StarFunc result for job id Q9NXR7

User Input

>input (383 residues)
MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHI
PYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALQNLASWNPSNPECLLLVVKEL
VQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVD
FSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAF
PGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLL
LMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAK
RAKAYFKTFVPQFQEAAFANGKL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q8K3W0	0.998	0.998	8.544E-72	383	0.992	0.992	Q8K3W0.pdb.gz	BABA2_MOUSE BRISC and BRCA1-A complex member 2 OS=Mus musculus OX=10090 GN=Babam2 PE=1 SV=2
2	PDB:6gvwC	0.765	0.765	5.418E-60	383	0.992	0.992	6gvwC.pdb.gz	Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
3	AFDB:F8W733	0.584	0.783	1.701E-36	284	0.590	0.796	F8W733.pdb.gz	F8W733_HUMAN BRISC and BRCA1-A complex member 2 (Fragment) OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=1
4	AFDB:B5MC31	0.230	0.246	1.214E-4	347	0.073	0.081	B5MC31.pdb.gz	B5MC31_HUMAN FA complementation group L OS=Homo sapiens OX=9606 GN=FANCL PE=1 SV=1
5	AFDB:Q3MUH5	0.199	0.202	1.348E-4	373	0.084	0.086	Q3MUH5.pdb.gz	Q3MUH5_CHICK Fanconi anemia protein FANCL OS=Gallus gallus OX=9031 GN=FANCL PE=1 SV=1
6	AFDB:Q9CR14	0.201	0.204	1.663E-4	375	0.052	0.053	Q9CR14.pdb.gz	FANCL_MOUSE E3 ubiquitin-protein ligase FANCL OS=Mus musculus OX=10090 GN=Fancl PE=1 SV=1
7	AFDB:Q9NW38	0.232	0.236	3.125E-4	375	0.081	0.083	Q9NW38.pdb.gz	FANCL_HUMAN E3 ubiquitin-protein ligase FANCL OS=Homo sapiens OX=9606 GN=FANCL PE=1 SV=2
8	AFDB:B8JHS6	0.207	0.213	6.187E-4	371	0.052	0.054	B8JHS6.pdb.gz
9	AFDB:Q8GUP4	0.222	0.262	9.419E-4	312	0.081	0.099	Q8GUP4.pdb.gz	Q8GUP4_ARATH Centromere protein O OS=Arabidopsis thaliana OX=3702 GN=MAJ23.70 PE=1 SV=1
10	AFDB:Q54CR0	0.179	0.147	3.324E-3	479	0.086	0.069	Q54CR0.pdb.gz	Q54CR0_DICDI RING-type domain-containing protein OS=Dictyostelium discoideum OX=44689 GN=DDB_G0292744 PE=4 SV=1
11	PDB:7kzpL	0.248	0.254	5.401E-3	370	0.089	0.092	7kzpL.pdb.gz	Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.
12	AFDB:Q6P3K6	0.202	0.200	1.447E-2	387	0.037	0.036	Q6P3K6.pdb.gz
13	PDB:2cyxA	0.150	0.269	2.612E-2	169	0.050	0.112	2cyxA.pdb.gz
14	PDB:7apkE	0.177	0.144	4.418E-2	523	0.091	0.067	7apkE.pdb.gz
15	PDB:7apkM	0.161	0.128	4.418E-2	549	0.097	0.067	7apkM.pdb.gz
16	PDB:6xlfC	0.102	0.119	5.172E-2	316	0.063	0.076	6xlfC.pdb.gz	Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
17	PDB:3ptfA	0.192	0.398	5.451E-2	153	0.042	0.105	3ptfA.pdb.gz
18	PDB:4x57C	0.195	0.432	5.451E-2	149	0.055	0.141	4x57C.pdb.gz
19	PDB:6cyrA	0.177	0.376	5.451E-2	153	0.047	0.118	6cyrA.pdb.gz
20	PDB:6l1dA	0.085	0.137	6.055E-2	200	0.044	0.085	6l1dA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q8K3W0	0.0	793	383	0.992	0.992	BABA2_MOUSE BRISC and BRCA1-A complex member 2 OS=Mus musculus OX=10090 GN=Babam2 PE=1 SV=2
2	Q9NXR7	0.0	798	383	1.000	1.000	BABA2_HUMAN BRISC and BRCA1-A complex member 2 OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=2
3	F8W733	1.58e-165	466	284	0.590	0.796	F8W733_HUMAN BRISC and BRCA1-A complex member 2 (Fragment) OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=1
4	C9J2G0	7.21e-110	320	153	0.399	1.000	C9J2G0_HUMAN BRISC and BRCA1-A complex member 2 (Fragment) OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=1
5	Q38BP4	1.4	33.5	1056	0.131	0.047	Q38BP4_TRYB2 DNA repair helicase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.70.3870 PE=4 SV=1
6	Q05961	7.9	30.8	358	0.104	0.112	OAS1A_RAT 2'-5'-oligoadenylate synthase 1A OS=Rattus norvegicus OX=10116 GN=Oas1a PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF06113 BRE	1.4e-139	476.0	Brain and reproductive organ-expressed protein (BRE)
2	PF17640 UL17	1.6e+02	13.7	Uncharacterized UL17
3	PF00179 UQ_con	1.1e+02	13.9	Ubiquitin-conjugating enzyme

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 246437.XP_006162196.1

Rank	PPI partner	STRING score	Description
1	246437.XP_006147200.1	0.999	BRISC and BRCA1-A complex member 1
2	246437.XP_006171132.1	0.999	BRCA1/BRCA2-containing complex subunit 3
3	246437.XP_006144024.1	0.998	Family with sequence similarity 175 member B
4	246437.XP_006151449.1	0.998	BRCA1-A complex subunit Abraxas
5	246437.XP_006158937.1	0.993	Ubiquitin interaction motif containing 1
6	246437.XP_006171967.1	0.993	Interconversion of serine and glycine.
7	246437.XP_006156147.1	0.980	E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule [...]
8	246437.XP_006162659.1	0.961	BRCA1-associated RING domain protein 1-like
9	246437.XP_006161711.1	0.901	Interconversion of serine and glycine.
10	246437.XP_006141012.1	0.887	Anaphase-promoting complex subunit 15 isoform X1
11	246437.XP_006150420.1	0.886	Ubiquitin-conjugating enzyme E2 S
12	246437.XP_006143928.1	0.884	E3 ubiquitin-protein ligase RING2
13	246437.XP_006150907.1	0.875	Anaphase-promoting complex subunit 13 isoform X1
14	246437.XP_006169555.1	0.875	Anaphase-promoting complex subunit 10 isoform X1
15	246437.XP_006170156.1	0.875	Anaphase promoting complex subunit 16
16	246437.XP_006155925.1	0.871	Polycomb group RING finger protein 2
17	246437.XP_006154975.1	0.868	Histone H2A deubiquitinase MYSM1
18	246437.XP_006160334.1	0.868	26S proteasome non-ATPase regulatory subunit 14
19	246437.XP_006171914.1	0.868	MPN domain-containing protein
20	246437.XP_006149439.1	0.810	Ubiquitin-conjugating enzyme E2 C-like

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005164	1.000	tumor necrosis factor receptor binding
GO:0003824	0.753	catalytic activity
GO:0140096	0.725	catalytic activity, acting on a protein

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.997	cellular process
GO:0044238	0.997	primary metabolic process
GO:0050794	0.997	regulation of cellular process
GO:0006807	0.996	nitrogen compound metabolic process
GO:0043170	0.996	macromolecule metabolic process
GO:0070647	0.993	protein modification by small protein conjugation or removal
GO:0048523	0.992	negative regulation of cellular process
GO:0048522	0.990	positive regulation of cellular process
GO:0051052	0.987	regulation of DNA metabolic process
GO:0006281	0.987	DNA repair
GO:0000278	0.985	mitotic cell cycle
GO:0006508	0.985	proteolysis
GO:1903047	0.983	mitotic cell cycle process
GO:2001022	0.982	positive regulation of response to DNA damage stimulus
GO:0010212	0.981	response to ionizing radiation
GO:1902749	0.977	regulation of cell cycle G2/M phase transition
GO:0000077	0.977	DNA damage checkpoint signaling
GO:0006282	0.970	regulation of DNA repair
GO:0051054	0.970	positive regulation of DNA metabolic process
GO:0070646	0.969	protein modification by small protein removal
GO:1901990	0.965	regulation of mitotic cell cycle phase transition
GO:1902750	0.965	negative regulation of cell cycle G2/M phase transition
GO:0045930	0.963	negative regulation of mitotic cell cycle
GO:0044773	0.945	mitotic DNA damage checkpoint signaling
GO:1901991	0.943	negative regulation of mitotic cell cycle phase transition
GO:0010389	0.939	regulation of G2/M transition of mitotic cell cycle
GO:0016579	0.939	protein deubiquitination
GO:0007095	0.918	mitotic G2 DNA damage checkpoint signaling
GO:0071478	0.916	cellular response to radiation
GO:0071479	0.872	cellular response to ionizing radiation
GO:0006302	0.861	double-strand break repair
GO:0045739	0.792	positive regulation of DNA repair
GO:0010941	0.580	regulation of cell death
GO:0043067	0.571	regulation of programmed cell death
GO:0032446	0.461	protein modification by small protein conjugation
GO:0042981	0.458	regulation of apoptotic process
GO:0060548	0.457	negative regulation of cell death
GO:0043066	0.450	negative regulation of apoptotic process
GO:0016567	0.388	protein ubiquitination

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0032991	0.996	protein-containing complex
GO:0005829	0.996	cytosol
GO:0005634	0.996	nucleus
GO:0005654	0.992	nucleoplasm
GO:0000151	0.982	ubiquitin ligase complex
GO:0000152	0.950	nuclear ubiquitin ligase complex
GO:0043232	0.723	intracellular non-membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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