StarFunc result for job id Q9NQ33

User Input

>input (180 residues)
MDNRGNSSLPDKLPIFPDSARLPLTRSFYLEPMVTFHVHPEAPVSSPYSEELPRLPFPSD
SLILGNYSEPCPFSFPMPYPNYRGCEYSYGPAFTRKRNERERQRVKCVNEGYAQLRHHLP
EEYLEKRLSKVETLRAAIKYINYLQSLLYPDKAETKNNPGKVSSMIATTSHHADPMFRIV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9NQ33	1.000	1.000	3.096E-29	180	1.000	1.000	Q9NQ33.pdb.gz	ASCL3_HUMAN Achaete-scute homolog 3 OS=Homo sapiens OX=9606 GN=ASCL3 PE=1 SV=2
2	AFDB:Q9JJR7	0.456	0.470	1.142E-19	174	0.661	0.684	Q9JJR7.pdb.gz	ASCL3_MOUSE Achaete-scute homolog 3 OS=Mus musculus OX=10090 GN=Ascl3 PE=2 SV=1
3	AFDB:M0QWB7	0.334	0.320	2.558E-7	188	0.389	0.372	M0QWB7.pdb.gz	ASCL5_MOUSE Achaete-scute homolog 5 OS=Mus musculus OX=10090 GN=Ascl5 PE=1 SV=1
4	AFDB:Q6XD76	0.348	0.363	6.092E-7	172	0.339	0.355	Q6XD76.pdb.gz	ASCL4_HUMAN Achaete-scute homolog 4 OS=Homo sapiens OX=9606 GN=ASCL4 PE=1 SV=1
5	AFDB:Q7RTS3	0.320	0.183	1.112E-4	328	0.272	0.149	Q7RTS3.pdb.gz	PTF1A_HUMAN Pancreas transcription factor 1 subunit alpha OS=Homo sapiens OX=9606 GN=PTF1A PE=1 SV=1
6	AFDB:Q1LXV2	0.318	0.289	1.358E-4	199	0.211	0.191	Q1LXV2.pdb.gz
7	AFDB:Q90259	0.319	0.293	2.477E-4	196	0.256	0.235	Q90259.pdb.gz	ASL1A_DANRE Achaete-scute homolog 1a OS=Danio rerio OX=7955 GN=ascl1a PE=2 SV=1
8	AFDB:P19360	0.326	0.232	3.458E-4	260	0.317	0.219	P19360.pdb.gz	ASCL2_RAT Achaete-scute homolog 2 OS=Rattus norvegicus OX=10116 GN=Ascl2 PE=1 SV=1
9	AFDB:P10084	0.331	0.182	3.952E-4	345	0.267	0.139	P10084.pdb.gz	AST4_DROME Achaete-scute complex protein T4 OS=Drosophila melanogaster OX=7227 GN=sc PE=1 SV=2
10	AFDB:Q7RTS1	0.319	0.306	4.829E-4	189	0.217	0.206	Q7RTS1.pdb.gz	BHA15_HUMAN Class A basic helix-loop-helix protein 15 OS=Homo sapiens OX=9606 GN=BHLHA15 PE=1 SV=1
11	PDB:6v8oO	0.127	0.078	2.054	384	0.100	0.047	6v8oO.pdb.gz	Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement.
12	PDB:3hefB	0.124	0.161	3.066	130	0.061	0.085	3hefB.pdb.gz
13	PDB:4i43A	0.086	0.061	4.004	334	0.061	0.033	4i43A.pdb.gz
14	PDB:6f40P	0.073	0.059	4.004	246	0.067	0.049	6f40P.pdb.gz	Molecular mechanism of promoter opening by RNA polymerase III.
15	PDB:7vghB	0.094	0.023	4.004	1183	0.044	0.007	7vghB.pdb.gz	Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding.
16	PDB:8ap7F	0.132	0.163	4.576	135	0.078	0.104	8ap7F.pdb.gz	An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases.
17	PDB:6mzcM	0.204	0.335	4.892	104	0.067	0.115	6mzcM.pdb.gz
18	PDB:7suk5	0.151	0.112	5.230	296	0.094	0.057	7suk5.pdb.gz	Artificial intelligence-assisted cryoEM structure of Bfr2-Lcp5 complex observed in the yeast small subunit processome.
19	PDB:7ungi	0.117	0.088	5.230	250	0.189	0.136	7ungi.pdb.gz	SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.
20	PDB:7pqcA	0.125	0.065	5.591	445	0.061	0.025	7pqcA.pdb.gz	A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q9NQ33	2.65e-132	369	180	1.000	1.000	ASCL3_HUMAN Achaete-scute homolog 3 OS=Homo sapiens OX=9606 GN=ASCL3 PE=1 SV=2
2	Q9JJR7	2.58e-73	220	174	0.661	0.684	ASCL3_MOUSE Achaete-scute homolog 3 OS=Mus musculus OX=10090 GN=Ascl3 PE=2 SV=1
3	M0QWB7	7.26e-27	102	188	0.350	0.335	ASCL5_MOUSE Achaete-scute homolog 5 OS=Mus musculus OX=10090 GN=Ascl5 PE=1 SV=1
4	Q6XD76	3.55e-25	97.4	172	0.283	0.297	ASCL4_HUMAN Achaete-scute homolog 4 OS=Homo sapiens OX=9606 GN=ASCL4 PE=1 SV=1
5	Q10007	1.90e-16	76.6	268	0.306	0.205	HLH6_CAEEL Helix-loop-helix protein 6 OS=Caenorhabditis elegans OX=6239 GN=hlh-6 PE=2 SV=1
6	Q7ZSX3	2.23e-10	60.1	265	0.178	0.121	PTF1A_DANRE Pancreas transcription factor 1 subunit alpha OS=Danio rerio OX=7955 GN=ptf1a PE=2 SV=1
7	P10083	2.32e-10	59.3	201	0.178	0.159	AST5_DROME Achaete-scute complex protein T5 OS=Drosophila melanogaster OX=7227 GN=ac PE=1 SV=1
8	Q7RTS3	2.85e-10	60.1	328	0.156	0.085	PTF1A_HUMAN Pancreas transcription factor 1 subunit alpha OS=Homo sapiens OX=9606 GN=PTF1A PE=1 SV=1
9	Q64305	4.17e-10	59.7	326	0.156	0.086	PTF1A_RAT Pancreas transcription factor 1 subunit alpha OS=Rattus norvegicus OX=10116 GN=Ptf1a PE=1 SV=1
10	Q9QX98	4.53e-10	59.3	324	0.156	0.086	PTF1A_MOUSE Pancreas transcription factor 1 subunit alpha OS=Mus musculus OX=10090 GN=Ptf1a PE=1 SV=1
11	Q02067	2.51e-09	56.6	231	0.211	0.165	ASCL1_MOUSE Achaete-scute homolog 1 OS=Mus musculus OX=10090 GN=Ascl1 PE=1 SV=2
12	P19359	2.97e-09	56.6	233	0.211	0.163	ASCL1_RAT Achaete-scute homolog 1 OS=Rattus norvegicus OX=10116 GN=Ascl1 PE=2 SV=1
13	Q22717	2.97e-09	55.5	170	0.161	0.171	HLH3_CAEEL Helix-loop-helix protein 3 OS=Caenorhabditis elegans OX=6239 GN=hlh-3 PE=1 SV=2
14	P10084	3.03e-09	57.0	345	0.156	0.081	AST4_DROME Achaete-scute complex protein T4 OS=Drosophila melanogaster OX=7227 GN=sc PE=1 SV=2
15	Q09961	3.04e-09	55.1	148	0.161	0.196	HLH14_CAEEL Helix-loop-helix protein 14 OS=Caenorhabditis elegans OX=6239 GN=hlh-14 PE=1 SV=3
16	P50553	3.17e-09	56.6	236	0.211	0.161	ASCL1_HUMAN Achaete-scute homolog 1 OS=Homo sapiens OX=9606 GN=ASCL1 PE=1 SV=2
17	Q90259	8.28e-09	54.7	196	0.150	0.138	ASL1A_DANRE Achaete-scute homolog 1a OS=Danio rerio OX=7955 GN=ascl1a PE=2 SV=1
18	P34555	1.55e-08	54.3	205	0.156	0.137	HLH4_CAEEL Helix-loop-helix protein 4 OS=Caenorhabditis elegans OX=6239 GN=hlh-4 PE=2 SV=1
19	P22091	1.75e-08	55.1	329	0.261	0.143	TAL1_MOUSE T-cell acute lymphocytic leukemia protein 1 homolog OS=Mus musculus OX=10090 GN=Tal1 PE=1 SV=1
20	O73823	2.19e-08	54.7	394	0.228	0.104	TAL1_XENLA T-cell acute lymphocytic leukemia protein 1 OS=Xenopus laevis OX=8355 GN=tal1 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16593 Cas9-BH	4.6	18.3	Bridge helix of CRISPR-associated endonuclease Cas9
2	PF00010 HLH	5.4e-13	60.0	Helix-loop-helix DNA-binding domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000435770

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000365280	0.712	DNA-binding protein inhibitor ID-1
2	9606.ENSP00000250003	0.663	Myoblast determination protein 1
3	9606.ENSP00000350012	0.652	Long-chain-fatty-acid--CoA ligase 3
4	9606.ENSP00000262965	0.643	Transcription factor E2-alpha
5	9606.ENSP00000368566	0.572	Long-chain-fatty-acid--CoA ligase 6
6	9606.ENSP00000339787	0.552	Long-chain-fatty-acid--CoA ligase 4
7	9606.ENSP00000328478	0.507	Cyclic nucleotide-gated olfactory channel

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0003677	0.996	DNA binding
GO:0043565	0.980	sequence-specific DNA binding
GO:1990837	0.968	sequence-specific double-stranded DNA binding
GO:0003700	0.953	DNA-binding transcription factor activity
GO:0000976	0.938	transcription cis-regulatory region binding
GO:0000981	0.656	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000977	0.646	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000987	0.329	cis-regulatory region sequence-specific DNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

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[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0065007	0.995	biological regulation
GO:0050794	0.994	regulation of cellular process
GO:0019222	0.992	regulation of metabolic process
GO:0080090	0.976	regulation of primary metabolic process
GO:0051171	0.976	regulation of nitrogen compound metabolic process
GO:0010468	0.976	regulation of gene expression
GO:0031326	0.965	regulation of cellular biosynthetic process
GO:0051252	0.953	regulation of RNA metabolic process
GO:0006355	0.936	regulation of DNA-templated transcription
GO:0006357	0.858	regulation of transcription by RNA polymerase II
GO:0009987	0.689	cellular process
GO:0045892	0.684	negative regulation of DNA-templated transcription
GO:0032502	0.661	developmental process
GO:0048856	0.622	anatomical structure development
GO:0048518	0.461	positive regulation of biological process
GO:0048522	0.413	positive regulation of cellular process
GO:0032501	0.388	multicellular organismal process
GO:0009893	0.312	positive regulation of metabolic process
GO:0000122	0.310	negative regulation of transcription by RNA polymerase II

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005634	0.999	nucleus
GO:0032991	0.976	protein-containing complex
GO:0043232	0.916	intracellular non-membrane-bounded organelle
GO:0005737	0.775	cytoplasm
GO:0005667	0.558	transcription regulator complex
GO:0016020	0.499	membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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