StarFunc result for job id Q9NV35

User Input

>input (164 residues)
MTASAQPRGRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEECA
QRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSEPKNVEPEKNESW
EWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVGYKGNHL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9NV35	1.000	1.000	3.164E-36	164	1.000	1.000	Q9NV35.pdb.gz	NUD15_HUMAN Nucleotide triphosphate diphosphatase NUDT15 OS=Homo sapiens OX=9606 GN=NUDT15 PE=1 SV=1
2	PDB:7b66A	0.946	0.963	3.474E-32	161	0.976	0.994	7b66A.pdb.gz	Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
3	AFDB:Q8BG93	0.955	0.921	8.102E-32	170	0.890	0.859	Q8BG93.pdb.gz	NUD15_MOUSE Nucleotide triphosphate diphosphatase NUDT15 OS=Mus musculus OX=10090 GN=Nudt15 PE=1 SV=1
4	PDB:5gp0I	0.762	0.891	1.440E-16	139	0.366	0.432	5gp0I.pdb.gz	Structural Insights into the Substrate Recognition Mechanism of Arabidopsis GPP-Bound NUDX1 for Noncanonical Monoterpene Biosynthesis.
5	AFDB:Q9CA40	0.787	0.874	4.300E-16	147	0.366	0.408	Q9CA40.pdb.gz	NUDT1_ARATH Nudix hydrolase 1 OS=Arabidopsis thaliana OX=3702 GN=NUDT1 PE=1 SV=1
6	AFDB:Q5BE28	0.778	0.783	7.886E-15	163	0.384	0.387	Q5BE28.pdb.gz	Q5BE28_EMENI NUDIX domain, putative (AFU_orthologue AFUA_5G13840) OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_01202 PE=3 SV=1
7	PDB:5otnA	0.603	0.631	2.302E-9	156	0.195	0.205	5otnA.pdb.gz	MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
8	AFDB:Q7ZWC3	0.583	0.610	4.459E-9	156	0.183	0.192	Q7ZWC3.pdb.gz	8ODP_DANRE Oxidized purine nucleoside triphosphate hydrolase OS=Danio rerio OX=7955 GN=nudt1 PE=1 SV=1
9	AFDB:Q9SJC4	0.589	0.367	4.459E-9	283	0.226	0.131	Q9SJC4.pdb.gz	NUDT6_ARATH Nudix hydrolase 6 OS=Arabidopsis thaliana OX=3702 GN=NUDT6 PE=1 SV=1
10	AFDB:P0AEI6	0.645	0.687	7.783E-9	153	0.220	0.235	P0AEI6.pdb.gz	NUDJ_ECOLI Phosphatase NudJ OS=Escherichia coli (strain K12) OX=83333 GN=nudJ PE=1 SV=1
11	PDB:2gb5A	0.609	0.398	8.446E-9	265	0.146	0.091	2gb5A.pdb.gz	Crystal structure of NADH pyrophosphatase (EC 3.6.1.22) (1790429) from Escherichia coli K12 at 2.30 A resolution
12	AFDB:P53368	0.567	0.593	8.809E-9	156	0.207	0.218	P53368.pdb.gz	8ODP_MOUSE Oxidized purine nucleoside triphosphate hydrolase OS=Mus musculus OX=10090 GN=Nudt1 PE=1 SV=1
13	AFDB:A0A024R858	0.606	0.561	9.371E-9	179	0.195	0.179	A0A024R858.pdb.gz
14	PDB:5mzgA	0.585	0.613	1.568E-8	155	0.207	0.219	5mzgA.pdb.gz	Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
15	AFDB:P32056	0.641	0.658	1.970E-8	159	0.207	0.214	P32056.pdb.gz	GMM_ECOLI GDP-mannose mannosyl hydrolase OS=Escherichia coli (strain K12) OX=83333 GN=gmm PE=1 SV=2
16	PDB:6aa3A	0.609	0.616	2.274E-8	162	0.183	0.185	6aa3A.pdb.gz	Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening.
17	PDB:2kdvA	0.589	0.589	5.084E-8	164	0.183	0.183	2kdvA.pdb.gz
18	PDB:1vc8A	0.549	0.689	5.753E-8	126	0.226	0.294	1vc8A.pdb.gz	Crystal Structure of Nudix Protein Ndx1 from Thermus thermophilus HB8 in binary complex with diadenosine hexaphosphate
19	PDB:4hfqA	0.597	0.493	8.873E-8	203	0.165	0.133	4hfqA.pdb.gz
20	PDB:2gt4A	0.512	0.524	3.255E-7	160	0.165	0.169	2gt4A.pdb.gz	X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q9NV35	5.06e-121	339	164	1.000	1.000	NUD15_HUMAN Nucleotide triphosphate diphosphatase NUDT15 OS=Homo sapiens OX=9606 GN=NUDT15 PE=1 SV=1
2	Q8BG93	1.08e-96	278	170	0.793	0.765	NUD15_MOUSE Nucleotide triphosphate diphosphatase NUDT15 OS=Mus musculus OX=10090 GN=Nudt15 PE=1 SV=1
3	Q9CA40	8.09e-31	110	147	0.354	0.395	NUDT1_ARATH Nudix hydrolase 1 OS=Arabidopsis thaliana OX=3702 GN=NUDT1 PE=1 SV=1
4	Q5BE28	8.45e-25	95.9	163	0.335	0.337	Q5BE28_EMENI NUDIX domain, putative (AFU_orthologue AFUA_5G13840) OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_01202 PE=3 SV=1
5	P53368	6.12e-05	43.1	156	0.238	0.250	8ODP_MOUSE Oxidized purine nucleoside triphosphate hydrolase OS=Mus musculus OX=10090 GN=Nudt1 PE=1 SV=1
6	Q7ZWC3	1.16e-04	42.4	156	0.134	0.141	8ODP_DANRE Oxidized purine nucleoside triphosphate hydrolase OS=Danio rerio OX=7955 GN=nudt1 PE=1 SV=1
7	P36639	1.18e-04	42.4	156	0.238	0.250	8ODP_HUMAN Oxidized purine nucleoside triphosphate hydrolase OS=Homo sapiens OX=9606 GN=NUDT1 PE=1 SV=4
8	P53369	2.35e-04	41.6	156	0.134	0.141	8ODP_RAT Oxidized purine nucleoside triphosphate hydrolase OS=Rattus norvegicus OX=10116 GN=Nudt1 PE=1 SV=1
9	P93740	4.76e-04	41.6	280	0.195	0.114	NUD23_ARATH Nudix hydrolase 23, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=NUDT23 PE=1 SV=2
10	Q9RV46	0.001	40.4	194	0.195	0.165	Y1184_DEIRA Nudix hydrolase DR_1184 OS=Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) OX=243230 GN=DR_1184 PE=1 SV=1
11	C8VDH4	0.002	39.3	207	0.232	0.184	C8VDH4_EMENI MutT/nudix family protein (AFU_orthologue AFUA_5G08240) OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_07711 PE=4 SV=1
12	P0AEI6	0.002	38.9	153	0.195	0.209	NUDJ_ECOLI Phosphatase NudJ OS=Escherichia coli (strain K12) OX=83333 GN=nudJ PE=1 SV=1
13	P53164	0.009	37.7	384	0.213	0.091	NPY1_YEAST NAD-capped RNA hydrolase NPY1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=NPY1 PE=1 SV=1
14	P0A776	0.018	36.6	176	0.140	0.131	RPPH_ECOLI RNA pyrophosphohydrolase OS=Escherichia coli (strain K12) OX=83333 GN=rppH PE=1 SV=1
15	Q9SJC4	0.024	36.6	283	0.213	0.124	NUDT6_ARATH Nudix hydrolase 6 OS=Arabidopsis thaliana OX=3702 GN=NUDT6 PE=1 SV=1
16	Q94B74	0.040	35.8	278	0.195	0.115	NUDT2_ARATH Nudix hydrolase 2 OS=Arabidopsis thaliana OX=3702 GN=NUDT2 PE=1 SV=1
17	Q9UKK9	0.040	35.8	219	0.171	0.128	NUDT5_HUMAN ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1
18	Q75UV1	0.041	35.0	126	0.195	0.254	NDX1_THETH Diadenosine hexaphosphate hydrolase OS=Thermus thermophilus OX=274 GN=ndx1 PE=1 SV=1
19	Q6ZVK8	0.044	35.8	323	0.140	0.071	NUD18_HUMAN 8-oxo-dGDP phosphatase NUDT18 OS=Homo sapiens OX=9606 GN=NUDT18 PE=1 SV=3
20	P41354	0.074	34.7	154	0.189	0.201	MUTX_STRPN 8-oxo-dGTP diphosphatase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=mutX PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF10104 Brr6_like_C_C	66	14.7	Di-sulfide bridge nucleocytoplasmic transport domain
2	PF00293 NUDIX	7e-16	69.9	NUDIX domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000258662

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000312304	0.870	Thiopurine S-methyltransferase
2	9606.ENSP00000419628	0.861	ADP-sugar pyrophosphatase
3	9606.ENSP00000369456	0.808	Inosine triphosphate pyrophosphatase
4	9606.ENSP00000480722	0.797	8-oxo-dGDP phosphatase NUDT18
5	9606.ENSP00000230792	0.794	Peroxisomal NADH pyrophosphatase NUDT12
6	9606.ENSP00000380241	0.776	7,8-dihydro-8-oxoguanine triphosphatase
7	9606.ENSP00000334437	0.683	Nucleoside diphosphate-linked moiety X motif 17
8	9606.ENSP00000380251	0.657	Nucleoside diphosphate-linked moiety X motif 19
9	9606.ENSP00000368455	0.654	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
10	9606.ENSP00000349874	0.648	Nucleoside diphosphate-linked moiety X motif 13
11	9606.ENSP00000476119	0.622	Diphosphoinositol polyphosphate phosphohydrolase 1
12	9606.ENSP00000279206	0.610	Nucleoside diphosphate-linked moiety X motif 22
13	9606.ENSP00000387278	0.605	MAGUK p55 subfamily member 4
14	9606.ENSP00000422375	0.603	U8 snoRNA-decapping enzyme
15	9606.ENSP00000361170	0.602	Adenine DNA glycosylase
16	9606.ENSP00000268533	0.575	Peroxisomal coenzyme A diphosphatase NUDT7
17	9606.ENSP00000365883	0.574	Nucleoside diphosphate-linked moiety X motif 8
18	9606.ENSP00000370194	0.552	GDP-mannose 4,6 dehydratase
19	9606.ENSP00000261326	0.547	Molybdenum cofactor sulfurase
20	9606.ENSP00000376349	0.542	Uridine diphosphate glucose pyrophosphatase

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0047429	1.000	nucleoside triphosphate diphosphatase activity
GO:0017110	0.997	nucleoside diphosphate phosphatase activity
GO:0005515	0.995	protein binding
GO:0008413	0.819	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0043169	0.447	cation binding
GO:0046872	0.431	metal ion binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0006139	0.987	nucleobase-containing compound metabolic process
GO:0009144	0.984	purine nucleoside triphosphate metabolic process
GO:1901292	0.982	nucleoside phosphate catabolic process
GO:0050896	0.944	response to stimulus
GO:0006950	0.894	response to stress
GO:1901564	0.863	organonitrogen compound metabolic process
GO:0009117	0.749	nucleotide metabolic process
GO:1901135	0.633	carbohydrate derivative metabolic process
GO:0072521	0.623	purine-containing compound metabolic process
GO:0050789	0.526	regulation of biological process
GO:0043170	0.491	macromolecule metabolic process
GO:0051716	0.476	cellular response to stimulus
GO:0006163	0.453	purine nucleotide metabolic process
GO:0060255	0.401	regulation of macromolecule metabolic process
GO:0009166	0.358	nucleotide catabolic process
GO:0090304	0.353	nucleic acid metabolic process
GO:0044260	0.340	cellular macromolecule metabolic process
GO:0042221	0.327	response to chemical
GO:0019692	0.322	deoxyribose phosphate metabolic process
GO:0009394	0.309	2'-deoxyribonucleotide metabolic process
GO:1901565	0.304	organonitrogen compound catabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.997	cytosol
GO:0070013	0.460	intracellular organelle lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.6.1.9	1.000	nucleotide diphosphatase.
RHEA:36799	0.997	a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate
EC:3.6.1.6	0.997	nucleoside diphosphate phosphatase.
RHEA:60032	0.819	8-oxo-GTP + H2O = 8-oxo-GDP + H(+) + phosphate
EC:3.6.1.69	0.819	8-oxo-(d)GTP phosphatase.

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