StarFunc result for job id Q9NRX5

User Input

>input (453 residues)
MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPG
MEEQLNKIPGFCENEKGVVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAA
VHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNE
SWVEKMEEGNSRCWYAALLSATALNYLLSLVAIVLFFVYYTHPASCSENKAFISVNMLLC
VGASVMSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETNCNPSLLSIIGYNTT
STVPKEGQSVQWWHAQGIIGLILFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGGAR
SDGSLEDGDDVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQW
TAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q7TNK0	0.982	0.982	6.599E-56	453	0.962	0.962	Q7TNK0.pdb.gz	SERC1_RAT Serine incorporator 1 OS=Rattus norvegicus OX=10116 GN=Serinc1 PE=1 SV=1
2	AFDB:Q9QZI9	0.905	0.870	1.082E-38	472	0.607	0.583	Q9QZI9.pdb.gz	SERC3_MOUSE Serine incorporator 3 OS=Mus musculus OX=10090 GN=Serinc3 PE=1 SV=2
3	AFDB:Q96SA4	0.902	0.898	3.370E-38	455	0.552	0.549	Q96SA4.pdb.gz	SERC2_HUMAN Serine incorporator 2 OS=Homo sapiens OX=9606 GN=SERINC2 PE=2 SV=3
4	AFDB:Q13530	0.897	0.860	5.134E-38	473	0.616	0.590	Q13530.pdb.gz	SERC3_HUMAN Serine incorporator 3 OS=Homo sapiens OX=9606 GN=SERINC3 PE=1 SV=2
5	AFDB:Q4FZV1	0.892	0.898	1.487E-36	450	0.530	0.533	Q4FZV1.pdb.gz	Q4FZV1_RAT Serine incorporator 2 OS=Rattus norvegicus OX=10116 GN=Serinc2 PE=2 SV=1
6	PDB:7ru6A	0.659	0.935	1.951E-23	315	0.459	0.660	7ru6A.pdb.gz	Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.
7	AFDB:Q8BHJ6	0.783	0.770	1.362E-22	461	0.406	0.399	Q8BHJ6.pdb.gz	SERC5_MOUSE Serine incorporator 5 OS=Mus musculus OX=10090 GN=Serinc5 PE=2 SV=1
8	AFDB:Q86VE9	0.727	0.776	8.071E-21	423	0.360	0.385	Q86VE9.pdb.gz	SERC5_HUMAN Serine incorporator 5 OS=Homo sapiens OX=9606 GN=SERINC5 PE=2 SV=1
9	AFDB:Q12116	0.646	0.622	1.762E-18	473	0.296	0.283	Q12116.pdb.gz	TMS1_YEAST Membrane protein TMS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TMS1 PE=1 SV=1
10	AFDB:Q93YS8	0.605	0.680	1.392E-13	394	0.210	0.241	Q93YS8.pdb.gz	Q93YS8_ARATH Serinc-domain containing serine and sphingolipid biosynthesis protein OS=Arabidopsis thaliana OX=3702 GN=MEE55 PE=2 SV=1
11	AFDB:Q86K54	0.498	0.649	1.992E-4	333	0.146	0.198	Q86K54.pdb.gz	Q86K54_DICDI Uncharacterized protein OS=Dictyostelium discoideum OX=44689 GN=DDB_G0277237 PE=4 SV=1
12	PDB:5j4nA	0.134	0.137	6.117E-1	437	0.104	0.108	5j4nA.pdb.gz	Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC.
13	PDB:6j8gA	0.114	0.069	8.565E-1	1140	0.113	0.045	6j8gA.pdb.gz	Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins.
14	PDB:7cmhB	0.134	0.133	9.318E-1	458	0.113	0.111	7cmhB.pdb.gz	Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex.
15	PDB:2wsxA	0.116	0.109	9.718E-1	496	0.119	0.109	2wsxA.pdb.gz	Structural Basis of Na(+)-Independent and Cooperative Substrate/Product Antiport in Cait.
16	PDB:8bc0B	0.163	0.129	1.199	636	0.102	0.072	8bc0B.pdb.gz	Structural basis for the activation of the lipid scramblase TMEM16F.
17	PDB:4ja4A	0.147	0.150	1.251	442	0.102	0.104	4ja4A.pdb.gz
18	PDB:5ogeG	0.206	0.265	1.544	306	0.082	0.121	5ogeG.pdb.gz
19	PDB:7we4A	0.139	0.079	1.544	1122	0.135	0.054	7we4A.pdb.gz	Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8.
20	PDB:5oxpA	0.137	0.135	1.610	462	0.113	0.110	5oxpA.pdb.gz	Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q13530	0.0	554	473	0.618	0.592	SERC3_HUMAN Serine incorporator 3 OS=Homo sapiens OX=9606 GN=SERINC3 PE=1 SV=2
2	Q7TNK0	0.0	904	453	0.962	0.962	SERC1_RAT Serine incorporator 1 OS=Rattus norvegicus OX=10116 GN=Serinc1 PE=1 SV=1
3	Q9NRX5	0.0	930	453	1.000	1.000	SERC1_HUMAN Serine incorporator 1 OS=Homo sapiens OX=9606 GN=SERINC1 PE=1 SV=1
4	Q9QZI8	0.0	902	453	0.958	0.958	SERC1_MOUSE Serine incorporator 1 OS=Mus musculus OX=10090 GN=Serinc1 PE=1 SV=1
5	Q9QZI9	0.0	515	472	0.611	0.587	SERC3_MOUSE Serine incorporator 3 OS=Mus musculus OX=10090 GN=Serinc3 PE=1 SV=2
6	Q96SA4	7.13e-176	502	455	0.554	0.552	SERC2_HUMAN Serine incorporator 2 OS=Homo sapiens OX=9606 GN=SERINC2 PE=2 SV=3
7	Q4FZV1	1.67e-166	478	450	0.536	0.540	Q4FZV1_RAT Serine incorporator 2 OS=Rattus norvegicus OX=10116 GN=Serinc2 PE=2 SV=1
8	Q8BHJ6	1.77e-103	317	461	0.404	0.397	SERC5_MOUSE Serine incorporator 5 OS=Mus musculus OX=10090 GN=Serinc5 PE=2 SV=1
9	Q63175	4.61e-92	288	460	0.373	0.367	SERC5_RAT Serine incorporator 5 OS=Rattus norvegicus OX=10116 GN=Serinc5 PE=2 SV=1
10	Q86VE9	1.63e-91	285	423	0.362	0.388	SERC5_HUMAN Serine incorporator 5 OS=Homo sapiens OX=9606 GN=SERINC5 PE=2 SV=1
11	Q12116	5.65e-54	189	473	0.316	0.302	TMS1_YEAST Membrane protein TMS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TMS1 PE=1 SV=1
12	Q93YS8	1.66e-32	129	394	0.216	0.249	Q93YS8_ARATH Serinc-domain containing serine and sphingolipid biosynthesis protein OS=Arabidopsis thaliana OX=3702 GN=MEE55 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF18914 DUF5666	3.8e+02	12.8	Domain of unknown function (DUF5666)
2	PF03348 Serinc	3.3e-170	578.4	Serine incorporator (Serinc)

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 61622.XP_010373719.1

Rank	PPI partner	STRING score	Description
1	61622.XP_010371731.1	0.647	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 759 ESTs, 2 Proteins, and 94% coverage of the annotated genomic feature by RNAseq alignments
2	61622.XP_010378496.1	0.614	E3 ubiquitin-protein ligase Praja-2
3	61622.XP_010374687.1	0.591	RUN and SH3 domain containing 2
4	61622.XP_010352575.1	0.573	TEPSIN, adaptor related protein complex 4 accessory protein
5	61622.XP_010387005.1	0.568	DTW domain-containing protein 2
6	61622.XP_010374979.1	0.549	C-type lectin domain family 12 member B
7	61622.XP_010353930.1	0.540	TLD domain-containing protein 1 isoform X1
8	61622.XP_010380492.1	0.540	Zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform X1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.998	protein binding
GO:0019899	0.874	enzyme binding
GO:0030674	0.826	protein-macromolecule adaptor activity
GO:0015171	0.388	amino acid transmembrane transporter activity
GO:0015175	0.382	neutral L-amino acid transmembrane transporter activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0065007	0.998	biological regulation
GO:0009987	0.997	cellular process
GO:0044237	0.976	cellular metabolic process
GO:0044238	0.972	primary metabolic process
GO:0071704	0.971	organic substance metabolic process
GO:0006807	0.947	nitrogen compound metabolic process
GO:1901564	0.944	organonitrogen compound metabolic process
GO:0065009	0.837	regulation of molecular function
GO:0006575	0.724	cellular modified amino acid metabolic process
GO:0050789	0.719	regulation of biological process
GO:0019637	0.688	organophosphate metabolic process
GO:0044093	0.669	positive regulation of molecular function
GO:0006629	0.657	lipid metabolic process
GO:0050790	0.635	regulation of catalytic activity
GO:0071840	0.634	cellular component organization or biogenesis
GO:0050794	0.617	regulation of cellular process
GO:0044255	0.584	cellular lipid metabolic process
GO:0043085	0.583	positive regulation of catalytic activity
GO:0006796	0.463	phosphate-containing compound metabolic process
GO:0044091	0.395	membrane biogenesis
GO:0048518	0.382	positive regulation of biological process
GO:0051338	0.335	regulation of transferase activity
GO:0006644	0.332	phospholipid metabolic process
GO:0051347	0.325	positive regulation of transferase activity
GO:0046486	0.320	glycerolipid metabolic process
GO:0048522	0.310	positive regulation of cellular process
GO:0006650	0.308	glycerophospholipid metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	0.999	plasma membrane
GO:0043231	0.957	intracellular membrane-bounded organelle
GO:0005737	0.946	cytoplasm
GO:0012505	0.938	endomembrane system
GO:0031090	0.604	organelle membrane
GO:0031984	0.321	organelle subcompartment

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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