StarFunc result for job id Q9NUB1

User Input

>input (689 residues)
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPA
LSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVR
KSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVA
AMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVK
HCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM
PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLF
ESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI
NCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVL
MDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEG
GYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD
SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELG
DTTTLEDPSIIAEILSVYQKCKDKQAAAK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:D3ZZN3	0.748	0.755	0.000	682	0.859	0.868	D3ZZN3.pdb.gz	D3ZZN3_RAT Acetyl-coenzyme A synthetase OS=Rattus norvegicus OX=10116 GN=Acss1 PE=3 SV=1
2	AFDB:Q9NUB1	1.000	1.000	0.000	689	1.000	1.000	Q9NUB1.pdb.gz	ACS2L_HUMAN Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Homo sapiens OX=9606 GN=ACSS1 PE=1 SV=2
3	AFDB:Q5E268	0.886	0.940	9.107E-89	649	0.459	0.487	Q5E268.pdb.gz	Q5E268_ALIF1 Acetyl-coenzyme A synthetase OS=Aliivibrio fischeri (strain ATCC 700601 / ES114) OX=312309 GN=acs PE=3 SV=2
4	AFDB:P16928	0.722	0.743	4.145E-87	670	0.443	0.455	P16928.pdb.gz	ACSA_EMENI Acetyl-coenzyme A synthetase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=facA PE=2 SV=2
5	AFDB:P78773	0.726	0.755	4.906E-87	662	0.428	0.446	P78773.pdb.gz	ACSA_SCHPO Probable acetyl-coenzyme A synthetase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC191.02c PE=1 SV=2
6	AFDB:Q726Y7	0.881	0.918	9.624E-87	661	0.434	0.452	Q726Y7.pdb.gz	Q726Y7_DESVH Acetyl-coenzyme A synthetase OS=Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) OX=882 GN=acsA PE=1 SV=1
7	AFDB:P52910	0.730	0.736	6.493E-86	683	0.437	0.441	P52910.pdb.gz	ACS2_YEAST Acetyl-coenzyme A synthetase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ACS2 PE=1 SV=1
8	AFDB:G3V9U0	0.876	0.861	6.490E-85	701	0.446	0.438	G3V9U0.pdb.gz	G3V9U0_RAT propionate--CoA ligase OS=Rattus norvegicus OX=10116 GN=Acss2 PE=1 SV=2
9	AFDB:Q01574	0.720	0.696	1.076E-84	713	0.428	0.414	Q01574.pdb.gz	ACS1_YEAST Acetyl-coenzyme A synthetase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ACS1 PE=1 SV=2
10	AFDB:P27550	0.721	0.761	2.955E-84	652	0.440	0.465	P27550.pdb.gz	ACSA_ECOLI Acetyl-coenzyme A synthetase OS=Escherichia coli (strain K12) OX=83333 GN=acs PE=1 SV=2
11	PDB:2p20A	0.720	0.772	1.433E-82	641	0.443	0.476	2p20A.pdb.gz	Biochemical and Crystallographic Analysis of Substrate Binding and Conformational Changes in Acetyl-CoA Synthetase.
12	PDB:1ry2A	0.851	0.952	2.505E-76	615	0.417	0.467	1ry2A.pdb.gz	Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP
13	PDB:3b7wA	0.593	0.751	1.407E-43	537	0.212	0.272	3b7wA.pdb.gz	Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
14	PDB:1ultA	0.588	0.745	4.076E-37	533	0.187	0.242	1ultA.pdb.gz
15	PDB:5ie2A	0.635	0.850	2.458E-36	506	0.165	0.225	5ie2A.pdb.gz	Crystal Structures of Arabidopsis thaliana Oxalyl-CoA Synthetase Essential for Oxalate Degradation
16	PDB:6q2mA	0.677	0.846	2.750E-36	544	0.171	0.217	6q2mA.pdb.gz	Mutagenesis and Structural Studies Reveal the Basis for the Activity and Stability Properties That Distinguish thePhotinusLuciferasesscintillansandpyralis.
17	PDB:3r44A	0.580	0.774	3.443E-36	502	0.179	0.245	3r44A.pdb.gz	The Mycobacterium tuberculosis Very-Long-Chain Fatty Acyl-CoA Synthetase: Structural Basis for Housing Lipid Substrates Longer than the Enzyme.
18	PDB:7kydA	0.655	0.833	1.963E-35	534	0.165	0.213	7kydA.pdb.gz	FruitFire: a luciferase based on a fruit fly metabolic enzyme.
19	PDB:3rg2C	0.545	0.608	4.073E-35	613	0.155	0.175	3rg2C.pdb.gz	Structural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein Domains.
20	PDB:5bsmA	0.670	0.860	3.848E-34	530	0.168	0.219	5bsmA.pdb.gz	Structural Basis for Specificity and Flexibility in a Plant 4-Coumarate:CoA Ligase.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A8I6AD12	560	702	0.435	0.427	A0A8I6AD12_RAT propionate--CoA ligase OS=Rattus norvegicus OX=10116 GN=Acss2 PE=1 SV=1
2	A0A8I6GJ11	594	758	0.470	0.427	A0A8I6GJ11_RAT propionate--CoA ligase OS=Rattus norvegicus OX=10116 GN=Acss2 PE=1 SV=1
3	B1WC11	598	701	0.466	0.458	B1WC11_RAT propionate--CoA ligase OS=Rattus norvegicus OX=10116 GN=Acss2 PE=2 SV=1
4	B9DGD6	594	743	0.435	0.404	ACS_ARATH Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal OS=Arabidopsis thaliana OX=3702 GN=ACS PE=1 SV=1
5	D3ZZN3	1229	682	0.859	0.868	D3ZZN3_RAT Acetyl-coenzyme A synthetase OS=Rattus norvegicus OX=10116 GN=Acss1 PE=3 SV=1
6	G3V9U0	598	745	0.466	0.431	G3V9U0_RAT propionate--CoA ligase OS=Rattus norvegicus OX=10116 GN=Acss2 PE=1 SV=2
7	P16928	603	670	0.443	0.455	ACSA_EMENI Acetyl-coenzyme A synthetase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=facA PE=2 SV=2
8	P27550	627	652	0.448	0.474	ACSA_ECOLI Acetyl-coenzyme A synthetase OS=Escherichia coli (strain K12) OX=83333 GN=acs PE=1 SV=2
9	P52910	594	683	0.440	0.444	ACS2_YEAST Acetyl-coenzyme A synthetase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ACS2 PE=1 SV=1
10	P78773	584	662	0.443	0.461	ACSA_SCHPO Probable acetyl-coenzyme A synthetase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC191.02c PE=1 SV=2
11	Q01574	586	713	0.434	0.419	ACS1_YEAST Acetyl-coenzyme A synthetase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ACS1 PE=1 SV=2
12	Q57XD7	533	673	0.414	0.423	Q57XD7_TRYB2 Acetyl-coenzyme A synthetase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.26A17.430 PE=3 SV=1
13	Q5E268	649	649	0.466	0.495	Q5E268_ALIF1 Acetyl-coenzyme A synthetase OS=Aliivibrio fischeri (strain ATCC 700601 / ES114) OX=312309 GN=acs PE=3 SV=2
14	Q6FLU2	565	704	0.425	0.416	ACS1_CANGA Acetyl-coenzyme A synthetase 1 OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=ACS1 PE=3 SV=1
15	Q726Y7	599	661	0.441	0.460	Q726Y7_DESVH Acetyl-coenzyme A synthetase OS=Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) OX=882 GN=acsA PE=1 SV=1
16	Q8ZKF6	627	652	0.451	0.477	ACSA_SALTY Acetyl-coenzyme A synthetase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) OX=99287 GN=acs PE=1 SV=1
17	Q99NB1	1246	682	0.869	0.878	ACS2L_MOUSE Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Mus musculus OX=10090 GN=Acss1 PE=1 SV=1
18	Q9NR19	601	701	0.460	0.452	ACSA_HUMAN Acetyl-coenzyme A synthetase, cytoplasmic OS=Homo sapiens OX=9606 GN=ACSS2 PE=1 SV=1
19	Q9NUB1	1421	689	1.000	1.000	ACS2L_HUMAN Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Homo sapiens OX=9606 GN=ACSS1 PE=1 SV=2
20	Q9QXG4	599	701	0.466	0.458	ACSA_MOUSE Acetyl-coenzyme A synthetase, cytoplasmic OS=Mus musculus OX=10090 GN=Acss2 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16177 ACAS_N	1.7e-10	51.9	Acetyl-coenzyme A synthetase N-terminus
2	PF00501 AMP-binding	8.1e-87	303.2	AMP-binding enzyme
3	PF13193 AMP-binding_C	1.6e-18	78.8	AMP-binding enzyme C-terminal domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000316924

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000372191	0.994	NAD-dependent protein deacetylase sirtuin-3, mitochondrial
2	9606.ENSP00000483300	0.965	Acetyl-CoA carboxylase 1
3	9606.ENSP00000342056	0.959	Citrate synthase, mitochondrial
4	9606.ENSP00000341044	0.950	Acetyl-CoA carboxylase 2
5	9606.ENSP00000261733	0.946	Aldehyde dehydrogenase, mitochondrial
6	9606.ENSP00000280346	0.945	Dihydrolipoamide S-acetyltransferase
7	9606.ENSP00000345774	0.945	Fatty aldehyde dehydrogenase
8	9606.ENSP00000265838	0.941	Acetyl-CoA acetyltransferase, mitochondrial
9	9606.ENSP00000293217	0.935	Peroxisomal acyl-coenzyme A oxidase 1
10	9606.ENSP00000303246	0.935	Acyl-coenzyme A thioesterase 12
11	9606.ENSP00000348775	0.932	Peroxisomal acyl-coenzyme A oxidase 3
12	9606.ENSP00000356015	0.932	Acetyl-CoA acetyltransferase, cytosolic
13	9606.ENSP00000255084	0.931	Aldehyde dehydrogenase family 3 member B2
14	9606.ENSP00000473990	0.930	Aldehyde dehydrogenase family 3 member B1
15	9606.ENSP00000411821	0.927	Aldehyde dehydrogenase, dimeric NADP-preferring
16	9606.ENSP00000242592	0.923	Short-chain specific acyl-CoA dehydrogenase, mitochondrial
17	9606.ENSP00000450436	0.923	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
18	9606.ENSP00000365462	0.922	This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites . Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA (PubMed:8434582, PubMed:6765947, PubMed:10101253). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, [...]
19	9606.ENSP00000449535	0.921	Acyl-CoA synthetase short-chain family member 3, mitochondrial
20	9606.ENSP00000419027	0.917	This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites . Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA . Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxy [...]

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0003987	1.000	acetate-CoA ligase activity
GO:0005488	0.982	binding
GO:0005515	0.942	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.996	organic substance metabolic process
GO:0044238	0.996	primary metabolic process
GO:0044237	0.996	cellular metabolic process
GO:0009058	0.992	biosynthetic process
GO:0006637	0.985	acyl-CoA metabolic process
GO:0071616	0.980	acyl-CoA biosynthetic process
GO:0006084	0.944	acetyl-CoA metabolic process
GO:0006085	0.919	acetyl-CoA biosynthetic process
GO:0006082	0.424	organic acid metabolic process
GO:0019752	0.413	carboxylic acid metabolic process
GO:0006629	0.362	lipid metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005759	0.999	mitochondrial matrix

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:23176	1.000	acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate
EC:6.2.1.1	1.000	acetate--CoA ligase.

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