StarFunc result for job id Q9H6Y7

User Input

>input (350 residues)
MHPAAFPLPVVVAAVLWGAAPTRGLIRATSDHNASMDFADLPALFGATLSQEGLQGFLVE
AHPDNACSPIAPPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNVNSNELL
NMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGARVLLVPDNTFPLGYYLIPFTGI
VGLLVLAMGAVMIARCIQHRKRLQRNRLTKEQLKQIPTHDYQKGDQYDVCAICLDEYEDG
DKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPR
DHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9H6Y7	1.000	1.000	5.309E-69	350	1.000	1.000	Q9H6Y7.pdb.gz	RN167_HUMAN E3 ubiquitin-protein ligase RNF167 OS=Homo sapiens OX=9606 GN=RNF167 PE=1 SV=1
2	AFDB:O43567	0.499	0.465	4.106E-42	381	0.457	0.420	O43567.pdb.gz	RNF13_HUMAN E3 ubiquitin-protein ligase RNF13 OS=Homo sapiens OX=9606 GN=RNF13 PE=1 SV=1
3	AFDB:Q9VI20	0.594	0.406	3.517E-30	536	0.289	0.188	Q9VI20.pdb.gz	GZL_DROME E3 ubiquitin-protein ligase Godzilla OS=Drosophila melanogaster OX=7227 GN=gzl PE=1 SV=1
4	AFDB:Q8WWF5	0.469	0.388	8.719E-30	429	0.366	0.298	Q8WWF5.pdb.gz	ZNRF4_HUMAN E3 ubiquitin-protein ligase ZNRF4 OS=Homo sapiens OX=9606 GN=ZNRF4 PE=1 SV=3
5	AFDB:Q8VZ14	0.414	0.335	7.211E-27	448	0.283	0.221	Q8VZ14.pdb.gz	RMR2_ARATH Receptor homology region, transmembrane domain- and RING domain-containing protein 2 OS=Arabidopsis thaliana OX=3702 GN=RMR2 PE=2 SV=1
6	AFDB:Q9M622	0.404	0.447	4.124E-22	310	0.249	0.281	Q9M622.pdb.gz	RMR1_ARATH Receptor homology region, transmembrane domain- and RING domain-containing protein 1 OS=Arabidopsis thaliana OX=3702 GN=RMR1 PE=1 SV=1
7	AFDB:Q14B02	0.317	0.294	1.650E-19	382	0.223	0.204	Q14B02.pdb.gz	RN133_MOUSE E3 ubiquitin-protein ligase RNF133 OS=Mus musculus OX=10090 GN=Rnf133 PE=1 SV=1
8	AFDB:Q8NC42	0.316	0.279	3.210E-19	400	0.211	0.185	Q8NC42.pdb.gz	RN149_HUMAN E3 ubiquitin-protein ligase RNF149 OS=Homo sapiens OX=9606 GN=RNF149 PE=2 SV=2
9	AFDB:Q86XS8	0.296	0.252	4.345E-19	419	0.263	0.220	Q86XS8.pdb.gz	GOLI_HUMAN E3 ubiquitin-protein ligase RNF130 OS=Homo sapiens OX=9606 GN=RNF130 PE=1 SV=1
10	AFDB:Q3U2C5	0.303	0.274	6.637E-19	394	0.214	0.190	Q3U2C5.pdb.gz	RN149_MOUSE E3 ubiquitin-protein ligase RNF149 OS=Mus musculus OX=10090 GN=Rnf149 PE=1 SV=3
11	PDB:7zqsB	0.265	0.155	3.080E-3	639	0.077	0.042	7zqsB.pdb.gz	Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing.
12	PDB:4tweA	0.255	0.138	5.641E-3	706	0.080	0.040	4tweA.pdb.gz	Structural and biochemical characterization of a novel aminopeptidase from human intestine.
13	PDB:3fedA	0.159	0.088	2.136E-2	690	0.063	0.032	3fedA.pdb.gz	Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
14	PDB:1jdbF	0.216	0.203	4.416E-2	380	0.060	0.055	1jdbF.pdb.gz	The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution.
15	PDB:6etyA	0.172	0.093	4.416E-2	696	0.066	0.033	6etyA.pdb.gz	Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors.
16	PDB:4cogA	0.169	0.252	1.574E-1	207	0.049	0.082	4cogA.pdb.gz	Structure of Bacterial Kynurenine Formamidase Reveals a Crowded Binuclear-Zinc Catalytic Site Primed to Generate a Potent Nucleophile.
17	PDB:5douD	0.209	0.068	2.263E-1	1430	0.054	0.013	5douD.pdb.gz	Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
18	PDB:4bf9A	0.127	0.138	2.554E-1	318	0.049	0.053	4bf9A.pdb.gz	Major Reorientation of tRNA Substrates Defines Specificity of Dihydrouridine Synthases.
19	PDB:6uelA	0.190	0.065	2.714E-1	1333	0.046	0.012	6uelA.pdb.gz	Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket.
20	PDB:2ji4A	0.119	0.135	3.254E-1	302	0.034	0.040	2ji4A.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q9H6Y7	0.0	721	350	1.000	1.000	RN167_HUMAN E3 ubiquitin-protein ligase RNF167 OS=Homo sapiens OX=9606 GN=RNF167 PE=1 SV=1
2	O54965	2.80e-105	315	381	0.466	0.428	RNF13_MOUSE E3 ubiquitin-protein ligase RNF13 OS=Mus musculus OX=10090 GN=Rnf13 PE=1 SV=2
3	O43567	3.88e-105	315	381	0.460	0.423	RNF13_HUMAN E3 ubiquitin-protein ligase RNF13 OS=Homo sapiens OX=9606 GN=RNF13 PE=1 SV=1
4	Q8WWF5	6.44e-69	224	429	0.377	0.308	ZNRF4_HUMAN E3 ubiquitin-protein ligase ZNRF4 OS=Homo sapiens OX=9606 GN=ZNRF4 PE=1 SV=3
5	Q9VI20	5.10e-46	166	536	0.277	0.181	GZL_DROME E3 ubiquitin-protein ligase Godzilla OS=Drosophila melanogaster OX=7227 GN=gzl PE=1 SV=1
6	C9JYN7	1.47e-43	150	165	0.209	0.442	C9JYN7_HUMAN RING-type E3 ubiquitin transferase (Fragment) OS=Homo sapiens OX=9606 GN=RNF13 PE=1 SV=1
7	C9J8T4	9.44e-42	145	163	0.203	0.436	C9J8T4_HUMAN RING-type E3 ubiquitin transferase (Fragment) OS=Homo sapiens OX=9606 GN=RNF13 PE=1 SV=1
8	C9J383	1.64e-40	142	192	0.220	0.401	C9J383_HUMAN RING-type E3 ubiquitin transferase (Fragment) OS=Homo sapiens OX=9606 GN=RNF13 PE=1 SV=1
9	Q9M622	2.01e-36	135	310	0.283	0.319	RMR1_ARATH Receptor homology region, transmembrane domain- and RING domain-containing protein 1 OS=Arabidopsis thaliana OX=3702 GN=RMR1 PE=1 SV=1
10	Q8VZ14	4.84e-30	121	448	0.260	0.203	RMR2_ARATH Receptor homology region, transmembrane domain- and RING domain-containing protein 2 OS=Arabidopsis thaliana OX=3702 GN=RMR2 PE=2 SV=1
11	C9JRV0	7.20e-25	99.4	115	0.134	0.409	C9JRV0_HUMAN RING-type E3 ubiquitin transferase (Fragment) OS=Homo sapiens OX=9606 GN=RNF13 PE=1 SV=1
12	Q9DAH2	3.45e-23	100	327	0.234	0.251	ZNRF4_MOUSE E3 ubiquitin-protein ligase ZNRF4 OS=Mus musculus OX=10090 GN=Znrf4 PE=1 SV=1
13	Q9ULK6	1.45e-20	94.4	438	0.246	0.196	RN150_HUMAN RING finger protein 150 OS=Homo sapiens OX=9606 GN=RNF150 PE=1 SV=2
14	Q06003	1.17e-19	91.7	461	0.189	0.143	GOLI_DROME E3 ubiquitin-protein ligase goliath OS=Drosophila melanogaster OX=7227 GN=gol PE=1 SV=3
15	Q3U2C5	5.67e-18	86.3	394	0.206	0.183	RN149_MOUSE E3 ubiquitin-protein ligase RNF149 OS=Mus musculus OX=10090 GN=Rnf149 PE=1 SV=3
16	Q8VEM1	2.88e-17	84.7	419	0.191	0.160	GOLI_MOUSE E3 ubiquitin-protein ligase RNF130 OS=Mus musculus OX=10090 GN=Rnf130 PE=2 SV=1
17	Q86XS8	4.86e-17	84.0	419	0.189	0.158	GOLI_HUMAN E3 ubiquitin-protein ligase RNF130 OS=Homo sapiens OX=9606 GN=RNF130 PE=1 SV=1
18	Q641J8	6.65e-17	84.0	622	0.089	0.050	RF12A_XENLA E3 ubiquitin-protein ligase RNF12-A OS=Xenopus laevis OX=8355 GN=rnf12-a PE=1 SV=1
19	E7FH41	1.25e-16	83.2	638	0.086	0.047	E7FH41_DANRE E3 ubiquitin-protein ligase RLIM OS=Danio rerio OX=7955 GN=rlim PE=1 SV=2
20	Q9NVW2	3.17e-16	82.0	624	0.086	0.048	RNF12_HUMAN E3 ubiquitin-protein ligase RLIM OS=Homo sapiens OX=9606 GN=RLIM PE=1 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF02225 PA	4.2e-07	41.3	PA domain
2	PF00628 PHD	1.2e+02	14.0	PHD-finger
3	PF14447 Prok-RING_4	0.37	22.0	Prokaryotic RING finger family 4
4	PF12906 RINGv	40	15.8	RING-variant domain
5	PF12861 zf-ANAPC11	7.8	18.0	Anaphase-promoting complex subunit 11 RING-H2 finger
6	PF17122 zf-C3H2C3	8e+02	11.5	Zinc-finger
7	PF00097 zf-C3HC4	2.8e-05	35.2	Zinc finger, C3HC4 type (RING finger)
8	PF13923 zf-C3HC4_2	2.9e-06	38.3	Zinc finger, C3HC4 type (RING finger)
9	PF13920 zf-C3HC4_3	0.0049	28.0	Zinc finger, C3HC4 type (RING finger)
10	PF12678 zf-rbx1	0.0038	28.8	RING-H2 zinc finger domain
11	PF17123 zf-RING_11	1.1e-08	45.9	RING-like zinc finger
12	PF17120 zf-RING_16	1.6e+02	13.3	RING/Ubox like zinc-binding domain
13	PF13639 zf-RING_2	6.8e-10	50.5	Ring finger domain
14	PF14570 zf-RING_4	4.7e+02	12.0	RING/Ubox like zinc-binding domain
15	PF14634 zf-RING_5	5.8e-05	34.3	zinc-RING finger domain
16	PF13445 zf-RING_UBOX	0.0051	28.1	RING-type zinc-finger

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000262482

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000303709	0.898	Ubiquitin-conjugating enzyme E2 E1
2	9606.ENSP00000369948	0.792	Solute carrier family 22 member 18
3	9606.ENSP00000407818	0.746	Ubiquitin carboxyl-terminal hydrolase 46
4	9606.ENSP00000433282	0.729	Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein
5	9606.ENSP00000363019	0.695	Ubiquitin-conjugating enzyme E2 D1
6	9606.ENSP00000331933	0.683	WSC domain containing 2
7	9606.ENSP00000328287	0.669	E3 ubiquitin-protein ligase RNF123
8	9606.ENSP00000355434	0.645	Olfactory receptor 2L13
9	9606.ENSP00000419101	0.611	Voltage-dependent calcium channel subunit alpha-2/delta-3
10	9606.ENSP00000268668	0.610	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
11	9606.ENSP00000357297	0.606	E3 ubiquitin-protein ligase RNF146
12	9606.ENSP00000422375	0.572	U8 snoRNA-decapping enzyme
13	9606.ENSP00000381717	0.556	Ubiquitin-conjugating enzyme E2 D2
14	9606.ENSP00000215574	0.549	Ubiquitin-conjugating enzyme E2 R1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0061630	1.000	ubiquitin protein ligase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.988	cellular process
GO:0016567	0.987	protein ubiquitination
GO:0023051	0.977	regulation of signaling
GO:0010646	0.977	regulation of cell communication
GO:0048583	0.943	regulation of response to stimulus
GO:0009966	0.893	regulation of signal transduction
GO:0048519	0.843	negative regulation of biological process
GO:0000209	0.733	protein polyubiquitination
GO:0048523	0.684	negative regulation of cellular process
GO:0051179	0.644	localization
GO:0050896	0.621	response to stimulus
GO:1902531	0.590	regulation of intracellular signal transduction
GO:0044237	0.554	cellular metabolic process
GO:0051603	0.473	proteolysis involved in protein catabolic process
GO:0044260	0.415	cellular macromolecule metabolic process
GO:0006511	0.410	ubiquitin-dependent protein catabolic process
GO:0051716	0.317	cellular response to stimulus
GO:0048518	0.301	positive regulation of biological process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	1.000	cytoplasm
GO:0043231	1.000	intracellular membrane-bounded organelle
GO:0012505	0.998	endomembrane system
GO:0031090	0.997	organelle membrane
GO:0031982	0.992	vesicle
GO:0005829	0.972	cytosol
GO:0031410	0.954	cytoplasmic vesicle
GO:0005768	0.921	endosome
GO:0098588	0.868	bounding membrane of organelle
GO:0005773	0.857	vacuole
GO:0012506	0.850	vesicle membrane
GO:0000323	0.847	lytic vacuole
GO:0030659	0.830	cytoplasmic vesicle membrane
GO:0005764	0.800	lysosome
GO:0005774	0.796	vacuolar membrane
GO:0005765	0.781	lysosomal membrane
GO:0010008	0.773	endosome membrane
GO:0036019	0.762	endolysosome
GO:0036020	0.543	endolysosome membrane
GO:0005634	0.404	nucleus
GO:0031981	0.375	nuclear lumen
GO:0032991	0.373	protein-containing complex
GO:0005654	0.354	nucleoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.-.-.-	1.000	Transferases.

[back to server]