StarFunc result for job id Q9H270

User Input

>input (941 residues)
MAAYLQWRRFVFFDKELVKEPLSNDGAAPGATPASGSAASKFLCLPPGITVCDSGRGSLV
FGDMEGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASVGEDEEGINPLVKIWNLEK
RDGGNPLCTRIFPAIPGTEPTVVSCLTVHENLNFMAIGFTDGSVTLNKGDITRDRHSKTQ
ILHKGNYPVTGLAFRQAGKTTHLFVVTTENVQSYIVSGKDYPRVELDTHGCGLRCSALSD
PSQDLQFIVAGDECVYLYQPDERGPCFAFEGHKLIAHWFRGYLIIVSRDRKVSPKSEFTS
RDSQSSDKQILNIYDLCNKFIAYSTVFEDVVDVLAEWGSLYVLTRDGRVHALQEKDTQTK
LEMLFKKNLFEMAINLAKSQHLDSDGLAQIFMQYGDHLYSKGNHDGAVQQYIRTIGKLEP
SYVIRKFLDAQRIHNLTAYLQTLHRQSLANADHTTLLLNCYTKLKDSSKLEEFIKKKSES
EVHFDVETAIKVLRQAGYYSHALYLAENHAHHEWYLKIQLEDIKNYQEALRYIGKLPFEQ
AESNMKRYGKILMHHIPEQTTQLLKGLCTDYRPSLEGRSDREAPGCRANSEEFIPIFANN
PRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEKDPQVKEKLHAEAISLLKSGRFC
DVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQHEQYRQVISVCERHGEQDPSLW
EQALSYFARKEEDCKEYVAAVLKHIENKNLMPPLLVVQTLAHNSTATLSVIRDYLVQKLQ
KQSQQIAQDELRVRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGH
SFHQHCFESYSESDADCPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLRCSNDSFSVIAD
YFGRGVFNKLTLLTDPPTARLTSSLEAGLQRDLLMHSRRGT

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:F1QVG9	0.583	0.591	0.000	927	0.740	0.751	F1QVG9.pdb.gz
2	AFDB:Q53FX3	0.588	0.588	0.000	941	0.995	0.995	Q53FX3.pdb.gz	Q53FX3_HUMAN Vacuolar protein sorting 11 (Yeast homolog) variant (Fragment) OS=Homo sapiens OX=9606 PE=2 SV=1
3	AFDB:Q9SJ40	0.480	0.484	1.070E-71	932	0.399	0.402	Q9SJ40.pdb.gz	VPS11_ARATH Vacuolar protein-sorting-associated protein 11 homolog OS=Arabidopsis thaliana OX=3702 GN=VPS11 PE=1 SV=1
4	AFDB:A0A1D8PMF6	0.503	0.437	5.868E-52	1100	0.258	0.221	A0A1D8PMF6.pdb.gz	A0A1D8PMF6_CANAL E3 ubiquitin-protein ligase PEP5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=VPS11 PE=3 SV=1
5	AFDB:Q57YS6	0.467	0.398	2.238E-48	1123	0.294	0.247	Q57YS6.pdb.gz	Q57YS6_TRYB2 RING-type domain-containing protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.10K10.560 PE=4 SV=1
6	AFDB:Q9P6N4	0.455	0.471	2.028E-46	906	0.209	0.217	Q9P6N4.pdb.gz	PEP5_SCHPO E3 ubiquitin-protein ligase pep5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=vps11 PE=3 SV=1
7	AFDB:P87295	0.448	0.489	6.023E-35	847	0.164	0.182	P87295.pdb.gz	PEP5L_SCHPO Pep5-like zinc finger protein C16A10.03c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC16A10.03c PE=4 SV=2
8	PDB:7zu0A	0.441	0.436	8.000E-35	954	0.210	0.208	7zu0A.pdb.gz
9	AFDB:Q8SX81	0.396	0.444	5.719E-32	830	0.182	0.206	Q8SX81.pdb.gz	Q8SX81_DROME LD20292p OS=Drosophila melanogaster OX=7227 GN=Vps11 PE=1 SV=1
10	AFDB:G5EAW8	0.386	0.379	3.505E-24	963	0.153	0.150	G5EAW8.pdb.gz	G5EAW8_EMENI Pep3/Vps18/deep orange domain-containing protein OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=digA PE=3 SV=1
11	AFDB:B5DFJ4	0.388	0.378	3.677E-24	973	0.153	0.148	B5DFJ4.pdb.gz	B5DFJ4_RAT Vacuolar protein sorting-associated protein 18 homolog OS=Rattus norvegicus OX=10116 GN=Vps18 PE=1 SV=1
12	PDB:7zu0C	0.195	0.208	1.522E-12	842	0.113	0.126	7zu0C.pdb.gz
13	PDB:7qpgR	0.280	0.135	2.458E-12	2208	0.138	0.059	7qpgR.pdb.gz
14	PDB:1xi4A	0.249	0.162	1.316E-11	1630	0.113	0.065	1xi4A.pdb.gz
15	PDB:7mq8LR	0.193	0.229	1.253E-10	773	0.077	0.093	7mq8LR.pdb.gz	Nucleolar maturation of the human small subunit processome.
16	PDB:3zwlD	0.273	0.658	2.572E-10	352	0.045	0.119	3zwlD.pdb.gz
17	PDB:7mqaLO	0.261	0.297	2.831E-10	819	0.072	0.083	7mqaLO.pdb.gz	Nucleolar maturation of the human small subunit processome.
18	PDB:7qdrC	0.255	0.707	2.970E-10	305	0.051	0.157	7qdrC.pdb.gz
19	PDB:6qk7A	0.220	0.183	4.154E-10	1161	0.095	0.077	6qk7A.pdb.gz	Molecular basis of tRNA recognition by the Elongator complex.
20	PDB:7r5jK0	0.216	0.190	4.154E-10	1086	0.112	0.097	7r5jK0.pdb.gz	AI-based structure prediction empowers integrative structural analysis of human nuclear pores

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q4G0A0	0.0	1465	927	0.740	0.751	Q4G0A0_DANRE Vacuolar protein sorting-associated protein 11 homolog OS=Danio rerio OX=7955 GN=zgc:112329 PE=1 SV=1
2	Q53FX3	0.0	1962	941	0.996	0.996	Q53FX3_HUMAN Vacuolar protein sorting 11 (Yeast homolog) variant (Fragment) OS=Homo sapiens OX=9606 PE=2 SV=1
3	Q658K0	0.0	1951	940	0.993	0.994	Q658K0_HUMAN Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens OX=9606 GN=DKFZp564P2364 PE=2 SV=1
4	Q91W86	0.0	1928	941	0.974	0.974	VPS11_MOUSE Vacuolar protein sorting-associated protein 11 homolog OS=Mus musculus OX=10090 GN=Vps11 PE=1 SV=3
5	Q9H270	0.0	1971	941	1.000	1.000	VPS11_HUMAN Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens OX=9606 GN=VPS11 PE=1 SV=1
6	Q9SJ40	0.0	665	932	0.395	0.399	VPS11_ARATH Vacuolar protein-sorting-associated protein 11 homolog OS=Arabidopsis thaliana OX=3702 GN=VPS11 PE=1 SV=1
7	Q57YS6	1.35e-81	288	1123	0.307	0.257	Q57YS6_TRYB2 RING-type domain-containing protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.10K10.560 PE=4 SV=1
8	Q9P6N4	1.75e-48	188	906	0.222	0.231	PEP5_SCHPO E3 ubiquitin-protein ligase pep5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=vps11 PE=3 SV=1
9	A0A1D8PMF6	1.64e-43	174	1100	0.168	0.144	A0A1D8PMF6_CANAL E3 ubiquitin-protein ligase PEP5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=VPS11 PE=3 SV=1
10	P12868	9.75e-33	139	1029	0.153	0.140	PEP5_YEAST E3 ubiquitin-protein ligase PEP5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PEP5 PE=1 SV=2
11	Q8SX81	4.76e-28	124	830	0.116	0.131	Q8SX81_DROME LD20292p OS=Drosophila melanogaster OX=7227 GN=Vps11 PE=1 SV=1
12	P87295	7.11e-14	78.6	847	0.188	0.209	PEP5L_SCHPO Pep5-like zinc finger protein C16A10.03c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC16A10.03c PE=4 SV=2
13	Q8R307	9.57e-08	58.5	973	0.084	0.081	VPS18_MOUSE Vacuolar protein sorting-associated protein 18 homolog OS=Mus musculus OX=10090 GN=Vps18 PE=1 SV=2
14	B5DFJ4	1.87e-07	57.8	973	0.083	0.080	B5DFJ4_RAT Vacuolar protein sorting-associated protein 18 homolog OS=Rattus norvegicus OX=10116 GN=Vps18 PE=1 SV=1
15	Q9P253	6.88e-07	55.8	973	0.082	0.079	VPS18_HUMAN Vacuolar protein sorting-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=VPS18 PE=1 SV=2
16	P59015	5.48e-05	49.7	974	0.045	0.043	VPS18_DANRE Vacuolar protein sorting-associated protein 18 homolog OS=Danio rerio OX=7955 GN=vps18 PE=2 SV=2
17	Q9LW77	5.25e-04	46.2	492	0.034	0.065	HRD1A_ARATH ERAD-associated E3 ubiquitin-protein ligase HRD1A OS=Arabidopsis thaliana OX=3702 GN=HRD1A PE=2 SV=1
18	Q24314	0.002	44.3	1002	0.031	0.029	VPS18_DROME Vacuolar protein sorting-associated protein 18 homolog OS=Drosophila melanogaster OX=7227 GN=dor PE=1 SV=3
19	F1QB30	0.004	43.1	620	0.028	0.042	F1QB30_DANRE Autocrine motility factor receptor a OS=Danio rerio OX=7955 GN=amfr PE=4 SV=1
20	Q6NPT7	0.004	43.1	460	0.021	0.043	HRD1B_ARATH ERAD-associated E3 ubiquitin-protein ligase HRD1B OS=Arabidopsis thaliana OX=3702 GN=HRD1B PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF06461 CHDII_SANT-like	5.1e+02	11.9	CHD subfamily II, SANT-like domain
2	PF00637 Clathrin	3.3e-14	64.4	Region in Clathrin and VPS
3	PF18709 DLP_helical	2.2e+02	12.4	Dynamin-like helical domain
4	PF13414 TPR_11	1.2e+02	13.8	TPR repeat
5	PF12451 VPS11_C	1.7e-14	65.1	Vacuolar protein sorting protein 11 C terminal
6	PF12861 zf-ANAPC11	4.6e+02	12.3	Anaphase-promoting complex subunit 11 RING-H2 finger
7	PF17122 zf-C3H2C3	3.8	18.9	Zinc-finger
8	PF00097 zf-C3HC4	0.98	20.7	Zinc finger, C3HC4 type (RING finger)
9	PF13923 zf-C3HC4_2	8.8e-05	33.6	Zinc finger, C3HC4 type (RING finger)
10	PF13920 zf-C3HC4_3	29	15.9	Zinc finger, C3HC4 type (RING finger)
11	PF12678 zf-rbx1	0.65	21.6	RING-H2 zinc finger domain
12	PF13639 zf-RING_2	0.0013	30.4	Ring finger domain
13	PF14634 zf-RING_5	12	17.3	zinc-RING finger domain
14	PF13445 zf-RING_UBOX	10	17.6	RING-type zinc-finger

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000481126

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000220509	0.999	Vacuolar protein sorting-associated protein 18 homolog
2	9606.ENSP00000267199	0.999	Vacuolar protein sorting-associated protein 33A
3	9606.ENSP00000309457	0.999	Vacuolar protein sorting-associated protein 41 homolog
4	9606.ENSP00000335193	0.999	Vam6/Vps39-like protein
5	9606.ENSP00000369810	0.999	Vacuolar protein sorting-associated protein 16 homolog
6	9606.ENSP00000377027	0.999	Transforming growth factor-beta receptor-associated protein 1
7	9606.ENSP00000404704	0.999	Vacuolar protein sorting-associated protein 8 homolog
8	9606.ENSP00000327650	0.995	Vacuolar protein sorting-associated protein 33B
9	9606.ENSP00000265062	0.994	Ras-related protein Rab-7a
10	9606.ENSP00000259400	0.934	Syntaxin-17
11	9606.ENSP00000358126	0.927	Vacuolar protein sorting-associated protein 45
12	9606.ENSP00000376792	0.927	Vesicle transport through interaction with t-SNAREs homolog 1A
13	9606.ENSP00000479762	0.927	Ras-related protein Rab-7b
14	9606.ENSP00000273047	0.907	Ras-related protein Rab-5A
15	9606.ENSP00000450731	0.881	Vesicle transport through interaction with t-SNAREs homolog 1B
16	9606.ENSP00000296473	0.874	Vacuolar fusion protein MON1 homolog A
17	9606.ENSP00000258301	0.856	Syntaxin-6
18	9606.ENSP00000356918	0.851	Syntaxin-7
19	9606.ENSP00000305255	0.849	Syntaxin-8
20	9606.ENSP00000420127	0.833	Ras-related protein Rab-9A

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0003824	0.887	catalytic activity
GO:0019787	0.565	ubiquitin-like protein transferase activity
GO:0004842	0.532	ubiquitin-protein transferase activity
GO:0061630	0.475	ubiquitin protein ligase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.989	cellular process
GO:0065007	0.987	biological regulation
GO:0006810	0.987	transport
GO:0050789	0.980	regulation of biological process
GO:0016043	0.972	cellular component organization
GO:0050794	0.971	regulation of cellular process
GO:0007034	0.934	vacuolar transport
GO:0016192	0.929	vesicle-mediated transport
GO:0048284	0.929	organelle fusion
GO:0016050	0.918	vesicle organization
GO:0061025	0.915	membrane fusion
GO:0006906	0.910	vesicle fusion
GO:0007041	0.909	lysosomal transport
GO:0009894	0.897	regulation of catabolic process
GO:0008333	0.884	endosome to lysosome transport
GO:0031323	0.675	regulation of cellular metabolic process
GO:0008152	0.646	metabolic process
GO:1901998	0.614	toxin transport
GO:0048518	0.495	positive regulation of biological process
GO:0048519	0.486	negative regulation of biological process
GO:0048522	0.436	positive regulation of cellular process
GO:0032879	0.423	regulation of localization
GO:0044237	0.416	cellular metabolic process
GO:0048523	0.401	negative regulation of cellular process
GO:0071704	0.373	organic substance metabolic process
GO:0044238	0.371	primary metabolic process
GO:0060341	0.346	regulation of cellular localization
GO:0006807	0.331	nitrogen compound metabolic process
GO:0032880	0.315	regulation of protein localization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0012505	0.999	endomembrane system
GO:0005774	0.997	vacuolar membrane
GO:0032991	0.995	protein-containing complex
GO:0000323	0.995	lytic vacuole
GO:0005765	0.987	lysosomal membrane
GO:0099023	0.955	vesicle tethering complex
GO:0031982	0.946	vesicle
GO:0005768	0.935	endosome
GO:0005829	0.925	cytosol
GO:0030659	0.898	cytoplasmic vesicle membrane
GO:0005769	0.837	early endosome
GO:0098796	0.824	membrane protein complex
GO:0010008	0.767	endosome membrane
GO:0005770	0.751	late endosome
GO:0030897	0.437	HOPS complex
GO:0005634	0.336	nucleus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.-.-.-	0.565	Transferases.

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