StarFunc result for job id Q9BT81

User Input

>input (388 residues)
MASLLGAYPWPEGLECPALDAELSDGQSPPAVPRPPGDKGSESRIRRPMNAFMVWAKDER
KRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLRLQHMQDYPNYKYRPRRKK
QAKRLCKRVDPGFLLSSLSRDQNALPEKRSGSRGALGEKEDRGEYSPGTALPSLRGCYHE
GPAGGGGGGTPSSVDTYPYGLPTPPEMSPLDVLEPEQTFFSSPCQEEHGHPRRIPHLPGH
PYSPEYAPSPLHCSHPLGSLALGQSPGVSMMSPVPGCPPSPAYYSPATYHPLHSNLQAHL
GQLSPPPEHPGFDALDQLSQVELLGDMDRNEFDQYLNTPGHPDSATGAMALSGHVPVSQV
TPTGPTETSLISVLADATATYYNSYSVS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9BT81	1.000	1.000	3.583E-57	388	1.000	1.000	Q9BT81.pdb.gz	SOX7_HUMAN Transcription factor SOX-7 OS=Homo sapiens OX=9606 GN=SOX7 PE=1 SV=1
2	AFDB:P40646	0.477	0.486	1.365E-47	380	0.874	0.892	P40646.pdb.gz	SOX7_MOUSE Transcription factor SOX-7 OS=Mus musculus OX=10090 GN=Sox7 PE=1 SV=2
3	AFDB:O42342	0.408	0.435	6.950E-34	362	0.631	0.677	O42342.pdb.gz	SOX7_XENLA Transcription factor Sox-7 OS=Xenopus laevis OX=8355 GN=sox7 PE=2 SV=1
4	AFDB:Q6TEN5	0.375	0.373	7.197E-30	390	0.582	0.579	Q6TEN5.pdb.gz	Q6TEN5_DANRE SRY-box 7 OS=Danio rerio OX=7955 GN=SOX7 PE=2 SV=1
5	AFDB:Q3KQ35	0.261	0.266	4.223E-18	380	0.371	0.379	Q3KQ35.pdb.gz	S17AA_XENLA Transcription factor Sox-17-alpha-A OS=Xenopus laevis OX=8355 GN=sox17a-a PE=1 SV=1
6	AFDB:Q5PQZ5	0.241	0.227	2.819E-15	413	0.289	0.271	Q5PQZ5.pdb.gz	Q5PQZ5_DANRE SRY-box 17 OS=Danio rerio OX=7955 GN=sox17 PE=2 SV=1
7	AFDB:P35716	0.222	0.196	4.279E-11	441	0.294	0.259	P35716.pdb.gz	SOX11_HUMAN Transcription factor SOX-11 OS=Homo sapiens OX=9606 GN=SOX11 PE=1 SV=2
8	AFDB:P40657	0.240	0.129	6.686E-11	784	0.307	0.152	P40657.pdb.gz	SOX15_DROME Putative transcription factor SOX-15 OS=Drosophila melanogaster OX=7227 GN=Sox15 PE=2 SV=2
9	AFDB:P48435	0.212	0.208	6.686E-11	396	0.263	0.258	P48435.pdb.gz	SOX11_CHICK Transcription factor SOX-11 OS=Gallus gallus OX=9031 GN=SOX11 PE=2 SV=1
10	AFDB:Q2Z1R2	0.216	0.244	1.187E-10	340	0.237	0.271	Q2Z1R2.pdb.gz	SOX1B_DANRE Transcription factor Sox-1b OS=Danio rerio OX=7955 GN=sox1b PE=2 SV=1
11	PDB:1j5nA	0.164	0.612	2.373E-3	93	0.059	0.247	1j5nA.pdb.gz	The S. cerevisiae architectural HMGB protein NHP6A complexed with DNA: DNA and protein conformational changes upon binding
12	PDB:7ploI	0.118	0.102	2.195E-1	451	0.023	0.020	7ploI.pdb.gz	A conserved mechanism for regulating replisome disassembly in eukaryotes.
13	PDB:6zm7CE	0.098	0.293	2.044	124	0.026	0.081	6zm7CE.pdb.gz	Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
14	PDB:7fbyA	0.064	0.159	2.812	153	0.021	0.052	7fbyA.pdb.gz	Crystal Structure of PH0140 from Pyrococcus horikosii OT3
15	PDB:4i9qB	0.061	0.032	3.868	873	0.021	0.009	4i9qB.pdb.gz	A Remote Palm Domain Residue of RB69 DNA Polymerase Is Critical for Enzyme Activity and Influences the Conformation of the Active Site.
16	PDB:1kw2A	0.079	0.068	4.122	455	0.028	0.024	1kw2A.pdb.gz
17	PDB:1lotA	0.078	0.070	4.122	436	0.028	0.025	1lotA.pdb.gz	Crystal structure of the complex between actin and human vitamin D-binding protein at 2.5 A resolution.
18	PDB:6qnxA	0.085	0.041	4.683	928	0.023	0.010	6qnxA.pdb.gz	The structural basis for cohesin-CTCF-anchored loops.
19	PDB:5b63C	0.073	0.051	5.320	553	0.021	0.014	5b63C.pdb.gz	Crystal structures of E.coli arginyl-tRNA synthetase (ArgRS) in complex with substrate tRNA(Arg)
20	PDB:6gejS	0.080	0.123	5.320	208	0.054	0.101	6gejS.pdb.gz	Structure and dynamics of the yeast SWR1-nucleosome complex.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P40646	0.0	647	380	0.874	0.892	SOX7_MOUSE Transcription factor SOX-7 OS=Mus musculus OX=10090 GN=Sox7 PE=1 SV=2
2	Q9BT81	0.0	786	388	1.000	1.000	SOX7_HUMAN Transcription factor SOX-7 OS=Homo sapiens OX=9606 GN=SOX7 PE=1 SV=1
3	Q28GD5	2.50e-165	469	362	0.655	0.702	SOX7_XENTR Transcription factor Sox-7 OS=Xenopus tropicalis OX=8364 GN=sox7 PE=2 SV=1
4	O42342	1.08e-159	454	362	0.634	0.680	SOX7_XENLA Transcription factor Sox-7 OS=Xenopus laevis OX=8355 GN=sox7 PE=2 SV=1
5	Q6TEN5	2.14e-124	366	390	0.585	0.582	Q6TEN5_DANRE SRY-box 7 OS=Danio rerio OX=7955 GN=SOX7 PE=2 SV=1
6	Q90ZH8	4.57e-71	228	363	0.436	0.466	SX18A_XENLA Transcription factor Sox-18A OS=Xenopus laevis OX=8355 GN=sox18-a PE=1 SV=1
7	Q90ZH7	5.37e-68	221	361	0.425	0.457	SX18B_XENLA Transcription factor Sox-18B OS=Xenopus laevis OX=8355 GN=sox18-b PE=1 SV=1
8	Q3KQ35	1.10e-66	218	380	0.415	0.424	S17AA_XENLA Transcription factor Sox-17-alpha-A OS=Xenopus laevis OX=8355 GN=sox17a-a PE=1 SV=1
9	E7F9I2	1.86e-66	219	431	0.433	0.390	E7F9I2_DANRE SRY-box transcription factor 18 OS=Danio rerio OX=7955 GN=sox18 PE=4 SV=1
10	Q90ZH9	9.70e-66	215	377	0.420	0.432	S17AB_XENLA Transcription factor Sox-17-alpha-B OS=Xenopus laevis OX=8355 GN=sox17a-b PE=1 SV=1
11	Q61473	1.55e-59	200	419	0.407	0.377	SOX17_MOUSE Transcription factor SOX-17 OS=Mus musculus OX=10090 GN=Sox17 PE=1 SV=1
12	P43680	5.96e-54	184	377	0.369	0.379	SOX18_MOUSE Transcription factor SOX-18 OS=Mus musculus OX=10090 GN=Sox18 PE=1 SV=3
13	Q9H6I2	6.67e-53	183	414	0.278	0.261	SOX17_HUMAN Transcription factor SOX-17 OS=Homo sapiens OX=9606 GN=SOX17 PE=1 SV=1
14	O42601	2.36e-51	177	373	0.327	0.340	S17B1_XENLA Transcription factor Sox-17-beta.1 OS=Xenopus laevis OX=8355 GN=sox17b.1 PE=1 SV=1
15	Q5PQZ5	1.47e-48	171	413	0.278	0.262	Q5PQZ5_DANRE SRY-box 17 OS=Danio rerio OX=7955 GN=sox17 PE=2 SV=1
16	P35713	2.38e-45	162	384	0.369	0.372	SOX18_HUMAN Transcription factor SOX-18 OS=Homo sapiens OX=9606 GN=SOX18 PE=1 SV=2
17	P40657	4.18e-36	142	784	0.168	0.083	SOX15_DROME Putative transcription factor SOX-15 OS=Drosophila melanogaster OX=7227 GN=Sox15 PE=2 SV=2
18	Q90Z46	5.61e-35	132	307	0.147	0.186	Q90Z46_DANRE Casanova OS=Danio rerio OX=7955 GN=cas PE=2 SV=1
19	P55863	1.47e-30	120	309	0.137	0.172	SOX3A_XENLA Transcription factor Sox-3-A OS=Xenopus laevis OX=8355 GN=sox3-a PE=1 SV=1
20	Q32PP9	2.03e-30	118	238	0.155	0.252	SOX14_DANRE Transcription factor Sox-14 OS=Danio rerio OX=7955 GN=sox14 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00505 HMG_box	9.2e-21	85.4	HMG (high mobility group) box
2	PF09011 HMG_box_2	4.7e-06	38.4	HMG-box domain
3	PF12067 Sox17_18_mid	7.1e-15	66.1	Sox 17/18 central domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000301921

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000313921	0.818	Mitochondrial peptide methionine sulfoxide reductase
2	9606.ENSP00000371923	0.815	Retinitis pigmentosa 1-like 1 protein
3	9606.ENSP00000269216	0.777	Transcription factor GATA-6
4	9606.ENSP00000334458	0.763	Transcription factor GATA-4
5	9606.ENSP00000400341	0.682	Hepatocyte nuclear factor 3-beta
6	9606.ENSP00000229307	0.649	Homeobox protein NANOG
7	9606.ENSP00000259915	0.642	POU domain, class 5, transcription factor 1
8	9606.ENSP00000442439	0.589	Homeobox protein MIXL1
9	9606.ENSP00000370408	0.587	Homeobox protein CDX-2
10	9606.ENSP00000384524	0.536	ETS translocation variant 2
11	9606.ENSP00000417061	0.513	Cilia- and flagella-associated protein 74
12	9606.ENSP00000345681	0.509	Endothelial transcription factor GATA-2
13	9606.ENSP00000462337	0.509	Vascular endothelial zinc finger 1
14	9606.ENSP00000282728	0.504	Hematopoietically-expressed homeobox protein HHEX

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0003700	1.000	DNA-binding transcription factor activity
GO:1990837	1.000	sequence-specific double-stranded DNA binding
GO:0005515	0.999	protein binding
GO:0000976	0.963	transcription cis-regulatory region binding
GO:0000981	0.955	DNA-binding transcription factor activity, RNA polymerase II-specific

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050789	0.997	regulation of biological process
GO:0050794	0.994	regulation of cellular process
GO:0032501	0.989	multicellular organismal process
GO:0048856	0.988	anatomical structure development
GO:0051173	0.981	positive regulation of nitrogen compound metabolic process
GO:0010604	0.979	positive regulation of macromolecule metabolic process
GO:0006355	0.975	regulation of DNA-templated transcription
GO:0007275	0.971	multicellular organism development
GO:0006357	0.933	regulation of transcription by RNA polymerase II
GO:0009891	0.928	positive regulation of biosynthetic process
GO:0031328	0.919	positive regulation of cellular biosynthetic process
GO:0051254	0.919	positive regulation of RNA metabolic process
GO:0048519	0.907	negative regulation of biological process
GO:0009653	0.906	anatomical structure morphogenesis
GO:0048523	0.886	negative regulation of cellular process
GO:0009987	0.881	cellular process
GO:0009888	0.850	tissue development
GO:0010557	0.822	positive regulation of macromolecule biosynthetic process
GO:0048731	0.819	system development
GO:0045893	0.812	positive regulation of DNA-templated transcription
GO:0048583	0.658	regulation of response to stimulus
GO:0023051	0.651	regulation of signaling
GO:0010646	0.651	regulation of cell communication
GO:0045944	0.616	positive regulation of transcription by RNA polymerase II
GO:0009966	0.552	regulation of signal transduction
GO:0050896	0.531	response to stimulus
GO:0048646	0.518	anatomical structure formation involved in morphogenesis
GO:0010605	0.452	negative regulation of macromolecule metabolic process
GO:0048869	0.426	cellular developmental process
GO:0042127	0.412	regulation of cell population proliferation
GO:0045892	0.408	negative regulation of DNA-templated transcription
GO:0030154	0.401	cell differentiation
GO:0048513	0.385	animal organ development
GO:0072359	0.383	circulatory system development
GO:0009790	0.355	embryo development
GO:0065009	0.335	regulation of molecular function

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	0.999	nucleoplasm
GO:0005737	0.993	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]