StarFunc result for job id Q96PV0

User Input

>input (1343 residues)
MSRSRASIHRGSIPAMSYAPFRDVRGPSMHRTQYVHSPYDRPGWNPRFCIISGNQLLMLD
EDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHLGRSRRKSVPGGKQYSMEG
APAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKES
HSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERD
KWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRS
ASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTE
QWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEF
AEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMERE
HLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQ
ANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCP
AIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSM
QQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLND
ISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLNSS
MDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKS
VSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSIT
AAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHH
HHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRR
QLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSA
AQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQT
PSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEE
EIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIK
SIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAP
PAPPPPPRLQITENGEFRNTADH

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:E7F1U4	0.417	0.373	0.000	1507	0.637	0.567	E7F1U4.pdb.gz	E7F1U4_DANRE Ras/Rap GTPase-activating protein SynGAP1b OS=Danio rerio OX=7955 GN=si:dkey-246f6.1 PE=1 SV=4
2	AFDB:Q96PV0	1.000	1.000	0.000	1343	1.000	1.000	Q96PV0.pdb.gz	SYGP1_HUMAN Ras/Rap GTPase-activating protein SynGAP OS=Homo sapiens OX=9606 GN=SYNGAP1 PE=1 SV=4
3	AFDB:E9QHX3	0.409	0.440	2.282E-102	1246	0.577	0.622	E9QHX3.pdb.gz
4	AFDB:Q3UHC7	0.440	0.491	5.791E-88	1189	0.458	0.517	Q3UHC7.pdb.gz	DAB2P_MOUSE Disabled homolog 2-interacting protein OS=Mus musculus OX=10090 GN=Dab2ip PE=1 SV=1
5	AFDB:E9PW37	0.427	0.444	8.632E-82	1286	0.423	0.442	E9PW37.pdb.gz	E9PW37_MOUSE RAS protein activator like 2 OS=Mus musculus OX=10090 GN=Rasal2 PE=1 SV=1
6	PDB:7pgrN	0.195	0.113	1.439E-12	2423	0.061	0.034	7pgrN.pdb.gz	The structure of neurofibromin isoform 2 reveals different functional states.
7	PDB:7mp5A	0.190	0.157	5.732E-12	1629	0.053	0.044	7mp5A.pdb.gz
8	PDB:7r04A	0.202	0.120	2.283E-11	2326	0.060	0.034	7r04A.pdb.gz	Structural basis of activation of the tumor suppressor protein neurofibromin.
9	PDB:7r03B	0.189	0.115	2.647E-11	2246	0.057	0.034	7r03B.pdb.gz
10	PDB:7r04B	0.187	0.114	9.553E-11	2229	0.055	0.033	7r04B.pdb.gz	Structural basis of activation of the tumor suppressor protein neurofibromin.
11	PDB:1cjyA	0.085	0.168	2.885E-6	633	0.031	0.065	1cjyA.pdb.gz	Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism.
12	PDB:6pyuA	0.074	0.103	6.676E-6	930	0.045	0.066	6pyuA.pdb.gz	Design of selective PI3K delta inhibitors using an iterative scaffold-hopping workflow.
13	PDB:7lq1A	0.075	0.103	2.409E-5	950	0.046	0.065	7lq1A.pdb.gz	Discovery of a new series of PI3K-delta inhibitors from Virtual Screening.
14	PDB:4rj9A	0.073	0.503	3.295E-4	161	0.015	0.124	4rj9A.pdb.gz
15	PDB:6kz8A	0.077	0.129	3.462E-4	784	0.017	0.029	6kz8A.pdb.gz	Crystal structure of plant PLD alpha 1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D.
16	AFDB:Q96JE7	0.055	0.063	3.945E-4	1060	0.137	0.174	Q96JE7.pdb.gz	SC16B_HUMAN Protein transport protein Sec16B OS=Homo sapiens OX=9606 GN=SEC16B PE=1 SV=2
17	AFDB:Q13233	0.056	0.051	5.049E-4	1512	0.107	0.095	Q13233.pdb.gz	M3K1_HUMAN Mitogen-activated protein kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP3K1 PE=1 SV=4
18	AFDB:A1Z7G7	0.053	0.048	6.463E-4	1697	0.126	0.100	A1Z7G7.pdb.gz	LPHN_DROME Latrophilin Cirl OS=Drosophila melanogaster OX=7227 GN=Cirl PE=1 SV=2
19	AFDB:A0A5F8MPU3	0.085	0.053	9.592E-4	2282	0.098	0.058	A0A5F8MPU3.pdb.gz	CTSRT_MOUSE Cation channel sperm-associated targeting subunit tau OS=Mus musculus OX=10090 GN=C2cd6 PE=1 SV=1
20	AFDB:P17672	0.057	0.056	3.636E-3	1355	0.087	0.086	P17672.pdb.gz	E75BA_DROME Ecdysone-induced protein 75B, isoform A OS=Drosophila melanogaster OX=7227 GN=Eip75B PE=2 SV=2

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	D3YUS5	0.0	885	1261	0.360	0.384	D3YUS5_MOUSE RAS protein activator like 2 OS=Mus musculus OX=10090 GN=Rasal2 PE=1 SV=1
2	E7F1U4	0.0	1405	1507	0.587	0.524	E7F1U4_DANRE Ras/Rap GTPase-activating protein SynGAP1b OS=Danio rerio OX=7955 GN=si:dkey-246f6.1 PE=1 SV=4
3	E9PW37	0.0	877	1286	0.360	0.376	E9PW37_MOUSE RAS protein activator like 2 OS=Mus musculus OX=10090 GN=Rasal2 PE=1 SV=1
4	F6SEU4	0.0	2722	1340	0.990	0.993	SYGP1_MOUSE Ras/Rap GTPase-activating protein SynGAP OS=Mus musculus OX=10090 GN=Syngap1 PE=1 SV=2
5	Q0VAV5	0.0	874	1268	0.360	0.381	Q0VAV5_MOUSE RAS protein activator like 2 OS=Mus musculus OX=10090 GN=Rasal2 PE=2 SV=1
6	Q3UHC7	0.0	1066	1189	0.465	0.526	DAB2P_MOUSE Disabled homolog 2-interacting protein OS=Mus musculus OX=10090 GN=Dab2ip PE=1 SV=1
7	Q5VWQ8	0.0	1069	1189	0.462	0.521	DAB2P_HUMAN Disabled homolog 2-interacting protein OS=Homo sapiens OX=9606 GN=DAB2IP PE=1 SV=2
8	Q6P730	0.0	880	996	0.390	0.526	DAB2P_RAT Disabled homolog 2-interacting protein OS=Rattus norvegicus OX=10116 GN=Dab2ip PE=1 SV=1
9	Q96PV0	0.0	2754	1343	1.000	1.000	SYGP1_HUMAN Ras/Rap GTPase-activating protein SynGAP OS=Homo sapiens OX=9606 GN=SYNGAP1 PE=1 SV=4
10	Q9QUH6	0.0	2635	1308	0.958	0.983	SYGP1_RAT Ras/Rap GTPase-activating protein SynGAP OS=Rattus norvegicus OX=10116 GN=Syngap1 PE=1 SV=2
11	Q9UJF2	0.0	957	1139	0.433	0.510	NGAP_HUMAN Ras GTPase-activating protein nGAP OS=Homo sapiens OX=9606 GN=RASAL2 PE=1 SV=2
12	Q8T498	1.38e-138	464	1580	0.194	0.165	GAP2_DROME Ras GTPase-activating protein raskol OS=Drosophila melanogaster OX=7227 GN=raskol PE=1 SV=3
13	Q8MLZ5	3.08e-133	442	1207	0.168	0.186	GAP2_CAEEL Ras GTPase-activating protein gap-2 OS=Caenorhabditis elegans OX=6239 GN=gap-2 PE=2 SV=2
14	Q86YV0	1.51e-121	405	1011	0.193	0.256	RASL3_HUMAN RAS protein activator like-3 OS=Homo sapiens OX=9606 GN=RASAL3 PE=1 SV=2
15	Q8BU92	7.14e-100	326	383	0.127	0.446	Q8BU92_MOUSE Uncharacterized protein (Fragment) OS=Mus musculus OX=10090 GN=Rasal2 PE=2 SV=2
16	D3YWZ9	3.13e-85	283	323	0.115	0.477	D3YWZ9_MOUSE RAS protein activator like 2 (Fragment) OS=Mus musculus OX=10090 GN=Rasal2 PE=1 SV=1
17	D3Z1T6	7.35e-56	193	176	0.077	0.585	D3Z1T6_MOUSE RAS protein activator like 2 (Fragment) OS=Mus musculus OX=10090 GN=Rasal2 PE=1 SV=1
18	Q54Y08	1.67e-38	158	877	0.073	0.112	NGAP_DICDI Probable Ras GTPase-activating-like protein ngap OS=Dictyostelium discoideum OX=44689 GN=ngap PE=2 SV=1
19	E9PYG6	4.49e-36	151	1038	0.100	0.129	E9PYG6_MOUSE RAS p21 protein activator 1 OS=Mus musculus OX=10090 GN=Rasa1 PE=1 SV=1
20	P50904	5.47e-36	151	1038	0.100	0.129	RASA1_RAT Ras GTPase-activating protein 1 OS=Rattus norvegicus OX=10116 GN=Rasa1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00168 C2	0.00013	33.5	C2 domain
2	PF12004 DUF3498	8.1e-190	644.0	Domain of unknown function (DUF3498)
3	PF02601 Exonuc_VII_L	80	14.2	Exonuclease VII, large subunit
4	PF00169 PH	0.23	23.3	PH domain
5	PF08458 PH_2	1.7e+02	14.0	Plant pleckstrin homology-like region
6	PF15406 PH_6	3.7e+02	12.8	Pleckstrin homology domain
7	PF00616 RasGAP	4.5e-24	96.9	GTPase-activator protein for Ras-like GTPase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000403636

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000382428	0.995	Disks large homolog 4
2	9606.ENSP00000477455	0.982	Glutamate receptor ionotropic, NMDA 2B
3	9606.ENSP00000407586	0.958	GTPase HRas
4	9606.ENSP00000439807	0.949	Multiple PDZ domain protein
5	9606.ENSP00000263925	0.943	E3 ubiquitin-protein ligase LNX
6	9606.ENSP00000360608	0.917	Glutamate receptor ionotropic, NMDA 1
7	9606.ENSP00000363480	0.912	Disks large homolog 3
8	9606.ENSP00000324560	0.883	Serine/threonine-protein kinase ULK1
9	9606.ENSP00000365272	0.873	Disks large homolog 2
10	9606.ENSP00000379818	0.867	Glutamate receptor ionotropic, NMDA 2A
11	9606.ENSP00000378914	0.856	Serine/threonine-protein kinase ULK2
12	9606.ENSP00000428994	0.835	Glutamate receptor 1
13	9606.ENSP00000379098	0.828	Calcium/calmodulin-dependent protein kinase type II subunit beta
14	9606.ENSP00000400258	0.828	Disks large-associated protein 2
15	9606.ENSP00000469689	0.811	SH3 and multiple ankyrin repeat domains protein 2
16	9606.ENSP00000293441	0.795	SH3 and multiple ankyrin repeat domains protein 1
17	9606.ENSP00000379712	0.791	IQ motif and SEC7 domain-containing protein 2
18	9606.ENSP00000334382	0.785	Homer protein homolog 1
19	9606.ENSP00000256078	0.783	GTPase KRas
20	9606.ENSP00000316377	0.773	Disks large-associated protein 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005096	1.000	GTPase activator activity
GO:0019899	0.766	enzyme binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0023051	0.988	regulation of signaling
GO:0010646	0.988	regulation of cell communication
GO:1902531	0.977	regulation of intracellular signal transduction
GO:0048523	0.961	negative regulation of cellular process
GO:0048167	0.959	regulation of synaptic plasticity
GO:0009987	0.875	cellular process
GO:0051056	0.867	regulation of small GTPase mediated signal transduction
GO:0032501	0.847	multicellular organismal process
GO:0046580	0.790	negative regulation of Ras protein signal transduction
GO:0050896	0.784	response to stimulus
GO:0032502	0.730	developmental process
GO:0048856	0.672	anatomical structure development
GO:0007275	0.603	multicellular organism development
GO:0007154	0.500	cell communication
GO:0048731	0.500	system development
GO:0023052	0.472	signaling
GO:0051716	0.468	cellular response to stimulus
GO:0019222	0.426	regulation of metabolic process
GO:0060255	0.385	regulation of macromolecule metabolic process
GO:0071840	0.382	cellular component organization or biogenesis
GO:0007165	0.371	signal transduction
GO:0048518	0.356	positive regulation of biological process
GO:0016043	0.348	cellular component organization
GO:0080090	0.316	regulation of primary metabolic process
GO:0048522	0.307	positive regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043226	0.999	organelle
GO:0005829	0.999	cytosol
GO:0016020	0.996	membrane
GO:0043229	0.979	intracellular organelle
GO:0030054	0.978	cell junction
GO:0005886	0.975	plasma membrane
GO:0043232	0.956	intracellular non-membrane-bounded organelle
GO:0043227	0.893	membrane-bounded organelle
GO:0043231	0.819	intracellular membrane-bounded organelle
GO:0045202	0.809	synapse
GO:0032991	0.698	protein-containing complex
GO:0098984	0.682	neuron to neuron synapse
GO:0098978	0.679	glutamatergic synapse
GO:0099572	0.608	postsynaptic specialization
GO:0070013	0.488	intracellular organelle lumen
GO:0031981	0.409	nuclear lumen
GO:0032279	0.385	asymmetric synapse
GO:0120025	0.384	plasma membrane bounded cell projection
GO:0036477	0.345	somatodendritic compartment
GO:0043005	0.343	neuron projection
GO:0005654	0.336	nucleoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]