StarFunc result for job id Q9BY32

User Input

>input (194 residues)
MAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEA
VRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFAL
STGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFR
ALLELQEYFGSLAA

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9D892	0.991	0.971	2.049E-42	198	0.892	0.874	Q9D892.pdb.gz	ITPA_MOUSE Inosine triphosphate pyrophosphatase OS=Mus musculus OX=10090 GN=Itpa PE=1 SV=2
2	PDB:2carA	0.936	0.927	1.401E-41	196	1.000	0.990	2carA.pdb.gz
3	AFDB:A0A0S2Z423	0.733	0.921	3.524E-30	153	0.773	0.980	A0A0S2Z423.pdb.gz	A0A0S2Z423_HUMAN Inosine triphosphatase isoform 2 (Fragment) OS=Homo sapiens OX=9606 GN=ITPA PE=2 SV=1
4	AFDB:Q9UU89	0.923	0.952	9.737E-28	188	0.438	0.452	Q9UU89.pdb.gz	ITPA_SCHPO Inosine triphosphate pyrophosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC830.10 PE=3 SV=1
5	AFDB:P47119	0.886	0.873	4.878E-25	197	0.412	0.406	P47119.pdb.gz	ITPA_YEAST Inosine triphosphate pyrophosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=HAM1 PE=1 SV=1
6	AFDB:O28046	0.849	0.907	1.663E-21	181	0.320	0.343	O28046.pdb.gz	IXTPA_ARCFU dITP/XTP pyrophosphatase OS=Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) OX=224325 GN=AF_2237 PE=1 SV=1
7	AFDB:Q57679	0.857	0.896	3.017E-21	185	0.325	0.341	Q57679.pdb.gz	IXTPA_METJA dITP/XTP pyrophosphatase OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) OX=243232 GN=MJ0226 PE=1 SV=2
8	PDB:2mjpA	0.824	0.866	4.269E-20	184	0.320	0.337	2mjpA.pdb.gz	Structure-based identification of a novel NTPase from Methanococcus jannaschii.
9	AFDB:Q9PMS6	0.816	0.793	1.548E-16	200	0.258	0.250	Q9PMS6.pdb.gz	IXTPA_CAMJE dITP/XTP pyrophosphatase OS=Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) OX=192222 GN=Cj1374c PE=1 SV=1
10	AFDB:P52061	0.832	0.820	2.660E-15	197	0.278	0.274	P52061.pdb.gz	IXTPA_ECOLI dITP/XTP pyrophosphatase OS=Escherichia coli (strain K12) OX=83333 GN=rdgB PE=1 SV=1
11	PDB:2pyuA	0.790	0.743	1.307E-14	208	0.289	0.269	2pyuA.pdb.gz	Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli.
12	AFDB:P25536	0.469	0.463	2.599E-6	197	0.180	0.178	P25536.pdb.gz	NTPPA_ECOLI dTTP/UTP pyrophosphatase OS=Escherichia coli (strain K12) OX=83333 GN=yhdE PE=1 SV=1
13	AFDB:Q9D927	0.450	0.384	9.131E-6	233	0.149	0.124	Q9D927.pdb.gz	Q9D927_MOUSE Uncharacterized protein OS=Mus musculus OX=10090 GN=1810009N02Rik PE=2 SV=1
14	PDB:4p0eA	0.483	0.494	2.823E-5	189	0.170	0.175	4p0eA.pdb.gz
15	PDB:4jhcA	0.445	0.449	7.614E-5	192	0.052	0.052	4jhcA.pdb.gz
16	PDB:4q35B	0.366	0.443	1.397E-3	150	0.082	0.107	4q35B.pdb.gz	Structural basis for lipopolysaccharide insertion in the bacterial outer membrane.
17	PDB:1u5wC	0.326	0.356	1.493E-3	174	0.093	0.103	1u5wC.pdb.gz
18	PDB:1c2tA	0.254	0.242	1.969E-2	209	0.088	0.081	1c2tA.pdb.gz	New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.
19	PDB:6ahrG	0.132	0.185	1.969E-2	131	0.067	0.099	6ahrG.pdb.gz	Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
20	PDB:3da8A	0.318	0.298	2.740E-2	213	0.129	0.117	3da8A.pdb.gz	Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A0S2Z3W7	1.46e-143	399	194	1.000	1.000	A0A0S2Z3W7_HUMAN Epididymis secretory sperm binding protein (Fragment) OS=Homo sapiens OX=9606 GN=ITPA PE=2 SV=1
2	Q9BY32	1.46e-143	399	194	1.000	1.000	ITPA_HUMAN Inosine triphosphate pyrophosphatase OS=Homo sapiens OX=9606 GN=ITPA PE=1 SV=2
3	Q9D892	2.95e-129	363	198	0.902	0.884	ITPA_MOUSE Inosine triphosphate pyrophosphatase OS=Mus musculus OX=10090 GN=Itpa PE=1 SV=2
4	A0A0S2Z423	6.65e-104	297	153	0.789	1.000	A0A0S2Z423_HUMAN Inosine triphosphatase isoform 2 (Fragment) OS=Homo sapiens OX=9606 GN=ITPA PE=2 SV=1
5	Q9UU89	3.65e-60	187	188	0.443	0.457	ITPA_SCHPO Inosine triphosphate pyrophosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC830.10 PE=3 SV=1
6	P47119	8.29e-41	139	197	0.428	0.421	ITPA_YEAST Inosine triphosphate pyrophosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=HAM1 PE=1 SV=1
7	Q57679	2.79e-26	101	185	0.314	0.330	IXTPA_METJA dITP/XTP pyrophosphatase OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) OX=243232 GN=MJ0226 PE=1 SV=2
8	O28046	6.27e-26	100	181	0.314	0.337	IXTPA_ARCFU dITP/XTP pyrophosphatase OS=Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) OX=224325 GN=AF_2237 PE=1 SV=1
9	P52061	3.83e-13	67.0	197	0.299	0.294	IXTPA_ECOLI dITP/XTP pyrophosphatase OS=Escherichia coli (strain K12) OX=83333 GN=rdgB PE=1 SV=1
10	Q9PMS6	1.94e-11	62.4	200	0.278	0.270	IXTPA_CAMJE dITP/XTP pyrophosphatase OS=Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) OX=192222 GN=Cj1374c PE=1 SV=1
11	Q9C690	1.5	31.6	379	0.108	0.055	BH122_ARATH Transcription factor bHLH122 OS=Arabidopsis thaliana OX=3702 GN=BHLH122 PE=1 SV=1
12	Q54J08	1.8	31.6	2282	0.124	0.011	ACAC_DICDI Acetyl-CoA carboxylase OS=Dictyostelium discoideum OX=44689 GN=accA PE=3 SV=1
13	A0A2R8YH03	3.0	31.2	2645	0.144	0.011	A0A2R8YH03_HUMAN Transcription activation suppressor family member 2 OS=Homo sapiens OX=9606 GN=TASOR2 PE=1 SV=1
14	Q5VWN6	3.4	30.8	2430	0.144	0.012	TASO2_HUMAN Protein TASOR 2 OS=Homo sapiens OX=9606 GN=TASOR2 PE=1 SV=1
15	Q6PDN3	5.3	30.4	1941	0.067	0.007	MYLK_MOUSE Myosin light chain kinase, smooth muscle OS=Mus musculus OX=10090 GN=Mylk PE=1 SV=3
16	P90757	5.5	30.4	1437	0.057	0.008	P90757_CAEEL WD_REPEATS_REGION domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=che-11 PE=4 SV=5
17	Q9HUA1	5.8	30.0	299	0.088	0.057	Q9HUA1_PSEAE Probable binding protein component of ABC transporter OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=PA5082 PE=4 SV=1
18	Q9BZC7	6.0	30.0	2435	0.082	0.007	ABCA2_HUMAN ATP-binding cassette sub-family A member 2 OS=Homo sapiens OX=9606 GN=ABCA2 PE=1 SV=4
19	A0A087WXK5	6.2	30.0	2466	0.082	0.006	A0A087WXK5_HUMAN ATP-binding cassette sub-family A member 2 OS=Homo sapiens OX=9606 GN=ABCA2 PE=1 SV=1
20	Q93XK2	6.2	30.0	853	0.072	0.016	STSYN_PEA Stachyose synthase OS=Pisum sativum OX=3888 GN=STS1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01725 Ham1p_like	2.8e-52	188.9	Ham1 family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000369456

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000312304	0.979	Thiopurine S-methyltransferase
2	9606.ENSP00000355493	0.974	Adenylosuccinate synthetase isozyme 2
3	9606.ENSP00000236959	0.970	Bifunctional purine biosynthesis protein PURH
4	9606.ENSP00000430075	0.964	AMP deaminase 1
5	9606.ENSP00000333019	0.963	Adenylosuccinate synthetase isozyme 1
6	9606.ENSP00000419851	0.958	GMP synthase [glutamine-hydrolyzing]
7	9606.ENSP00000355689	0.957	Guanylate kinase
8	9606.ENSP00000422375	0.951	U8 snoRNA-decapping enzyme
9	9606.ENSP00000321584	0.950	Inosine-5'-monophosphate dehydrogenase 2
10	9606.ENSP00000410186	0.950	Adenylate kinase 9
11	9606.ENSP00000345096	0.949	Inosine-5'-monophosphate dehydrogenase 1
12	9606.ENSP00000373674	0.949	5'(3')-deoxyribonucleotidase, mitochondrial
13	9606.ENSP00000367615	0.944	Adenine phosphoribosyltransferase
14	9606.ENSP00000245552	0.943	5'(3')-deoxyribonucleotidase, cytosolic type
15	9606.ENSP00000356785	0.940	Nucleoside diphosphate kinase 7
16	9606.ENSP00000379802	0.939	AMP deaminase 3
17	9606.ENSP00000360561	0.938	Ectonucleoside triphosphate diphosphohydrolase 8
18	9606.ENSP00000301825	0.937	Ectonucleoside triphosphate diphosphohydrolase 3
19	9606.ENSP00000320171	0.936	Pyruvate kinase PKM
20	9606.ENSP00000259727	0.934	GMP reductase 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.996	protein binding
GO:0047429	0.995	nucleoside triphosphate diphosphatase activity
GO:0042802	0.975	identical protein binding
GO:0035870	0.835	dITP diphosphatase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.997	organic substance metabolic process
GO:0044237	0.997	cellular metabolic process
GO:0044238	0.996	primary metabolic process
GO:1901360	0.991	organic cyclic compound metabolic process
GO:0046483	0.990	heterocycle metabolic process
GO:0006725	0.990	cellular aromatic compound metabolic process
GO:0034641	0.990	cellular nitrogen compound metabolic process
GO:1901135	0.981	carbohydrate derivative metabolic process
GO:0006163	0.981	purine nucleotide metabolic process
GO:0034655	0.950	nucleobase-containing compound catabolic process
GO:1901292	0.934	nucleoside phosphate catabolic process
GO:0009259	0.916	ribonucleotide metabolic process
GO:0009150	0.910	purine ribonucleotide metabolic process
GO:0009141	0.873	nucleoside triphosphate metabolic process
GO:0009166	0.867	nucleotide catabolic process
GO:1901136	0.830	carbohydrate derivative catabolic process
GO:1901565	0.790	organonitrogen compound catabolic process
GO:0009144	0.782	purine nucleoside triphosphate metabolic process
GO:0009199	0.762	ribonucleoside triphosphate metabolic process
GO:0072523	0.743	purine-containing compound catabolic process
GO:0071840	0.730	cellular component organization or biogenesis
GO:0006195	0.725	purine nucleotide catabolic process
GO:0009205	0.709	purine ribonucleoside triphosphate metabolic process
GO:0009154	0.604	purine ribonucleotide catabolic process
GO:0016043	0.526	cellular component organization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	1.000	cytosol
GO:0005654	0.997	nucleoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.6.1.9	0.995	nucleotide diphosphatase.
RHEA:28342	0.835	dITP + H2O = dIMP + diphosphate + H(+)
EC:3.6.1.66	0.835	XTP/dITP diphosphatase.

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