StarFunc result for job id Q9NVM4

User Input

>input (692 residues)
MKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVK
DRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVIN
KHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATV
YAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTV
LSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFW
AHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVR
QMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTVLKPDSVCLCVSDGSLLSVLAHH
LGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKVSLLLGEPF
FTTSLLPWHNLYFWYVRTAVDQHLGPGAMVMPQAASLHAVVVEFRDLWRIRSPCGDCEGF
DVHIMDDMIKRALDFRESREAEPHPLWEYPCRSLSEPWQILTFDFQQPVPLQPLCAEGTV
ELRRPGQSHAAVLWMEYHLTPECTLSTGLLEPADPEGGCCWNPHCKQAVYFFSPAPDPRA
LLGGPRTVSYAVEFHPDTGDIIMEFRHADTPD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:4c4aA	0.920	0.993	0.000	641	0.805	0.869	4c4aA.pdb.gz	Structural Insight Into Arginine Methylation by the Mouse Protein Arginine Methyltransferase 7: A Zinc Finger Freezes the Mimic of the Dimeric State Into a Single Active Site.
2	AFDB:A0A024R726	0.997	0.997	0.000	692	1.000	1.000	A0A024R726.pdb.gz
3	AFDB:A2AV36	0.965	0.978	0.000	683	0.623	0.631	A2AV36.pdb.gz	ANM7_DANRE Protein arginine N-methyltransferase 7 OS=Danio rerio OX=7955 GN=prmt7 PE=2 SV=1
4	AFDB:Q922X9	0.992	0.992	0.000	692	0.851	0.851	Q922X9.pdb.gz	ANM7_MOUSE Protein arginine N-methyltransferase 7 OS=Mus musculus OX=10090 GN=Prmt7 PE=1 SV=1
5	AFDB:Q9W1V1	0.924	0.927	1.534E-85	690	0.364	0.365	Q9W1V1.pdb.gz	ANM7_DROME Protein arginine N-methyltransferase 7 OS=Drosophila melanogaster OX=7227 GN=Art7 PE=2 SV=4
6	AFDB:Q6P2P2	0.703	0.586	4.666E-40	845	0.199	0.163	Q6P2P2.pdb.gz	ANM9_HUMAN Protein arginine N-methyltransferase 9 OS=Homo sapiens OX=9606 GN=PRMT9 PE=1 SV=1
7	AFDB:Q582G4	0.377	0.642	5.466E-23	390	0.111	0.197	Q582G4.pdb.gz	ANM7_TRYB2 Protein arginine N-methyltransferase 7 OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=PRMT7 PE=1 SV=1
8	AFDB:Q4QIZ0	0.379	0.578	1.937E-21	438	0.129	0.203	Q4QIZ0.pdb.gz	Q4QIZ0_LEIMA Putative arginine N-methyltransferase, type III OS=Leishmania major OX=5664 GN=PRMT7 PE=4 SV=1
9	AFDB:Q6NWG4	0.352	0.657	7.275E-21	349	0.108	0.215	Q6NWG4.pdb.gz	ANM6_DANRE Protein arginine N-methyltransferase 6 OS=Danio rerio OX=7955 GN=prmt6 PE=2 SV=2
10	AFDB:Q9SU94	0.348	0.583	3.644E-20	390	0.103	0.182	Q9SU94.pdb.gz	ANM11_ARATH Protein arginine N-methyltransferase 1.1 OS=Arabidopsis thaliana OX=3702 GN=PRMT11 PE=1 SV=1
11	AFDB:Q7Q2B7	0.365	0.404	8.156E-20	622	0.105	0.117	Q7Q2B7.pdb.gz	CARM1_ANOGA Histone-arginine methyltransferase CARMER OS=Anopheles gambiae OX=7165 GN=CARM1 PE=1 SV=5
12	PDB:6nt2A	0.335	0.653	2.800E-19	330	0.095	0.200	6nt2A.pdb.gz	Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
13	PDB:6dnzA	0.319	0.652	2.223E-18	317	0.087	0.189	6dnzA.pdb.gz	Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme).
14	PDB:4y2hB	0.349	0.642	3.730E-18	352	0.097	0.190	4y2hB.pdb.gz	Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.
15	PDB:1g6q1	0.339	0.660	1.401E-17	328	0.100	0.210	1g6q1.pdb.gz
16	PDB:6ughA	0.345	0.398	1.322E-16	594	0.075	0.088	6ughA.pdb.gz
17	PDB:4g56A	0.329	0.367	1.483E-16	617	0.079	0.089	4g56A.pdb.gz	Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity
18	PDB:7bo7AAA	0.346	0.381	1.571E-16	625	0.075	0.083	7bo7AAA.pdb.gz	CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437
19	PDB:3r0qG	0.335	0.627	6.251E-16	353	0.098	0.193	3r0qG.pdb.gz	Crystal structure of the plant epigenetic protein arginine methyltransferase 10.
20	PDB:3ua4A	0.341	0.367	1.177E-15	640	0.072	0.078	3ua4A.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A2AV36	0.0	900	683	0.624	0.633	ANM7_DANRE Protein arginine N-methyltransferase 7 OS=Danio rerio OX=7955 GN=prmt7 PE=2 SV=1
2	Q922X9	0.0	1240	692	0.851	0.851	ANM7_MOUSE Protein arginine N-methyltransferase 7 OS=Mus musculus OX=10090 GN=Prmt7 PE=1 SV=1
3	Q9NVM4	0.0	1443	692	1.000	1.000	ANM7_HUMAN Protein arginine N-methyltransferase 7 OS=Homo sapiens OX=9606 GN=PRMT7 PE=1 SV=1
4	Q9W1V1	2.16e-155	467	690	0.371	0.372	ANM7_DROME Protein arginine N-methyltransferase 7 OS=Drosophila melanogaster OX=7227 GN=Art7 PE=2 SV=4
5	Q6P2P2	2.82e-17	88.6	845	0.113	0.092	ANM9_HUMAN Protein arginine N-methyltransferase 9 OS=Homo sapiens OX=9606 GN=PRMT9 PE=1 SV=1
6	Q4QIZ0	3.82e-17	86.7	438	0.120	0.189	Q4QIZ0_LEIMA Putative arginine N-methyltransferase, type III OS=Leishmania major OX=5664 GN=PRMT7 PE=4 SV=1
7	Q582G4	1.20e-16	84.7	390	0.108	0.192	ANM7_TRYB2 Protein arginine N-methyltransferase 7 OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=PRMT7 PE=1 SV=1
8	Q5A943	1.35e-15	80.9	339	0.107	0.218	Q5A943_CANAL Protein-arginine omega-N methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=HMT1 PE=4 SV=1
9	Q8SX32	6.19e-14	75.9	341	0.111	0.226	Q8SX32_DROME Arginine methyltransferase 8 OS=Drosophila melanogaster OX=7227 GN=Art8 PE=1 SV=1
10	Q9SU94	5.70e-13	73.6	390	0.084	0.149	ANM11_ARATH Protein arginine N-methyltransferase 1.1 OS=Arabidopsis thaliana OX=3702 GN=PRMT11 PE=1 SV=1
11	Q9URX7	1.79e-12	71.6	340	0.111	0.226	ANM1_SCHPO Protein arginine N-methyltransferase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rmt1 PE=1 SV=2
12	P38074	1.83e-12	71.6	348	0.113	0.224	HMT1_YEAST Protein arginine N-methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=HMT1 PE=1 SV=1
13	Q8ILK1	5.61e-12	70.5	401	0.100	0.172	Q8ILK1_PLAF7 Protein arginine N-methyltransferase 1 OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1426200 PE=4 SV=1
14	Q9VH48	5.77e-12	71.2	530	0.114	0.149	CARM1_DROME Probable histone-arginine methyltransferase CARMER OS=Drosophila melanogaster OX=7227 GN=Art4 PE=1 SV=1
15	O70467	1.09e-11	70.1	528	0.121	0.159	ANM3_RAT Protein arginine N-methyltransferase 3 OS=Rattus norvegicus OX=10116 GN=Prmt3 PE=1 SV=1
16	Q6NWG4	1.11e-11	69.3	349	0.120	0.238	ANM6_DANRE Protein arginine N-methyltransferase 6 OS=Danio rerio OX=7955 GN=prmt6 PE=2 SV=2
17	Q922H1	2.61e-11	68.9	528	0.121	0.159	ANM3_MOUSE Protein arginine N-methyltransferase 3 OS=Mus musculus OX=10090 GN=Prmt3 PE=1 SV=3
18	C8V494	4.50e-11	67.4	345	0.114	0.229	C8V494_EMENI RmtA OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_10526 PE=4 SV=1
19	Q84W92	5.75e-11	67.8	535	0.084	0.108	ANM13_ARATH Probable histone-arginine methyltransferase 1.3 OS=Arabidopsis thaliana OX=3702 GN=PRMT13 PE=1 SV=3
20	Q7Q2B7	1.11e-10	67.0	622	0.110	0.122	CARM1_ANOGA Histone-arginine methyltransferase CARMER OS=Anopheles gambiae OX=7165 GN=CARM1 PE=1 SV=5

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03602 Cons_hypoth95	1.6e+02	13.3	Conserved hypothetical protein 95
2	PF08241 Methyltransf_11	3.5e+02	13.3	Methyltransferase domain
3	PF12847 Methyltransf_18	24	16.4	Methyltransferase domain
4	PF13489 Methyltransf_23	3.7e+02	12.3	Methyltransferase domain
5	PF13649 Methyltransf_25	0.14	24.2	Methyltransferase domain
6	PF02475 Met_10	2.6e+02	12.7	Met-10+ like-protein
7	PF05175 MTS	1.3e+02	13.6	Methyltransferase small domain
8	PF01135 PCMT	4.6e+02	11.9	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
9	PF06325 PrmA	4.5e-05	34.6	Ribosomal protein L11 methyltransferase (PrmA)
10	PF04816 TrmK	2.8e+02	12.4	tRNA (adenine(22)-N(1))-methyltransferase
11	PF01411 tRNA-synt_2c	1.9e+02	12.0	tRNA synthetases class II (A)

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000343103

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000319169	0.976	Protein arginine N-methyltransferase 5
2	9606.ENSP00000415579	0.962	Transcriptional repressor CTCFL
3	9606.ENSP00000235090	0.823	Methylosome protein 50
4	9606.ENSP00000256383	0.699	Eukaryotic translation initiation factor 2 subunit 1
5	9606.ENSP00000364119	0.694	Eukaryotic translation initiation factor 2 subunit 2
6	9606.ENSP00000262238	0.673	Transcriptional repressor protein YY1
7	9606.ENSP00000366430	0.664	Protein LZIC
8	9606.ENSP00000264010	0.656	Transcriptional repressor CTCF
9	9606.ENSP00000215829	0.653	Small nuclear ribonucleoprotein Sm D3
10	9606.ENSP00000244537	0.643	Histone cluster 1 H4 family member f
11	9606.ENSP00000369162	0.635	Serine/threonine-protein kinase RIO1
12	9606.ENSP00000395654	0.620	Transcription activator BRG1
13	9606.ENSP00000480186	0.617	DNA polymerase delta subunit 2
14	9606.ENSP00000221801	0.609	rRNA 2'-O-methyltransferase fibrillarin
15	9606.ENSP00000403802	0.609	F-box only protein 10
16	9606.ENSP00000412566	0.602	Small nuclear ribonucleoprotein-associated proteins B and B
17	9606.ENSP00000332194	0.579	Histone H2A type 2-C
18	9606.ENSP00000382091	0.576	RNA demethylase ALKBH5
19	9606.ENSP00000300413	0.575	Small nuclear ribonucleoprotein Sm D1
20	9606.ENSP00000406046	0.571	DNA polymerase delta catalytic subunit

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0008469	1.000	histone arginine N-methyltransferase activity
GO:0044877	0.997	protein-containing complex binding
GO:0043021	0.994	ribonucleoprotein complex binding
GO:0035243	0.964	protein-arginine omega-N symmetric methyltransferase activity
GO:0140939	0.874	histone H4 methyltransferase activity
GO:0042393	0.788	histone binding
GO:0044020	0.354	histone H4R3 methyltransferase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0065007	0.996	biological regulation
GO:0009987	0.996	cellular process
GO:0044238	0.993	primary metabolic process
GO:0006807	0.992	nitrogen compound metabolic process
GO:0044237	0.992	cellular metabolic process
GO:0043170	0.990	macromolecule metabolic process
GO:0032259	0.984	methylation
GO:0044260	0.984	cellular macromolecule metabolic process
GO:0008213	0.984	protein alkylation
GO:0050789	0.967	regulation of biological process
GO:0043414	0.954	macromolecule methylation
GO:0018193	0.944	peptidyl-amino acid modification
GO:0019222	0.934	regulation of metabolic process
GO:0071840	0.918	cellular component organization or biogenesis
GO:0060255	0.910	regulation of macromolecule metabolic process
GO:0006479	0.903	protein methylation
GO:0006325	0.894	chromatin organization
GO:0008380	0.876	RNA splicing
GO:0010468	0.837	regulation of gene expression
GO:0018195	0.827	peptidyl-arginine modification
GO:0043933	0.761	protein-containing complex organization
GO:0050794	0.737	regulation of cellular process
GO:0016071	0.696	mRNA metabolic process
GO:0044085	0.691	cellular component biogenesis
GO:0006397	0.635	mRNA processing
GO:0000377	0.607	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0065009	0.588	regulation of molecular function
GO:0022607	0.580	cellular component assembly
GO:0040029	0.491	epigenetic regulation of gene expression
GO:0065003	0.476	protein-containing complex assembly
GO:0051171	0.409	regulation of nitrogen compound metabolic process
GO:0000398	0.393	mRNA splicing, via spliceosome
GO:0016570	0.384	histone modification
GO:0080090	0.376	regulation of primary metabolic process
GO:0031323	0.375	regulation of cellular metabolic process
GO:0019219	0.350	regulation of nucleobase-containing compound metabolic process
GO:0071826	0.345	ribonucleoprotein complex subunit organization
GO:0000387	0.341	spliceosomal snRNP assembly
GO:0051252	0.311	regulation of RNA metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	1.000	nucleoplasm
GO:0005730	0.995	nucleolus
GO:0001650	0.986	fibrillar center
GO:0005737	0.978	cytoplasm
GO:0005829	0.965	cytosol
GO:0032991	0.518	protein-containing complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.1.1.-	1.000	Methyltransferases.
RHEA:48108	0.964	L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine
EC:2.1.1.320	0.964	type II protein arginine methyltransferase.

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