StarFunc result for job id Q9BUE0

User Input

>input (208 residues)
MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCDNMEPETFLDHEMVFLL
KGQQASPFVLRARRSMDRAGAPWHLRYLGQPEMGDKNRHALVRNCVDIATSENLTDFLME
MGFRMDHEFVAKGHLFRKGIMKIMVYKIFRILVPGNTDSTEALSLSYLVELSVVAPAGQD
MVSDDMKNFAEQLKPLVHLEKIDPKRLM

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:B0BN39	0.974	0.974	1.120E-37	208	0.990	0.990	B0BN39.pdb.gz	B0BN39_RAT Mediator of RNA polymerase II transcription subunit 18 OS=Rattus norvegicus OX=10116 GN=Med18 PE=2 SV=1
2	PDB:7enar	0.900	0.909	6.211E-33	206	0.990	1.000	7enar.pdb.gz	Structures of the human Mediator and Mediator-bound preinitiation complex.
3	PDB:7nvre	0.771	0.954	1.448E-25	167	0.793	0.988	7nvre.pdb.gz	Structures of mammalian RNA polymerase II pre-initiation complexes.
4	AFDB:Q9XZT1	0.876	0.840	4.494E-24	217	0.500	0.479	Q9XZT1.pdb.gz	MED18_DROME Mediator of RNA polymerase II transcription subunit 18 OS=Drosophila melanogaster OX=7227 GN=MED18 PE=1 SV=1
5	AFDB:Q9SJZ6	0.836	0.795	9.272E-16	219	0.212	0.201	Q9SJZ6.pdb.gz	MED18_ARATH Mediator of RNA polymerase II transcription subunit 18 OS=Arabidopsis thaliana OX=3702 GN=MED18 PE=1 SV=1
6	AFDB:O14198	0.748	0.752	3.982E-13	207	0.154	0.155	O14198.pdb.gz	MED18_SCHPO Mediator of RNA polymerase II transcription subunit 18 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=med18 PE=1 SV=3
7	PDB:2hzsD	0.725	0.706	4.955E-12	214	0.159	0.154	2hzsD.pdb.gz	Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20.
8	PDB:4gwpE	0.737	0.615	9.892E-12	253	0.168	0.138	4gwpE.pdb.gz
9	AFDB:P32585	0.736	0.512	7.702E-11	307	0.173	0.117	P32585.pdb.gz	MED18_YEAST Mediator of RNA polymerase II transcription subunit 18 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=SRB5 PE=1 SV=1
10	PDB:5n9jX	0.704	0.707	1.340E-10	207	0.163	0.164	5n9jX.pdb.gz
11	PDB:2hzmF	0.664	0.585	9.087E-10	238	0.159	0.139	2hzmF.pdb.gz
12	AFDB:Q9C664	0.537	0.188	3.819E-7	674	0.120	0.037	Q9C664.pdb.gz	TTM2_ARATH Inorganic pyrophosphatase TTM2 OS=Arabidopsis thaliana OX=3702 GN=TTM2 PE=1 SV=1
13	AFDB:Q9C9B9	0.566	0.204	3.819E-7	643	0.149	0.048	Q9C9B9.pdb.gz	TTM1_ARATH Inorganic pyrophosphatase TTM1 OS=Arabidopsis thaliana OX=3702 GN=TTM1 PE=1 SV=1
14	AFDB:Q10317	0.435	0.458	2.329E-6	193	0.101	0.109	Q10317.pdb.gz	MED20_SCHPO Mediator of RNA polymerase II transcription subunit 20 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=med20 PE=1 SV=2
15	PDB:5a5yA	0.502	0.496	3.105E-6	211	0.115	0.114	5a5yA.pdb.gz	Structural Determinants for Substrate Binding and Catalysis in Triphosphate Tunnel Metalloenzymes.
16	AFDB:O93803	0.440	0.204	3.565E-6	520	0.120	0.048	O93803.pdb.gz	CET1_CANAL mRNA-capping enzyme subunit beta OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=CET1 PE=3 SV=2
17	AFDB:Q6NPF4	0.449	0.432	1.089E-5	219	0.087	0.082	Q6NPF4.pdb.gz	MD20A_ARATH Mediator of RNA polymerase II transcription subunit 20a OS=Arabidopsis thaliana OX=3702 GN=MED20A PE=1 SV=1
18	PDB:5a60A	0.520	0.279	1.305E-5	429	0.125	0.061	5a60A.pdb.gz	Structural Determinants for Substrate Binding and Catalysis in Triphosphate Tunnel Metalloenzymes.
19	PDB:5n9jY	0.382	0.418	1.703E-5	185	0.087	0.097	5n9jY.pdb.gz
20	PDB:6rieO	0.428	0.141	3.988E-5	822	0.087	0.022	6rieO.pdb.gz	Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q9BUE0	6.92e-156	431	208	1.000	1.000	MED18_HUMAN Mediator of RNA polymerase II transcription subunit 18 OS=Homo sapiens OX=9606 GN=MED18 PE=1 SV=1
2	B0BN39	9.75e-155	428	208	0.990	0.990	B0BN39_RAT Mediator of RNA polymerase II transcription subunit 18 OS=Rattus norvegicus OX=10116 GN=Med18 PE=2 SV=1
3	Q9CZ82	1.24e-154	428	208	0.986	0.986	MED18_MOUSE Mediator of RNA polymerase II transcription subunit 18 OS=Mus musculus OX=10090 GN=Med18 PE=1 SV=1
4	A0A8I6ACJ8	1.51e-135	379	201	0.875	0.905	A0A8I6ACJ8_RAT Mediator of RNA polymerase II transcription subunit 18 OS=Rattus norvegicus OX=10116 GN=Med18 PE=1 SV=1
5	Q9XZT1	1.48e-63	197	217	0.505	0.484	MED18_DROME Mediator of RNA polymerase II transcription subunit 18 OS=Drosophila melanogaster OX=7227 GN=MED18 PE=1 SV=1
6	Q9SJZ6	1.25e-07	52.4	219	0.245	0.233	MED18_ARATH Mediator of RNA polymerase II transcription subunit 18 OS=Arabidopsis thaliana OX=3702 GN=MED18 PE=1 SV=1
7	Q46822	0.74	32.3	182	0.077	0.088	IDI_ECOLI Isopentenyl-diphosphate Delta-isomerase OS=Escherichia coli (strain K12) OX=83333 GN=idi PE=1 SV=1
8	O14198	3.9	30.4	207	0.188	0.188	MED18_SCHPO Mediator of RNA polymerase II transcription subunit 18 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=med18 PE=1 SV=3
9	Q7T2B0	4.7	30.4	723	0.106	0.030	CTL4_DANRE Choline transporter-like protein 4 OS=Danio rerio OX=7955 GN=slc44a4 PE=2 SV=1
10	G5EGQ6	8.3	30.0	2684	0.077	0.006	TEN1_CAEEL Teneurin-1 OS=Caenorhabditis elegans OX=6239 GN=ten-1 PE=1 SV=1
11	H1ZUX0	8.3	30.0	2837	0.077	0.006	H1ZUX0_CAEEL EGF-like domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=ten-1 PE=1 SV=1
12	H1ZUX1	8.3	30.0	2763	0.077	0.006	H1ZUX1_CAEEL EGF-like domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=ten-1 PE=1 SV=1
13	Q8I7J1	8.3	29.6	860	0.077	0.019	Q8I7J1_CAEEL Teneurin-1 OS=Caenorhabditis elegans OX=6239 GN=ten-1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF09637 Med18	3.7e-37	140.1	Med18 protein

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000362948

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000251871	0.999	Mediator of RNA polymerase II transcription subunit 17
2	9606.ENSP00000265350	0.999	Mediator of RNA polymerase II transcription subunit 20
3	9606.ENSP00000290663	0.999	Mediator of RNA polymerase II transcription subunit 8
4	9606.ENSP00000314343	0.999	Mediator of RNA polymerase II transcription subunit 29
5	9606.ENSP00000481920	0.999	Mediator of RNA polymerase II transcription subunit 6
6	9606.ENSP00000293777	0.998	Mediator of RNA polymerase II transcription subunit 11
7	9606.ENSP00000323720	0.998	Mediator of RNA polymerase II transcription subunit 14
8	9606.ENSP00000482438	0.998	Mediator of RNA polymerase II transcription subunit 22
9	9606.ENSP00000255764	0.997	Mediator of RNA polymerase II transcription subunit 10
10	9606.ENSP00000258648	0.997	Mediator of RNA polymerase II transcription subunit 4
11	9606.ENSP00000337340	0.997	Mediator of RNA polymerase II transcription subunit 19
12	9606.ENSP00000370938	0.997	Cyclin-dependent kinase 8
13	9606.ENSP00000292035	0.996	Mediator of RNA polymerase II transcription subunit 27
14	9606.ENSP00000325612	0.996	Mediator of RNA polymerase II transcription subunit 16
15	9606.ENSP00000363193	0.996	Mediator of RNA polymerase II transcription subunit 12
16	9606.ENSP00000380888	0.996	Mediator of RNA polymerase II transcription subunit 13
17	9606.ENSP00000300651	0.995	Mediator of RNA polymerase II transcription subunit 1
18	9606.ENSP00000225728	0.994	Mediator of RNA polymerase II transcription subunit 31
19	9606.ENSP00000263205	0.994	Mediator of RNA polymerase II transcription subunit 15
20	9606.ENSP00000263390	0.994	Mediator of RNA polymerase II transcription subunit 26

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0019787	0.999	ubiquitin-like protein transferase activity
GO:0061659	0.987	ubiquitin-like protein ligase activity
GO:0004842	0.987	ubiquitin-protein transferase activity
GO:0061630	0.976	ubiquitin protein ligase activity
GO:0140110	0.399	transcription regulator activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0036211	0.995	protein modification process
GO:0016567	0.989	protein ubiquitination
GO:0050794	0.335	regulation of cellular process
GO:0060255	0.331	regulation of macromolecule metabolic process
GO:0010556	0.310	regulation of macromolecule biosynthetic process
GO:0080090	0.305	regulation of primary metabolic process
GO:0051171	0.305	regulation of nitrogen compound metabolic process
GO:0010468	0.305	regulation of gene expression
GO:0031323	0.304	regulation of cellular metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0032991	1.000	protein-containing complex
GO:0005654	0.998	nucleoplasm
GO:0090575	0.943	RNA polymerase II transcription regulator complex
GO:0070847	0.908	core mediator complex
GO:1902494	0.863	catalytic complex
GO:0016592	0.841	mediator complex
GO:1990234	0.772	transferase complex
GO:0140535	0.725	intracellular protein-containing complex
GO:0000151	0.666	ubiquitin ligase complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.-.-.-	0.999	Transferases.

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