StarFunc result for job id Q9P104

User Input

>input (306 residues)
MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVT
ELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDIS
LGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWP
LSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQS
VKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFP
AYRSEH

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q91ZM9	0.848	0.848	2.521E-50	306	0.984	0.984	Q91ZM9.pdb.gz	DOK5_MOUSE Docking protein 5 OS=Mus musculus OX=10090 GN=Dok5 PE=1 SV=1
2	AFDB:Q2MHE5	0.784	0.728	9.347E-41	331	0.703	0.650	Q2MHE5.pdb.gz	DOK6_MOUSE Docking protein 6 OS=Mus musculus OX=10090 GN=Dok6 PE=1 SV=1
3	AFDB:A4IFJ7	0.776	0.730	1.668E-37	326	0.552	0.518	A4IFJ7.pdb.gz	A4IFJ7_BOVIN DOK4 protein OS=Bos taurus OX=9913 GN=DOK4 PE=2 SV=1
4	AFDB:Q9W3R6	0.342	0.178	1.273E-18	622	0.225	0.111	Q9W3R6.pdb.gz	Q9W3R6_DROME Insulin receptor substrate 1 OS=Drosophila melanogaster OX=7227 GN=Dok PE=2 SV=1
5	AFDB:B0S6R3	0.311	0.188	1.025E-17	530	0.239	0.138	B0S6R3.pdb.gz
6	AFDB:P97465	0.306	0.202	1.339E-17	482	0.232	0.147	P97465.pdb.gz	DOK1_MOUSE Docking protein 1 OS=Mus musculus OX=10090 GN=Dok1 PE=1 SV=2
7	AFDB:Q99704	0.307	0.206	1.490E-17	481	0.242	0.154	Q99704.pdb.gz	DOK1_HUMAN Docking protein 1 OS=Homo sapiens OX=9606 GN=DOK1 PE=1 SV=1
8	AFDB:O60496	0.291	0.224	6.663E-17	412	0.222	0.165	O60496.pdb.gz	DOK2_HUMAN Docking protein 2 OS=Homo sapiens OX=9606 GN=DOK2 PE=1 SV=2
9	AFDB:O70469	0.325	0.252	1.200E-16	412	0.235	0.175	O70469.pdb.gz	DOK2_MOUSE Docking protein 2 OS=Mus musculus OX=10090 GN=Dok2 PE=1 SV=1
10	AFDB:Q7L591	0.304	0.192	5.084E-16	496	0.216	0.133	Q7L591.pdb.gz	DOK3_HUMAN Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 PE=1 SV=2
11	PDB:3ljuX	0.256	0.215	1.557E-5	373	0.078	0.064	3ljuX.pdb.gz	Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
12	PDB:7c3mA	0.262	0.147	5.327E-5	577	0.121	0.064	7c3mA.pdb.gz
13	PDB:6hhgA	0.260	0.209	1.254E-4	386	0.092	0.073	6hhgA.pdb.gz	Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
14	PDB:6xtbE	0.232	0.296	2.140E-4	235	0.092	0.119	6xtbE.pdb.gz
15	PDB:6r9tA	0.255	0.039	2.381E-4	2185	0.114	0.016	6r9tA.pdb.gz
16	PDB:7nkyQ	0.208	0.161	5.035E-4	404	0.069	0.052	7nkyQ.pdb.gz	Structural basis of nucleosome transcription mediated by Chd1 and FACT.
17	PDB:6s9wA	0.256	0.194	5.312E-4	411	0.085	0.063	6s9wA.pdb.gz	Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity.
18	PDB:7r04B	0.244	0.043	1.633E-3	2229	0.049	0.007	7r04B.pdb.gz	Structural basis of activation of the tumor suppressor protein neurofibromin.
19	PDB:4rm8A	0.266	0.223	2.374E-3	368	0.072	0.060	4rm8A.pdb.gz
20	PDB:7mp5A	0.251	0.054	2.642E-3	1629	0.059	0.011	7mp5A.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q91ZM9	0.0	636	306	0.984	0.984	DOK5_MOUSE Docking protein 5 OS=Mus musculus OX=10090 GN=Dok5 PE=1 SV=1
2	Q9P104	0.0	646	306	1.000	1.000	DOK5_HUMAN Docking protein 5 OS=Homo sapiens OX=9606 GN=DOK5 PE=1 SV=2
3	Q6PKX4	1.01e-166	468	331	0.706	0.653	DOK6_HUMAN Docking protein 6 OS=Homo sapiens OX=9606 GN=DOK6 PE=1 SV=1
4	Q2MHE5	1.30e-166	468	331	0.706	0.653	DOK6_MOUSE Docking protein 6 OS=Mus musculus OX=10090 GN=Dok6 PE=1 SV=1
5	Q99KE3	3.15e-134	385	325	0.588	0.554	DOK4_MOUSE Docking protein 4 OS=Mus musculus OX=10090 GN=Dok4 PE=1 SV=1
6	A4IFJ7	3.72e-134	385	326	0.592	0.555	A4IFJ7_BOVIN DOK4 protein OS=Bos taurus OX=9913 GN=DOK4 PE=2 SV=1
7	Q8TEW6	2.26e-133	383	326	0.588	0.552	DOK4_HUMAN Docking protein 4 OS=Homo sapiens OX=9606 GN=DOK4 PE=1 SV=2
8	Q99704	4.79e-13	71.6	481	0.219	0.139	DOK1_HUMAN Docking protein 1 OS=Homo sapiens OX=9606 GN=DOK1 PE=1 SV=1
9	O70469	5.33e-13	71.2	412	0.134	0.100	DOK2_MOUSE Docking protein 2 OS=Mus musculus OX=10090 GN=Dok2 PE=1 SV=1
10	O60496	3.07e-12	68.9	412	0.160	0.119	DOK2_HUMAN Docking protein 2 OS=Homo sapiens OX=9606 GN=DOK2 PE=1 SV=2
11	P97465	4.16e-11	65.5	482	0.092	0.058	DOK1_MOUSE Docking protein 1 OS=Mus musculus OX=10090 GN=Dok1 PE=1 SV=2
12	Q9QZK7	8.27e-10	61.6	444	0.150	0.104	DOK3_MOUSE Docking protein 3 OS=Mus musculus OX=10090 GN=Dok3 PE=1 SV=1
13	Q7L591	4.21e-09	59.7	496	0.111	0.069	DOK3_HUMAN Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 PE=1 SV=2
14	O43559	5.47e-08	56.2	492	0.072	0.045	FRS3_HUMAN Fibroblast growth factor receptor substrate 3 OS=Homo sapiens OX=9606 GN=FRS3 PE=1 SV=3
15	Q52RG8	1.08e-07	55.1	492	0.069	0.043	FRS3_RAT Fibroblast growth factor receptor substrate 3 OS=Rattus norvegicus OX=10116 GN=Frs3 PE=2 SV=3
16	E7F4P8	9.41e-07	52.8	1099	0.190	0.053	E7F4P8_DANRE Insulin receptor substrate 1 OS=Danio rerio OX=7955 GN=irs1 PE=4 SV=1
17	D4A244	1.32e-06	52.0	508	0.078	0.047	D4A244_RAT Fibroblast growth factor receptor substrate 2 OS=Rattus norvegicus OX=10116 GN=Frs2 PE=1 SV=1
18	Q8C180	1.43e-06	51.6	508	0.078	0.047	FRS2_MOUSE Fibroblast growth factor receptor substrate 2 OS=Mus musculus OX=10090 GN=Frs2 PE=1 SV=3
19	Q8WU20	1.82e-06	51.6	508	0.078	0.047	FRS2_HUMAN Fibroblast growth factor receptor substrate 2 OS=Homo sapiens OX=9606 GN=FRS2 PE=1 SV=4
20	A0A384NQ31	1.97e-06	51.2	512	0.078	0.047	A0A384NQ31_HUMAN Epididymis secretory sperm binding protein OS=Homo sapiens OX=9606 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF02174 IRS	4.8e-25	98.7	PTB domain (IRS-1 type)
2	PF00169 PH	0.85	21.5	PH domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000262593

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000347942	0.956	Proto-oncogene tyrosine-protein kinase receptor Ret
2	9606.ENSP00000409007	0.936	Glial cell line-derived neurotrophic factor
3	9606.ENSP00000347591	0.909	GDNF family receptor alpha-1
4	9606.ENSP00000277120	0.870	BDNF/NT-3 growth factors receptor
5	9606.ENSP00000372221	0.701	Serpin B5
6	9606.ENSP00000361980	0.688	cAMP-dependent protein kinase inhibitor gamma
7	9606.ENSP00000361202	0.663	Insulin receptor substrate 4
8	9606.ENSP00000313423	0.662	GDNF family receptor alpha-4
9	9606.ENSP00000428518	0.642	GDNF family receptor alpha-2
10	9606.ENSP00000023939	0.628	Protein RTF2 homolog
11	9606.ENSP00000344432	0.625	Protein Dok-7
12	9606.ENSP00000356432	0.614	BMP/retinoic acid-inducible neural-specific protein 3
13	9606.ENSP00000302648	0.613	Neurturin
14	9606.ENSP00000245810	0.600	Persephin
15	9606.ENSP00000274721	0.600	GDNF family receptor alpha-3
16	9606.ENSP00000387435	0.600	Artemin
17	9606.ENSP00000360552	0.596	Teashirt homolog 2
18	9606.ENSP00000484928	0.594	Cadherin-4
19	9606.ENSP00000288861	0.590	Calcium and integrin binding family member 4
20	9606.ENSP00000483486	0.587	ADP-ribosylation factor-related protein 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005102	0.412	signaling receptor binding
GO:0019899	0.372	enzyme binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.996	regulation of cellular process
GO:0023051	0.993	regulation of signaling
GO:0010646	0.993	regulation of cell communication
GO:0048583	0.990	regulation of response to stimulus
GO:0007165	0.990	signal transduction
GO:0007166	0.965	cell surface receptor signaling pathway
GO:0007167	0.960	enzyme-linked receptor protein signaling pathway
GO:0032501	0.958	multicellular organismal process
GO:0009966	0.958	regulation of signal transduction
GO:0007169	0.946	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275	0.942	multicellular organism development
GO:0048518	0.938	positive regulation of biological process
GO:0048731	0.928	system development
GO:0048522	0.928	positive regulation of cellular process
GO:1902533	0.842	positive regulation of intracellular signal transduction
GO:0007399	0.819	nervous system development
GO:0043408	0.782	regulation of MAPK cascade
GO:0043410	0.368	positive regulation of MAPK cascade
GO:0030154	0.359	cell differentiation

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.998	cytosol
GO:0043231	0.749	intracellular membrane-bounded organelle
GO:0071944	0.379	cell periphery
GO:0005886	0.364	plasma membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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