StarFunc result for job id Q9P2M7

User Input

>input (1197 residues)
MAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGIAGQPFV
VLNSGEKGGDSFGVQIKGANDQGASGALSSDLELPENPYSQVKGFPAPSQSSTSDEEPGA
YWNGKLLRSHSQASLAGPGPVDPSNRSNSMLELAPKVASPGSTIDTAPLSSVDSLINKFD
SQLGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVG
TSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAA
PPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTR
KVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQN
MKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV
EEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAE
RQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEK
IEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQL
AVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLR
ETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQE
EEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRL
LDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSG
GLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKG
LEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQ
NKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELS
IQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQ
ARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESNLQTSSC

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:B9EK46	0.208	0.207	0.000	1203	0.999	0.994	B9EK46.pdb.gz	B9EK46_HUMAN Cingulin OS=Homo sapiens OX=9606 GN=CGN PE=1 SV=1
2	AFDB:P59242	0.306	0.306	0.000	1191	0.867	0.872	P59242.pdb.gz	CING_MOUSE Cingulin OS=Mus musculus OX=10090 GN=Cgn PE=1 SV=1
3	AFDB:Q9PTD7	0.125	0.113	4.069E-53	1360	0.512	0.451	Q9PTD7.pdb.gz	CING_XENLA Cingulin OS=Xenopus laevis OX=8355 GN=cgn PE=1 SV=3
4	AFDB:Q0VF96	0.118	0.109	1.469E-27	1302	0.312	0.287	Q0VF96.pdb.gz	CGNL1_HUMAN Cingulin-like protein 1 OS=Homo sapiens OX=9606 GN=CGNL1 PE=1 SV=2
5	AFDB:Q6AW69	0.114	0.106	4.435E-26	1298	0.302	0.278	Q6AW69.pdb.gz	CGNL1_MOUSE Cingulin-like protein 1 OS=Mus musculus OX=10090 GN=Cgnl1 PE=1 SV=3
6	AFDB:Q61595	0.079	0.072	2.094E-8	1327	0.158	0.142	Q61595.pdb.gz	KTN1_MOUSE Kinectin OS=Mus musculus OX=10090 GN=Ktn1 PE=1 SV=1
7	AFDB:Q86UP2	0.073	0.066	2.216E-7	1357	0.158	0.139	Q86UP2.pdb.gz	KTN1_HUMAN Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1
8	AFDB:Q8TES7	0.114	0.119	6.322E-7	1133	0.125	0.132	Q8TES7.pdb.gz	FBF1_HUMAN Fas-binding factor 1 OS=Homo sapiens OX=9606 GN=FBF1 PE=1 SV=2
9	AFDB:Q62036	0.079	0.088	7.207E-7	1060	0.150	0.170	Q62036.pdb.gz	CP131_MOUSE Centrosomal protein of 131 kDa OS=Mus musculus OX=10090 GN=Cep131 PE=1 SV=2
10	AFDB:Q6ZQ06	0.089	0.078	8.773E-7	1403	0.160	0.136	Q6ZQ06.pdb.gz	CE162_MOUSE Centrosomal protein of 162 kDa OS=Mus musculus OX=10090 GN=Cep162 PE=1 SV=2
11	PDB:7dcoL	0.052	0.113	1.945	435	0.025	0.069	7dcoL.pdb.gz	Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
12	PDB:5gm6c	0.036	0.093	2.528	415	0.026	0.075	5gm6c.pdb.gz	Structure of a yeast activated spliceosome at 3.5 angstrom resolution
13	PDB:5gmkc	0.036	0.089	2.528	436	0.026	0.071	5gmkc.pdb.gz	Structure of a yeast catalytic step I spliceosome at 3.4 angstrom resolution
14	PDB:2rvqD	0.034	0.205	5.198	129	0.009	0.085	2rvqD.pdb.gz
15	PDB:6yl2B	0.035	0.183	5.198	192	0.009	0.057	6yl2B.pdb.gz	Structural and DNA binding studies of the transcriptional repressor Rv2506 (BkaR) from Mycobacterium tuberculosis supports a role in L-Leucine catabolism
16	PDB:7lbmt	0.038	0.257	5.550	116	0.019	0.198	7lbmt.pdb.gz	Structure of the human Mediator-bound transcription preinitiation complex.
17	PDB:4v6xCR	0.033	0.145	5.926	189	0.016	0.101	4v6xCR.pdb.gz	Structures of the human and Drosophila 80S ribosome.
18	PDB:6yxxAf	0.028	0.178	6.328	139	0.013	0.115	6yxxAf.pdb.gz	Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis.
19	PDB:7l08AS	0.035	0.250	6.328	135	0.013	0.111	7l08AS.pdb.gz	Distinct mechanisms of the human mitoribosome recycling and antibiotic resistance.
20	PDB:7pntS	0.039	0.279	6.328	136	0.011	0.096	7pntS.pdb.gz	Mechanism of mitoribosomal small subunit biogenesis and preinitiation.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	B9EK46	0.0	2355	1203	0.999	0.994	B9EK46_HUMAN Cingulin OS=Homo sapiens OX=9606 GN=CGN PE=1 SV=1
2	P59242	0.0	1887	1191	0.865	0.870	CING_MOUSE Cingulin OS=Mus musculus OX=10090 GN=Cgn PE=1 SV=1
3	Q9P2M7	0.0	2358	1203	1.000	0.995	CING_HUMAN Cingulin OS=Homo sapiens OX=9606 GN=CGN PE=1 SV=3
4	Q9PTD7	0.0	687	1368	0.440	0.385	CING_XENLA Cingulin OS=Xenopus laevis OX=8355 GN=cgn PE=1 SV=3
5	Q0VF96	2.07e-110	378	1302	0.220	0.202	CGNL1_HUMAN Cingulin-like protein 1 OS=Homo sapiens OX=9606 GN=CGNL1 PE=1 SV=2
6	Q6AW69	3.51e-102	354	1297	0.211	0.194	CGNL1_MOUSE Cingulin-like protein 1 OS=Mus musculus OX=10090 GN=Cgnl1 PE=1 SV=3
7	H0Y4A8	5.47e-77	251	131	0.109	0.992	H0Y4A8_HUMAN Cingulin (Fragment) OS=Homo sapiens OX=9606 GN=CGN PE=1 SV=1
8	P10587	9.79e-30	131	1979	0.126	0.076	MYH11_CHICK Myosin-11 OS=Gallus gallus OX=9031 GN=MYH11 PE=1 SV=4
9	Q99323	2.40e-29	130	2057	0.142	0.083	MYSN_DROME Myosin heavy chain, non-muscle OS=Drosophila melanogaster OX=7227 GN=zip PE=1 SV=2
10	G3V9Y1	3.69e-24	113	1986	0.213	0.128	G3V9Y1_RAT Myosin heavy chain 10 OS=Rattus norvegicus OX=10116 GN=Myh10 PE=1 SV=2
11	Q9JLT0	4.75e-24	112	1976	0.213	0.129	MYH10_RAT Myosin-10 OS=Rattus norvegicus OX=10116 GN=Myh10 PE=1 SV=1
12	Q61879	6.44e-24	112	1976	0.213	0.129	MYH10_MOUSE Myosin-10 OS=Mus musculus OX=10090 GN=Myh10 PE=1 SV=2
13	F1R3G4	8.26e-24	112	1992	0.214	0.129	F1R3G4_DANRE Myosin, heavy chain 10, non-muscle OS=Danio rerio OX=7955 GN=myh10 PE=1 SV=1
14	I3ISA3	8.98e-24	111	1986	0.214	0.129	I3ISA3_DANRE Myosin, heavy chain 10, non-muscle OS=Danio rerio OX=7955 GN=myh10 PE=1 SV=1
15	P35580	1.02e-23	111	1976	0.117	0.071	MYH10_HUMAN Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3
16	Q4U0S2	4.63e-23	109	1974	0.127	0.077	Q4U0S2_DANRE Myosin-11 OS=Danio rerio OX=7955 GN=myh11 PE=1 SV=1
17	A6QLN6	5.92e-23	108	1972	0.114	0.069	A6QLN6_BOVIN MYH11 protein OS=Bos taurus OX=9913 GN=MYH11 PE=1 SV=1
18	P35579	4.21e-21	103	1960	0.118	0.072	MYH9_HUMAN Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4
19	Q258K2	7.54e-21	102	1960	0.117	0.071	MYH9_CANLF Myosin-9 OS=Canis lupus familiaris OX=9615 GN=MYH9 PE=2 SV=1
20	Q8VDD5	2.66e-20	100	1960	0.109	0.067	MYH9_MOUSE Myosin-9 OS=Mus musculus OX=10090 GN=Myh9 PE=1 SV=4

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF11559 ADIP	3	19.4	Afadin- and alpha -actinin-Binding
2	PF07889 DUF1664	3.1	19.3	Protein of unknown function (DUF1664)
3	PF01576 Myosin_tail_1	5.6e-32	122.3	Myosin tail
4	PF18595 Nuf2_DHR10-like	1.1	20.7	Nuf2, DHR10-like domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000271636

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000281537	0.999	Tight junction protein ZO-1
2	9606.ENSP00000354837	0.996	Rho guanine nucleotide exchange factor 2
3	9606.ENSP00000357005	0.970	Junctional adhesion molecule A
4	9606.ENSP00000352995	0.964	Rho guanine nucleotide exchange factor 18
5	9606.ENSP00000438262	0.959	Tight junction protein ZO-2
6	9606.ENSP00000465419	0.958	Tight junction protein ZO-3
7	9606.ENSP00000347379	0.948	Occludin
8	9606.ENSP00000400175	0.928	Transforming protein RhoA
9	9606.ENSP00000471635	0.924	Uncharacterized protein
10	9606.ENSP00000334458	0.817	Transcription factor GATA-4
11	9606.ENSP00000375960	0.815	Afadin
12	9606.ENSP00000245934	0.809	Symplekin
13	9606.ENSP00000404190	0.799	Rac GTPase-activating protein 1
14	9606.ENSP00000317985	0.783	Rho-associated protein kinase 2
15	9606.ENSP00000376204	0.766	Histone-lysine N-methyltransferase ASH1L
16	9606.ENSP00000363921	0.753	Partitioning defective 3 homolog
17	9606.ENSP00000323264	0.726	MARVEL domain-containing protein 2
18	9606.ENSP00000367830	0.721	Protein kinase C zeta type
19	9606.ENSP00000219255	0.702	Partitioning defective 6 homolog alpha
20	9606.ENSP00000261769	0.697	Cadherin-1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0008092	0.840	cytoskeletal protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0045216	0.995	cell-cell junction organization
GO:0022607	0.987	cellular component assembly
GO:0032502	0.977	developmental process
GO:0048856	0.973	anatomical structure development
GO:0007043	0.958	cell-cell junction assembly
GO:0043297	0.945	apical junction assembly
GO:0007010	0.927	cytoskeleton organization
GO:0030154	0.923	cell differentiation
GO:0120193	0.899	tight junction organization
GO:0065007	0.873	biological regulation
GO:0009888	0.867	tissue development
GO:0060429	0.857	epithelium development
GO:0050789	0.852	regulation of biological process
GO:0050794	0.834	regulation of cellular process
GO:0009653	0.805	anatomical structure morphogenesis
GO:0030855	0.649	epithelial cell differentiation
GO:0048468	0.599	cell development
GO:0050896	0.590	response to stimulus
GO:0048518	0.584	positive regulation of biological process
GO:0048522	0.568	positive regulation of cellular process
GO:0032501	0.516	multicellular organismal process
GO:0002064	0.508	epithelial cell development
GO:0007017	0.502	microtubule-based process
GO:0120192	0.497	tight junction assembly
GO:0051179	0.426	localization
GO:0000902	0.376	cell morphogenesis
GO:0000904	0.374	cell morphogenesis involved in differentiation
GO:0051716	0.361	cellular response to stimulus
GO:0000226	0.359	microtubule cytoskeleton organization
GO:0003382	0.335	epithelial cell morphogenesis
GO:0051128	0.310	regulation of cellular component organization
GO:0007165	0.305	signal transduction

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005923	0.999	bicellular tight junction
GO:0005886	0.997	plasma membrane
GO:0005829	0.942	cytosol
GO:0043226	0.941	organelle
GO:0043227	0.821	membrane-bounded organelle
GO:0043229	0.733	intracellular organelle
GO:0043231	0.661	intracellular membrane-bounded organelle
GO:0032991	0.460	protein-containing complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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