StarFunc result for job id Q96SW2

User Input

>input (442 residues)
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
ALLPTIPDTEDEISPDKVILCL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q56AP7	0.988	0.981	3.378E-83	445	0.957	0.951	Q56AP7.pdb.gz	CRBN_RAT Protein cereblon OS=Rattus norvegicus OX=10116 GN=Crbn PE=1 SV=1
2	PDB:6h0gB	0.890	0.980	7.611E-70	401	0.907	1.000	6h0gB.pdb.gz	Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
3	PDB:5fqdE	0.805	0.968	9.997E-66	367	0.824	0.992	5fqdE.pdb.gz	Structural Basis of Lenalidomide-Induced Ck1Alpha Degradation by the Crl4(Crbn) Ubiquitin Ligase.
4	AFDB:Q68EH9	0.875	0.896	3.414E-64	431	0.692	0.710	Q68EH9.pdb.gz	CRBN_DANRE Protein cereblon OS=Danio rerio OX=7955 GN=crbn PE=1 SV=1
5	AFDB:Q9VH36	0.706	0.543	2.890E-27	585	0.238	0.179	Q9VH36.pdb.gz	CRBN_DROME Protein cereblon OS=Drosophila melanogaster OX=7227 GN=ohgt PE=1 SV=1
6	AFDB:Q9FXH3	0.342	0.523	1.951E-11	278	0.131	0.209	Q9FXH3.pdb.gz	Q9FXH3_ARATH ATP-dependent protease La (LON) domain protein OS=Arabidopsis thaliana OX=3702 GN=LCP1 PE=1 SV=1
7	AFDB:Q9FWT4	0.351	0.535	2.008E-10	278	0.120	0.191	Q9FWT4.pdb.gz	Q9FWT4_ARATH ATP-dependent protease La (LON) domain protein OS=Arabidopsis thaliana OX=3702 GN=At1g75460 PE=1 SV=1
8	AFDB:P0A9M0	0.348	0.204	7.549E-10	784	0.084	0.047	P0A9M0.pdb.gz	LON_ECOLI Lon protease OS=Escherichia coli (strain K12) OX=83333 GN=lon PE=1 SV=1
9	AFDB:A0A059VAZ3	0.353	0.203	1.125E-8	793	0.068	0.038	A0A059VAZ3.pdb.gz	A0A059VAZ3_9DEIN Lon protease OS=Meiothermus taiwanensis OX=172827 GN=lonA1 PE=1 SV=1
10	AFDB:F4ICB5	0.325	0.294	3.079E-8	491	0.088	0.079	F4ICB5.pdb.gz	F4ICB5_ARATH Zinc finger (C3HC4-type RING finger) family protein OS=Arabidopsis thaliana OX=3702 GN=IAP1 PE=1 SV=1
11	AFDB:Q9I2T9	0.342	0.198	4.462E-8	798	0.088	0.049	Q9I2T9.pdb.gz	Q9I2T9_PSEAE Lon protease OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=lon PE=2 SV=1
12	AFDB:Q9M9L8	0.331	0.167	7.579E-8	924	0.097	0.047	Q9M9L8.pdb.gz	LONM3_ARATH Lon protease homolog 3, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=LON3 PE=3 SV=1
13	PDB:7fd4B	0.344	0.204	1.010E-5	779	0.079	0.045	7fd4B.pdb.gz	Complete three-dimensional structures of the Lon protease translocating a protein substrate.
14	PDB:6symA	0.150	0.439	3.430E-3	135	0.038	0.126	6symA.pdb.gz	Structure of Peptide methionine sulfoxide reductase MsrB at 1.63 Angstrom resolution
15	PDB:4n2pA	0.090	0.201	1.223E-2	143	0.034	0.105	4n2pA.pdb.gz	A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation.
16	PDB:3tgoD	0.099	0.180	3.631E-1	186	0.057	0.134	3tgoD.pdb.gz
17	PDB:4hkhA	0.113	0.276	4.732E-1	149	0.014	0.040	4hkhA.pdb.gz
18	PDB:5w5yO	0.057	0.044	5.261E-1	640	0.048	0.033	5w5yO.pdb.gz	Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
19	PDB:3eaaA	0.126	0.281	5.849E-1	162	0.027	0.074	3eaaA.pdb.gz
20	PDB:5lmxB	0.097	0.050	5.849E-1	1115	0.063	0.025	5lmxB.pdb.gz	The dynamic assembly of distinct RNA polymerase I complexes modulates rDNA transcription.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q56AP7	0.0	860	445	0.946	0.939	CRBN_RAT Protein cereblon OS=Rattus norvegicus OX=10116 GN=Crbn PE=1 SV=1
2	Q68EH9	0.0	617	431	0.679	0.696	CRBN_DANRE Protein cereblon OS=Danio rerio OX=7955 GN=crbn PE=1 SV=1
3	Q8C7D2	0.0	862	445	0.946	0.939	CRBN_MOUSE Protein cereblon OS=Mus musculus OX=10090 GN=Crbn PE=1 SV=1
4	Q96SW2	0.0	926	442	1.000	1.000	CRBN_HUMAN Protein cereblon OS=Homo sapiens OX=9606 GN=CRBN PE=1 SV=1
5	Q9VH36	7.32e-39	150	585	0.247	0.186	CRBN_DROME Protein cereblon OS=Drosophila melanogaster OX=7227 GN=ohgt PE=1 SV=1
6	Q7TQ77	0.049	38.5	709	0.097	0.061	Q7TQ77_RAT Ac1288 OS=Rattus norvegicus OX=10116 GN=AABR07026291.1 PE=1 SV=1
7	Q9FXH3	0.19	36.2	278	0.052	0.083	Q9FXH3_ARATH ATP-dependent protease La (LON) domain protein OS=Arabidopsis thaliana OX=3702 GN=LCP1 PE=1 SV=1
8	Q17RB8	0.55	35.0	773	0.068	0.039	LONF1_HUMAN LON peptidase N-terminal domain and RING finger protein 1 OS=Homo sapiens OX=9606 GN=LONRF1 PE=1 SV=2
9	Q9FWT4	1.0	33.9	278	0.050	0.079	Q9FWT4_ARATH ATP-dependent protease La (LON) domain protein OS=Arabidopsis thaliana OX=3702 GN=At1g75460 PE=1 SV=1
10	Q8BUK6	2.2	33.1	718	0.061	0.038	HOOK3_MOUSE Protein Hook homolog 3 OS=Mus musculus OX=10090 GN=Hook3 PE=1 SV=2
11	Q86VS8	2.7	32.7	718	0.059	0.036	HOOK3_HUMAN Protein Hook homolog 3 OS=Homo sapiens OX=9606 GN=HOOK3 PE=1 SV=2
12	Q6USK2	3.2	32.7	608	0.038	0.028	CERK_ARATH Ceramide kinase OS=Arabidopsis thaliana OX=3702 GN=CERK PE=1 SV=1
13	Q961K9	3.7	32.3	576	0.045	0.035	Q961K9_DROME glycerol kinase OS=Drosophila melanogaster OX=7227 GN=Gk2 PE=2 SV=1
14	Q9W095	3.7	32.3	576	0.045	0.035	Q9W095_DROME glycerol kinase OS=Drosophila melanogaster OX=7227 GN=Gk2 PE=2 SV=2
15	Q8L7G4	6.6	31.6	607	0.057	0.041	TPS09_ARATH Terpenoid synthase 9 OS=Arabidopsis thaliana OX=3702 GN=TPS09 PE=2 SV=2
16	Q05BL1	7.6	31.6	1048	0.054	0.023	Q05BL1_HUMAN TP53BP2 protein OS=Homo sapiens OX=9606 GN=TP53BP2 PE=1 SV=1
17	Q13625	7.7	31.6	1128	0.054	0.021	ASPP2_HUMAN Apoptosis-stimulating of p53 protein 2 OS=Homo sapiens OX=9606 GN=TP53BP2 PE=1 SV=2
18	Q9VZI3	8.8	31.2	708	0.057	0.035	UN112_DROME Unc-112-related protein OS=Drosophila melanogaster OX=7227 GN=Fit1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF06061 Baculo_ME53	6e+02	11.0	Baculoviridae ME53
2	PF02190 LON_substr_bdg	2.4e-21	88.1	ATP-dependent protease La (LON) substrate-binding domain
3	PF03226 Yippee-Mis18	5.1e-09	47.7	Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000231948

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000301764	0.999	DNA damage-binding protein 1
2	9606.ENSP00000364589	0.999	Cullin-4A
3	9606.ENSP00000216225	0.998	E3 ubiquitin-protein ligase RBX1
4	9606.ENSP00000331614	0.995	DNA-binding protein Ikaros
5	9606.ENSP00000421689	0.995	Casein kinase I isoform alpha
6	9606.ENSP00000344544	0.990	Zinc finger protein Aiolos
7	9606.ENSP00000384109	0.989	Cullin-4B
8	9606.ENSP00000263377	0.988	Bromodomain-containing protein 4
9	9606.ENSP00000398131	0.977	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
10	9606.ENSP00000456340	0.963	DET1 homolog
11	9606.ENSP00000254337	0.962	DDB1- and CUL4-associated factor 15
12	9606.ENSP00000256996	0.962	DNA damage-binding protein 2
13	9606.ENSP00000352928	0.930	DET1- and DDB1-associated protein 1
14	9606.ENSP00000371682	0.929	DDB1- and CUL4-associated factor 16
15	9606.ENSP00000355958	0.927	Denticleless protein homolog
16	9606.ENSP00000415556	0.912	DDB1- and CUL4-associated factor 11
17	9606.ENSP00000393183	0.911	DDB1- and CUL4-associated factor 1
18	9606.ENSP00000228872	0.910	Cyclin-dependent kinase inhibitor 1B
19	9606.ENSP00000483236	0.908	DDB1- and CUL4-associated factor 7
20	9606.ENSP00000356814	0.907	DDB1- and CUL4-associated factor 6

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0044325	0.971	transmembrane transporter binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.996	regulation of cellular process
GO:0071704	0.987	organic substance metabolic process
GO:0048519	0.983	negative regulation of biological process
GO:0044238	0.982	primary metabolic process
GO:0006807	0.977	nitrogen compound metabolic process
GO:0048523	0.973	negative regulation of cellular process
GO:0043170	0.964	macromolecule metabolic process
GO:0009987	0.962	cellular process
GO:0043271	0.955	negative regulation of monoatomic ion transport
GO:0048518	0.951	positive regulation of biological process
GO:0034762	0.950	regulation of transmembrane transport
GO:1901564	0.937	organonitrogen compound metabolic process
GO:0034766	0.926	negative regulation of monoatomic ion transmembrane transport
GO:0048522	0.923	positive regulation of cellular process
GO:0044237	0.922	cellular metabolic process
GO:0019538	0.911	protein metabolic process
GO:0010959	0.845	regulation of metal ion transport
GO:0065009	0.824	regulation of molecular function
GO:0032501	0.790	multicellular organismal process
GO:0036211	0.784	protein modification process
GO:0048583	0.728	regulation of response to stimulus
GO:0010646	0.724	regulation of cell communication
GO:0023051	0.721	regulation of signaling
GO:0032446	0.706	protein modification by small protein conjugation
GO:0044260	0.702	cellular macromolecule metabolic process
GO:0006508	0.630	proteolysis
GO:1901575	0.616	organic substance catabolic process
GO:0009057	0.597	macromolecule catabolic process
GO:0051603	0.527	proteolysis involved in protein catabolic process
GO:0051128	0.523	regulation of cellular component organization
GO:0016567	0.517	protein ubiquitination
GO:0043632	0.487	modification-dependent macromolecule catabolic process
GO:0019941	0.479	modification-dependent protein catabolic process
GO:0006511	0.470	ubiquitin-dependent protein catabolic process
GO:0019222	0.422	regulation of metabolic process
GO:1904062	0.411	regulation of monoatomic cation transmembrane transport
GO:0009966	0.367	regulation of signal transduction
GO:0051171	0.340	regulation of nitrogen compound metabolic process
GO:0044087	0.334	regulation of cellular component biogenesis

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	1.000	cytoplasm
GO:0032991	0.995	protein-containing complex
GO:0005829	0.990	cytosol
GO:0043231	0.985	intracellular membrane-bounded organelle
GO:0005634	0.984	nucleus
GO:0070013	0.952	intracellular organelle lumen
GO:0005654	0.936	nucleoplasm
GO:0080008	0.902	Cul4-RING E3 ubiquitin ligase complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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