StarFunc result for job id Q9BXL7

User Input

>input (1154 residues)
MPGGGPEMDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEV
LNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVV
EEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERY
YKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME
EECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKA
ILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEM
YKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE
MVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTS
EESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSCG
SLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALD
LDDDSHERYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVR
GPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCIR
GERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRL
NLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTIPSYSRAQQ
LLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLL
QFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSL
IPYSLVRAFYCERRRPVLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKT
ETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCE
KNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEELLRVVKDKIG
EEQRKTIWVDEDQL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q5F3W0	0.392	0.387	0.000	1170	0.795	0.785	Q5F3W0.pdb.gz	Q5F3W0_CHICK CARD domain-containing protein OS=Gallus gallus OX=9031 GN=RCJMB04_5k17 PE=2 SV=1
2	AFDB:Q8CIS0	0.588	0.586	0.000	1159	0.921	0.917	Q8CIS0.pdb.gz	CAR11_MOUSE Caspase recruitment domain-containing protein 11 OS=Mus musculus OX=10090 GN=Card11 PE=1 SV=2
3	AFDB:A0A494C1N2	0.328	0.373	7.296E-63	1013	0.289	0.329	A0A494C1N2.pdb.gz	A0A494C1N2_HUMAN Caspase recruitment domain family member 14 OS=Homo sapiens OX=9606 GN=CARD14 PE=1 SV=1
4	AFDB:Q9BWT7	0.222	0.243	3.539E-53	1032	0.327	0.365	Q9BWT7.pdb.gz	CAR10_HUMAN Caspase recruitment domain-containing protein 10 OS=Homo sapiens OX=9606 GN=CARD10 PE=1 SV=2
5	AFDB:Q9H257	0.237	0.439	2.274E-23	536	0.186	0.401	Q9H257.pdb.gz	CARD9_HUMAN Caspase recruitment domain-containing protein 9 OS=Homo sapiens OX=9606 GN=CARD9 PE=1 SV=2
6	AFDB:A2AIV8	0.213	0.390	4.843E-23	536	0.182	0.392	A2AIV8.pdb.gz	CARD9_MOUSE Caspase recruitment domain-containing protein 9 OS=Mus musculus OX=10090 GN=Card9 PE=1 SV=1
7	PDB:2xkxA	0.203	0.302	1.600E-15	721	0.085	0.136	2xkxA.pdb.gz
8	PDB:6nuiA	0.118	0.531	5.424E-5	198	0.036	0.207	6nuiA.pdb.gz
9	PDB:4f4jA	0.125	0.606	1.037E-4	189	0.027	0.164	4f4jA.pdb.gz
10	PDB:1lvgA	0.116	0.540	2.331E-4	190	0.034	0.205	1lvgA.pdb.gz	Structural characterization of the closed conformation of mouse guanylate kinase.
11	PDB:1z6gA	0.123	0.580	2.331E-4	191	0.030	0.183	1z6gA.pdb.gz
12	PDB:7mixC	0.117	0.286	2.741E-4	324	0.053	0.188	7mixC.pdb.gz	Structure of human Ca v 2.2 channel blocked by the painkiller ziconotide.
13	AFDB:Q8N9W4	0.100	0.123	4.551E-4	909	0.091	0.116	Q8N9W4.pdb.gz	GG6L2_HUMAN Golgin subfamily A member 6-like protein 2 OS=Homo sapiens OX=9606 GN=GOLGA6L2 PE=1 SV=3
14	AFDB:Q8MNT0	0.075	0.078	6.641E-4	1099	0.075	0.079	Q8MNT0.pdb.gz	Q8MNT0_CAEEL PDZ domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=lim-8 PE=1 SV=1
15	AFDB:Q5KU26	0.093	0.127	7.809E-4	742	0.088	0.137	Q5KU26.pdb.gz	COL12_HUMAN Collectin-12 OS=Homo sapiens OX=9606 GN=COLEC12 PE=1 SV=3
16	AFDB:P34339	0.068	0.072	8.242E-4	1076	0.098	0.105	P34339.pdb.gz	EIF3A_CAEEL Eukaryotic translation initiation factor 3 subunit A OS=Caenorhabditis elegans OX=6239 GN=egl-45 PE=3 SV=1
17	PDB:2anbA	0.125	0.563	1.719E-3	206	0.024	0.136	2anbA.pdb.gz	Calorimetric and crystallographic analysis of the oligomeric structure of Escherichia coli GMP kinase
18	PDB:7pc3A	0.074	0.197	2.648E-3	405	0.020	0.057	7pc3A.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.
19	PDB:7p70A	0.067	0.187	3.661E-3	407	0.016	0.044	7p70A.pdb.gz	Quantitative fragmentomics allow affinity mapping of interactomes.
20	PDB:7qqnC	0.066	0.176	1.201E-2	414	0.015	0.041	7qqnC.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q5F3W0	0.0	1823	1170	0.792	0.781	Q5F3W0_CHICK CARD domain-containing protein OS=Gallus gallus OX=9031 GN=RCJMB04_5k17 PE=2 SV=1
2	Q8CIS0	0.0	2170	1159	0.922	0.918	CAR11_MOUSE Caspase recruitment domain-containing protein 11 OS=Mus musculus OX=10090 GN=Card11 PE=1 SV=2
3	Q9BXL7	0.0	2380	1154	1.000	1.000	CAR11_HUMAN Caspase recruitment domain-containing protein 11 OS=Homo sapiens OX=9606 GN=CARD11 PE=1 SV=3
4	A0A494C1N2	4.63e-129	422	1013	0.299	0.341	A0A494C1N2_HUMAN Caspase recruitment domain family member 14 OS=Homo sapiens OX=9606 GN=CARD14 PE=1 SV=1
5	Q9BXL6	1.76e-127	417	1004	0.302	0.347	CAR14_HUMAN Caspase recruitment domain-containing protein 14 OS=Homo sapiens OX=9606 GN=CARD14 PE=1 SV=2
6	Q17RA1	2.04e-122	404	1030	0.319	0.357	Q17RA1_HUMAN Caspase recruitment domain family, member 10 OS=Homo sapiens OX=9606 GN=CARD10 PE=1 SV=1
7	P58660	3.34e-122	403	1021	0.204	0.230	CAR10_MOUSE Caspase recruitment domain-containing protein 10 OS=Mus musculus OX=10090 GN=Card10 PE=1 SV=1
8	Q9BWT7	7.49e-122	403	1032	0.319	0.357	CAR10_HUMAN Caspase recruitment domain-containing protein 10 OS=Homo sapiens OX=9606 GN=CARD10 PE=1 SV=2
9	Q9H257	1.06e-109	355	536	0.178	0.382	CARD9_HUMAN Caspase recruitment domain-containing protein 9 OS=Homo sapiens OX=9606 GN=CARD9 PE=1 SV=2
10	Q9EPY0	1.30e-108	352	536	0.176	0.379	CARD9_RAT Caspase recruitment domain-containing protein 9 OS=Rattus norvegicus OX=10116 GN=Card9 PE=1 SV=1
11	A2AIV8	3.25e-107	348	536	0.175	0.377	CARD9_MOUSE Caspase recruitment domain-containing protein 9 OS=Mus musculus OX=10090 GN=Card9 PE=1 SV=1
12	M9PD90	4.46e-18	93.2	1915	0.110	0.066	M9PD90_DROME Discs large 5, isoform D OS=Drosophila melanogaster OX=7227 GN=Dlg5 PE=1 SV=1
13	Q9VKG8	4.46e-18	93.2	1916	0.110	0.066	Q9VKG8_DROME Discs large 5, isoform A OS=Drosophila melanogaster OX=7227 GN=Dlg5 PE=1 SV=1
14	E9Q9R9	1.69e-12	74.7	1921	0.103	0.062	DLG5_MOUSE Disks large homolog 5 OS=Mus musculus OX=10090 GN=Dlg5 PE=1 SV=1
15	O62683	1.01e-10	68.6	898	0.110	0.141	ZO3_CANLF Tight junction protein ZO-3 OS=Canis lupus familiaris OX=9615 GN=TJP3 PE=1 SV=1
16	Q8TDM6	3.24e-10	67.4	1919	0.096	0.058	DLG5_HUMAN Disks large homolog 5 OS=Homo sapiens OX=9606 GN=DLG5 PE=1 SV=4
17	O95049	8.70e-10	65.5	919	0.107	0.134	ZO3_HUMAN Tight junction protein ZO-3 OS=Homo sapiens OX=9606 GN=TJP3 PE=1 SV=3
18	P70625	2.88e-09	63.9	813	0.062	0.087	P70625_RAT Zonula occludens 2 protein (Fragment) OS=Rattus norvegicus OX=10116 GN=ZO-2 PE=2 SV=2
19	Q3ZB99	6.20e-09	62.8	1164	0.062	0.061	Q3ZB99_RAT Tight junction protein 2 OS=Rattus norvegicus OX=10116 GN=Tjp2 PE=1 SV=1
20	A0A8J8Y4W9	6.64e-09	62.8	1166	0.062	0.061	A0A8J8Y4W9_RAT Tight junction protein 2 OS=Rattus norvegicus OX=10116 GN=Tjp2 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00619 CARD	1.2e-18	78.2	Caspase recruitment domain
2	PF00625 Guanylate_kin	0.52	21.5	Guanylate kinase
3	PF00595 PDZ	0.4	22.4	PDZ domain
4	PF17820 PDZ_6	6.2	18.1	PDZ domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000380150

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000319279	0.999	Mucosa-associated lymphoid tissue lymphoma translocation protein 1
2	9606.ENSP00000359612	0.999	B-cell lymphoma/leukemia 10
3	9606.ENSP00000263125	0.997	Protein kinase C theta type
4	9606.ENSP00000483825	0.997	NF-kappa-B essential modulator
5	9606.ENSP00000358335	0.993	Mitogen-activated protein kinase kinase kinase 7
6	9606.ENSP00000433623	0.983	TNF receptor-associated factor 6
7	9606.ENSP00000305355	0.982	Protein kinase C beta type
8	9606.ENSP00000359424	0.976	Inhibitor of nuclear factor kappa-B kinase subunit alpha
9	9606.ENSP00000430684	0.973	Inhibitor of nuclear factor kappa-B kinase subunit beta
10	9606.ENSP00000421689	0.945	Casein kinase I isoform alpha
11	9606.ENSP00000316176	0.938	Ubiquitin-conjugating enzyme E2 N
12	9606.ENSP00000220751	0.936	Receptor-interacting serine/threonine-protein kinase 2
13	9606.ENSP00000344220	0.933	3-phosphoinositide-dependent protein kinase 1
14	9606.ENSP00000340305	0.930	Ubiquitin-conjugating enzyme E2 variant 1
15	9606.ENSP00000384570	0.913	Caspase recruitment domain-containing protein 10
16	9606.ENSP00000456226	0.900	Interferon induced transmembrane protein domain containing
17	9606.ENSP00000427114	0.893	FYN-binding protein 1
18	9606.ENSP00000451828	0.893	RAC-alpha serine/threonine-protein kinase
19	9606.ENSP00000353731	0.883	Dipeptidyl peptidase 4
20	9606.ENSP00000465039	0.881	Mitogen-activated protein kinase kinase kinase kinase 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0019899	0.695	enzyme binding
GO:0002020	0.318	protease binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.997	cellular process
GO:0050794	0.997	regulation of cellular process
GO:0050896	0.996	response to stimulus
GO:0048583	0.990	regulation of response to stimulus
GO:0060255	0.990	regulation of macromolecule metabolic process
GO:0030155	0.986	regulation of cell adhesion
GO:0050865	0.986	regulation of cell activation
GO:0007165	0.986	signal transduction
GO:0048522	0.985	positive regulation of cellular process
GO:0002376	0.981	immune system process
GO:0002684	0.981	positive regulation of immune system process
GO:0080090	0.979	regulation of primary metabolic process
GO:0051171	0.978	regulation of nitrogen compound metabolic process
GO:0035556	0.978	intracellular signal transduction
GO:0043123	0.976	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044093	0.975	positive regulation of molecular function
GO:0010468	0.975	regulation of gene expression
GO:0031323	0.974	regulation of cellular metabolic process
GO:0050778	0.973	positive regulation of immune response
GO:0009893	0.967	positive regulation of metabolic process
GO:0010604	0.963	positive regulation of macromolecule metabolic process
GO:1903039	0.957	positive regulation of leukocyte cell-cell adhesion
GO:0050870	0.950	positive regulation of T cell activation
GO:0032663	0.948	regulation of interleukin-2 production
GO:0007249	0.948	I-kappaB kinase/NF-kappaB signaling
GO:0051090	0.942	regulation of DNA-binding transcription factor activity
GO:0051091	0.925	positive regulation of DNA-binding transcription factor activity
GO:0050854	0.918	regulation of antigen receptor-mediated signaling pathway
GO:0051092	0.915	positive regulation of NF-kappaB transcription factor activity
GO:0001819	0.901	positive regulation of cytokine production
GO:0051173	0.753	positive regulation of nitrogen compound metabolic process
GO:0050793	0.653	regulation of developmental process
GO:0007166	0.639	cell surface receptor signaling pathway
GO:2000026	0.624	regulation of multicellular organismal development
GO:0071704	0.579	organic substance metabolic process
GO:0044238	0.577	primary metabolic process
GO:0006807	0.523	nitrogen compound metabolic process
GO:0031325	0.495	positive regulation of cellular metabolic process
GO:0008284	0.493	positive regulation of cell population proliferation
GO:0043170	0.469	macromolecule metabolic process
GO:0051246	0.439	regulation of protein metabolic process
GO:1901564	0.434	organonitrogen compound metabolic process
GO:0044237	0.429	cellular metabolic process
GO:0032501	0.414	multicellular organismal process
GO:0002764	0.408	immune response-regulating signaling pathway
GO:0048856	0.406	anatomical structure development
GO:0019538	0.385	protein metabolic process
GO:0070663	0.379	regulation of leukocyte proliferation
GO:0002757	0.378	immune response-activating signaling pathway
GO:0042221	0.367	response to chemical
GO:0048519	0.357	negative regulation of biological process
GO:0070665	0.347	positive regulation of leukocyte proliferation
GO:0051247	0.337	positive regulation of protein metabolic process
GO:0071840	0.333	cellular component organization or biogenesis
GO:0048523	0.324	negative regulation of cellular process
GO:0010033	0.321	response to organic substance
GO:0019220	0.320	regulation of phosphate metabolic process
GO:0031399	0.313	regulation of protein modification process
GO:0050856	0.303	regulation of T cell receptor signaling pathway
GO:0032743	0.303	positive regulation of interleukin-2 production

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0005829	0.999	cytosol
GO:0032991	0.993	protein-containing complex
GO:0043226	0.986	organelle
GO:0043227	0.979	membrane-bounded organelle
GO:0043229	0.916	intracellular organelle
GO:0043231	0.911	intracellular membrane-bounded organelle
GO:0031982	0.882	vesicle
GO:0005576	0.806	extracellular region
GO:0005615	0.586	extracellular space
GO:0031981	0.424	nuclear lumen
GO:0140535	0.361	intracellular protein-containing complex
GO:0005654	0.354	nucleoplasm
GO:0070062	0.319	extracellular exosome

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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