StarFunc result for job id Q9HCK5

User Input

>input (861 residues)
MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRV
NREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKV
SVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYH
PLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPL
TDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQ
YFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATAR
SAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVA
TPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQ
PCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQ
VKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKK
PSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTR
FKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCA
DKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADE
LQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRD
PQALAKAVQIHHDTQHTMYFA

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:4krfA	0.938	0.988	0.000	817	0.792	0.835	4krfA.pdb.gz	The making of a slicer: activation of human argonaute-1.
2	PDB:4w5tA	0.908	0.967	0.000	807	0.747	0.797	4w5tA.pdb.gz	Gene regulation. Structural basis for microRNA targeting.
3	PDB:5vm9C	0.890	0.974	0.000	785	0.764	0.838	5vm9C.pdb.gz	Human Argonaute3 has slicer activity.
4	PDB:5weaA	0.858	0.965	0.000	764	0.702	0.791	5weaA.pdb.gz	Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition.
5	PDB:6oonA	0.909	0.996	0.000	785	0.912	1.000	6oonA.pdb.gz	Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters.
6	AFDB:E7EXY4	0.962	0.949	0.000	873	0.785	0.774	E7EXY4.pdb.gz
7	AFDB:G5EES3	0.956	0.806	0.000	1023	0.664	0.559	G5EES3.pdb.gz	G5EES3_CAEEL Protein argonaute-2 OS=Caenorhabditis elegans OX=6239 GN=alg-1 PE=1 SV=1
8	AFDB:O16720	0.959	0.908	0.000	910	0.653	0.618	O16720.pdb.gz	O16720_CAEEL Protein argonaute-2 OS=Caenorhabditis elegans OX=6239 GN=alg-2 PE=1 SV=2
9	AFDB:Q32KD4	0.966	0.846	0.000	984	0.719	0.629	Q32KD4.pdb.gz	Q32KD4_DROME Argonaute-1, isoform A OS=Drosophila melanogaster OX=7227 GN=AGO1 PE=1 SV=1
10	AFDB:Q8CJF8	0.999	0.999	0.000	861	0.988	0.988	Q8CJF8.pdb.gz	AGO4_MOUSE Protein argonaute-4 OS=Mus musculus OX=10090 GN=Ago4 PE=2 SV=2
11	AFDB:Q8CJF9	0.968	0.969	0.000	860	0.820	0.821	Q8CJF9.pdb.gz	AGO3_MOUSE Protein argonaute-3 OS=Mus musculus OX=10090 GN=Ago3 PE=2 SV=2
12	AFDB:Q8CJG1	0.974	0.978	0.000	857	0.829	0.833	Q8CJG1.pdb.gz	AGO1_MOUSE Protein argonaute-1 OS=Mus musculus OX=10090 GN=Ago1 PE=1 SV=2
13	AFDB:O04379	0.898	0.744	8.651E-99	1048	0.430	0.353	O04379.pdb.gz	AGO1_ARATH Protein argonaute 1 OS=Arabidopsis thaliana OX=3702 GN=AGO1 PE=1 SV=1
14	AFDB:D6RUV9	0.912	0.744	1.018E-98	1061	0.437	0.354	D6RUV9.pdb.gz	D6RUV9_TOBAC ARGONAUTE 1 OS=Nicotiana tabacum OX=4097 GN=AGO1 PE=1 SV=1
15	AFDB:Q69VD5	0.898	0.793	1.177E-97	979	0.424	0.373	Q69VD5.pdb.gz	PNH1_ORYSJ Protein argonaute PNH1 OS=Oryza sativa subsp. japonica OX=39947 GN=PHN1 PE=2 SV=1
16	PDB:7swfA	0.711	0.780	3.146E-77	778	0.403	0.446	7swfA.pdb.gz	The molecular mechanism of microRNA duplex selectivity of Arabidopsis ARGONAUTE10.
17	PDB:5guhA	0.681	0.765	4.446E-57	759	0.221	0.250	5guhA.pdb.gz	Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA
18	PDB:6kr6A	0.622	0.738	9.354E-50	713	0.200	0.241	6kr6A.pdb.gz	Crystal structure of Drosophila Piwi.
19	PDB:7kpvD	0.454	0.447	1.124E-14	876	0.108	0.106	7kpvD.pdb.gz
20	PDB:1r6zZ	0.127	0.214	1.559E-5	499	0.050	0.086	1r6zZ.pdb.gz	The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A6I8PTZ8	1501	891	0.828	0.800	A0A6I8PTZ8_HUMAN Argonaute RISC component 1 OS=Homo sapiens OX=9606 GN=AGO1 PE=1 SV=1
2	D6RUV9	664	1061	0.430	0.349	D6RUV9_TOBAC ARGONAUTE 1 OS=Nicotiana tabacum OX=4097 GN=AGO1 PE=1 SV=1
3	G5EES3	1194	1023	0.668	0.562	G5EES3_CAEEL Protein argonaute-2 OS=Caenorhabditis elegans OX=6239 GN=alg-1 PE=1 SV=1
4	G5EGR6	1192	1002	0.668	0.574	G5EGR6_CAEEL Protein argonaute-2 OS=Caenorhabditis elegans OX=6239 GN=alg-1 PE=1 SV=1
5	K4I874	1442	873	0.784	0.773	K4I874_DANRE Protein argonaute-2 OS=Danio rerio OX=7955 GN=AGO2 PE=1 SV=1
6	O04379	681	1048	0.436	0.358	AGO1_ARATH Protein argonaute 1 OS=Arabidopsis thaliana OX=3702 GN=AGO1 PE=1 SV=1
7	O16720	1160	910	0.659	0.623	O16720_CAEEL Protein argonaute-2 OS=Caenorhabditis elegans OX=6239 GN=alg-2 PE=1 SV=2
8	Q27IR0	1232	851	0.686	0.694	Q27IR0_DROME Argonaute-1 (Fragment) OS=Drosophila melanogaster OX=7227 GN=AGO1 PE=1 SV=1
9	Q32KD4	1295	984	0.719	0.629	Q32KD4_DROME Argonaute-1, isoform A OS=Drosophila melanogaster OX=7227 GN=AGO1 PE=1 SV=1
10	Q5TA58	1407	782	0.776	0.854	Q5TA58_HUMAN Argonaute RISC component 1 OS=Homo sapiens OX=9606 GN=AGO1 PE=1 SV=1
11	Q69VD5	670	979	0.423	0.372	PNH1_ORYSJ Protein argonaute PNH1 OS=Oryza sativa subsp. japonica OX=39947 GN=PHN1 PE=2 SV=1
12	Q7KY08	1294	950	0.719	0.652	Q7KY08_DROME Argonaute protein OS=Drosophila melanogaster OX=7227 GN=AGO1 PE=1 SV=1
13	Q851R2	635	1058	0.410	0.334	MEL1_ORYSJ Protein argonaute MEL1 OS=Oryza sativa subsp. japonica OX=39947 GN=MEL1 PE=2 SV=1
14	Q86B39	1162	891	0.659	0.636	Q86B39_CAEEL Protein argonaute-2 OS=Caenorhabditis elegans OX=6239 GN=alg-2 PE=1 SV=1
15	Q8CJF8	1787	861	0.988	0.988	AGO4_MOUSE Protein argonaute-4 OS=Mus musculus OX=10090 GN=Ago4 PE=2 SV=2
16	Q8CJF9	1462	860	0.823	0.824	AGO3_MOUSE Protein argonaute-3 OS=Mus musculus OX=10090 GN=Ago3 PE=2 SV=2
17	Q8CJG0	1429	860	0.780	0.781	AGO2_MOUSE Protein argonaute-2 OS=Mus musculus OX=10090 GN=Ago2 PE=1 SV=3
18	Q8CJG1	1501	857	0.828	0.832	AGO1_MOUSE Protein argonaute-1 OS=Mus musculus OX=10090 GN=Ago1 PE=1 SV=2
19	Q8T059	682	424	0.380	0.771	Q8T059_DROME LD26301p OS=Drosophila melanogaster OX=7227 GN=AGO1 PE=2 SV=1
20	Q960T1	922	601	0.519	0.744	Q960T1_DROME LD36719p OS=Drosophila melanogaster OX=7227 GN=AGO1 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF08699 ArgoL1	4.5e-19	79.2	Argonaute linker 1 domain
2	PF16488 ArgoL2	1.1e-10	53.0	Argonaute linker 2 domain
3	PF16487 ArgoMid	2.6e-29	112.7	Mid domain of argonaute
4	PF16486 ArgoN	1.4e-26	105.1	N-terminal domain of argonaute
5	PF02170 PAZ	5.9e-26	102.6	PAZ domain
6	PF02171 Piwi	6.9e-102	352.3	Piwi domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 60711.ENSCSAP00000016923

Rank	PPI partner	STRING score	Description
1	60711.ENSCSAP00000006910	0.945	Dicer 1, ribonuclease type III
2	60711.ENSCSAP00000001487	0.927	Trinucleotide repeat containing 6C
3	60711.ENSCSAP00000002846	0.903	Trinucleotide repeat containing 6A
4	60711.ENSCSAP00000001789	0.892	Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1
5	60711.ENSCSAP00000018397	0.867	Protein kinase, interferon-inducible double stranded RNA dependent activator
6	60711.ENSCSAP00000002308	0.857	Trinucleotide repeat containing 6B
7	60711.ENSCSAP00000007724	0.824	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
8	60711.ENSCSAP00000013240	0.812	Drosha, ribonuclease type III
9	60711.ENSCSAP00000005763	0.718	Tripartite motif containing 71, E3 ubiquitin protein ligase
10	60711.ENSCSAP00000018990	0.705	Tripartite motif containing 56
11	60711.ENSCSAP00000015478	0.698	DEAD (Asp-Glu-Ala-Asp) box helicase 6
12	60711.ENSCSAP00000002004	0.693	Damage-specific DNA binding protein 2, 48kDa
13	60711.ENSCSAP00000006512	0.691	annotation not available
14	60711.ENSCSAP00000004856	0.686	UBX domain protein 7
15	60711.ENSCSAP00000011109	0.684	Uncharacterized protein
16	60711.ENSCSAP00000003722	0.672	Importin 8
17	60711.ENSCSAP00000003218	0.661	Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase.
18	60711.ENSCSAP00000016427	0.653	Mov10 RISC complex RNA helicase
19	60711.ENSCSAP00000002505	0.652	RAD52 motif containing 1
20	60711.ENSCSAP00000007551	0.640	Acts as a tumor suppressor in many tumor types

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0035198	0.999	miRNA binding
GO:0003824	0.951	catalytic activity
GO:0140098	0.883	catalytic activity, acting on RNA
GO:0004540	0.836	ribonuclease activity
GO:0004521	0.830	RNA endonuclease activity
GO:0016891	0.790	RNA endonuclease activity, producing 5'-phosphomonoesters
GO:0003727	0.754	single-stranded RNA binding
GO:0003725	0.710	double-stranded RNA binding
GO:0019899	0.683	enzyme binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.998	organic substance metabolic process
GO:0044237	0.997	cellular metabolic process
GO:0006807	0.996	nitrogen compound metabolic process
GO:0044238	0.995	primary metabolic process
GO:0043170	0.990	macromolecule metabolic process
GO:0031323	0.989	regulation of cellular metabolic process
GO:0034641	0.984	cellular nitrogen compound metabolic process
GO:1901360	0.983	organic cyclic compound metabolic process
GO:0046483	0.983	heterocycle metabolic process
GO:0006725	0.983	cellular aromatic compound metabolic process
GO:0031326	0.981	regulation of cellular biosynthetic process
GO:0048519	0.978	negative regulation of biological process
GO:0010468	0.962	regulation of gene expression
GO:2000112	0.960	regulation of cellular macromolecule biosynthetic process
GO:0090304	0.942	nucleic acid metabolic process
GO:0009892	0.941	negative regulation of metabolic process
GO:0010608	0.931	post-transcriptional regulation of gene expression
GO:0080090	0.927	regulation of primary metabolic process
GO:0051171	0.927	regulation of nitrogen compound metabolic process
GO:0010605	0.927	negative regulation of macromolecule metabolic process
GO:0016070	0.921	RNA metabolic process
GO:0034660	0.894	ncRNA metabolic process
GO:0010467	0.889	gene expression
GO:0031047	0.887	RNA-mediated gene silencing
GO:0034470	0.880	ncRNA processing
GO:0071840	0.847	cellular component organization or biogenesis
GO:0070918	0.825	regulatory ncRNA processing
GO:0010558	0.806	negative regulation of macromolecule biosynthetic process
GO:0048523	0.767	negative regulation of cellular process
GO:0035196	0.760	miRNA processing
GO:0031324	0.729	negative regulation of cellular metabolic process
GO:0048518	0.710	positive regulation of biological process
GO:0031327	0.691	negative regulation of cellular biosynthetic process
GO:0051172	0.656	negative regulation of nitrogen compound metabolic process
GO:0051246	0.600	regulation of protein metabolic process
GO:0016043	0.574	cellular component organization
GO:0048522	0.559	positive regulation of cellular process
GO:0034248	0.553	regulation of amide metabolic process
GO:0016441	0.533	post-transcriptional gene silencing
GO:0035194	0.466	RNA-mediated post-transcriptional gene silencing
GO:0009893	0.445	positive regulation of metabolic process
GO:0010604	0.440	positive regulation of macromolecule metabolic process
GO:0051248	0.435	negative regulation of protein metabolic process
GO:0006417	0.422	regulation of translation
GO:2000113	0.414	negative regulation of cellular macromolecule biosynthetic process
GO:0019219	0.382	regulation of nucleobase-containing compound metabolic process
GO:0032502	0.373	developmental process
GO:0051252	0.372	regulation of RNA metabolic process
GO:0017148	0.362	negative regulation of translation
GO:0032501	0.358	multicellular organismal process
GO:0051173	0.345	positive regulation of nitrogen compound metabolic process
GO:0031325	0.344	positive regulation of cellular metabolic process
GO:0044260	0.309	cellular macromolecule metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	0.999	cytoplasm
GO:0043232	0.998	intracellular non-membrane-bounded organelle
GO:1990904	0.996	ribonucleoprotein complex
GO:0043231	0.996	intracellular membrane-bounded organelle
GO:0005634	0.994	nucleus
GO:0036464	0.988	cytoplasmic ribonucleoprotein granule
GO:0016442	0.966	RISC complex
GO:0005829	0.957	cytosol
GO:0005654	0.941	nucleoplasm
GO:0016020	0.889	membrane
GO:1902494	0.751	catalytic complex
GO:1905348	0.412	endonuclease complex
GO:1902555	0.398	endoribonuclease complex
GO:0000932	0.335	P-body

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.1.-.-	0.836	Acting on ester bonds.
EC:3.1.26.-	0.790	Endoribonucleases producing 5'-phosphomonoesters.

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