StarFunc result for job id Q9NS98

User Input

>input (782 residues)
MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQA
MYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFV
RVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFAS
TFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAARIPENSDQDN
DKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPG
GAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHR
DGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRP
RHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEV
VLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYC
AWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTF
LECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEH
GFSQTVVRLALVVIVASQLDNLFPPEPKPEEPPARGGLASTPPKAWYKDILQLIGFANLP
RVDEYCERVWCRGTTECSGCFRSRSRGKQARGKSWAGLELGKKMKSRVHAEHNRTPREVE
AT

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:M9MM97	0.846	0.857	0.000	771	0.550	0.558	M9MM97.pdb.gz	M9MM97_DANRE Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl OS=Danio rerio OX=7955 GN=fc22d04 PE=3 SV=1
2	AFDB:Q4LFA9	0.879	0.881	0.000	780	0.863	0.865	Q4LFA9.pdb.gz	SEM3G_MOUSE Semaphorin-3G OS=Mus musculus OX=10090 GN=Sema3g PE=2 SV=1
3	AFDB:Q9NS98	1.000	1.000	0.000	782	1.000	1.000	Q9NS98.pdb.gz	SEM3G_HUMAN Semaphorin-3G OS=Homo sapiens OX=9606 GN=SEMA3G PE=1 SV=1
4	AFDB:O42237	0.866	0.863	3.528E-97	785	0.506	0.504	O42237.pdb.gz	SEM3E_CHICK Semaphorin-3E OS=Gallus gallus OX=9031 GN=SEMA3E PE=2 SV=1
5	AFDB:O15041	0.859	0.867	2.183E-96	775	0.500	0.505	O15041.pdb.gz	SEM3E_HUMAN Semaphorin-3E OS=Homo sapiens OX=9606 GN=SEMA3E PE=1 SV=1
6	AFDB:O08665	0.818	0.828	8.269E-94	772	0.453	0.459	O08665.pdb.gz	SEM3A_MOUSE Semaphorin-3A OS=Mus musculus OX=10090 GN=Sema3a PE=1 SV=2
7	AFDB:M9MM94	0.820	0.827	5.983E-93	775	0.467	0.471	M9MM94.pdb.gz
8	AFDB:Q1LYS1	0.838	0.853	6.303E-93	768	0.471	0.479	Q1LYS1.pdb.gz	Q1LYS1_DANRE Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E OS=Danio rerio OX=7955 GN=fj37c11 PE=3 SV=1
9	AFDB:Q9W7J1	0.832	0.759	6.640E-93	860	0.436	0.397	Q9W7J1.pdb.gz	SE3AA_DANRE Semaphorin-3aa OS=Danio rerio OX=7955 GN=sema3aa PE=2 SV=1
10	AFDB:A0A2R8Q5P4	0.788	0.815	1.307E-92	756	0.462	0.478	A0A2R8Q5P4.pdb.gz
11	PDB:6qp7A	0.640	0.796	3.318E-49	620	0.235	0.297	6qp7A.pdb.gz	Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.
12	PDB:3nvqA	0.638	0.832	1.238E-40	588	0.205	0.272	3nvqA.pdb.gz
13	PDB:3nvnA	0.431	0.837	1.055E-21	383	0.095	0.193	3nvnA.pdb.gz	Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1.
14	PDB:2hesX	0.265	0.581	1.756E-6	308	0.050	0.127	2hesX.pdb.gz
15	PDB:7wb4c	0.291	0.579	2.278E-6	346	0.056	0.127	7wb4c.pdb.gz
16	PDB:6jp6A	0.128	0.104	2.400E-6	998	0.064	0.050	6jp6A.pdb.gz
17	PDB:4a11B	0.259	0.486	3.114E-6	365	0.069	0.148	4a11B.pdb.gz
18	PDB:6nd4H	0.109	0.103	3.280E-6	834	0.072	0.067	6nd4H.pdb.gz	Conformational switches control early maturation of the eukaryotic small ribosomal subunit.
19	PDB:7mqaLW	0.289	0.464	3.640E-6	452	0.068	0.117	7mqaLW.pdb.gz	Nucleolar maturation of the human small subunit processome.
20	PDB:7mq8LW	0.284	0.454	4.256E-6	453	0.064	0.110	7mq8LW.pdb.gz	Nucleolar maturation of the human small subunit processome.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A1D5PZ68	622	751	0.391	0.407	A0A1D5PZ68_CHICK Semaphorin-3C OS=Gallus gallus OX=9031 GN=SEMA3C PE=3 SV=1
2	A0A2R8Q5T8	627	791	0.417	0.412	A0A2R8Q5T8_DANRE Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb OS=Danio rerio OX=7955 GN=sema3fb PE=3 SV=1
3	E7F6C0	629	787	0.418	0.416	E7F6C0_DANRE Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb OS=Danio rerio OX=7955 GN=sema3fb PE=3 SV=1
4	F1NVZ5	705	808	0.467	0.452	F1NVZ5_CHICK Semaphorin 3A OS=Gallus gallus OX=9031 GN=SEMA3A PE=3 SV=2
5	M9MM97	899	771	0.551	0.559	M9MM97_DANRE Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl OS=Danio rerio OX=7955 GN=fc22d04 PE=3 SV=1
6	O08665	716	772	0.462	0.468	SEM3A_MOUSE Semaphorin-3A OS=Mus musculus OX=10090 GN=Sema3a PE=1 SV=2
7	O15041	775	775	0.495	0.499	SEM3E_HUMAN Semaphorin-3E OS=Homo sapiens OX=9606 GN=SEMA3E PE=1 SV=1
8	O42236	619	751	0.390	0.406	SEM3C_CHICK Semaphorin-3C OS=Gallus gallus OX=9031 GN=SEMA3C PE=2 SV=1
9	O42237	798	785	0.501	0.499	SEM3E_CHICK Semaphorin-3E OS=Gallus gallus OX=9031 GN=SEMA3E PE=2 SV=1
10	O88632	597	785	0.408	0.406	SEM3F_MOUSE Semaphorin-3F OS=Mus musculus OX=10090 GN=Sema3f PE=2 SV=2
11	P70275	791	775	0.499	0.503	SEM3E_MOUSE Semaphorin-3E OS=Mus musculus OX=10090 GN=Sema3e PE=1 SV=3
12	Q13214	640	749	0.445	0.465	SEM3B_HUMAN Semaphorin-3B OS=Homo sapiens OX=9606 GN=SEMA3B PE=1 SV=1
13	Q13275	595	785	0.413	0.411	SEM3F_HUMAN Semaphorin-3F OS=Homo sapiens OX=9606 GN=SEMA3F PE=2 SV=2
14	Q14563	711	771	0.459	0.466	SEM3A_HUMAN Semaphorin-3A OS=Homo sapiens OX=9606 GN=SEMA3A PE=1 SV=1
15	Q1LYS1	734	768	0.473	0.482	Q1LYS1_DANRE Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E OS=Danio rerio OX=7955 GN=fj37c11 PE=3 SV=1
16	Q4LFA9	1344	780	0.863	0.865	SEM3G_MOUSE Semaphorin-3G OS=Mus musculus OX=10090 GN=Sema3g PE=2 SV=1
17	Q62181	621	751	0.414	0.431	SEM3C_MOUSE Semaphorin-3C OS=Mus musculus OX=10090 GN=Sema3c PE=1 SV=2
18	Q63548	717	772	0.463	0.469	SEM3A_RAT Semaphorin-3A OS=Rattus norvegicus OX=10116 GN=Sema3a PE=2 SV=1
19	Q8BH34	672	777	0.437	0.440	SEM3D_MOUSE Semaphorin-3D OS=Mus musculus OX=10090 GN=Sema3d PE=1 SV=1
20	Q90607	708	772	0.467	0.473	SEM3A_CHICK Semaphorin-3A OS=Gallus gallus OX=9031 GN=SEMA3A PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00047 ig	0.00044	31.7	Immunoglobulin domain
2	PF13927 Ig_3	28	16.7	Immunoglobulin domain
3	PF18452 Ig_6	89	14.4	Immunoglobulin domain
4	PF01437 PSI	7.8	18.4	Plexin repeat
5	PF01403 Sema	6e-55	197.4	Sema domain
6	PF07686 V-set	2.4e+02	13.3	Immunoglobulin V-set domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000231721

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000265371	0.963	Neuropilin-1
2	9606.ENSP00000352882	0.904	Plexin-A4
3	9606.ENSP00000353582	0.896	Neuropilin-2
4	9606.ENSP00000317128	0.892	Plexin-D1
5	9606.ENSP00000442736	0.892	Plexin-B3
6	9606.ENSP00000351338	0.890	Plexin-B1
7	9606.ENSP00000377061	0.887	Plexin-A1
8	9606.ENSP00000358696	0.886	Plexin-A3
9	9606.ENSP00000173229	0.686	Netrin-1
10	9606.ENSP00000478570	0.614	Vascular endothelial growth factor A
11	9606.ENSP00000275815	0.606	Ephrin type-A receptor 1
12	9606.ENSP00000332164	0.573	Slit homolog 3 protein
13	9606.ENSP00000280527	0.567	Cysteine-rich motor neuron 1 protein
14	9606.ENSP00000376753	0.562	PDZ domain-containing protein GIPC1
15	9606.ENSP00000337838	0.561	Reticulon-4
16	9606.ENSP00000481021	0.559	Putative protein SEM1, isoform 2
17	9606.ENSP00000247271	0.556	Oligodendrocyte-myelin glycoprotein
18	9606.ENSP00000346839	0.545	Fibronectin type III domain containing
19	9606.ENSP00000263923	0.544	Vascular endothelial growth factor receptor 2
20	9606.ENSP00000258526	0.540	Plexin-C1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005102	1.000	signaling receptor binding
GO:0038191	0.946	neuropilin binding
GO:0098772	0.656	molecular function regulator activity
GO:0140677	0.596	molecular function activator activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.991	cellular process
GO:0048856	0.982	anatomical structure development
GO:0050794	0.974	regulation of cellular process
GO:0009653	0.974	anatomical structure morphogenesis
GO:0050896	0.973	response to stimulus
GO:0016043	0.956	cellular component organization
GO:0032501	0.948	multicellular organismal process
GO:0007275	0.907	multicellular organism development
GO:0048519	0.901	negative regulation of biological process
GO:0048523	0.881	negative regulation of cellular process
GO:0030154	0.869	cell differentiation
GO:0048731	0.862	system development
GO:0048468	0.842	cell development
GO:0007399	0.821	nervous system development
GO:0022603	0.807	regulation of anatomical structure morphogenesis
GO:0048518	0.763	positive regulation of biological process
GO:0051128	0.756	regulation of cellular component organization
GO:0051239	0.746	regulation of multicellular organismal process
GO:0120035	0.745	regulation of plasma membrane bounded cell projection organization
GO:0051241	0.735	negative regulation of multicellular organismal process
GO:0030030	0.716	cell projection organization
GO:0048522	0.698	positive regulation of cellular process
GO:0008361	0.678	regulation of cell size
GO:0010977	0.674	negative regulation of neuron projection development
GO:0051716	0.673	cellular response to stimulus
GO:0061387	0.655	regulation of extent of cell growth
GO:0007154	0.648	cell communication
GO:0023052	0.642	signaling
GO:2000026	0.641	regulation of multicellular organismal development
GO:0030308	0.637	negative regulation of cell growth
GO:0045595	0.627	regulation of cell differentiation
GO:0050771	0.613	negative regulation of axonogenesis
GO:0030516	0.585	regulation of axon extension
GO:0048640	0.558	negative regulation of developmental growth
GO:0032989	0.528	cellular component morphogenesis
GO:0007165	0.515	signal transduction
GO:0042221	0.428	response to chemical
GO:0120039	0.417	plasma membrane bounded cell projection morphogenesis
GO:0030182	0.415	neuron differentiation
GO:0048666	0.407	neuron development
GO:0030517	0.404	negative regulation of axon extension
GO:0007166	0.326	cell surface receptor signaling pathway
GO:0031175	0.326	neuron projection development
GO:0048583	0.324	regulation of response to stimulus
GO:0006935	0.315	chemotaxis
GO:0048812	0.308	neuron projection morphogenesis

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005615	0.999	extracellular space
GO:0043227	0.993	membrane-bounded organelle
GO:0005886	0.957	plasma membrane
GO:0031982	0.854	vesicle
GO:0005622	0.749	intracellular anatomical structure
GO:0043229	0.710	intracellular organelle
GO:0043231	0.667	intracellular membrane-bounded organelle
GO:0005737	0.654	cytoplasm
GO:0070062	0.647	extracellular exosome
GO:0012505	0.622	endomembrane system
GO:0070013	0.377	intracellular organelle lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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