StarFunc result for job id Q9NUN7

User Input

>input (267 residues)
MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLE
KRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYH
LLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLG
IFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRT
LYLRYRPKVKFLFGIWPVILFEPLRKH

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9NUN7	1.000	1.000	4.074E-39	267	1.000	1.000	Q9NUN7.pdb.gz	ACER3_HUMAN Alkaline ceramidase 3 OS=Homo sapiens OX=9606 GN=ACER3 PE=1 SV=3
2	AFDB:Q9D099	0.999	0.999	4.795E-36	267	0.884	0.884	Q9D099.pdb.gz	ACER3_MOUSE Alkaline ceramidase 3 OS=Mus musculus OX=10090 GN=Acer3 PE=1 SV=1
3	PDB:6g7oA	0.875	0.670	1.388E-30	350	0.910	0.694	6g7oA.pdb.gz	Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy.
4	AFDB:Q02896	0.893	0.758	4.274E-16	317	0.345	0.290	Q02896.pdb.gz	YDC1_YEAST Alkaline ceramidase YDC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YDC1 PE=1 SV=1
5	AFDB:P38298	0.882	0.751	6.826E-16	316	0.322	0.272	P38298.pdb.gz	YPC1_YEAST Alkaline ceramidase YPC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YPC1 PE=1 SV=1
6	AFDB:Q94IB9	0.850	0.888	1.040E-15	255	0.266	0.278	Q94IB9.pdb.gz	ACER_ARATH Alkaline ceramidase OS=Arabidopsis thaliana OX=3702 GN=ACER PE=2 SV=1
7	AFDB:Q5QJU3	0.755	0.735	5.921E-10	275	0.243	0.236	Q5QJU3.pdb.gz	ACER2_HUMAN Alkaline ceramidase 2 OS=Homo sapiens OX=9606 GN=ACER2 PE=1 SV=2
8	AFDB:Q9VIP7	0.728	0.691	5.921E-10	283	0.232	0.219	Q9VIP7.pdb.gz	ACASE_DROME Alkaline ceramidase OS=Drosophila melanogaster OX=7227 GN=bwa PE=2 SV=2
9	AFDB:Q8TDN7	0.759	0.767	6.814E-10	264	0.184	0.186	Q8TDN7.pdb.gz	ACER1_HUMAN Alkaline ceramidase 1 OS=Homo sapiens OX=9606 GN=ACER1 PE=1 SV=1
10	AFDB:Q8R4X1	0.782	0.766	1.186E-8	273	0.184	0.179	Q8R4X1.pdb.gz	ACER1_MOUSE Alkaline ceramidase 1 OS=Mus musculus OX=10090 GN=Acer1 PE=1 SV=1
11	AFDB:P25625	0.606	0.462	9.974E-5	357	0.127	0.095	P25625.pdb.gz	PER1_YEAST Protein PER1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PER1 PE=1 SV=1
12	PDB:4k5yC	0.437	0.457	3.949E-3	248	0.090	0.097	4k5yC.pdb.gz	Structure of class B GPCR corticotropin-releasing factor receptor 1.
13	PDB:7epaA	0.477	0.194	1.852E-2	782	0.105	0.036	7epaA.pdb.gz
14	PDB:6nwdA	0.410	0.436	1.941E-2	246	0.075	0.081	6nwdA.pdb.gz	X-ray Crystallographic Structure and Oligomerization of Gloeobacter Rhodopsin.
15	PDB:7td3R	0.369	0.346	2.958E-2	292	0.120	0.110	7td3R.pdb.gz	Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
16	PDB:6vn7R	0.395	0.400	3.248E-2	263	0.064	0.065	6vn7R.pdb.gz	Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy.
17	PDB:7t6bR	0.429	0.432	3.248E-2	264	0.097	0.098	7t6bR.pdb.gz	Structure of S1PR2-heterotrimeric G 13 signaling complex.
18	PDB:7yu4A	0.469	0.469	4.105E-2	266	0.071	0.071	7yu4A.pdb.gz	Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.
19	PDB:7td1R	0.444	0.411	4.725E-2	293	0.094	0.085	7td1R.pdb.gz	Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
20	PDB:7vv6R	0.449	0.444	5.437E-2	271	0.094	0.092	7vv6R.pdb.gz	Structure, function and pharmacology of human itch receptor complexes.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q9D099	0.0	504	267	0.884	0.884	ACER3_MOUSE Alkaline ceramidase 3 OS=Mus musculus OX=10090 GN=Acer3 PE=1 SV=1
2	Q9NUN7	0.0	548	267	1.000	1.000	ACER3_HUMAN Alkaline ceramidase 3 OS=Homo sapiens OX=9606 GN=ACER3 PE=1 SV=3
3	Q02896	5.39e-43	150	317	0.341	0.287	YDC1_YEAST Alkaline ceramidase YDC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YDC1 PE=1 SV=1
4	P38298	7.33e-41	145	316	0.348	0.294	YPC1_YEAST Alkaline ceramidase YPC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YPC1 PE=1 SV=1
5	Q94IB9	4.73e-29	112	255	0.281	0.294	ACER_ARATH Alkaline ceramidase OS=Arabidopsis thaliana OX=3702 GN=ACER PE=2 SV=1
6	Q9VIP7	7.61e-12	66.2	283	0.277	0.261	ACASE_DROME Alkaline ceramidase OS=Drosophila melanogaster OX=7227 GN=bwa PE=2 SV=2
7	Q8VD53	8.04e-12	65.9	275	0.240	0.233	ACER2_MOUSE Alkaline ceramidase 2 OS=Mus musculus OX=10090 GN=Acer2 PE=1 SV=1
8	Q5QJU3	1.10e-11	65.5	275	0.240	0.233	ACER2_HUMAN Alkaline ceramidase 2 OS=Homo sapiens OX=9606 GN=ACER2 PE=1 SV=2
9	Q8TDN7	1.55e-07	53.5	264	0.112	0.114	ACER1_HUMAN Alkaline ceramidase 1 OS=Homo sapiens OX=9606 GN=ACER1 PE=1 SV=1
10	Q8R4X1	2.53e-07	52.8	273	0.169	0.165	ACER1_MOUSE Alkaline ceramidase 1 OS=Mus musculus OX=10090 GN=Acer1 PE=1 SV=1
11	P70227	0.78	33.9	2670	0.090	0.009	ITPR3_MOUSE Inositol 1,4,5-trisphosphate receptor type 3 OS=Mus musculus OX=10090 GN=Itpr3 PE=1 SV=3
12	Q8WN95	0.78	33.9	2664	0.090	0.009	ITPR3_BOVIN Inositol 1,4,5-trisphosphate receptor type 3 OS=Bos taurus OX=9913 GN=ITPR3 PE=2 SV=1
13	P0C6X9	2.2	32.3	7176	0.094	0.003	R1AB_CVMA5 Replicase polyprotein 1ab OS=Murine coronavirus (strain A59) OX=11142 GN=rep PE=1 SV=1
14	P0C6V0	2.3	32.3	4468	0.094	0.006	R1A_CVMA5 Replicase polyprotein 1a OS=Murine coronavirus (strain A59) OX=11142 GN=1a PE=1 SV=1
15	P0C6V1	3.1	32.0	4474	0.071	0.004	R1A_CVMJH Replicase polyprotein 1a OS=Murine coronavirus (strain JHM) OX=11144 GN=1a PE=1 SV=1
16	Q63269	3.8	31.6	2670	0.086	0.009	ITPR3_RAT Inositol 1,4,5-trisphosphate receptor type 3 OS=Rattus norvegicus OX=10116 GN=Itpr3 PE=1 SV=1
17	F1R5E2	5.4	30.8	702	0.067	0.026	F1R5E2_DANRE Tectonic family member 2 OS=Danio rerio OX=7955 GN=tctn2 PE=3 SV=2
18	Q13936	6.1	30.8	2221	0.075	0.009	CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C OS=Homo sapiens OX=9606 GN=CACNA1C PE=1 SV=4
19	Q14573	6.4	30.8	2671	0.082	0.008	ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3 OS=Homo sapiens OX=9606 GN=ITPR3 PE=1 SV=2
20	P45543	9.1	30.0	261	0.067	0.069	FRLD_ECOLI Fructoselysine 6-kinase OS=Escherichia coli (strain K12) OX=83333 GN=frlD PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF05875 Ceramidase	6.2e-73	257.0	Ceramidase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000434480

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000378897	0.980	Neutral ceramidase
2	9606.ENSP00000307126	0.979	Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2
3	9606.ENSP00000315137	0.970	Sphingosine-1-phosphate phosphatase 2
4	9606.ENSP00000313681	0.965	Sphingosine kinase 1
5	9606.ENSP00000245222	0.962	Sphingosine kinase 2
6	9606.ENSP00000316476	0.959	Sphingolipid delta(4)-desaturase DES1
7	9606.ENSP00000247225	0.957	Sphingosine-1-phosphate phosphatase 1
8	9606.ENSP00000371152	0.955	Acid ceramidase
9	9606.ENSP00000385083	0.953	3-ketodihydrosphingosine reductase
10	9606.ENSP00000376453	0.943	Ceramide synthase 6
11	9606.ENSP00000271688	0.937	Ceramide synthase 2
12	9606.ENSP00000219368	0.936	Fatty acid 2-hydroxylase
13	9606.ENSP00000251363	0.931	Ceramide synthase 4
14	9606.ENSP00000325485	0.931	Ceramide synthase 5
15	9606.ENSP00000284382	0.924	Ceramide synthase 3
16	9606.ENSP00000360296	0.906	Phospholipid phosphatase 3
17	9606.ENSP00000329697	0.904	Phospholipid phosphatase 2
18	9606.ENSP00000228318	0.857	Phosphate carrier protein, mitochondrial
19	9606.ENSP00000349142	0.813	ATP synthase subunit gamma, mitochondrial
20	9606.ENSP00000354829	0.787	Phosphatidylcholine:ceramide cholinephosphotransferase 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0070774	1.000	phytoceramidase activity
GO:0005488	0.999	binding
GO:0043167	0.780	ion binding
GO:0005509	0.754	calcium ion binding
GO:0008270	0.720	zinc ion binding
GO:0071633	0.633	dihydroceramidase activity
GO:0005515	0.422	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.996	organic substance metabolic process
GO:0044237	0.996	cellular metabolic process
GO:0044238	0.995	primary metabolic process
GO:1901566	0.990	organonitrogen compound biosynthetic process
GO:0044271	0.987	cellular nitrogen compound biosynthetic process
GO:0006672	0.985	ceramide metabolic process
GO:0008610	0.981	lipid biosynthetic process
GO:0030149	0.980	sphingolipid catabolic process
GO:0034312	0.978	diol biosynthetic process
GO:0030148	0.974	sphingolipid biosynthetic process
GO:0046519	0.951	sphingoid metabolic process
GO:0065007	0.583	biological regulation
GO:0050789	0.574	regulation of biological process
GO:0050794	0.555	regulation of cellular process
GO:0032502	0.525	developmental process
GO:0048856	0.518	anatomical structure development
GO:0048518	0.420	positive regulation of biological process
GO:0006670	0.376	sphingosine metabolic process
GO:0046512	0.367	sphingosine biosynthetic process
GO:0048522	0.341	positive regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0098588	0.998	bounding membrane of organelle
GO:0005794	0.998	Golgi apparatus
GO:0005789	0.995	endoplasmic reticulum membrane
GO:0000139	0.958	Golgi membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.2.1.-	1.000	Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds.
RHEA:20856	1.000	an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine
EC:3.5.1.23	1.000	ceramidase.

[back to server]