StarFunc result for job id Q96QK1

User Input

>input (796 residues)
MPTTQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSP
KSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVK
SFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSM
DFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQ
IVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIII
ALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMK
CYPDRVDYVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKH
FHPLFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPD
PEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLA
FRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELAELPLRLFLQGALAAGEIGFENHE
TVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKL
LKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLF
IEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLR
RESPESEGPIYEGLIL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:G3V8A5	0.982	0.982	8.570E-95	796	0.992	0.992	G3V8A5.pdb.gz	G3V8A5_RAT Vacuolar protein sorting-associated protein 35 OS=Rattus norvegicus OX=10116 GN=Vps35 PE=1 SV=1
2	PDB:7blnA	0.897	0.927	1.792E-69	769	0.966	1.000	7blnA.pdb.gz
3	AFDB:Q9W277	0.967	0.936	2.049E-68	822	0.616	0.596	Q9W277.pdb.gz	Q9W277_DROME Vacuolar protein sorting-associated protein 35 OS=Drosophila melanogaster OX=7227 GN=Vps35 PE=1 SV=4
4	PDB:7u6fD1	0.861	0.931	1.382E-64	733	0.910	0.988	7u6fD1.pdb.gz
5	AFDB:Q21053	0.914	0.887	1.631E-59	821	0.485	0.470	Q21053.pdb.gz	Q21053_CAEEL Vacuolar protein sorting-associated protein 35 OS=Caenorhabditis elegans OX=6239 GN=vps-35 PE=1 SV=3
6	AFDB:Q54C24	0.897	0.913	3.938E-51	781	0.435	0.443	Q54C24.pdb.gz	VPS35_DICDI Vacuolar protein sorting-associated protein 35 OS=Dictyostelium discoideum OX=44689 GN=vps35 PE=3 SV=1
7	AFDB:Q7X659	0.900	0.909	1.347E-50	787	0.431	0.436	Q7X659.pdb.gz	VP35A_ARATH Vacuolar protein sorting-associated protein 35A OS=Arabidopsis thaliana OX=3702 GN=VPS35A PE=1 SV=1
8	AFDB:A8R7K9	0.863	0.869	5.550E-50	790	0.438	0.442	A8R7K9.pdb.gz	VP35C_ARATH Vacuolar protein sorting-associated protein 35C OS=Arabidopsis thaliana OX=3702 GN=VPS35C PE=2 SV=1
9	AFDB:O74552	0.838	0.800	1.713E-43	836	0.343	0.327	O74552.pdb.gz	VPS35_SCHPO Vacuolar protein sorting-associated protein 35 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=vps35 PE=1 SV=2
10	AFDB:P34110	0.809	0.689	4.833E-39	944	0.344	0.290	P34110.pdb.gz	VPS35_YEAST Vacuolar protein sorting-associated protein 35 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=VPS35 PE=1 SV=2
11	AFDB:Q8IIQ6	0.698	0.551	9.748E-35	1050	0.305	0.231	Q8IIQ6.pdb.gz	Q8IIQ6_PLAF7 Vacuolar protein sorting-associated protein 35 OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1110500 PE=3 SV=1
12	AFDB:Q7Z3J2	0.481	0.407	3.045E-12	963	0.134	0.111	Q7Z3J2.pdb.gz	VP35L_HUMAN VPS35 endosomal protein-sorting factor-like OS=Homo sapiens OX=9606 GN=VPS35L PE=1 SV=2
13	PDB:4bujB	0.142	0.096	1.027E-6	1367	0.139	0.081	4bujB.pdb.gz
14	PDB:6xu2A	0.175	0.141	2.917E-6	1091	0.128	0.093	6xu2A.pdb.gz	X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
15	PDB:7qdrB	0.126	0.095	6.146E-6	1212	0.123	0.081	7qdrB.pdb.gz
16	PDB:7dkhI	0.141	0.129	1.880E-5	914	0.112	0.097	7dkhI.pdb.gz
17	PDB:6tc0C	0.179	0.153	2.629E-5	994	0.131	0.105	6tc0C.pdb.gz
18	PDB:7nj1A	0.136	0.095	3.541E-5	1448	0.124	0.068	7nj1A.pdb.gz
19	PDB:5yu7A	0.277	0.216	4.267E-5	1118	0.152	0.108	5yu7A.pdb.gz
20	PDB:7mqaLM	0.377	0.186	4.597E-5	2041	0.133	0.052	7mqaLM.pdb.gz	Nucleolar maturation of the human small subunit processome.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A8R7K9	0.0	617	790	0.441	0.444	VP35C_ARATH Vacuolar protein sorting-associated protein 35C OS=Arabidopsis thaliana OX=3702 GN=VPS35C PE=2 SV=1
2	G3V8A5	0.0	1640	796	0.994	0.994	G3V8A5_RAT Vacuolar protein sorting-associated protein 35 OS=Rattus norvegicus OX=10116 GN=Vps35 PE=1 SV=1
3	Q21053	0.0	794	821	0.484	0.469	Q21053_CAEEL Vacuolar protein sorting-associated protein 35 OS=Caenorhabditis elegans OX=6239 GN=vps-35 PE=1 SV=3
4	Q53FR4	0.0	1645	796	0.999	0.999	Q53FR4_HUMAN Vacuolar protein sorting 35 variant (Fragment) OS=Homo sapiens OX=9606 PE=2 SV=1
5	Q54C24	0.0	620	781	0.433	0.442	VPS35_DICDI Vacuolar protein sorting-associated protein 35 OS=Dictyostelium discoideum OX=44689 GN=vps35 PE=3 SV=1
6	Q7KVL7	0.0	1016	803	0.612	0.606	Q7KVL7_DROME Vacuolar protein sorting-associated protein 35 OS=Drosophila melanogaster OX=7227 GN=Vps35 PE=1 SV=2
7	Q7X659	0.0	617	787	0.438	0.443	VP35A_ARATH Vacuolar protein sorting-associated protein 35A OS=Arabidopsis thaliana OX=3702 GN=VPS35A PE=1 SV=1
8	Q95RP4	0.0	670	547	0.401	0.583	Q95RP4_DROME LD17594p OS=Drosophila melanogaster OX=7227 GN=Vps35 PE=2 SV=1
9	Q96QK1	0.0	1647	796	1.000	1.000	VPS35_HUMAN Vacuolar protein sorting-associated protein 35 OS=Homo sapiens OX=9606 GN=VPS35 PE=1 SV=2
10	Q9EQH3	0.0	1639	796	0.994	0.994	VPS35_MOUSE Vacuolar protein sorting-associated protein 35 OS=Mus musculus OX=10090 GN=Vps35 PE=1 SV=1
11	Q9W277	0.0	1017	822	0.612	0.592	Q9W277_DROME Vacuolar protein sorting-associated protein 35 OS=Drosophila melanogaster OX=7227 GN=Vps35 PE=1 SV=4
12	O74552	1.95e-152	468	836	0.349	0.333	VPS35_SCHPO Vacuolar protein sorting-associated protein 35 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=vps35 PE=1 SV=2
13	P34110	6.05e-86	295	944	0.214	0.180	VPS35_YEAST Vacuolar protein sorting-associated protein 35 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=VPS35 PE=1 SV=2
14	Q8IIQ6	4.00e-81	283	1050	0.190	0.144	Q8IIQ6_PLAF7 Vacuolar protein sorting-associated protein 35 OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1110500 PE=3 SV=1
15	Q8I8U7	4.3	33.5	3790	0.031	0.007	TRA1_DROME Transcription-associated protein 1 OS=Drosophila melanogaster OX=7227 GN=Nipped-A PE=1 SV=4
16	P47110	6.1	32.3	350	0.028	0.063	DPOD3_YEAST DNA polymerase delta subunit 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=POL32 PE=1 SV=1
17	Q96MX0	8.5	31.6	182	0.025	0.110	CKLF3_HUMAN CKLF-like MARVEL transmembrane domain-containing protein 3 OS=Homo sapiens OX=9606 GN=CMTM3 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF11559 ADIP	9.2e+02	11.3	Afadin- and alpha -actinin-Binding
2	PF05527 DUF758	1.1e+02	14.2	Domain of unknown function (DUF758)
3	PF08165 FerA	1.1e+02	14.2	FerA (NUC095) domain
4	PF14423 Imm5	2.8e+02	13.0	Immunity protein Imm5
5	PF03635 Vps35	5.4e-292	982.4	Vacuolar protein sorting-associated protein 35

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 61622.XP_010353155.1

Rank	PPI partner	STRING score	Description
1	61622.XP_010361118.1	0.999	VPS26, retromer complex component A
2	61622.XP_010377397.1	0.999	VPS29, retromer complex component
3	61622.XP_010360343.1	0.997	VPS26, retromer complex component B
4	61622.XP_010353777.1	0.994	Sorting nexin 1
5	61622.XP_010359712.1	0.994	Sorting nexin-2
6	61622.XP_010380795.1	0.991	Sorting nexin-3
7	61622.XP_010375449.1	0.986	TBC1 domain family member 5
8	61622.XP_010364893.1	0.982	Involved in several stages of intracellular trafficking.
9	61622.XP_010379784.1	0.982	Involved in several stages of intracellular trafficking.
10	61622.XP_010354771.1	0.960	Sorting nexin 12
11	61622.XP_010352930.1	0.957	RAB7A, member RAS oncogene family
12	61622.XP_010364985.1	0.923	Sorting nexin-8
13	61622.XP_010373626.1	0.896	cyclin-G-associated kinase isoform X1
14	61622.XP_010354765.1	0.894	Sortilin-related receptor
15	61622.XP_010366032.1	0.894	Sorting nexin 7
16	61622.XP_010368744.1	0.894	Sorting nexin family member 30
17	61622.XP_010353113.1	0.889	Sorting nexin-4
18	61622.XP_010360786.1	0.882	RAB7B, member RAS oncogene family
19	61622.XP_010353736.1	0.879	Sortilin 1
20	61622.XP_010355368.1	0.877	Wntless Wnt ligand secretion mediator

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0050780	1.000	dopamine receptor binding
GO:0031748	0.614	D1 dopamine receptor binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0046907	0.995	intracellular transport
GO:0042147	0.986	retrograde transport, endosome to Golgi
GO:0050789	0.967	regulation of biological process
GO:0050794	0.913	regulation of cellular process
GO:0008104	0.691	protein localization
GO:0048522	0.687	positive regulation of cellular process
GO:0051128	0.678	regulation of cellular component organization
GO:0071840	0.649	cellular component organization or biogenesis
GO:0032879	0.598	regulation of localization
GO:0016043	0.597	cellular component organization
GO:0048519	0.574	negative regulation of biological process
GO:0019222	0.570	regulation of metabolic process
GO:0051049	0.559	regulation of transport
GO:0045184	0.529	establishment of protein localization
GO:0048583	0.519	regulation of response to stimulus
GO:0051668	0.514	localization within membrane
GO:0009894	0.514	regulation of catabolic process
GO:0048523	0.510	negative regulation of cellular process
GO:0015031	0.490	protein transport
GO:0098876	0.453	vesicle-mediated transport to the plasma membrane
GO:0060255	0.451	regulation of macromolecule metabolic process
GO:0006996	0.440	organelle organization
GO:0023051	0.428	regulation of signaling
GO:0032456	0.425	endocytic recycling
GO:0010646	0.421	regulation of cell communication
GO:0060341	0.409	regulation of cellular localization
GO:0080090	0.402	regulation of primary metabolic process
GO:0051171	0.400	regulation of nitrogen compound metabolic process
GO:0072657	0.344	protein localization to membrane
GO:0006886	0.338	intracellular protein transport
GO:0023056	0.336	positive regulation of signaling
GO:0010647	0.322	positive regulation of cell communication
GO:0010941	0.319	regulation of cell death
GO:0009966	0.315	regulation of signal transduction
GO:0048584	0.314	positive regulation of response to stimulus
GO:0051246	0.311	regulation of protein metabolic process
GO:0065008	0.305	regulation of biological quality

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0012505	0.999	endomembrane system
GO:0098796	0.997	membrane protein complex
GO:0031090	0.996	organelle membrane
GO:0031410	0.996	cytoplasmic vesicle
GO:0005768	0.990	endosome
GO:0098588	0.983	bounding membrane of organelle
GO:0030904	0.980	retromer complex
GO:0005829	0.967	cytosol
GO:0030659	0.947	cytoplasmic vesicle membrane
GO:0005576	0.895	extracellular region
GO:0010008	0.866	endosome membrane
GO:1903561	0.851	extracellular vesicle
GO:0070062	0.842	extracellular exosome
GO:0005764	0.785	lysosome
GO:0071944	0.492	cell periphery
GO:0070013	0.491	intracellular organelle lumen
GO:0005886	0.484	plasma membrane
GO:0005765	0.448	lysosomal membrane
GO:0005769	0.379	early endosome
GO:0005634	0.346	nucleus
GO:0031981	0.327	nuclear lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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