StarFunc result for job id Q9NRG1

User Input

>input (225 residues)
MAGSSEEAPDYGRGVVIMDDWPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDI
MKDIGYSDIMVLCVLKGGYKFCADLVEHLKNISRNSDRFVSMKVDFIRLKSYRNDQSMGE
MQIIGGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDG
FRPDYAGFEIPNLFVVGYALDYNEYFRDLNHICVINEHGKEKYRV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9NRG1	1.000	1.000	2.608E-50	225	1.000	1.000	Q9NRG1.pdb.gz	PRDC1_HUMAN Phosphoribosyltransferase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PRTFDC1 PE=1 SV=1
2	PDB:2jbhB	0.897	0.946	3.932E-41	213	0.947	1.000	2jbhB.pdb.gz	Structural and Functional Studies of the Human Phosphoribosyltransferase Domain Containing Protein 1.
3	AFDB:A0A140VJL3	0.910	0.939	2.067E-37	218	0.640	0.661	A0A140VJL3.pdb.gz	A0A140VJL3_HUMAN Hypoxanthine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=2 SV=1
4	PDB:1bzyA	0.925	0.972	5.886E-36	214	0.640	0.673	1bzyA.pdb.gz	The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor.
5	PDB:5brnB	0.840	0.972	1.561E-29	194	0.578	0.670	5brnB.pdb.gz	Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.
6	AFDB:Q8IJS1	0.923	0.899	1.353E-28	231	0.427	0.416	Q8IJS1.pdb.gz	Q8IJS1_PLAF7 Hypoxanthine phosphoribosyltransferase OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1012400 PE=3 SV=1
7	AFDB:Q9NF11	0.864	0.907	5.082E-26	214	0.440	0.463	Q9NF11.pdb.gz	Q9NF11_CAEEL Hypoxanthine phosphoribosyltransferase OS=Caenorhabditis elegans OX=6239 GN=hprt-1 PE=1 SV=1
8	PDB:5knyB	0.705	0.841	1.820E-17	187	0.289	0.348	5knyB.pdb.gz	Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with pyrrolidine nucleoside phosphonate
9	AFDB:Q07010	0.745	0.795	2.188E-17	210	0.240	0.257	Q07010.pdb.gz	HPRT_TRYBB Hypoxanthine-guanine phosphoribosyltransferase OS=Trypanosoma brucei brucei OX=5702 GN=HGPRT PE=1 SV=1
10	AFDB:P9WHQ9	0.715	0.792	2.618E-17	202	0.284	0.317	P9WHQ9.pdb.gz	HGPRT_MYCTU Hypoxanthine-guanine phosphoribosyltransferase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=hpt PE=1 SV=1
11	AFDB:Q38CA1	0.744	0.717	5.703E-17	234	0.280	0.269	Q38CA1.pdb.gz	Q38CA1_TRYB2 Hypoxanthine-guanine phosphoribosyltransferase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.70.6660 PE=1 SV=1
12	AFDB:Q4QCC2	0.725	0.687	9.776E-17	238	0.258	0.244	Q4QCC2.pdb.gz	Q4QCC2_LEIMA Xanthine phosphoribosyltransferase OS=Leishmania major OX=5664 GN=XRPT PE=4 SV=1
13	AFDB:Q4QCC3	0.747	0.794	1.102E-16	211	0.289	0.308	Q4QCC3.pdb.gz	Q4QCC3_LEIMA Hypoxanthine phosphoribosyltransferase OS=Leishmania major OX=5664 GN=HGPRT PE=3 SV=1
14	PDB:6mxcC	0.728	0.744	1.165E-16	220	0.253	0.259	6mxcC.pdb.gz	Crystal structures of Trypanosoma brucei hypoxanthine - guanine - xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP.
15	AFDB:P0A9M2	0.669	0.837	1.676E-16	178	0.258	0.326	P0A9M2.pdb.gz	HPRT_ECOLI Hypoxanthine phosphoribosyltransferase OS=Escherichia coli (strain K12) OX=83333 GN=hpt PE=1 SV=1
16	PDB:5knxB	0.683	0.864	4.349E-16	176	0.249	0.318	5knxB.pdb.gz	Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase
17	PDB:6apsA	0.672	0.812	1.892E-14	185	0.222	0.270	6apsA.pdb.gz	Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.
18	PDB:1w30B	0.552	0.685	1.652E-9	177	0.156	0.198	1w30B.pdb.gz
19	PDB:1a95B	0.422	0.607	2.181E-6	150	0.129	0.193	1a95B.pdb.gz	Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase.
20	PDB:2ehjA	0.474	0.508	1.035E-5	208	0.120	0.130	2ehjA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q9NRG1	6.32e-167	460	225	1.000	1.000	PRDC1_HUMAN Phosphoribosyltransferase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PRTFDC1 PE=1 SV=1
2	P00493	4.57e-107	309	218	0.649	0.670	HPRT_MOUSE Hypoxanthine-guanine phosphoribosyltransferase OS=Mus musculus OX=10090 GN=Hprt1 PE=1 SV=3
3	P27605	2.26e-106	307	218	0.640	0.661	HPRT_RAT Hypoxanthine-guanine phosphoribosyltransferase OS=Rattus norvegicus OX=10116 GN=Hprt1 PE=1 SV=1
4	A0A140VJL3	7.45e-106	306	218	0.640	0.661	A0A140VJL3_HUMAN Hypoxanthine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=2 SV=1
5	P00492	7.45e-106	306	218	0.640	0.661	HPRT_HUMAN Hypoxanthine-guanine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=1 SV=2
6	Q9W719	4.92e-103	298	218	0.631	0.651	HPRT_CHICK Hypoxanthine-guanine phosphoribosyltransferase OS=Gallus gallus OX=9031 GN=HPRT1 PE=2 SV=1
7	Q8IJS1	2.44e-58	186	231	0.440	0.429	Q8IJS1_PLAF7 Hypoxanthine phosphoribosyltransferase OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1012400 PE=3 SV=1
8	Q9NF11	5.77e-57	181	214	0.440	0.463	Q9NF11_CAEEL Hypoxanthine phosphoribosyltransferase OS=Caenorhabditis elegans OX=6239 GN=hprt-1 PE=1 SV=1
9	Q38CA1	1.85e-25	101	234	0.253	0.244	Q38CA1_TRYB2 Hypoxanthine-guanine phosphoribosyltransferase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.70.6660 PE=1 SV=1
10	Q4QCC2	1.31e-23	96.7	238	0.249	0.235	Q4QCC2_LEIMA Xanthine phosphoribosyltransferase OS=Leishmania major OX=5664 GN=XRPT PE=4 SV=1
11	Q07010	4.14e-20	86.7	210	0.213	0.229	HPRT_TRYBB Hypoxanthine-guanine phosphoribosyltransferase OS=Trypanosoma brucei brucei OX=5702 GN=HGPRT PE=1 SV=1
12	P0A9M2	6.69e-20	85.5	178	0.258	0.326	HPRT_ECOLI Hypoxanthine phosphoribosyltransferase OS=Escherichia coli (strain K12) OX=83333 GN=hpt PE=1 SV=1
13	Q4QCC3	6.99e-20	86.3	211	0.240	0.256	Q4QCC3_LEIMA Hypoxanthine phosphoribosyltransferase OS=Leishmania major OX=5664 GN=HGPRT PE=3 SV=1
14	P9WHQ9	1.77e-19	84.7	202	0.280	0.312	HGPRT_MYCTU Hypoxanthine-guanine phosphoribosyltransferase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=hpt PE=1 SV=1
15	F4IA25	3.70e-15	73.2	198	0.253	0.288	F4IA25_ARATH Hypoxanthine phosphoribosyltransferase OS=Arabidopsis thaliana OX=3702 GN=HGPT PE=1 SV=1
16	P65946	1.29e-05	46.2	173	0.178	0.231	PYRR_STRPN Bifunctional protein PyrR OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=pyrR PE=1 SV=1
17	P9WHK3	0.81	32.3	193	0.080	0.093	PYRR_MYCTU Bifunctional protein PyrR OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=pyrR PE=1 SV=1
18	F4JNE2	1.6	32.3	4219	0.067	0.004	F4JNE2_ARATH Pleckstrin homology (PH) domain-containing protein OS=Arabidopsis thaliana OX=3702 GN=DL4605C PE=1 SV=1
19	P08394	1.6	32.3	1180	0.142	0.027	RECB_ECOLI RecBCD enzyme subunit RecB OS=Escherichia coli (strain K12) OX=83333 GN=recB PE=1 SV=1
20	P63544	1.9	31.2	170	0.076	0.100	APT_STRPN Adenine phosphoribosyltransferase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=apt PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF19176 DUF5858	1.3e+02	13.8	Family of unknown function (DUF5858)
2	PF00156 Pribosyltran	1e-22	91.7	Phosphoribosyl transferase domain
3	PF15609 PRTase_2	3.2e+02	12.2	Phosphoribosyl transferase
4	PF14681 UPRTase	1.1e+02	13.7	Uracil phosphoribosyltransferase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000318602

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000398502	0.879	Protein-lysine N-methyltransferase EEF2KMT
2	9606.ENSP00000298556	0.846	Hypoxanthine-guanine phosphoribosyltransferase
3	9606.ENSP00000371253	0.756	Trifunctional purine biosynthetic protein adenosine-3
4	9606.ENSP00000355260	0.605	Protein phosphatase 1 regulatory subunit 14C
5	9606.ENSP00000447000	0.605	Uncharacterized protein
6	9606.ENSP00000229239	0.597	Glyceraldehyde-3-phosphate dehydrogenase
7	9606.ENSP00000222286	0.595	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
8	9606.ENSP00000355493	0.583	Adenylosuccinate synthetase isozyme 2
9	9606.ENSP00000444215	0.579	Tumor necrosis factor alpha-induced protein 8-like protein 1
10	9606.ENSP00000342295	0.569	Ankyrin repeat domain-containing protein 55
11	9606.ENSP00000469958	0.568	Zinc finger protein 626
12	9606.ENSP00000262407	0.566	Integrin alpha-IIb
13	9606.ENSP00000061240	0.560	Tolloid-like protein 1
14	9606.ENSP00000484669	0.556	Cleavage and polyadenylation specificity factor subunit 1
15	9606.ENSP00000419851	0.540	GMP synthase [glutamine-hydrolyzing]
16	9606.ENSP00000361965	0.510	Adenosine deaminase

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0042802	1.000	identical protein binding
GO:0043169	0.999	cation binding
GO:0004422	0.999	hypoxanthine phosphoribosyltransferase activity
GO:0046983	0.997	protein dimerization activity
GO:0000287	0.991	magnesium ion binding
GO:0042803	0.879	protein homodimerization activity
GO:0097159	0.584	organic cyclic compound binding
GO:1901363	0.582	heterocyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.996	cellular process
GO:0071704	0.995	organic substance metabolic process
GO:1901564	0.991	organonitrogen compound metabolic process
GO:0055086	0.987	nucleobase-containing small molecule metabolic process
GO:0072522	0.949	purine-containing compound biosynthetic process
GO:0043094	0.948	cellular metabolic compound salvage
GO:0034654	0.941	nucleobase-containing compound biosynthetic process
GO:0006753	0.913	nucleoside phosphate metabolic process
GO:0009119	0.885	ribonucleoside metabolic process
GO:0043101	0.850	purine-containing compound salvage
GO:0009117	0.822	nucleotide metabolic process
GO:0046128	0.820	purine ribonucleoside metabolic process
GO:1901137	0.809	carbohydrate derivative biosynthetic process
GO:1901293	0.765	nucleoside phosphate biosynthetic process
GO:0006163	0.732	purine nucleotide metabolic process
GO:0009161	0.729	ribonucleoside monophosphate metabolic process
GO:0009165	0.727	nucleotide biosynthetic process
GO:0009259	0.717	ribonucleotide metabolic process
GO:0006164	0.711	purine nucleotide biosynthetic process
GO:0009150	0.708	purine ribonucleotide metabolic process
GO:0009112	0.696	nucleobase metabolic process
GO:0006144	0.671	purine nucleobase metabolic process
GO:0009156	0.542	ribonucleoside monophosphate biosynthetic process
GO:0009167	0.531	purine ribonucleoside monophosphate metabolic process
GO:0009260	0.524	ribonucleotide biosynthetic process
GO:0009168	0.493	purine ribonucleoside monophosphate biosynthetic process
GO:0009152	0.449	purine ribonucleotide biosynthetic process
GO:0046040	0.313	IMP metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.998	cytosol
GO:0043226	0.949	organelle
GO:0043227	0.810	membrane-bounded organelle
GO:0043229	0.763	intracellular organelle
GO:0043231	0.743	intracellular membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:17973	0.999	diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
EC:2.4.2.8	0.999	hypoxanthine phosphoribosyltransferase.

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