StarFunc result for job id Q9P2R7

User Input

>input (463 residues)
MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMS
MELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVK
IVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGP
VLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENM
VKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDER
DKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEA
FKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKALI
ADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A2R8Y6Y7	0.916	0.876	3.924E-88	484	0.998	0.955	A0A2R8Y6Y7.pdb.gz	A0A2R8Y6Y7_HUMAN Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=1
2	AFDB:E5KS60	0.899	0.899	7.718E-88	463	1.000	1.000	E5KS60.pdb.gz	E5KS60_HUMAN Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=1
3	AFDB:F1LM47	0.906	0.902	4.030E-85	465	0.892	0.888	F1LM47.pdb.gz	F1LM47_RAT Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Rattus norvegicus OX=10116 GN=Sucla2 PE=1 SV=1
4	AFDB:Q95U38	0.901	0.830	1.546E-66	503	0.542	0.499	Q95U38.pdb.gz	Q95U38_DROME Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Drosophila melanogaster OX=7227 GN=ScsbetaA PE=1 SV=1
5	AFDB:P53588	0.911	0.969	4.266E-66	435	0.566	0.602	P53588.pdb.gz	SUCB1_CAEEL Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Caenorhabditis elegans OX=6239 GN=suca-1 PE=3 SV=1
6	AFDB:O94415	0.890	0.950	4.421E-62	433	0.501	0.536	O94415.pdb.gz	SUCB_SCHPO Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC1620.08 PE=3 SV=1
7	AFDB:B1H270	0.830	0.884	3.088E-58	434	0.464	0.495	B1H270.pdb.gz	B1H270_RAT Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Rattus norvegicus OX=10116 GN=Suclg2 PE=2 SV=1
8	AFDB:P53312	0.836	0.905	5.129E-58	427	0.421	0.457	P53312.pdb.gz	SUCB_YEAST Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=LSC2 PE=1 SV=1
9	AFDB:O82662	0.827	0.908	6.074E-58	421	0.458	0.504	O82662.pdb.gz	SUCB_ARATH Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=At2g20420 PE=1 SV=1
10	AFDB:Q84LB6	0.843	0.935	1.984E-57	417	0.454	0.504	Q84LB6.pdb.gz	SUCB_SOLLC Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Solanum lycopersicum OX=4081 PE=1 SV=1
11	PDB:1eudB	0.789	0.919	3.055E-54	395	0.451	0.529	1eudB.pdb.gz
12	PDB:1jkjB	0.816	0.970	3.783E-49	388	0.393	0.469	1jkjB.pdb.gz	Two glutamate residues, Glu 208 alpha and Glu 197 beta, are crucial for phosphorylation and dephosphorylation of the active-site histidine residue in succinyl-CoA synthetase.
13	PDB:7jmkD	0.727	0.942	6.210E-44	354	0.410	0.537	7jmkD.pdb.gz	Second distinct conformation of the phosphohistidine loop in succinyl-CoA synthetase
14	PDB:6qfbC	0.658	0.322	1.011E-20	1011	0.177	0.081	6qfbC.pdb.gz	Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
15	PDB:6qfbB	0.652	0.314	1.132E-20	1035	0.184	0.082	6qfbB.pdb.gz	Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
16	PDB:3vpbB	0.269	0.419	3.343E-6	282	0.065	0.106	3vpbB.pdb.gz	Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus
17	PDB:4c5aA	0.263	0.379	1.715E-5	306	0.089	0.134	4c5aA.pdb.gz	Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.
18	PDB:7aleA	0.172	0.186	2.149E-5	419	0.091	0.100	7aleA.pdb.gz	Cellular and biochemical validation of a potent PAICS inhibitor
19	PDB:1bxrA	0.271	0.128	2.405E-5	1073	0.102	0.044	1bxrA.pdb.gz	Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding.
20	PDB:3lwbB	0.268	0.392	3.776E-5	298	0.069	0.107	3lwbB.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A2R8Y6Y7	0.0	933	484	0.998	0.955	A0A2R8Y6Y7_HUMAN Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=1
2	A0A2R8YDQ9	0.0	824	405	0.875	1.000	A0A2R8YDQ9_HUMAN Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=1
3	A0A8I6A1U8	0.0	796	458	0.844	0.854	A0A8I6A1U8_RAT Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Rattus norvegicus OX=10116 GN=Sucla2 PE=1 SV=1
4	B2RZ24	0.0	802	438	0.855	0.904	B2RZ24_RAT Succinate-CoA ligase subunit beta (Fragment) OS=Rattus norvegicus OX=10116 GN=Sucla2 PE=2 SV=1
5	E5KS60	0.0	947	463	1.000	1.000	E5KS60_HUMAN Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=1
6	F1LM47	0.0	840	465	0.892	0.888	F1LM47_RAT Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Rattus norvegicus OX=10116 GN=Sucla2 PE=1 SV=1
7	P53588	0.0	532	435	0.564	0.600	SUCB1_CAEEL Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Caenorhabditis elegans OX=6239 GN=suca-1 PE=3 SV=1
8	Q5T9Q5	0.0	574	298	0.605	0.940	Q5T9Q5_HUMAN Succinate-CoA ligase ADP-forming subunit beta (Fragment) OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=1
9	Q9P2R7	0.0	947	463	1.000	1.000	SUCB1_HUMAN Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=3
10	Q9Z2I9	0.0	856	463	0.911	0.911	SUCB1_MOUSE Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Sucla2 PE=1 SV=2
11	A0A0B4JCW4	5.54e-180	513	451	0.533	0.548	A0A0B4JCW4_DROME Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Drosophila melanogaster OX=7227 GN=ScsbetaA PE=1 SV=1
12	A0A126GUR6	1.64e-179	511	452	0.536	0.549	A0A126GUR6_DROME Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Drosophila melanogaster OX=7227 GN=ScsbetaA PE=1 SV=1
13	Q9VHJ8	6.37e-179	512	502	0.533	0.492	Q9VHJ8_DROME Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Drosophila melanogaster OX=7227 GN=ScsbetaA PE=1 SV=2
14	Q95U38	3.46e-178	510	503	0.536	0.493	Q95U38_DROME Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Drosophila melanogaster OX=7227 GN=ScsbetaA PE=1 SV=1
15	O94415	1.04e-164	473	433	0.495	0.529	SUCB_SCHPO Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC1620.08 PE=3 SV=1
16	A0A2R8Y6E6	2.62e-160	454	224	0.477	0.987	A0A2R8Y6E6_HUMAN Succinate-CoA ligase ADP-forming subunit beta OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=1
17	A0A2R8Y5P6	3.23e-160	453	221	0.477	1.000	A0A2R8Y5P6_HUMAN Succinate-CoA ligase ADP-forming subunit beta OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=1
18	Q84LB6	5.02e-146	425	417	0.458	0.508	SUCB_SOLLC Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Solanum lycopersicum OX=4081 PE=1 SV=1
19	O82662	7.75e-145	422	421	0.462	0.508	SUCB_ARATH Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=At2g20420 PE=1 SV=1
20	P53590	7.19e-143	417	433	0.460	0.492	SUCB2_PIG Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (Fragment) OS=Sus scrofa OX=9823 GN=SUCLG2 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF08442 ATP-grasp_2	2.2e-71	251.2	ATP-grasp domain
2	PF13549 ATP-grasp_5	5.5e-07	40.8	ATP-grasp domain
3	PF08716 CoV_NSP7	2.7e+02	13.6	Coronavirus replicase NSP7
4	PF02786 CPSase_L_D2	16	16.5	Carbamoyl-phosphate synthase L chain, ATP binding domain
5	PF01071 GARS_A	29	15.9	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
6	PF00549 Ligase_CoA	1.3e-23	95.0	CoA-ligase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000367923

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000377446	0.999	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
2	9606.ENSP00000264932	0.995	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
3	9606.ENSP00000335304	0.995	Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
4	9606.ENSP00000299518	0.994	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
5	9606.ENSP00000364649	0.986	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
6	9606.ENSP00000205402	0.982	Dihydrolipoyl dehydrogenase, mitochondrial
7	9606.ENSP00000280346	0.974	Dihydrolipoamide S-acetyltransferase
8	9606.ENSP00000356953	0.968	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
9	9606.ENSP00000364699	0.961	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
10	9606.ENSP00000222673	0.957	2-oxoglutarate dehydrogenase, mitochondrial
11	9606.ENSP00000274813	0.948	Methylmalonyl-CoA mutase, mitochondrial
12	9606.ENSP00000307241	0.939	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
13	9606.ENSP00000392709	0.934	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
14	9606.ENSP00000356972	0.927	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
15	9606.ENSP00000216254	0.920	Aconitate hydratase, mitochondrial
16	9606.ENSP00000363216	0.904	2-oxoglutarate dehydrogenase-like, mitochondrial
17	9606.ENSP00000332369	0.900	5-aminolevulinate synthase, erythroid-specific, mitochondrial
18	9606.ENSP00000370223	0.885	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
19	9606.ENSP00000355518	0.883	Fumarate hydratase, mitochondrial
20	9606.ENSP00000306397	0.880	Cytochrome b-c1 complex subunit Rieske, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004774	1.000	succinate-CoA ligase activity
GO:0005515	0.995	protein binding
GO:0004775	0.842	succinate-CoA ligase (ADP-forming) activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.998	organic substance metabolic process
GO:0044238	0.998	primary metabolic process
GO:0044237	0.998	cellular metabolic process
GO:0006807	0.996	nitrogen compound metabolic process
GO:0006637	0.993	acyl-CoA metabolic process
GO:0043648	0.941	dicarboxylic acid metabolic process
GO:0006091	0.927	generation of precursor metabolites and energy
GO:0009060	0.903	aerobic respiration
GO:0006099	0.804	tricarboxylic acid cycle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	0.999	mitochondrion
GO:0070013	0.965	intracellular organelle lumen
GO:0016020	0.413	membrane
GO:0032991	0.389	protein-containing complex
GO:0005759	0.363	mitochondrial matrix

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:6.2.1.-	1.000	Acid--thiol ligases.
RHEA:17661	0.842	ATP + CoA + succinate = ADP + phosphate + succinyl-CoA
EC:6.2.1.5	0.842	succinate--CoA ligase (ADP-forming).

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