StarFunc result for job id Q9H9L3

User Input

>input (353 residues)
MSTLLLNLDFGEPPPKKALEGNAKHRNFVKKRRLLERRGFLSKKNQPPSKAPKLHSEPSK
KGETPTVDGTWKTPSFPKKKTAASSNGSGQPLDKKAAVSWLTPAPSKKADSVAAKVDLLG
EFQSALPKINSHPTRSQKKSSQKKSSKKNHPQKNAPQNSTQAHSENKCSGASQKLPRKMV
AIDCEMVGTGPKGHVSSLARCSIVNYNGDVLYDEYILPPCHIVDYRTRWSGIRKQHMVNA
TPFKIARGQILKILTGKIVVGHAIHNDFKALQYFHPKSLTRDTSHIPPLNRKADCPENAT
MSLKHLTKKLLNRDIQVGKSGHSSVEDAQATMELYKLVEVEWEEHLARNPPTD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9H9L3	1.000	1.000	3.051E-65	353	1.000	1.000	Q9H9L3.pdb.gz	I20L2_HUMAN Interferon-stimulated 20 kDa exonuclease-like 2 OS=Homo sapiens OX=9606 GN=ISG20L2 PE=1 SV=1
2	AFDB:Q8WTP8	0.494	0.536	6.907E-28	325	0.385	0.418	Q8WTP8.pdb.gz	AEN_HUMAN Apoptosis-enhancing nuclease OS=Homo sapiens OX=9606 GN=AEN PE=1 SV=2
3	AFDB:Q96AZ6	0.464	0.884	2.379E-23	181	0.246	0.481	Q96AZ6.pdb.gz	ISG20_HUMAN Interferon-stimulated gene 20 kDa protein OS=Homo sapiens OX=9606 GN=ISG20 PE=1 SV=2
4	AFDB:Q08237	0.471	0.573	1.343E-22	289	0.280	0.343	Q08237.pdb.gz	REXO4_YEAST RNA exonuclease 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=REX4 PE=1 SV=1
5	AFDB:O94375	0.454	0.613	7.577E-22	260	0.221	0.300	O94375.pdb.gz	REXO4_SCHPO RNA exonuclease 4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rex4 PE=3 SV=1
6	PDB:1wljA	0.430	0.887	1.025E-21	168	0.241	0.506	1wljA.pdb.gz	Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease
7	PDB:5z9xA	0.372	0.452	2.321E-11	288	0.147	0.181	5z9xA.pdb.gz	Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1.
8	AFDB:Q8IX06	0.410	0.221	2.519E-11	675	0.229	0.120	Q8IX06.pdb.gz	GOR_HUMAN Putative exonuclease GOR OS=Homo sapiens OX=9606 GN=REXO1L1P PE=5 SV=2
9	PDB:6r5kA	0.369	0.135	5.031E-10	1040	0.159	0.054	6r5kA.pdb.gz	Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase.
10	PDB:3v9xB	0.351	0.554	3.491E-6	212	0.105	0.175	3v9xB.pdb.gz	How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T-product complexes
11	PDB:1zbuB	0.360	0.408	2.894E-5	304	0.065	0.076	1zbuB.pdb.gz	Structural basis for 3'-end specific recognition of histone mRNA stem-loop by 3'-exonuclease, a human nuclease that also targets siRNA
12	PDB:2p51A	0.323	0.430	1.741E-4	255	0.068	0.094	2p51A.pdb.gz	The 1.4-A crystal structure of the S. pombe Pop2p deadenylase subunit unveils the configuration of an active enzyme
13	PDB:1s5jA	0.275	0.145	2.399E-4	727	0.096	0.047	1s5jA.pdb.gz	Insights into DNA replication: the crystal structure of DNA polymerase B1 from the archaeon Sulfolobus solfataricus
14	PDB:6styA	0.294	0.474	2.558E-4	198	0.082	0.146	6styA.pdb.gz	Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA.
15	PDB:3c95A	0.298	0.241	2.727E-4	446	0.096	0.076	3c95A.pdb.gz
16	PDB:3ngyC	0.270	0.483	3.100E-4	182	0.105	0.203	3ngyC.pdb.gz	Structural basis for RNA trimming by RNase T in stable RNA 3'-end maturation
17	AFDB:Q99MT2	0.163	0.074	4.991E-2	958	0.119	0.044	Q99MT2.pdb.gz	MSH4_MOUSE MutS protein homolog 4 OS=Mus musculus OX=10090 GN=Msh4 PE=2 SV=1
18	AFDB:Q9LMX5	0.085	0.086	6.876E-2	348	0.099	0.101	Q9LMX5.pdb.gz	AFP2_ARATH Ninja-family protein AFP2 OS=Arabidopsis thaliana OX=3702 GN=AFP2 PE=1 SV=1
19	AFDB:E7F350	0.071	0.034	1.392E-1	995	0.127	0.045	E7F350.pdb.gz	E7F350_DANRE DIS3-like exonuclease 2 OS=Danio rerio OX=7955 GN=dis3l2 PE=1 SV=1
20	AFDB:Q9LXG8	0.062	0.049	1.798E-1	548	0.105	0.068	Q9LXG8.pdb.gz	WRK72_ARATH Probable WRKY transcription factor 72 OS=Arabidopsis thaliana OX=3702 GN=WRKY72 PE=2 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q9H9L3	0.0	730	353	1.000	1.000	I20L2_HUMAN Interferon-stimulated 20 kDa exonuclease-like 2 OS=Homo sapiens OX=9606 GN=ISG20L2 PE=1 SV=1
2	Q8WTP8	6.38e-75	236	325	0.312	0.338	AEN_HUMAN Apoptosis-enhancing nuclease OS=Homo sapiens OX=9606 GN=AEN PE=1 SV=2
3	Q96AZ6	2.24e-47	160	181	0.238	0.464	ISG20_HUMAN Interferon-stimulated gene 20 kDa protein OS=Homo sapiens OX=9606 GN=ISG20 PE=1 SV=2
4	Q08237	1.36e-43	154	289	0.244	0.298	REXO4_YEAST RNA exonuclease 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=REX4 PE=1 SV=1
5	O94375	7.39e-42	148	260	0.221	0.300	REXO4_SCHPO RNA exonuclease 4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rex4 PE=3 SV=1
6	Q9GZR2	3.16e-39	145	422	0.204	0.171	REXO4_HUMAN RNA exonuclease 4 OS=Homo sapiens OX=9606 GN=REXO4 PE=1 SV=2
7	H0YMJ6	3.39e-31	118	179	0.150	0.296	H0YMJ6_HUMAN Apoptosis enhancing nuclease (Fragment) OS=Homo sapiens OX=9606 GN=AEN PE=1 SV=1
8	Q54EC1	2.85e-23	103	694	0.190	0.097	Q54EC1_DICDI RNA exonuclease 1 OS=Dictyostelium discoideum OX=44689 GN=rexo1 PE=4 SV=1
9	P53331	1.18e-20	95.1	553	0.178	0.114	REXO1_YEAST RNA exonuclease 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RNH70 PE=1 SV=1
10	C7LAE5	1.19e-20	95.5	852	0.167	0.069	C7LAE5_DROME IP20073p OS=Drosophila melanogaster OX=7227 GN=prage PE=2 SV=1
11	Q8IRW9	1.47e-20	95.1	742	0.167	0.080	Q8IRW9_DROME Prage, isoform D OS=Drosophila melanogaster OX=7227 GN=prage PE=4 SV=1
12	Q960E5	1.55e-20	95.1	757	0.167	0.078	Q960E5_DROME SD04906p OS=Drosophila melanogaster OX=7227 GN=prage PE=2 SV=1
13	Q8T023	1.58e-20	95.1	787	0.167	0.075	Q8T023_DROME LD38414p OS=Drosophila melanogaster OX=7227 GN=prage PE=2 SV=1
14	Q9W557	1.71e-20	95.1	761	0.167	0.078	Q9W557_DROME Prage, isoform A OS=Drosophila melanogaster OX=7227 GN=prage PE=4 SV=2
15	Q9ZU79	1.80e-20	93.2	344	0.156	0.160	Q9ZU79_ARATH RNA exonuclease 4 OS=Arabidopsis thaliana OX=3702 GN=At2g48100 PE=1 SV=2
16	O76875	3.93e-20	93.6	515	0.167	0.115	O76875_DROME EG:131F2.2 protein OS=Drosophila melanogaster OX=7227 GN=prage PE=4 SV=1
17	O94443	7.22e-19	90.1	631	0.167	0.094	YFE9_SCHPO Uncharacterized exonuclease C637.09 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC637.09 PE=3 SV=2
18	Q8RXK2	1.19e-16	83.6	782	0.144	0.065	SDN3_ARATH Small RNA degrading nuclease 3 OS=Arabidopsis thaliana OX=3702 GN=SDN3 PE=1 SV=1
19	Q9VRX7	2.43e-16	82.4	681	0.150	0.078	Q9VRX7_DROME LD29573p OS=Drosophila melanogaster OX=7227 GN=Rexo5 PE=1 SV=1
20	A3KPE8	9.89e-16	80.1	409	0.153	0.132	SDN1_ARATH Small RNA degrading nuclease 1 OS=Arabidopsis thaliana OX=3702 GN=SDN1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01612 DNA_pol_A_exo1	4.9	18.4	3'-5' exonuclease
2	PF00929 RNase_T	1.5e-08	46.8	Exonuclease

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000323424

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000396673	0.758	pre-rRNA processing protein FTSJ3
2	9606.ENSP00000292180	0.737	FAD synthase
3	9606.ENSP00000385158	0.698	Protein FAM161A
4	9606.ENSP00000356985	0.694	Death effector domain-containing protein
5	9606.ENSP00000334314	0.690	Echinoderm microtubule-associated protein-like 1
6	9606.ENSP00000477848	0.681	Protein AATF
7	9606.ENSP00000225298	0.674	U3 small nucleolar RNA-associated protein 18 homolog
8	9606.ENSP00000247003	0.664	Probable ATP-dependent RNA helicase DDX49
9	9606.ENSP00000364320	0.661	mRNA turnover protein 4 homolog
10	9606.ENSP00000274849	0.660	Activator of basal transcription 1
11	9606.ENSP00000350651	0.643	ERI1 exoribonuclease family member 2
12	9606.ENSP00000362105	0.633	Probable U3 small nucleolar RNA-associated protein 11
13	9606.ENSP00000402338	0.628	Ribosome production factor 2 homolog
14	9606.ENSP00000259239	0.626	U3 small nucleolar ribonucleoprotein protein IMP4
15	9606.ENSP00000285814	0.624	Nucleolar protein interacting with the FHA domain of MKI67
16	9606.ENSP00000254940	0.613	60S ribosome subunit biogenesis protein NIP7 homolog
17	9606.ENSP00000316786	0.608	Corticosteroid 11-beta-dehydrogenase isozyme 2
18	9606.ENSP00000429615	0.608	3'-5' exoribonuclease 1
19	9606.ENSP00000322396	0.607	Ribosome biogenesis regulatory protein homolog
20	9606.ENSP00000338862	0.603	Ribosome biogenesis protein BRX1 homolog

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.998	protein binding
GO:0003723	0.998	RNA binding
GO:0003824	0.957	catalytic activity
GO:0004527	0.759	exonuclease activity
GO:0140098	0.674	catalytic activity, acting on RNA
GO:0008408	0.656	3'-5' exonuclease activity
GO:0016796	0.487	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
GO:0004540	0.478	ribonuclease activity
GO:0004536	0.427	deoxyribonuclease activity
GO:0000175	0.365	3'-5'-RNA exonuclease activity
GO:0008296	0.331	3'-5'-DNA exonuclease activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.996	organic substance metabolic process
GO:0044237	0.996	cellular metabolic process
GO:0044238	0.995	primary metabolic process
GO:0006807	0.995	nitrogen compound metabolic process
GO:0090304	0.992	nucleic acid metabolic process
GO:0050896	0.833	response to stimulus
GO:0016070	0.730	RNA metabolic process
GO:0006950	0.649	response to stress
GO:0006974	0.621	cellular response to DNA damage stimulus
GO:0050789	0.606	regulation of biological process
GO:0071840	0.421	cellular component organization or biogenesis
GO:0050794	0.383	regulation of cellular process
GO:0010467	0.351	gene expression
GO:0034660	0.315	ncRNA metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005730	1.000	nucleolus
GO:0005654	0.999	nucleoplasm
GO:0016020	0.776	membrane
GO:0005737	0.709	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.1.-.-	0.759	Acting on ester bonds.
EC:3.1.15.-	0.487	Exonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters.
EC:3.1.13.-	0.365	Exoribonucleases producing 5'-phosphomonoesters.
EC:3.1.11.-	0.331	Exodeoxyribonucleases producing 5'-phosphomonoesters.

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