StarFunc result for job id Q9P296

User Input

>input (337 residues)
MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVA
GKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYA
SVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHF
PARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVV
GFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLR
RSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9P296	1.000	1.000	5.300E-46	337	1.000	1.000	Q9P296.pdb.gz	C5AR2_HUMAN C5a anaphylatoxin chemotactic receptor 2 OS=Homo sapiens OX=9606 GN=C5AR2 PE=1 SV=1
2	AFDB:Q695P6	0.885	0.871	3.615E-29	343	0.602	0.592	Q695P6.pdb.gz	C5AR2_RAT C5a anaphylatoxin chemotactic receptor 2 OS=Rattus norvegicus OX=10116 GN=C5ar2 PE=1 SV=1
3	AFDB:P97520	0.822	0.789	6.290E-20	352	0.389	0.372	P97520.pdb.gz	C5AR1_RAT C5a anaphylatoxin chemotactic receptor 1 OS=Rattus norvegicus OX=10116 GN=C5ar1 PE=1 SV=1
4	AFDB:P30993	0.810	0.779	5.327E-19	351	0.374	0.359	P30993.pdb.gz	C5AR1_MOUSE C5a anaphylatoxin chemotactic receptor 1 OS=Mus musculus OX=10090 GN=C5ar1 PE=1 SV=2
5	AFDB:P21730	0.830	0.800	8.606E-19	350	0.374	0.360	P21730.pdb.gz	C5AR1_HUMAN C5a anaphylatoxin chemotactic receptor 1 OS=Homo sapiens OX=9606 GN=C5AR1 PE=1 SV=2
6	AFDB:A0A060YND6	0.811	0.782	1.353E-16	350	0.323	0.311	A0A060YND6.pdb.gz	A0A060YND6_ONCMY G-protein coupled receptors family 1 profile domain-containing protein OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00034199001 PE=3 SV=1
7	AFDB:O55197	0.738	0.533	4.239E-15	473	0.309	0.220	O55197.pdb.gz	C3AR_RAT C3a anaphylatoxin chemotactic receptor OS=Rattus norvegicus OX=10116 GN=C3ar1 PE=1 SV=1
8	AFDB:O88680	0.740	0.533	4.428E-15	475	0.294	0.208	O88680.pdb.gz	C3AR_CAVPO C3a anaphylatoxin chemotactic receptor OS=Cavia porcellus OX=10141 GN=C3AR1 PE=2 SV=1
9	AFDB:O09047	0.738	0.530	4.625E-15	477	0.323	0.229	O09047.pdb.gz	C3AR_MOUSE C3a anaphylatoxin chemotactic receptor OS=Mus musculus OX=10090 GN=C3ar1 PE=1 SV=1
10	AFDB:A0T2N3	0.731	0.688	1.376E-14	359	0.279	0.262	A0T2N3.pdb.gz	APJB_DANRE Apelin receptor B OS=Danio rerio OX=7955 GN=aplnrb PE=1 SV=1
11	PDB:6lw5A	0.699	0.561	4.425E-12	427	0.249	0.197	6lw5A.pdb.gz	Structural basis of ligand binding modes at the human formyl peptide receptor 2.
12	PDB:7wicR	0.652	0.754	1.206E-11	288	0.199	0.233	7wicR.pdb.gz	Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes.
13	PDB:7eibA	0.674	0.762	1.637E-11	295	0.220	0.251	7eibA.pdb.gz	Molecular basis for kinin selectivity and activation of the human bradykinin receptors.
14	PDB:7wvuR	0.702	0.787	4.462E-11	298	0.237	0.268	7wvuR.pdb.gz	Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
15	PDB:8ef5M	0.662	0.765	5.796E-11	288	0.172	0.201	8ef5M.pdb.gz	Molecular recognition of morphine and fentanyl by the human mu-opioid receptor.
16	PDB:7mbyR	0.693	0.814	1.580E-10	283	0.193	0.230	7mbyR.pdb.gz	Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
17	PDB:7wq3R	0.670	0.771	1.801E-10	289	0.175	0.204	7wq3R.pdb.gz	Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
18	PDB:7f1qR	0.693	0.641	2.553E-10	367	0.193	0.177	7f1qR.pdb.gz
19	PDB:7vl9R	0.693	0.767	3.039E-10	302	0.184	0.205	7vl9R.pdb.gz	Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
20	PDB:7vktA	0.698	0.811	3.464E-10	287	0.240	0.282	7vktA.pdb.gz	Structural basis of leukotriene B4 receptor 1 activation.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q9P296	0.0	669	337	1.000	1.000	C5AR2_HUMAN C5a anaphylatoxin chemotactic receptor 2 OS=Homo sapiens OX=9606 GN=C5AR2 PE=1 SV=1
2	Q695P6	8.88e-139	399	343	0.602	0.592	C5AR2_RAT C5a anaphylatoxin chemotactic receptor 2 OS=Rattus norvegicus OX=10116 GN=C5ar2 PE=1 SV=1
3	P97520	3.00e-74	234	352	0.401	0.384	C5AR1_RAT C5a anaphylatoxin chemotactic receptor 1 OS=Rattus norvegicus OX=10116 GN=C5ar1 PE=1 SV=1
4	P21730	1.28e-72	230	350	0.392	0.377	C5AR1_HUMAN C5a anaphylatoxin chemotactic receptor 1 OS=Homo sapiens OX=9606 GN=C5AR1 PE=1 SV=2
5	P30993	8.92e-70	223	351	0.398	0.382	C5AR1_MOUSE C5a anaphylatoxin chemotactic receptor 1 OS=Mus musculus OX=10090 GN=C5ar1 PE=1 SV=2
6	E7FF45	5.27e-44	157	372	0.273	0.247	E7FF45_DANRE Chemokine-like receptor 1 OS=Danio rerio OX=7955 GN=fpr1 PE=3 SV=1
7	C1BI79	9.53e-39	142	358	0.264	0.249	C1BI79_ONCMY Chemokine receptor-like 1 OS=Oncorhynchus mykiss OX=8022 GN=CML1 PE=2 SV=1
8	O88536	3.07e-37	138	351	0.291	0.279	FPR2_MOUSE Formyl peptide receptor 2 OS=Mus musculus OX=10090 GN=Fpr2 PE=1 SV=1
9	P33766	4.77e-37	138	364	0.285	0.264	FPR1_MOUSE fMet-Leu-Phe receptor OS=Mus musculus OX=10090 GN=Fpr1 PE=2 SV=1
10	D4A7Q2	5.98e-37	137	355	0.279	0.265	D4A7Q2_RAT Formyl peptide receptor 1 OS=Rattus norvegicus OX=10116 GN=Fpr1 PE=3 SV=1
11	A0A060YND6	6.76e-36	135	350	0.323	0.311	A0A060YND6_ONCMY G-protein coupled receptors family 1 profile domain-containing protein OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00034199001 PE=3 SV=1
12	Q6UNA4	6.76e-36	135	350	0.323	0.311	C5AR1_ONCMY C5a anaphylatoxin chemotactic receptor 1 OS=Oncorhynchus mykiss OX=8022 GN=c5ar1 PE=2 SV=1
13	Q99788	6.77e-36	135	373	0.309	0.279	CML1_HUMAN Chemerin-like receptor 1 OS=Homo sapiens OX=9606 GN=CMKLR1 PE=1 SV=2
14	A0A8I6AM80	2.91e-34	130	351	0.276	0.265	A0A8I6AM80_RAT Formyl peptide receptor 2 OS=Rattus norvegicus OX=10116 GN=Fpr2 PE=3 SV=1
15	O35786	4.35e-34	130	372	0.297	0.269	CML1_RAT Chemerin-like receptor 1 OS=Rattus norvegicus OX=10116 GN=Cmklr1 PE=1 SV=2
16	P25090	4.83e-34	130	351	0.291	0.279	FPR2_HUMAN N-formyl peptide receptor 2 OS=Homo sapiens OX=9606 GN=FPR2 PE=1 SV=2
17	P21462	9.98e-34	129	350	0.282	0.271	FPR1_HUMAN fMet-Leu-Phe receptor OS=Homo sapiens OX=9606 GN=FPR1 PE=1 SV=3
18	Q8K087	1.56e-33	128	353	0.303	0.289	CML2_MOUSE Chemerin-like receptor 2 OS=Mus musculus OX=10090 GN=Cmklr2 PE=2 SV=1
19	P97468	6.02e-33	127	371	0.297	0.270	CML1_MOUSE Chemerin-like receptor 1 OS=Mus musculus OX=10090 GN=Cmklr1 PE=1 SV=1
20	O88680	1.63e-32	128	475	0.181	0.128	C3AR_CAVPO C3a anaphylatoxin chemotactic receptor OS=Cavia porcellus OX=10141 GN=C3AR1 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00001 7tm_1	1.2e-21	88.8	7 transmembrane receptor (rhodopsin family)

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000472620

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000386444	0.956	S-arrestin
2	9606.ENSP00000403701	0.937	Beta-arrestin-2
3	9606.ENSP00000223642	0.898	Complement C5
4	9606.ENSP00000245907	0.898	Complement C3
5	9606.ENSP00000396688	0.808	Complement C4-A
6	9606.ENSP00000415941	0.637	Complement C4-B
7	9606.ENSP00000247153	0.575	Properdin
8	9606.ENSP00000385035	0.558	Complement C1s subcomponent
9	9606.ENSP00000363089	0.547	Toll-like receptor 4
10	9606.ENSP00000261845	0.539	Mitogen-activated protein kinase 6
11	9606.ENSP00000313875	0.532	Membrane cofactor protein
12	9606.ENSP00000343027	0.520	Guanine nucleotide-binding protein G(i) subunit alpha-1
13	9606.ENSP00000438615	0.514	Complement C1r subcomponent

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004930	1.000	G protein-coupled receptor activity
GO:0005515	0.996	protein binding
GO:0008528	0.819	G protein-coupled peptide receptor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050794	0.992	regulation of cellular process
GO:0050896	0.965	response to stimulus
GO:0002682	0.959	regulation of immune system process
GO:0048583	0.947	regulation of response to stimulus
GO:0009987	0.942	cellular process
GO:0001817	0.932	regulation of cytokine production
GO:0002688	0.918	regulation of leukocyte chemotaxis
GO:0002683	0.895	negative regulation of immune system process
GO:0032675	0.879	regulation of interleukin-6 production
GO:0048518	0.849	positive regulation of biological process
GO:0032102	0.845	negative regulation of response to external stimulus
GO:0032715	0.817	negative regulation of interleukin-6 production
GO:0040013	0.801	negative regulation of locomotion
GO:0051716	0.778	cellular response to stimulus
GO:0048584	0.741	positive regulation of response to stimulus
GO:1903555	0.720	regulation of tumor necrosis factor superfamily cytokine production
GO:0071622	0.713	regulation of granulocyte chemotaxis
GO:0007154	0.694	cell communication
GO:0023052	0.677	signaling
GO:0007165	0.611	signal transduction
GO:0048522	0.493	positive regulation of cellular process
GO:0002376	0.481	immune system process
GO:0048523	0.471	negative regulation of cellular process
GO:0002684	0.458	positive regulation of immune system process
GO:0007186	0.448	G protein-coupled receptor signaling pathway
GO:0032677	0.391	regulation of interleukin-8 production
GO:0006955	0.347	immune response
GO:0009605	0.324	response to external stimulus
GO:0030336	0.310	negative regulation of cell migration

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0043227	0.815	membrane-bounded organelle
GO:0005622	0.600	intracellular anatomical structure
GO:0043231	0.533	intracellular membrane-bounded organelle
GO:0045177	0.396	apical part of cell
GO:0045178	0.313	basal part of cell
GO:0098590	0.313	plasma membrane region

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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