StarFunc result for job id Q9BVS5

User Input

>input (477 residues)
MLMAWCRGPVLLCLRQGLGTNSFLHGLGQEPFEGARSLCCRSSPRDLRDGEREHEAAQRK
APGAESCPSLPLSISDIGTGCLSSLENLRLPTLREESSPRELEDSSGDQGRCGPTHQGSE
DPSMLSQAQSATEVEERHVSPSCSTSRERPFQAGELILAETGEGETKFKKLFRLNNFGLL
NSNWGAVPFGKIVGKFPGQILRSSFGKQYMLRRPALEDYVVLMKRGTAITFPKDINMILS
MMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKL
SHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGGVCAVYV
VNITQVIELLDGIRTCELALSCEKISEVIVRDWLVCLAKQKNGILAQKVESKINTDVQLD
SQEKIGVKGELFQEDDHEESHSDFPYGSFPYVARPVHWQPGHTAFLVKLRKVKPQLN

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9BVS5	1.000	1.000	8.000E-93	477	1.000	1.000	Q9BVS5.pdb.gz	TR61B_HUMAN tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TRMT61B PE=1 SV=2
2	AFDB:Q8GBB2	0.494	0.902	3.320E-28	255	0.193	0.361	Q8GBB2.pdb.gz	TRMI_THET2 tRNA (adenine(58)-N(1))-methyltransferase TrmI OS=Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) OX=262724 GN=trmI PE=1 SV=2
3	AFDB:A0A178UJ48	0.517	0.759	1.127E-27	318	0.159	0.239	A0A178UJ48.pdb.gz	A0A178UJ48_ARATH tRNA (adenine(58)-N(1))-methyltransferase OS=Arabidopsis thaliana OX=3702 GN=At5g14600 PE=1 SV=1
4	AFDB:P9WFZ1	0.501	0.833	1.017E-26	280	0.187	0.318	P9WFZ1.pdb.gz	TRMI_MYCTU tRNA (adenine(58)-N(1))-methyltransferase TrmI OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=trmI PE=1 SV=1
5	PDB:1i9gA	0.512	0.906	5.031E-26	264	0.184	0.333	1i9gA.pdb.gz	Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv.
6	PDB:2pwyA	0.489	0.908	7.867E-25	251	0.189	0.359	2pwyA.pdb.gz	Crystal Structure of Thermus thermophilus tRNA m(1)A(58) Methyltransferase and Biophysical Characterization of Its Interaction with tRNA.
7	PDB:5ccxA	0.489	0.796	5.214E-21	283	0.117	0.198	5ccxA.pdb.gz	Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
8	PDB:5ergB	0.488	0.701	9.986E-19	324	0.126	0.185	5ergB.pdb.gz	Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae.
9	PDB:5ergA	0.418	0.572	1.432E-12	340	0.103	0.144	5ergA.pdb.gz	Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae.
10	PDB:5cd1B	0.420	0.605	3.723E-10	321	0.071	0.106	5cd1B.pdb.gz	Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
11	PDB:7mq8SD	0.251	0.481	4.207E-10	237	0.075	0.152	7mq8SD.pdb.gz	Nucleolar maturation of the human small subunit processome.
12	PDB:4by9E	0.241	0.470	5.372E-10	227	0.073	0.154	4by9E.pdb.gz	The Structure of the Box C/D Enzyme Reveals Regulation of RNA Methylation.
13	PDB:6jclG	0.266	0.543	4.847E-9	219	0.073	0.160	6jclG.pdb.gz	Structural and biochemical characterization of Rv0187, an O-methyltransferase from Mycobacterium tuberculosis.
14	PDB:5ccbB	0.411	0.520	1.140E-8	371	0.073	0.094	5ccbB.pdb.gz	Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
15	AFDB:F4HY34	0.103	0.056	7.926E-2	999	0.096	0.046	F4HY34.pdb.gz	F4HY34_ARATH NAD kinase 2 OS=Arabidopsis thaliana OX=3702 GN=NADK2 PE=1 SV=1
16	AFDB:P87323	0.093	0.087	1.374E-1	522	0.117	0.107	P87323.pdb.gz	MCS4_SCHPO Response regulator mcs4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=mcs4 PE=4 SV=1
17	AFDB:A0A0G2KGP5	0.126	0.056	1.865E-1	1350	0.103	0.036	A0A0G2KGP5.pdb.gz
18	AFDB:E9PSQ0	0.148	0.035	3.040E-1	2460	0.117	0.023	E9PSQ0.pdb.gz	E9PSQ0_RAT acetyl-CoA carboxylase OS=Rattus norvegicus OX=10116 GN=Acacb PE=1 SV=2
19	AFDB:Q38DF6	0.123	0.090	3.652E-1	735	0.113	0.073	Q38DF6.pdb.gz	Q38DF6_TRYB2 Probable eukaryotic initiation factor 4A OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb09.211.3510 PE=3 SV=1
20	AFDB:P49750	0.124	0.040	6.329E-1	2146	0.138	0.031	P49750.pdb.gz	YLPM1_HUMAN YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1 PE=1 SV=4

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q9BVS5	0.0	987	477	1.000	1.000	TR61B_HUMAN tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TRMT61B PE=1 SV=2
2	Q8GBB2	5.38e-32	125	255	0.164	0.306	TRMI_THET2 tRNA (adenine(58)-N(1))-methyltransferase TrmI OS=Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) OX=262724 GN=trmI PE=1 SV=2
3	P9WFZ1	4.86e-30	120	280	0.166	0.282	TRMI_MYCTU tRNA (adenine(58)-N(1))-methyltransferase TrmI OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=trmI PE=1 SV=1
4	A0A178UJ48	2.94e-14	75.9	318	0.164	0.245	A0A178UJ48_ARATH tRNA (adenine(58)-N(1))-methyltransferase OS=Arabidopsis thaliana OX=3702 GN=At5g14600 PE=1 SV=1
5	Q84K50	2.94e-14	75.9	318	0.164	0.245	Q84K50_ARATH tRNA (adenine(58)-N(1))-methyltransferase OS=Arabidopsis thaliana OX=3702 GN=TRM61 PE=1 SV=1
6	O14307	7.22e-12	68.9	364	0.099	0.129	TRM61_SCHPO tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit trm61 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=cpd1 PE=3 SV=1
7	P46959	7.93e-07	53.5	383	0.109	0.136	TRM61_YEAST tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=GCD14 PE=1 SV=1
8	Q96FX7	2.15e-05	48.5	289	0.101	0.166	TRM61_HUMAN tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens OX=9606 GN=TRMT61A PE=1 SV=1
9	A0A0H2UPK7	0.012	39.3	196	0.042	0.102	A0A0H2UPK7_STRPN Methyltransferase small domain-containing protein OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=SP_0841 PE=1 SV=1
10	Q9FK02	0.12	37.4	380	0.055	0.068	DIM1B_ARATH Ribosomal RNA small subunit methyltransferase, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=DIM1B PE=1 SV=1
11	O07431	0.16	36.2	220	0.031	0.068	CAMT_MYCTU Catechol O-methyltransferase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=Rv0187 PE=1 SV=1
12	Q3ED65	0.41	35.0	261	0.038	0.069	MENG_ARATH 2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=MENG PE=1 SV=2
13	Q581Z0	0.79	34.3	295	0.046	0.075	Q581Z0_TRYB2 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.26N11.380 PE=3 SV=1
14	Q42539	1.1	33.5	230	0.044	0.091	PIMT1_ARATH Protein-L-isoaspartate O-methyltransferase 1 OS=Arabidopsis thaliana OX=3702 GN=PIMT1 PE=1 SV=3
15	P32874	1.8	33.9	2273	0.082	0.017	HFA1_YEAST Acetyl-CoA carboxylase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=HFA1 PE=1 SV=2
16	P9WPB1	2.0	33.1	286	0.061	0.101	MMAA1_MYCTU Mycolic acid methyltransferase MmaA1 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=mmaA1 PE=1 SV=1
17	Q9FMI5	3.1	32.7	377	0.042	0.053	Q9FMI5_ARATH At5g64156 OS=Arabidopsis thaliana OX=3702 GN=MHJ24.13 PE=1 SV=1
18	Q585P9	4.1	32.3	344	0.036	0.049	Q585P9_TRYB2 rRNA adenine N(6)-methyltransferase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb06.28P18.360 PE=3 SV=1
19	P0C0R7	6.5	31.2	209	0.025	0.057	RLME_ECOLI Ribosomal RNA large subunit methyltransferase E OS=Escherichia coli (strain K12) OX=83333 GN=rlmE PE=1 SV=1
20	Q64J17	6.6	31.6	309	0.031	0.049	PIMT2_ARATH Protein-L-isoaspartate O-methyltransferase 2 OS=Arabidopsis thaliana OX=3702 GN=PIMT2 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF02353 CMAS	83	13.9	Mycolic acid cyclopropane synthetase
2	PF08123 DOT1	3.9e+02	11.9	Histone methylation protein DOT1
3	PF01728 FtsJ	1.3e+02	14.2	FtsJ-like methyltransferase
4	PF08704 GCD14	2e-16	72.0	tRNA methyltransferase complex GCD14 subunit
5	PF13578 Methyltransf_24	67	16.0	Methyltransferase domain
6	PF13649 Methyltransf_25	0.088	24.8	Methyltransferase domain
7	PF13847 Methyltransf_31	9.9	17.4	Methyltransferase domain
8	PF01135 PCMT	3.7e-06	38.4	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
9	PF00398 RrnaAD	51	14.4	Ribosomal RNA adenine dimethylase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000302801

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000203001	0.989	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
2	9606.ENSP00000314441	0.974	tRNA (guanine-N(7)-)-methyltransferase
3	9606.ENSP00000374399	0.880	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
4	9606.ENSP00000312356	0.863	tRNA methyltransferase 10 homolog C
5	9606.ENSP00000333934	0.862	tRNA (guanine(10)-N2)-methyltransferase homolog
6	9606.ENSP00000238146	0.843	ATP-dependent RNA helicase DDX55
7	9606.ENSP00000381266	0.835	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
8	9606.ENSP00000261249	0.817	tRNA (guanine(37)-N1)-methyltransferase
9	9606.ENSP00000419740	0.805	5-methylcytosine rRNA methyltransferase NSUN4
10	9606.ENSP00000303584	0.785	HemK methyltransferase family member 2
11	9606.ENSP00000396673	0.782	pre-rRNA processing protein FTSJ3
12	9606.ENSP00000247003	0.779	Probable ATP-dependent RNA helicase DDX49
13	9606.ENSP00000326948	0.772	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
14	9606.ENSP00000273962	0.747	tRNA methyltransferase 10 homolog A
15	9606.ENSP00000242257	0.743	rRNA methyltransferase 2, mitochondrial
16	9606.ENSP00000297579	0.742	DDB1- and CUL4-associated factor 13
17	9606.ENSP00000371101	0.741	Nucleolar protein 10
18	9606.ENSP00000455106	0.739	Ribosome biogenesis protein BOP1
19	9606.ENSP00000306080	0.735	rRNA methyltransferase 3, mitochondrial
20	9606.ENSP00000257347	0.726	Probable cysteine--tRNA ligase, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0008174	1.000	mRNA methyltransferase activity
GO:0008649	1.000	rRNA methyltransferase activity
GO:0016429	1.000	tRNA (adenine-N1-)-methyltransferase activity
GO:0061953	0.966	mRNA (adenine-N1-)-methyltransferase activity
GO:0016433	0.959	rRNA (adenine) methyltransferase activity
GO:1901363	0.321	heterocyclic compound binding
GO:0097159	0.321	organic cyclic compound binding
GO:0008171	0.319	O-methyltransferase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0044238	0.998	primary metabolic process
GO:0044237	0.998	cellular metabolic process
GO:0006807	0.996	nitrogen compound metabolic process
GO:0043170	0.995	macromolecule metabolic process
GO:0044085	0.991	cellular component biogenesis
GO:0140053	0.991	mitochondrial gene expression
GO:0000959	0.991	mitochondrial RNA metabolic process
GO:0043412	0.986	macromolecule modification
GO:0043933	0.985	protein-containing complex organization
GO:0065003	0.984	protein-containing complex assembly
GO:0006400	0.977	tRNA modification
GO:0032259	0.976	methylation
GO:0000963	0.962	mitochondrial RNA processing
GO:0001510	0.961	RNA methylation
GO:0016556	0.955	mRNA modification
GO:1900864	0.948	mitochondrial RNA modification
GO:0051260	0.937	protein homooligomerization
GO:0030488	0.937	tRNA methylation
GO:0065007	0.306	biological regulation

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005759	0.998	mitochondrial matrix
GO:0031981	0.963	nuclear lumen
GO:0005654	0.952	nucleoplasm
GO:0043232	0.550	intracellular non-membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.1.1.-	1.000	Methyltransferases.

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