StarFunc result for job id Q9H6I2

User Input

>input (414 residues)
MSSPDAGYASDDQSQTQSALPAVMAGLGPCPWAESLSPIGDMKVKGEAPANSGAPAGAAG
RAKGESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEE
AERLRVQHMQDHPNYKYRPRRRKQVKRLKRVEGGFLHGLAEPQAAALGPEGGRVAMDGLG
LQFPEQGFPAGPPLLPPHMGGHYRDCQSLGAPPLDGYPLPTPDTSPLDGVDPDPAFFAAP
MPGDCPAAGTYSYAQVSDYAGPPEPPAGPMHPRLGPEPAGPSIPGLLAPPSALHVYYGAM
GSPGAGGGRGFQMQPQHQHQHQHQHHPPGPGQPSPPPEALPCRDGTDPSQPAELLGEVDR
TEFEQYLHFVCKPEMGLPYQGHDSGVNLPDSHGAISSVVSDASSAVYYCNYPDV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9H6I2	0.999	0.999	1.265E-59	414	1.000	1.000	Q9H6I2.pdb.gz	SOX17_HUMAN Transcription factor SOX-17 OS=Homo sapiens OX=9606 GN=SOX17 PE=1 SV=1
2	AFDB:Q61473	0.419	0.415	2.250E-48	419	0.850	0.840	Q61473.pdb.gz	SOX17_MOUSE Transcription factor SOX-17 OS=Mus musculus OX=10090 GN=Sox17 PE=1 SV=1
3	AFDB:Q5PQZ5	0.217	0.217	2.344E-19	413	0.394	0.395	Q5PQZ5.pdb.gz	Q5PQZ5_DANRE SRY-box 17 OS=Danio rerio OX=7955 GN=sox17 PE=2 SV=1
4	AFDB:Q90ZH8	0.301	0.334	3.700E-19	363	0.362	0.413	Q90ZH8.pdb.gz	SX18A_XENLA Transcription factor Sox-18A OS=Xenopus laevis OX=8355 GN=sox18-a PE=1 SV=1
5	AFDB:Q6TEN5	0.311	0.328	1.738E-17	390	0.372	0.395	Q6TEN5.pdb.gz	Q6TEN5_DANRE SRY-box 7 OS=Danio rerio OX=7955 GN=SOX7 PE=2 SV=1
6	AFDB:Q06831	0.219	0.207	1.196E-11	440	0.242	0.227	Q06831.pdb.gz	SOX4_MOUSE Transcription factor SOX-4 OS=Mus musculus OX=10090 GN=Sox4 PE=1 SV=2
7	AFDB:P35716	0.206	0.194	1.030E-10	441	0.227	0.213	P35716.pdb.gz	SOX11_HUMAN Transcription factor SOX-11 OS=Homo sapiens OX=9606 GN=SOX11 PE=1 SV=2
8	AFDB:Q9DG48	0.197	0.214	1.099E-10	379	0.232	0.253	Q9DG48.pdb.gz	Q9DG48_XENLA Transcription factor SOX OS=Xenopus laevis OX=8355 GN=Sox4 PE=2 SV=1
9	AFDB:Q06945	0.210	0.185	1.337E-10	474	0.254	0.222	Q06945.pdb.gz	SOX4_HUMAN Transcription factor SOX-4 OS=Homo sapiens OX=9606 GN=SOX4 PE=1 SV=1
10	AFDB:Q9VLH8	0.239	0.183	1.736E-10	572	0.254	0.184	Q9VLH8.pdb.gz	Q9VLH8_DROME LD44245p OS=Drosophila melanogaster OX=7227 GN=SoxN PE=1 SV=1
11	PDB:1j5nA	0.148	0.603	1.328E-3	93	0.056	0.247	1j5nA.pdb.gz	The S. cerevisiae architectural HMGB protein NHP6A complexed with DNA: DNA and protein conformational changes upon binding
12	PDB:7ploI	0.111	0.102	3.634E-1	451	0.024	0.022	7ploI.pdb.gz	A conserved mechanism for regulating replisome disassembly in eukaryotes.
13	PDB:1lotA	0.071	0.067	1.176	436	0.027	0.025	1lotA.pdb.gz	Crystal structure of the complex between actin and human vitamin D-binding protein at 2.5 A resolution.
14	PDB:1kw2A	0.074	0.068	2.259	455	0.027	0.024	1kw2A.pdb.gz
15	PDB:6zm7CE	0.086	0.282	2.747	124	0.027	0.089	6zm7CE.pdb.gz	Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
16	PDB:5n9jV	0.069	0.214	2.932	99	0.029	0.121	5n9jV.pdb.gz
17	PDB:4i9qB	0.059	0.032	3.130	873	0.024	0.011	4i9qB.pdb.gz	A Remote Palm Domain Residue of RB69 DNA Polymerase Is Critical for Enzyme Activity and Influences the Conformation of the Active Site.
18	PDB:7fbyA	0.062	0.153	4.063	153	0.022	0.059	7fbyA.pdb.gz	Crystal Structure of PH0140 from Pyrococcus horikosii OT3
19	PDB:5olwA	0.085	0.142	4.630	224	0.029	0.054	5olwA.pdb.gz	Observing enzyme ternary transition state analogue complexes by19F NMR spectroscopy.
20	PDB:7n9sA	0.076	0.019	4.630	2365	0.024	0.004	7n9sA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q61473	0.0	656	419	0.841	0.831	SOX17_MOUSE Transcription factor SOX-17 OS=Mus musculus OX=10090 GN=Sox17 PE=1 SV=1
2	Q9H6I2	0.0	832	414	1.000	1.000	SOX17_HUMAN Transcription factor SOX-17 OS=Homo sapiens OX=9606 GN=SOX17 PE=1 SV=1
3	Q3KQ35	1.48e-133	390	380	0.527	0.574	S17AA_XENLA Transcription factor Sox-17-alpha-A OS=Xenopus laevis OX=8355 GN=sox17a-a PE=1 SV=1
4	Q90ZH9	1.43e-130	382	377	0.512	0.562	S17AB_XENLA Transcription factor Sox-17-alpha-B OS=Xenopus laevis OX=8355 GN=sox17a-b PE=1 SV=1
5	Q5PQZ5	3.01e-75	242	413	0.326	0.327	Q5PQZ5_DANRE SRY-box 17 OS=Danio rerio OX=7955 GN=sox17 PE=2 SV=1
6	O42342	1.83e-73	236	362	0.413	0.472	SOX7_XENLA Transcription factor Sox-7 OS=Xenopus laevis OX=8355 GN=sox7 PE=2 SV=1
7	Q28GD5	3.08e-72	232	362	0.408	0.467	SOX7_XENTR Transcription factor Sox-7 OS=Xenopus tropicalis OX=8364 GN=sox7 PE=2 SV=1
8	O42601	2.07e-71	231	373	0.384	0.426	S17B1_XENLA Transcription factor Sox-17-beta.1 OS=Xenopus laevis OX=8355 GN=sox17b.1 PE=1 SV=1
9	Q90ZH8	1.42e-66	218	363	0.362	0.413	SX18A_XENLA Transcription factor Sox-18A OS=Xenopus laevis OX=8355 GN=sox18-a PE=1 SV=1
10	E7F9I2	1.95e-63	212	431	0.391	0.376	E7F9I2_DANRE SRY-box transcription factor 18 OS=Danio rerio OX=7955 GN=sox18 PE=4 SV=1
11	Q90ZH7	4.64e-63	209	361	0.360	0.413	SX18B_XENLA Transcription factor Sox-18B OS=Xenopus laevis OX=8355 GN=sox18-b PE=1 SV=1
12	P40646	7.75e-63	209	380	0.403	0.439	SOX7_MOUSE Transcription factor SOX-7 OS=Mus musculus OX=10090 GN=Sox7 PE=1 SV=2
13	Q9BT81	3.06e-62	207	388	0.415	0.443	SOX7_HUMAN Transcription factor SOX-7 OS=Homo sapiens OX=9606 GN=SOX7 PE=1 SV=1
14	Q6TEN5	9.23e-58	196	390	0.389	0.413	Q6TEN5_DANRE SRY-box 7 OS=Danio rerio OX=7955 GN=SOX7 PE=2 SV=1
15	P43680	1.33e-56	192	377	0.355	0.390	SOX18_MOUSE Transcription factor SOX-18 OS=Mus musculus OX=10090 GN=Sox18 PE=1 SV=3
16	P35713	1.75e-46	166	384	0.251	0.271	SOX18_HUMAN Transcription factor SOX-18 OS=Homo sapiens OX=9606 GN=SOX18 PE=1 SV=2
17	P40657	6.46e-40	154	784	0.174	0.092	SOX15_DROME Putative transcription factor SOX-15 OS=Drosophila melanogaster OX=7227 GN=Sox15 PE=2 SV=2
18	Q90Z46	1.42e-36	137	307	0.155	0.208	Q90Z46_DANRE Casanova OS=Danio rerio OX=7955 GN=cas PE=2 SV=1
19	Q9DFH2	9.17e-34	133	462	0.145	0.130	Q9DFH2_DANRE HMG box transcription factor Sox9a OS=Danio rerio OX=7955 GN=jef PE=2 SV=1
20	Q04886	1.21e-33	133	464	0.145	0.129	SOX8_MOUSE Transcription factor SOX-8 OS=Mus musculus OX=10090 GN=Sox8 PE=2 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00505 HMG_box	3.2e-22	90.0	HMG (high mobility group) box
2	PF09011 HMG_box_2	1.1e-07	43.6	HMG-box domain
3	PF13412 HTH_24	4.5e+02	11.8	Winged helix-turn-helix DNA-binding
4	PF12067 Sox17_18_mid	2.5e-15	67.5	Sox 17/18 central domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000297316

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000344456	0.997	Catenin beta-1
2	9606.ENSP00000259915	0.996	POU domain, class 5, transcription factor 1
3	9606.ENSP00000400341	0.912	Hepatocyte nuclear factor 3-beta
4	9606.ENSP00000269216	0.872	Transcription factor GATA-6
5	9606.ENSP00000334458	0.866	Transcription factor GATA-4
6	9606.ENSP00000229307	0.862	Homeobox protein NANOG
7	9606.ENSP00000265165	0.860	Lymphoid enhancer-binding factor 1
8	9606.ENSP00000282111	0.849	Transcription factor 7-like 1
9	9606.ENSP00000340347	0.840	Transcription factor 7
10	9606.ENSP00000442439	0.788	Homeobox protein MIXL1
11	9606.ENSP00000404100	0.741	Paired box protein Pax-6
12	9606.ENSP00000296946	0.738	Brachyury protein
13	9606.ENSP00000379138	0.737	Alpha-fetoprotein
14	9606.ENSP00000370408	0.729	Homeobox protein CDX-2
15	9606.ENSP00000312987	0.726	Hepatocyte nuclear factor 4-alpha
16	9606.ENSP00000284523	0.725	Protein Wnt-3a
17	9606.ENSP00000417335	0.720	Roundabout homolog 2
18	9606.ENSP00000245451	0.714	Bone morphogenetic protein 4
19	9606.ENSP00000363804	0.702	Krueppel-like factor 4
20	9606.ENSP00000357206	0.700	Nestin

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0008013	1.000	beta-catenin binding
GO:0000981	0.999	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000976	0.999	transcription cis-regulatory region binding
GO:0061629	0.996	RNA polymerase II-specific DNA-binding transcription factor binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0032502	0.997	developmental process
GO:0050794	0.997	regulation of cellular process
GO:0007275	0.991	multicellular organism development
GO:0009987	0.988	cellular process
GO:0060255	0.986	regulation of macromolecule metabolic process
GO:0051171	0.985	regulation of nitrogen compound metabolic process
GO:0048522	0.976	positive regulation of cellular process
GO:0010604	0.976	positive regulation of macromolecule metabolic process
GO:0006355	0.976	regulation of DNA-templated transcription
GO:0031325	0.967	positive regulation of cellular metabolic process
GO:0048513	0.956	animal organ development
GO:0045893	0.947	positive regulation of DNA-templated transcription
GO:0009888	0.939	tissue development
GO:0048523	0.935	negative regulation of cellular process
GO:0048731	0.921	system development
GO:0009653	0.913	anatomical structure morphogenesis
GO:0030154	0.896	cell differentiation
GO:0006357	0.892	regulation of transcription by RNA polymerase II
GO:0045944	0.863	positive regulation of transcription by RNA polymerase II
GO:0072359	0.849	circulatory system development
GO:0009966	0.844	regulation of signal transduction
GO:0007492	0.719	endoderm development
GO:0009790	0.688	embryo development
GO:0009887	0.493	animal organ morphogenesis
GO:0050896	0.492	response to stimulus
GO:0035295	0.461	tube development
GO:0007507	0.437	heart development
GO:0048646	0.377	anatomical structure formation involved in morphogenesis
GO:0050793	0.367	regulation of developmental process
GO:0048598	0.355	embryonic morphogenesis
GO:0051716	0.330	cellular response to stimulus
GO:0009892	0.309	negative regulation of metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	0.995	nucleoplasm
GO:0032991	0.990	protein-containing complex
GO:0005667	0.840	transcription regulator complex
GO:0005737	0.356	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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