StarFunc result for job id Q9NZ01

User Input

>input (308 residues)
MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLK
DEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYDFT
SSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYIN
HPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLF
LLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLR
MPIIPFLL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:M0R2N5	0.991	0.883	3.149E-52	346	0.987	0.879	M0R2N5.pdb.gz	M0R2N5_HUMAN very-long-chain enoyl-CoA reductase OS=Homo sapiens OX=9606 GN=TECR PE=1 SV=1
2	AFDB:Q5HYJ1	0.910	0.779	2.085E-33	363	0.513	0.435	Q5HYJ1.pdb.gz	TECRL_HUMAN Trans-2,3-enoyl-CoA reductase-like OS=Homo sapiens OX=9606 GN=TECRL PE=1 SV=1
3	AFDB:Q95R45	0.937	0.943	1.296E-32	306	0.519	0.523	Q95R45.pdb.gz	Q95R45_DROME very-long-chain enoyl-CoA reductase (Fragment) OS=Drosophila melanogaster OX=7227 GN=Sc2 PE=2 SV=2
4	AFDB:Q9M2U2	0.880	0.874	1.434E-24	310	0.399	0.397	Q9M2U2.pdb.gz	TECR_ARATH Very-long-chain enoyl-CoA reductase OS=Arabidopsis thaliana OX=3702 GN=ECR PE=1 SV=1
5	AFDB:Q57ZC7	0.873	0.901	3.110E-22	298	0.347	0.359	Q57ZC7.pdb.gz	Q57ZC7_TRYB2 3-oxo-5-alpha-steroid 4-dehydrogenase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb03.30P12.550 PE=3 SV=1
6	AFDB:O94511	0.861	0.897	7.752E-22	295	0.354	0.369	O94511.pdb.gz	YN67_SCHPO Putative enoyl reductase C646.07c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC646.07c PE=3 SV=1
7	AFDB:A0A1D8PCD8	0.860	0.850	1.896E-20	312	0.328	0.324	A0A1D8PCD8.pdb.gz	A0A1D8PCD8_CANAL Trans-2-enoyl-CoA reductase (NADPH) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=TSC13 PE=3 SV=1
8	AFDB:Q99190	0.760	0.756	2.810E-14	310	0.295	0.294	Q99190.pdb.gz	TECR_YEAST Very-long-chain enoyl-CoA reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TSC13 PE=1 SV=1
9	AFDB:Q9LFS3	0.634	0.724	2.166E-11	268	0.185	0.213	Q9LFS3.pdb.gz	Q9LFS3_ARATH 3-oxo-5-alpha-steroid 4-dehydrogenase family protein OS=Arabidopsis thaliana OX=3702 GN=At5g16010 PE=1 SV=1
10	AFDB:Q20344	0.619	0.775	1.416E-10	243	0.162	0.206	Q20344.pdb.gz	Q20344_CAEEL 3-oxo-5-alpha-steroid 4-dehydrogenase OS=Caenorhabditis elegans OX=6239 GN=CELE_F42F12.3 PE=1 SV=1
11	PDB:7bw1A	0.596	0.738	1.179E-9	245	0.166	0.208	7bw1A.pdb.gz	Structure of human steroid 5 alpha-reductase 2 with anti-androgen drug finasteride.
12	PDB:3dbhI	0.215	0.698	3.739E-3	86	0.052	0.186	3dbhI.pdb.gz	Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.
13	PDB:3ai5A	0.223	0.229	4.138E-3	299	0.058	0.060	3ai5A.pdb.gz
14	PDB:6yvaC	0.228	0.435	5.070E-3	155	0.042	0.084	6yvaC.pdb.gz
15	PDB:7rbsB	0.237	0.445	6.874E-3	157	0.039	0.076	7rbsB.pdb.gz	Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin.
16	PDB:6mdhA	0.219	0.435	9.806E-3	149	0.032	0.067	6mdhA.pdb.gz
17	PDB:3plvA	0.226	0.808	1.085E-2	80	0.052	0.200	3plvA.pdb.gz	Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing.
18	PDB:7np7D4	0.203	0.154	1.085E-2	415	0.136	0.101	7np7D4.pdb.gz
19	PDB:4rm8A	0.216	0.183	1.803E-2	368	0.097	0.082	4rm8A.pdb.gz
20	PDB:3tixA	0.221	0.421	2.099E-2	153	0.071	0.144	3tixA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	M0R2N5	0.0	633	346	0.987	0.879	M0R2N5_HUMAN very-long-chain enoyl-CoA reductase OS=Homo sapiens OX=9606 GN=TECR PE=1 SV=1
2	Q9NZ01	0.0	640	308	1.000	1.000	TECR_HUMAN Very-long-chain enoyl-CoA reductase OS=Homo sapiens OX=9606 GN=TECR PE=1 SV=1
3	Q5HYJ1	5.56e-117	343	363	0.513	0.435	TECRL_HUMAN Trans-2,3-enoyl-CoA reductase-like OS=Homo sapiens OX=9606 GN=TECRL PE=1 SV=1
4	Q9VZL3	2.27e-112	329	302	0.529	0.540	Q9VZL3_DROME very-long-chain enoyl-CoA reductase OS=Drosophila melanogaster OX=7227 GN=Sc2 PE=1 SV=1
5	Q95R45	2.46e-111	327	306	0.526	0.529	Q95R45_DROME very-long-chain enoyl-CoA reductase (Fragment) OS=Drosophila melanogaster OX=7227 GN=Sc2 PE=2 SV=2
6	Q9M2U2	1.14e-60	197	310	0.386	0.384	TECR_ARATH Very-long-chain enoyl-CoA reductase OS=Arabidopsis thaliana OX=3702 GN=ECR PE=1 SV=1
7	O94511	5.62e-55	182	295	0.344	0.359	YN67_SCHPO Putative enoyl reductase C646.07c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC646.07c PE=3 SV=1
8	Q57ZC7	4.35e-50	169	298	0.347	0.359	Q57ZC7_TRYB2 3-oxo-5-alpha-steroid 4-dehydrogenase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb03.30P12.550 PE=3 SV=1
9	A0A1D8PCD8	4.96e-40	144	312	0.338	0.333	A0A1D8PCD8_CANAL Trans-2-enoyl-CoA reductase (NADPH) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=TSC13 PE=3 SV=1
10	Q99190	5.23e-29	114	310	0.273	0.271	TECR_YEAST Very-long-chain enoyl-CoA reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TSC13 PE=1 SV=1
11	Q9LFS3	1.45e-10	62.8	268	0.166	0.190	Q9LFS3_ARATH 3-oxo-5-alpha-steroid 4-dehydrogenase family protein OS=Arabidopsis thaliana OX=3702 GN=At5g16010 PE=1 SV=1
12	Q68FF9	7.24e-10	60.8	255	0.143	0.173	S5A1_MOUSE 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Mus musculus OX=10090 GN=Srd5a1 PE=2 SV=2
13	P31213	8.26e-10	60.5	254	0.143	0.173	S5A2_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=Homo sapiens OX=9606 GN=SRD5A2 PE=1 SV=2
14	P24008	3.90e-09	58.5	259	0.140	0.166	S5A1_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Rattus norvegicus OX=10116 GN=Srd5a1 PE=1 SV=2
15	Q20344	5.82e-09	57.8	243	0.107	0.136	Q20344_CAEEL 3-oxo-5-alpha-steroid 4-dehydrogenase OS=Caenorhabditis elegans OX=6239 GN=CELE_F42F12.3 PE=1 SV=1
16	P31214	6.94e-09	57.8	254	0.123	0.150	S5A2_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=Rattus norvegicus OX=10116 GN=Srd5a2 PE=1 SV=1
17	Q99N99	4.15e-08	55.5	254	0.159	0.193	S5A2_MOUSE 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=Mus musculus OX=10090 GN=Srd5a2 PE=2 SV=1
18	Q2QDF6	6.76e-08	55.1	258	0.127	0.151	DET2_GOSHI Steroid 5-alpha-reductase DET2 OS=Gossypium hirsutum OX=3635 GN=DET2 PE=1 SV=1
19	P18405	4.88e-06	49.3	259	0.117	0.139	S5A1_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Homo sapiens OX=9606 GN=SRD5A1 PE=1 SV=1
20	Q38944	7.37e-06	48.9	262	0.117	0.137	DET2_ARATH Steroid 5-alpha-reductase DET2 OS=Arabidopsis thaliana OX=3702 GN=DET2 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF02544 Steroid_dh	4.1e-26	103.2	3-oxo-5-alpha-steroid 4-dehydrogenase
2	PF00240 ubiquitin	2.3e+02	12.9	Ubiquitin family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000215567

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000373153	0.993	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2
2	9606.ENSP00000278353	0.985	Very-long-chain 3-oxoacyl-CoA reductase
3	9606.ENSP00000355308	0.974	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1
4	9606.ENSP00000261875	0.968	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
5	9606.ENSP00000419503	0.968	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4
6	9606.ENSP00000378105	0.944	Elongation of very long chain fatty acids protein 6
7	9606.ENSP00000328551	0.941	Ras-related protein Rab-28
8	9606.ENSP00000361595	0.921	Erythroid membrane-associated protein
9	9606.ENSP00000358831	0.916	Elongation of very long chain fatty acids protein 4
10	9606.ENSP00000311224	0.911	Acyl-coenzyme A thioesterase 1
11	9606.ENSP00000356155	0.910	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
12	9606.ENSP00000238651	0.902	Acyl-coenzyme A thioesterase 2, mitochondrial
13	9606.ENSP00000323071	0.902	Acyl-coenzyme A thioesterase 4
14	9606.ENSP00000357807	0.902	Acyl-coenzyme A thioesterase THEM5
15	9606.ENSP00000357804	0.901	Acyl-coenzyme A thioesterase THEM4
16	9606.ENSP00000367086	0.900	Cytosolic acyl coenzyme A thioester hydrolase
17	9606.ENSP00000346693	0.887	Elongation of very long chain fatty acids protein 2
18	9606.ENSP00000359380	0.879	Acyl-CoA desaturase
19	9606.ENSP00000307197	0.878	DnaJ homolog subfamily B member 7
20	9606.ENSP00000316329	0.858	Stearoyl-CoA desaturase 5

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0016627	0.999	oxidoreductase activity, acting on the CH-CH group of donors
GO:0005515	0.998	protein binding
GO:0016628	0.994	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0003995	0.991	acyl-CoA dehydrogenase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.995	organic substance metabolic process
GO:0006631	0.986	fatty acid metabolic process
GO:0009150	0.985	purine ribonucleotide metabolic process
GO:0006633	0.983	fatty acid biosynthetic process
GO:0035337	0.979	fatty-acyl-CoA metabolic process
GO:0071616	0.977	acyl-CoA biosynthetic process
GO:0030497	0.969	fatty acid elongation
GO:1901570	0.937	fatty acid derivative biosynthetic process
GO:0000038	0.918	very long-chain fatty acid metabolic process
GO:0006643	0.629	membrane lipid metabolic process
GO:0042761	0.481	very long-chain fatty acid biosynthetic process
GO:0006665	0.392	sphingolipid metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005783	1.000	endoplasmic reticulum
GO:0016020	0.991	membrane
GO:0005634	0.991	nucleus
GO:0031090	0.970	organelle membrane
GO:0031984	0.960	organelle subcompartment
GO:0005789	0.926	endoplasmic reticulum membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:1.3.-.-	0.999	Acting on the CH-CH group of donors.
EC:1.3.1.-	0.994	With NAD(+) or NADP(+) as acceptor.

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