StarFunc result for job id Q9NR19

User Input

>input (701 residues)
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC
EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG
WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG
DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG
ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY
FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV
GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG
KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:G3V9U0	0.970	0.970	0.000	701	0.937	0.937	G3V9U0.pdb.gz	G3V9U0_RAT propionate--CoA ligase OS=Rattus norvegicus OX=10116 GN=Acss2 PE=1 SV=2
2	AFDB:Q9VP61	0.760	0.794	0.000	670	0.599	0.627	Q9VP61.pdb.gz	ACSA_DROME Acetyl-coenzyme A synthetase OS=Drosophila melanogaster OX=7227 GN=AcCoAS PE=2 SV=1
3	AFDB:B9DGD6	0.913	0.862	9.875E-103	743	0.561	0.529	B9DGD6.pdb.gz	ACS_ARATH Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal OS=Arabidopsis thaliana OX=3702 GN=ACS PE=1 SV=1
4	AFDB:Q18496	0.921	0.949	5.068E-100	680	0.506	0.522	Q18496.pdb.gz	Q18496_CAEEL Acetyl-coenzyme A synthetase OS=Caenorhabditis elegans OX=6239 GN=acs-19 PE=1 SV=1
5	AFDB:Q57XD7	0.908	0.945	1.852E-98	673	0.486	0.507	Q57XD7.pdb.gz	Q57XD7_TRYB2 Acetyl-coenzyme A synthetase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.26A17.430 PE=3 SV=1
6	AFDB:Q5E268	0.898	0.969	3.655E-96	649	0.485	0.524	Q5E268.pdb.gz	Q5E268_ALIF1 Acetyl-coenzyme A synthetase OS=Aliivibrio fischeri (strain ATCC 700601 / ES114) OX=312309 GN=acs PE=3 SV=2
7	AFDB:P27550	0.741	0.796	7.650E-93	652	0.479	0.515	P27550.pdb.gz	ACSA_ECOLI Acetyl-coenzyme A synthetase OS=Escherichia coli (strain K12) OX=83333 GN=acs PE=1 SV=2
8	AFDB:Q726Y7	0.902	0.956	1.778E-92	661	0.482	0.511	Q726Y7.pdb.gz	Q726Y7_DESVH Acetyl-coenzyme A synthetase OS=Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) OX=882 GN=acsA PE=1 SV=1
9	PDB:2p20A	0.738	0.805	1.618E-88	641	0.478	0.523	2p20A.pdb.gz	Biochemical and Crystallographic Analysis of Substrate Binding and Conformational Changes in Acetyl-CoA Synthetase.
10	AFDB:Q9NUB1	0.856	0.870	4.696E-86	689	0.455	0.463	Q9NUB1.pdb.gz	ACS2L_HUMAN Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Homo sapiens OX=9606 GN=ACSS1 PE=1 SV=2
11	AFDB:P9WQD1	0.884	0.951	8.716E-86	651	0.437	0.470	P9WQD1.pdb.gz	ACSA_MYCTU Acetyl-coenzyme A synthetase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=acsA PE=1 SV=1
12	PDB:1ry2A	0.829	0.943	4.870E-75	615	0.408	0.465	1ry2A.pdb.gz	Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP
13	PDB:3b7wA	0.563	0.727	2.708E-41	537	0.207	0.270	3b7wA.pdb.gz	Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
14	PDB:5ie2A	0.628	0.857	6.375E-36	506	0.183	0.253	5ie2A.pdb.gz	Crystal Structures of Arabidopsis thaliana Oxalyl-CoA Synthetase Essential for Oxalate Degradation
15	PDB:5bsmA	0.654	0.854	4.562E-35	530	0.160	0.211	5bsmA.pdb.gz	Structural Basis for Specificity and Flexibility in a Plant 4-Coumarate:CoA Ligase.
16	PDB:7kydA	0.659	0.855	8.956E-35	534	0.161	0.212	7kydA.pdb.gz	FruitFire: a luciferase based on a fruit fly metabolic enzyme.
17	PDB:1ultA	0.552	0.709	1.189E-33	533	0.183	0.240	1ultA.pdb.gz
18	PDB:3r44A	0.547	0.739	4.335E-33	502	0.174	0.243	3r44A.pdb.gz	The Mycobacterium tuberculosis Very-Long-Chain Fatty Acyl-CoA Synthetase: Structural Basis for Housing Lipid Substrates Longer than the Enzyme.
19	PDB:6q2mA	0.648	0.825	5.131E-33	544	0.157	0.202	6q2mA.pdb.gz	Mutagenesis and Structural Studies Reveal the Basis for the Activity and Stability Properties That Distinguish thePhotinusLuciferasesscintillansandpyralis.
20	PDB:3rg2C	0.522	0.591	8.066E-32	613	0.155	0.178	3rg2C.pdb.gz	Structural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein Domains.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A8I6AD12	1273	702	0.882	0.880	A0A8I6AD12_RAT propionate--CoA ligase OS=Rattus norvegicus OX=10116 GN=Acss2 PE=1 SV=1
2	A0A8I6GJ11	1347	758	0.937	0.867	A0A8I6GJ11_RAT propionate--CoA ligase OS=Rattus norvegicus OX=10116 GN=Acss2 PE=1 SV=1
3	B1WC11	1352	701	0.936	0.936	B1WC11_RAT propionate--CoA ligase OS=Rattus norvegicus OX=10116 GN=Acss2 PE=2 SV=1
4	B9DGD6	800	743	0.551	0.520	ACS_ARATH Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal OS=Arabidopsis thaliana OX=3702 GN=ACS PE=1 SV=1
5	D3ZZN3	619	682	0.449	0.462	D3ZZN3_RAT Acetyl-coenzyme A synthetase OS=Rattus norvegicus OX=10116 GN=Acss1 PE=3 SV=1
6	G3V9U0	1356	745	0.937	0.882	G3V9U0_RAT propionate--CoA ligase OS=Rattus norvegicus OX=10116 GN=Acss2 PE=1 SV=2
7	P16928	618	670	0.441	0.461	ACSA_EMENI Acetyl-coenzyme A synthetase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=facA PE=2 SV=2
8	P27550	701	652	0.481	0.517	ACSA_ECOLI Acetyl-coenzyme A synthetase OS=Escherichia coli (strain K12) OX=83333 GN=acs PE=1 SV=2
9	P52910	600	683	0.438	0.449	ACS2_YEAST Acetyl-coenzyme A synthetase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ACS2 PE=1 SV=1
10	P78773	600	662	0.425	0.450	ACSA_SCHPO Probable acetyl-coenzyme A synthetase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC191.02c PE=1 SV=2
11	P9WQD1	567	651	0.441	0.475	ACSA_MYCTU Acetyl-coenzyme A synthetase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=acsA PE=1 SV=1
12	Q01574	586	713	0.438	0.431	ACS1_YEAST Acetyl-coenzyme A synthetase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ACS1 PE=1 SV=2
13	Q18496	722	680	0.502	0.518	Q18496_CAEEL Acetyl-coenzyme A synthetase OS=Caenorhabditis elegans OX=6239 GN=acs-19 PE=1 SV=1
14	Q57XD7	690	673	0.488	0.508	Q57XD7_TRYB2 Acetyl-coenzyme A synthetase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.26A17.430 PE=3 SV=1
15	Q5E268	708	649	0.489	0.529	Q5E268_ALIF1 Acetyl-coenzyme A synthetase OS=Aliivibrio fischeri (strain ATCC 700601 / ES114) OX=312309 GN=acs PE=3 SV=2
16	Q6FLU2	572	704	0.431	0.429	ACS1_CANGA Acetyl-coenzyme A synthetase 1 OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=ACS1 PE=3 SV=1
17	Q726Y7	662	661	0.486	0.516	Q726Y7_DESVH Acetyl-coenzyme A synthetase OS=Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) OX=882 GN=acsA PE=1 SV=1
18	Q8ZKF6	698	652	0.482	0.518	ACSA_SALTY Acetyl-coenzyme A synthetase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) OX=99287 GN=acs PE=1 SV=1
19	Q99NB1	613	682	0.444	0.456	ACS2L_MOUSE Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Mus musculus OX=10090 GN=Acss1 PE=1 SV=1
20	Q9NR19	1461	701	1.000	1.000	ACSA_HUMAN Acetyl-coenzyme A synthetase, cytoplasmic OS=Homo sapiens OX=9606 GN=ACSS2 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16177 ACAS_N	5.3e-16	69.6	Acetyl-coenzyme A synthetase N-terminus
2	PF00501 AMP-binding	1.5e-95	332.0	AMP-binding enzyme
3	PF13193 AMP-binding_C	3.2e-21	87.4	AMP-binding enzyme C-terminal domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000253382

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000483300	0.974	Acetyl-CoA carboxylase 1
2	9606.ENSP00000342056	0.972	Citrate synthase, mitochondrial
3	9606.ENSP00000341044	0.965	Acetyl-CoA carboxylase 2
4	9606.ENSP00000303246	0.962	Acyl-coenzyme A thioesterase 12
5	9606.ENSP00000372191	0.960	NAD-dependent protein deacetylase sirtuin-3, mitochondrial
6	9606.ENSP00000351742	0.954	Transcription factor EB
7	9606.ENSP00000212015	0.953	NAD-dependent protein deacetylase sirtuin-1
8	9606.ENSP00000356015	0.945	Acetyl-CoA acetyltransferase, cytosolic
9	9606.ENSP00000261733	0.944	Aldehyde dehydrogenase, mitochondrial
10	9606.ENSP00000265838	0.944	Acetyl-CoA acetyltransferase, mitochondrial
11	9606.ENSP00000293217	0.941	Peroxisomal acyl-coenzyme A oxidase 1
12	9606.ENSP00000255084	0.940	Aldehyde dehydrogenase family 3 member B2
13	9606.ENSP00000280346	0.938	Dihydrolipoamide S-acetyltransferase
14	9606.ENSP00000473990	0.938	Aldehyde dehydrogenase family 3 member B1
15	9606.ENSP00000345774	0.936	Fatty aldehyde dehydrogenase
16	9606.ENSP00000411821	0.932	Aldehyde dehydrogenase, dimeric NADP-preferring
17	9606.ENSP00000242592	0.923	Short-chain specific acyl-CoA dehydrogenase, mitochondrial
18	9606.ENSP00000348775	0.923	Peroxisomal acyl-coenzyme A oxidase 3
19	9606.ENSP00000450436	0.923	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
20	9606.ENSP00000449535	0.920	Acyl-CoA synthetase short-chain family member 3, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0003987	1.000	acetate-CoA ligase activity
GO:0005488	0.751	binding
GO:0005515	0.619	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.998	organic substance metabolic process
GO:0044237	0.998	cellular metabolic process
GO:0044281	0.997	small molecule metabolic process
GO:0044238	0.996	primary metabolic process
GO:0009058	0.980	biosynthetic process
GO:0006629	0.966	lipid metabolic process
GO:0006807	0.944	nitrogen compound metabolic process
GO:0008610	0.938	lipid biosynthetic process
GO:0032787	0.914	monocarboxylic acid metabolic process
GO:0044249	0.870	cellular biosynthetic process
GO:0044283	0.869	small molecule biosynthetic process
GO:0044255	0.631	cellular lipid metabolic process
GO:0006631	0.521	fatty acid metabolic process
GO:1901564	0.354	organonitrogen compound metabolic process
GO:1901360	0.348	organic cyclic compound metabolic process
GO:1901615	0.330	organic hydroxy compound metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	0.998	cytoplasm
GO:0070013	0.938	intracellular organelle lumen
GO:0005829	0.927	cytosol
GO:0043231	0.843	intracellular membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:23176	1.000	acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate
EC:6.2.1.1	1.000	acetate--CoA ligase.

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