StarFunc result for job id Q99704

User Input

>input (481 residues)
MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRL
DCKVIRLAECVSVAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFP
KGSWTLAPTDNPPKLSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEA
ERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGND
IFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPPALYAEPL
DSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKKPLYWDLYEHAQQQLLKAKLTDPKEDP
IYDEPEGLAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPL
LAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGS
T

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q99704	1.000	1.000	4.757E-83	481	1.000	1.000	Q99704.pdb.gz	DOK1_HUMAN Docking protein 1 OS=Homo sapiens OX=9606 GN=DOK1 PE=1 SV=1
2	AFDB:P97465	0.274	0.274	6.594E-66	482	0.838	0.836	P97465.pdb.gz	DOK1_MOUSE Docking protein 1 OS=Mus musculus OX=10090 GN=Dok1 PE=1 SV=2
3	AFDB:O60496	0.275	0.306	4.685E-32	412	0.320	0.374	O60496.pdb.gz	DOK2_HUMAN Docking protein 2 OS=Homo sapiens OX=9606 GN=DOK2 PE=1 SV=2
4	AFDB:O70469	0.273	0.307	8.605E-32	412	0.299	0.350	O70469.pdb.gz	DOK2_MOUSE Docking protein 2 OS=Mus musculus OX=10090 GN=Dok2 PE=1 SV=1
5	AFDB:P35568	0.200	0.081	5.119E-13	1242	0.173	0.067	P35568.pdb.gz	IRS1_HUMAN Insulin receptor substrate 1 OS=Homo sapiens OX=9606 GN=IRS1 PE=1 SV=1
6	AFDB:Q18820	0.204	0.104	2.282E-9	1003	0.129	0.062	Q18820.pdb.gz	Q18820_CAEEL IRS-type PTB domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=ist-1 PE=1 SV=4
7	AFDB:Q6NQZ5	0.164	0.104	1.938E-6	822	0.166	0.097	Q6NQZ5.pdb.gz	Q6NQZ5_DROME LD23309p OS=Drosophila melanogaster OX=7227 GN=sced PE=2 SV=1
8	AFDB:P46933	0.195	0.136	2.088E-5	711	0.094	0.063	P46933.pdb.gz	APBB1_RAT Amyloid beta precursor protein binding family B member 1 OS=Rattus norvegicus OX=10116 GN=Apbb1 PE=1 SV=3
9	AFDB:B4DJX4	0.181	0.094	4.284E-5	977	0.160	0.079	B4DJX4.pdb.gz	B4DJX4_HUMAN Pleckstrin homology domain containing A5 (Fragment) OS=Homo sapiens OX=9606 GN=PLEKHA5 PE=1 SV=1
10	AFDB:Q9HAU0	0.178	0.080	4.527E-5	1116	0.181	0.078	Q9HAU0.pdb.gz	PKHA5_HUMAN Pleckstrin homology domain-containing family A member 5 OS=Homo sapiens OX=9606 GN=PLEKHA5 PE=1 SV=1
11	PDB:6xtbE	0.163	0.298	1.219E-4	235	0.040	0.081	6xtbE.pdb.gz
12	PDB:6s9wA	0.145	0.167	2.502E-4	411	0.060	0.071	6s9wA.pdb.gz	Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity.
13	PDB:6hhgA	0.159	0.194	2.794E-4	386	0.060	0.075	6hhgA.pdb.gz	Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
14	PDB:3ljuX	0.156	0.195	4.348E-4	373	0.069	0.088	3ljuX.pdb.gz	Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
15	PDB:6r9tA	0.169	0.040	4.857E-4	2185	0.046	0.010	6r9tA.pdb.gz
16	PDB:4mk0A	0.180	0.139	5.733E-4	631	0.044	0.033	4mk0A.pdb.gz	Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.
17	PDB:6u426U	0.110	0.096	1.176E-3	569	0.096	0.081	6u426U.pdb.gz	Structure of the Decorated Ciliary Doublet Microtubule.
18	PDB:6upkH	0.136	0.155	1.467E-3	411	0.052	0.061	6upkH.pdb.gz	FACT caught in the act of manipulating the nucleosome.
19	PDB:3pvuA	0.166	0.133	1.732E-3	609	0.046	0.036	3pvuA.pdb.gz	Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
20	PDB:7nkyQ	0.135	0.157	2.161E-3	404	0.033	0.040	7nkyQ.pdb.gz	Structural basis of nucleosome transcription mediated by Chd1 and FACT.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P97465	0.0	766	482	0.838	0.836	DOK1_MOUSE Docking protein 1 OS=Mus musculus OX=10090 GN=Dok1 PE=1 SV=2
2	Q99704	0.0	981	481	1.000	1.000	DOK1_HUMAN Docking protein 1 OS=Homo sapiens OX=9606 GN=DOK1 PE=1 SV=1
3	O60496	2.45e-54	189	412	0.339	0.396	DOK2_HUMAN Docking protein 2 OS=Homo sapiens OX=9606 GN=DOK2 PE=1 SV=2
4	O70469	1.31e-51	182	412	0.318	0.371	DOK2_MOUSE Docking protein 2 OS=Mus musculus OX=10090 GN=Dok2 PE=1 SV=1
5	Q9QZK7	9.65e-51	180	444	0.235	0.255	DOK3_MOUSE Docking protein 3 OS=Mus musculus OX=10090 GN=Dok3 PE=1 SV=1
6	Q7L591	2.69e-50	180	496	0.237	0.230	DOK3_HUMAN Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 PE=1 SV=2
7	Q9W3R6	1.73e-15	81.3	622	0.139	0.108	Q9W3R6_DROME Insulin receptor substrate 1 OS=Drosophila melanogaster OX=7227 GN=Dok PE=2 SV=1
8	Q6PKX4	4.00e-14	75.5	331	0.141	0.205	DOK6_HUMAN Docking protein 6 OS=Homo sapiens OX=9606 GN=DOK6 PE=1 SV=1
9	Q2MHE5	4.04e-14	75.5	331	0.141	0.205	DOK6_MOUSE Docking protein 6 OS=Mus musculus OX=10090 GN=Dok6 PE=1 SV=1
10	Q91ZM9	4.58e-14	75.1	306	0.143	0.225	DOK5_MOUSE Docking protein 5 OS=Mus musculus OX=10090 GN=Dok5 PE=1 SV=1
11	Q9P104	5.31e-14	74.7	306	0.143	0.225	DOK5_HUMAN Docking protein 5 OS=Homo sapiens OX=9606 GN=DOK5 PE=1 SV=2
12	Q99KE3	6.21e-14	75.1	325	0.150	0.222	DOK4_MOUSE Docking protein 4 OS=Mus musculus OX=10090 GN=Dok4 PE=1 SV=1
13	A4IFJ7	8.34e-14	74.7	326	0.150	0.221	A4IFJ7_BOVIN DOK4 protein OS=Bos taurus OX=9913 GN=DOK4 PE=2 SV=1
14	Q8TEW6	1.09e-13	74.3	326	0.150	0.221	DOK4_HUMAN Docking protein 4 OS=Homo sapiens OX=9606 GN=DOK4 PE=1 SV=2
15	O43559	4.42e-10	63.9	492	0.083	0.081	FRS3_HUMAN Fibroblast growth factor receptor substrate 3 OS=Homo sapiens OX=9606 GN=FRS3 PE=1 SV=3
16	Q52RG8	4.75e-09	60.8	492	0.069	0.067	FRS3_RAT Fibroblast growth factor receptor substrate 3 OS=Rattus norvegicus OX=10116 GN=Frs3 PE=2 SV=3
17	D4A244	5.01e-09	60.8	508	0.060	0.057	D4A244_RAT Fibroblast growth factor receptor substrate 2 OS=Rattus norvegicus OX=10116 GN=Frs2 PE=1 SV=1
18	Q8C180	5.76e-09	60.5	508	0.060	0.057	FRS2_MOUSE Fibroblast growth factor receptor substrate 2 OS=Mus musculus OX=10090 GN=Frs2 PE=1 SV=3
19	A0A384NQ31	7.54e-09	60.1	512	0.058	0.055	A0A384NQ31_HUMAN Epididymis secretory sperm binding protein OS=Homo sapiens OX=9606 PE=1 SV=1
20	Q8WU20	8.04e-09	60.1	508	0.058	0.055	FRS2_HUMAN Fibroblast growth factor receptor substrate 2 OS=Homo sapiens OX=9606 GN=FRS2 PE=1 SV=4

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF05171 HemS	7.6e+02	11.4	Haemin-degrading HemS.ChuX domain
2	PF02174 IRS	2.1e-30	115.9	PTB domain (IRS-1 type)
3	PF00169 PH	1.3e-05	37.0	PH domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000233668

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000274376	0.999	Ras GTPase-activating protein 1
2	9606.ENSP00000417273	0.999	Cytoplasmic protein NCK1
3	9606.ENSP00000347942	0.994	Proto-oncogene tyrosine-protein kinase receptor Ret
4	9606.ENSP00000401303	0.987	SHC-transforming protein 1
5	9606.ENSP00000405338	0.986	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
6	9606.ENSP00000370912	0.982	Tyrosine-protein kinase Tec
7	9606.ENSP00000220003	0.979	Tyrosine-protein kinase CSK
8	9606.ENSP00000428924	0.975	Tyrosine-protein kinase Lyn
9	9606.ENSP00000362680	0.974	Proto-oncogene tyrosine-protein kinase Src
10	9606.ENSP00000361423	0.964	Tyrosine-protein kinase ABL1
11	9606.ENSP00000376345	0.958	Growth factor receptor-bound protein 2
12	9606.ENSP00000288135	0.956	Mast/stem cell growth factor receptor Kit
13	9606.ENSP00000360683	0.955	Tyrosine-protein phosphatase non-receptor type 1
14	9606.ENSP00000337825	0.953	Tyrosine-protein kinase Lck
15	9606.ENSP00000363117	0.953	Tyrosine-protein kinase Fgr
16	9606.ENSP00000444986	0.950	Tyrosine-protein kinase HCK
17	9606.ENSP00000351497	0.949	Low affinity immunoglobulin gamma Fc region receptor II-b
18	9606.ENSP00000346671	0.947	Tyrosine-protein kinase Fyn
19	9606.ENSP00000462468	0.938	Tyrosine-protein kinase Yes
20	9606.ENSP00000381793	0.931	Growth factor receptor-bound protein 10

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0019899	0.403	enzyme binding
GO:0005102	0.403	signaling receptor binding
GO:0019900	0.354	kinase binding
GO:0019901	0.342	protein kinase binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.999	regulation of cellular process
GO:0051716	0.997	cellular response to stimulus
GO:0023052	0.995	signaling
GO:0007154	0.995	cell communication
GO:0007166	0.991	cell surface receptor signaling pathway
GO:0007169	0.947	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0048583	0.776	regulation of response to stimulus
GO:0023051	0.500	regulation of signaling
GO:0010646	0.500	regulation of cell communication
GO:0048519	0.499	negative regulation of biological process
GO:0009966	0.489	regulation of signal transduction
GO:0048523	0.384	negative regulation of cellular process
GO:0042221	0.368	response to chemical
GO:0070887	0.339	cellular response to chemical stimulus
GO:1902531	0.317	regulation of intracellular signal transduction

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0005634	0.997	nucleus
GO:0005886	0.559	plasma membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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