1.000	7o2wA.pdb.gz
4	PDB:6lt0C	0.783	0.975	5.058E-50	385	0.796	0.995	6lt0C.pdb.gz
5	PDB:7mgeC	0.731	0.957	5.812E-46	365	0.755	0.995	7mgeC.pdb.gz	Structural basis for the ARF GAP activity and specificity of the C9orf72 complex.
6	PDB:6v4uA	0.526	0.682	3.983E-26	356	0.715	0.966	6v4uA.pdb.gz
7	AFDB:Q9VS33	0.240	0.249	9.473E-9	460	0.141	0.148	Q9VS33.pdb.gz	Q9VS33_DROME Folliculin OS=Drosophila melanogaster OX=7227 GN=BHD PE=2 SV=1
8	PDB:6ulgL	0.257	0.268	2.473E-7	458	0.116	0.122	6ulgL.pdb.gz	Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.
9	AFDB:Q76JQ2	0.272	0.233	2.492E-7	579	0.156	0.130	Q76JQ2.pdb.gz	FLCN_RAT Folliculin OS=Rattus norvegicus OX=10116 GN=Flcn PE=1 SV=1
10	PDB:6nzdH	0.261	0.314	3.916E-7	387	0.110	0.137	6nzdH.pdb.gz	Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
11	PDB:8dhbJ	0.241	0.309	5.321E-7	361	0.114	0.152	8dhbJ.pdb.gz	Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.
12	AFDB:Q9ULE3	0.220	0.125	1.827E-6	1009	0.110	0.053	Q9ULE3.pdb.gz	DEN2A_HUMAN DENN domain-containing protein 2A OS=Homo sapiens OX=9606 GN=DENND2A PE=1 SV=4
13	PDB:6ulgN	0.363	0.362	3.523E-6	483	0.121	0.120	6ulgN.pdb.gz	Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.
14	AFDB:O42907	0.202	0.215	3.550E-6	448	0.104	0.112	O42907.pdb.gz	YBAG_SCHPO Uncharacterized protein C119.16c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC119.16c PE=4 SV=1
15	AFDB:Q8IWF6	0.215	0.182	5.918E-6	608	0.154	0.122	Q8IWF6.pdb.gz	DEN6A_HUMAN Protein DENND6A OS=Homo sapiens OX=9606 GN=DENND6A PE=1 SV=1
16	AFDB:Q12500	0.210	0.146	9.864E-6	764	0.112	0.071	Q12500.pdb.gz	AVL9_YEAST Late secretory pathway protein AVL9 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=AVL9 PE=1 SV=1
17	PDB:6nzdI	0.309	0.363	1.141E-5	388	0.123	0.152	6nzdI.pdb.gz	Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
18	AFDB:Q8TCE6	0.267	0.338	1.210E-5	357	0.104	0.140	Q8TCE6.pdb.gz	DEN10_HUMAN DENN domain-containing protein 10 OS=Homo sapiens OX=9606 GN=DENND10 PE=1 SV=1
19	AFDB:P34239	0.338	0.214	1.410E-5	828	0.081	0.047	P34239.pdb.gz	LST4_YEAST Protein LST4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=LST4 PE=1 SV=1
20	PDB:6v4uB	0.256	0.289	2.106E-5	421	0.156	0.178	6v4uB.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A2R8Y5K2	0.0	988	492	1.000	0.978	A0A2R8Y5K2_HUMAN C9orf72-SMCR8 complex subunit OS=Homo sapiens OX=9606 GN=C9orf72 PE=1 SV=1
2	A0A2R8Y5U5	0.0	762	373	0.757	0.976	A0A2R8Y5U5_HUMAN C9orf72-SMCR8 complex subunit OS=Homo sapiens OX=9606 GN=C9orf72 PE=1 SV=1
3	Q6DFW0	0.0	987	481	0.981	0.981	CI072_MOUSE Guanine nucleotide exchange factor C9orf72 homolog OS=Mus musculus OX=10090 GN=C9orf72 PE=1 SV=2
4	Q6TLH8	0.0	749	462	0.730	0.760	Q6TLH8_DANRE Guanine nucleotide exchange C9orf72 homolog OS=Danio rerio OX=7955 GN=C9orf72 PE=1 SV=1
5	Q96LT7	0.0	998	481	1.000	1.000	CI072_HUMAN Guanine nucleotide exchange factor C9orf72 OS=Homo sapiens OX=9606 GN=C9orf72 PE=1 SV=2
6	O42951	0.050	37.7	231	0.044	0.091	PABC_SCHPO Putative aminodeoxychorismate lyase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC19G7.02 PE=3 SV=1
7	Q7TP58	0.19	36.6	395	0.058	0.071	Q7TP58_RAT Phosphoglycerate mutase OS=Rattus norvegicus OX=10116 GN=Bpgm PE=1 SV=1
8	A8MS82	0.32	36.2	729	0.081	0.053	A8MS82_ARATH HCO3-transporter family OS=Arabidopsis thaliana OX=3702 GN=BOR1 PE=1 SV=1
9	A0A1D8PRT2	4.8	32.3	537	0.042	0.037	A0A1D8PRT2_CANAL Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=VHR1 PE=4 SV=1
10	A4Q9E5	9.8	31.2	927	0.044	0.023	TTLL3_MOUSE Tubulin monoglycylase TTLL3 OS=Mus musculus OX=10090 GN=Ttll3 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF15019 C9orf72-like	2.2e-84	294.4	C9orf72-like protein family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000482753

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000296679	0.999	WD repeat-containing protein 41
2	9606.ENSP00000385025	0.999	Guanine nucleotide exchange protein SMCR8
3	9606.ENSP00000387286	0.993	Ras-related protein Rab-1A
4	9606.ENSP00000025008	0.983	RB1-inducible coiled-coil protein 1
5	9606.ENSP00000338990	0.977	Autophagy-related protein 101
6	9606.ENSP00000324560	0.976	Serine/threonine-protein kinase ULK1
7	9606.ENSP00000432412	0.971	Autophagy-related protein 13
8	9606.ENSP00000254108	0.944	RNA-binding protein FUS
9	9606.ENSP00000358466	0.944	Ras-related protein Rab-39B
10	9606.ENSP00000240185	0.908	TAR DNA-binding protein 43
11	9606.ENSP00000300935	0.908	Ras-related protein Rab-8A
12	9606.ENSP00000432660	0.895	Cofilin-1
13	9606.ENSP00000270142	0.890	Superoxide dismutase [Cu-Zn]
14	9606.ENSP00000351777	0.878	Transitional endoplasmic reticulum ATPase
15	9606.ENSP00000053867	0.865	Granulins
16	9606.ENSP00000340820	0.862	Microtubule-associated protein tau
17	9606.ENSP00000345195	0.859	Ubiquilin-2
18	9606.ENSP00000368022	0.859	Optineurin
19	9606.ENSP00000263780	0.858	Charged multivesicular body protein 2b
20	9606.ENSP00000265062	0.853	Ras-related protein Rab-7a

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0031267	1.000	small GTPase binding
GO:0140677	0.996	molecular function activator activity
GO:0030695	0.995	GTPase regulator activity
GO:0005085	0.994	guanyl-nucleotide exchange factor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.991	cellular process
GO:0031323	0.988	regulation of cellular metabolic process
GO:0048519	0.987	negative regulation of biological process
GO:0009894	0.985	regulation of catabolic process
GO:0032006	0.985	regulation of TOR signaling
GO:0031329	0.984	regulation of cellular catabolic process
GO:0033043	0.983	regulation of organelle organization
GO:0060255	0.979	regulation of macromolecule metabolic process
GO:0080090	0.964	regulation of primary metabolic process
GO:0051171	0.964	regulation of nitrogen compound metabolic process
GO:0071840	0.952	cellular component organization or biogenesis
GO:0048523	0.945	negative regulation of cellular process
GO:0016043	0.943	cellular component organization
GO:0010506	0.943	regulation of autophagy
GO:0051179	0.942	localization
GO:0051174	0.925	regulation of phosphorus metabolic process
GO:0051246	0.925	regulation of protein metabolic process
GO:0065009	0.924	regulation of molecular function
GO:0042325	0.911	regulation of phosphorylation
GO:0008152	0.894	metabolic process
GO:0006810	0.890	transport
GO:0032970	0.889	regulation of actin filament-based process
GO:1902903	0.889	regulation of supramolecular fiber organization
GO:0009892	0.888	negative regulation of metabolic process
GO:0031399	0.885	regulation of protein modification process
GO:1903432	0.879	regulation of TORC1 signaling
GO:0016049	0.875	cell growth
GO:0001932	0.868	regulation of protein phosphorylation
GO:0010605	0.852	negative regulation of macromolecule metabolic process
GO:0032501	0.848	multicellular organismal process
GO:0032502	0.842	developmental process
GO:0031324	0.839	negative regulation of cellular metabolic process
GO:0031331	0.835	positive regulation of cellular catabolic process
GO:0048856	0.830	anatomical structure development
GO:0044237	0.807	cellular metabolic process
GO:0032956	0.804	regulation of actin cytoskeleton organization
GO:0051172	0.787	negative regulation of nitrogen compound metabolic process
GO:0007275	0.770	multicellular organism development
GO:0051336	0.766	regulation of hydrolase activity
GO:0046907	0.758	intracellular transport
GO:0022607	0.752	cellular component assembly
GO:0048731	0.726	system development
GO:0010563	0.726	negative regulation of phosphorus metabolic process
GO:0007399	0.719	nervous system development
GO:0048869	0.716	cellular developmental process
GO:0042326	0.716	negative regulation of phosphorylation
GO:0031400	0.713	negative regulation of protein modification process
GO:0030154	0.712	cell differentiation
GO:0120036	0.711	plasma membrane bounded cell projection organization
GO:0048468	0.693	cell development
GO:0001933	0.691	negative regulation of protein phosphorylation
GO:0031175	0.656	neuron projection development
GO:0048812	0.647	neuron projection morphogenesis
GO:0061564	0.645	axon development
GO:0048675	0.641	axon extension
GO:0010508	0.639	positive regulation of autophagy
GO:0110053	0.632	regulation of actin filament organization
GO:0006996	0.601	organelle organization
GO:0044093	0.464	positive regulation of molecular function
GO:0044087	0.423	regulation of cellular component biogenesis
GO:0043085	0.421	positive regulation of catalytic activity
GO:0044088	0.375	regulation of vacuole organization
GO:0071704	0.367	organic substance metabolic process
GO:0009056	0.344	catabolic process
GO:0050896	0.342	response to stimulus
GO:0061919	0.331	process utilizing autophagic mechanism
GO:0070925	0.305	organelle assembly

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0043231	0.999	intracellular membrane-bounded organelle
GO:0090543	0.967	Flemming body
GO:0005576	0.959	extracellular region
GO:0005634	0.941	nucleus
GO:0016020	0.923	membrane
GO:0005615	0.824	extracellular space
GO:0032991	0.756	protein-containing complex
GO:0042995	0.621	cell projection
GO:0120025	0.610	plasma membrane bounded cell projection
GO:0043005	0.600	neuron projection
GO:0070013	0.592	intracellular organelle lumen
GO:0036477	0.581	somatodendritic compartment
GO:0012505	0.529	endomembrane system
GO:0044297	0.459	cell body
GO:0031982	0.437	vesicle
GO:0005886	0.421	plasma membrane
GO:1903561	0.417	extracellular vesicle
GO:0005654	0.402	nucleoplasm
GO:0070062	0.397	extracellular exosome
GO:0005773	0.387	vacuole
GO:0043025	0.379	neuronal cell body
GO:0098588	0.363	bounding membrane of organelle
GO:0043232	0.349	intracellular non-membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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