StarFunc result for job id Q9Y252

User Input

>input (685 residues)
MNQSRSRSDGGSEETLPQDHNHHENERRWQQERLHREEAYYQFINELNDEDYRLMRDHNL
LGTPGEITSEELQQRLDGVKEQLASQPDLRDGTNYRDSEVPRESSHEDSLLEWLNTFRRT
GNATRSGQNGNQTWRAVSRTNPNNGEFRFSLEIHVNHENRGFEIHGEDYTDIPLSDSNRD
HTANRQQRSTSPVARRTRSQTSVNFNGSSSNIPRTRLASRGQNPAEGSFSTLGRLRNGIG
GAAGIPRANASRTNFSSHTNQSGGSELRQREGQRFGAAHVWENGARSNVTVRNTNQRLEP
IRLRSTSNSRSRSPIQRQSGTVYHNSQRESRPVQQTTRRSVRRRGRTRVFLEQDRERERR
GTAYTPFSNSRLVSRITVEEGEESSRSSTAVRRHPTITLDLQVRRIRPGENRDRDSIANR
TRSRVGLAENTVTIESNSGGFRRTISRLERSGIRTYVSTITVPLRRISENELVEPSSVAL
RSILRQIMTGFGELSSLMEADSESELQRNGQHLPDMHSELSNLGTDNNRSQHREGSSQDR
QAQGDSTEMHGENETTQPHTRNSDSRGGRQLRNPNNLVETGTLPILRLAHFFLLNESDDD
DRIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVCISDYVTGNKLRQLPCMHEFHIHCID
RWLSENCTCPICRQPVLGSNIANNG

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A024RDP2	0.500	0.500	9.867E-99	685	1.000	1.000	A0A024RDP2.pdb.gz	A0A024RDP2_HUMAN Ring finger protein 6 isoform 1 (Fragment) OS=Homo sapiens OX=9606 GN=RNF6 PE=2 SV=1
2	AFDB:Q8SX72	0.115	0.092	1.233E-8	868	0.175	0.138	Q8SX72.pdb.gz	Q8SX72_DROME LD30050p OS=Drosophila melanogaster OX=7227 GN=mura PE=2 SV=1
3	AFDB:O49500	0.115	0.118	1.196E-5	666	0.158	0.162	O49500.pdb.gz	MBR2_ARATH E3 ubiquitin-protein ligase MBR2 OS=Arabidopsis thaliana OX=3702 GN=MBR2 PE=1 SV=1
4	AFDB:Q9ZQF9	0.111	0.108	1.713E-5	704	0.137	0.134	Q9ZQF9.pdb.gz	MBR1_ARATH E3 ubiquitin-protein ligase MBR1 OS=Arabidopsis thaliana OX=3702 GN=MBR1 PE=1 SV=1
5	AFDB:Q7XTV7	0.109	0.112	3.115E-5	667	0.174	0.178	Q7XTV7.pdb.gz	HIP1_ORYSJ Probable E3 ubiquitin-protein ligase HIP1 OS=Oryza sativa subsp. japonica OX=39947 GN=HIP1 PE=1 SV=2
6	AFDB:A1Z971	0.082	0.081	8.606E-3	700	0.149	0.146	A1Z971.pdb.gz	A1Z971_DROME Uncharacterized protein, isoform A OS=Drosophila melanogaster OX=7227 GN=dRNF34 PE=1 SV=1
7	AFDB:Q920B0	0.062	0.043	5.176E-2	1035	0.114	0.075	Q920B0.pdb.gz	FRM4B_MOUSE FERM domain-containing protein 4B OS=Mus musculus OX=10090 GN=Frmd4b PE=1 SV=2
8	AFDB:A5H447	0.052	0.054	7.410E-2	663	0.105	0.109	A5H447.pdb.gz	ZYX_XENLA Zyxin OS=Xenopus laevis OX=8355 GN=zyx PE=1 SV=1
9	PDB:6b1uA	0.049	0.067	8.819E-2	442	0.025	0.038	6b1uA.pdb.gz	Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4.
10	AFDB:Q387G7	0.057	0.048	9.992E-2	835	0.102	0.084	Q387G7.pdb.gz	Q387G7_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.03.0310 PE=4 SV=1
11	AFDB:Q9Y3M8	0.058	0.041	1.269E-1	1113	0.102	0.063	Q9Y3M8.pdb.gz	STA13_HUMAN StAR-related lipid transfer protein 13 OS=Homo sapiens OX=9606 GN=STARD13 PE=1 SV=2
12	PDB:2lgvA	0.060	0.386	1.703E-1	100	0.026	0.180	2lgvA.pdb.gz	Selective recruitment of an e2~ubiquitin complex by an e3 ubiquitin ligase.
13	PDB:7oniR	0.071	0.480	1.919E-1	86	0.025	0.198	7oniR.pdb.gz	CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
14	PDB:7myjC	0.047	0.067	2.037E-1	465	0.035	0.052	7myjC.pdb.gz	Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator.
15	PDB:4zhxA	0.055	0.085	2.163E-1	409	0.020	0.034	4zhxA.pdb.gz	Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.
16	PDB:5gm6a	0.064	0.323	2.163E-1	123	0.022	0.122	5gm6a.pdb.gz	Structure of a yeast activated spliceosome at 3.5 angstrom resolution
17	PDB:4a0cF	0.064	0.493	3.287E-1	80	0.022	0.188	4a0cF.pdb.gz	The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation
18	PDB:7pubCI	0.065	0.094	5.978E-1	427	0.038	0.061	7pubCI.pdb.gz	Mitoribosomal small subunit maturation involves formation of initiation-like complexes.
19	PDB:5o9zp	0.044	0.269	7.593E-1	73	0.007	0.068	5o9zp.pdb.gz	Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
20	PDB:4akrB	0.052	0.124	9.085E-1	245	0.009	0.024	4akrB.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A024RDP2	0.0	1385	685	1.000	1.000	A0A024RDP2_HUMAN Ring finger protein 6 isoform 1 (Fragment) OS=Homo sapiens OX=9606 GN=RNF6 PE=2 SV=1
2	Q9DBU5	0.0	930	667	0.731	0.751	RNF6_MOUSE E3 ubiquitin-protein ligase RNF6 OS=Mus musculus OX=10090 GN=Rnf6 PE=1 SV=1
3	Q9Y252	0.0	1385	685	1.000	1.000	RNF6_HUMAN E3 ubiquitin-protein ligase RNF6 OS=Homo sapiens OX=9606 GN=RNF6 PE=1 SV=1
4	A0A0S2Z4G9	1.02e-91	284	176	0.200	0.778	A0A0S2Z4G9_HUMAN Ring finger protein 6 isoform 2 OS=Homo sapiens OX=9606 GN=RNF6 PE=1 SV=1
5	E7FH41	4.46e-88	290	638	0.235	0.252	E7FH41_DANRE E3 ubiquitin-protein ligase RLIM OS=Danio rerio OX=7955 GN=rlim PE=1 SV=2
6	Q641J8	3.82e-87	287	622	0.223	0.246	RF12A_XENLA E3 ubiquitin-protein ligase RNF12-A OS=Xenopus laevis OX=8355 GN=rnf12-a PE=1 SV=1
7	Q9WTV7	2.14e-83	277	600	0.223	0.255	RNF12_MOUSE E3 ubiquitin-protein ligase RLIM OS=Mus musculus OX=10090 GN=Rlim PE=1 SV=2
8	Q9NVW2	2.29e-40	159	624	0.115	0.127	RNF12_HUMAN E3 ubiquitin-protein ligase RLIM OS=Homo sapiens OX=9606 GN=RLIM PE=1 SV=3
9	Q7X843	1.84e-15	80.5	349	0.058	0.115	ATL48_ARATH RING-H2 finger protein ATL48 OS=Arabidopsis thaliana OX=3702 GN=ATL48 PE=1 SV=2
10	Q7L0R7	5.10e-15	80.1	432	0.055	0.088	RNF44_HUMAN RING finger protein 44 OS=Homo sapiens OX=9606 GN=RNF44 PE=1 SV=1
11	Q9H0F5	4.46e-14	77.8	515	0.053	0.070	RNF38_HUMAN E3 ubiquitin-protein ligase RNF38 OS=Homo sapiens OX=9606 GN=RNF38 PE=1 SV=4
12	A0A8I5ZJ72	1.07e-13	76.6	577	0.051	0.061	A0A8I5ZJ72_RAT Ring finger protein 38 OS=Rattus norvegicus OX=10116 GN=Rnf38 PE=4 SV=1
13	Q9H6Y7	2.20e-13	74.3	350	0.063	0.123	RN167_HUMAN E3 ubiquitin-protein ligase RNF167 OS=Homo sapiens OX=9606 GN=RNF167 PE=1 SV=1
14	A0A8I5XVZ9	3.05e-13	75.1	526	0.051	0.067	A0A8I5XVZ9_RAT Ring finger protein 38 OS=Rattus norvegicus OX=10116 GN=Rnf38 PE=4 SV=1
15	A0A8I5ZQX4	3.11e-13	75.1	514	0.051	0.068	A0A8I5ZQX4_RAT Ring finger protein 38 OS=Rattus norvegicus OX=10116 GN=Rnf38 PE=4 SV=1
16	Q5XIX1	3.62e-13	74.3	432	0.051	0.081	Q5XIX1_RAT Ring finger protein 38 OS=Rattus norvegicus OX=10116 GN=Rnf38 PE=4 SV=1
17	A0A0G2K236	4.83e-13	74.7	573	0.051	0.061	A0A0G2K236_RAT Ring finger protein 38 OS=Rattus norvegicus OX=10116 GN=Rnf38 PE=4 SV=1
18	A0A0G2K8H9	5.08e-13	74.7	623	0.051	0.056	A0A0G2K8H9_RAT Ring finger protein 38 OS=Rattus norvegicus OX=10116 GN=Rnf38 PE=4 SV=1
19	Q8R4E3	6.62e-13	73.6	432	0.051	0.081	Q8R4E3_RAT RING finger protein OIP1 OS=Rattus norvegicus OX=10116 GN=Rnf38 PE=2 SV=1
20	Q8SX72	6.80e-13	74.7	868	0.053	0.041	Q8SX72_DROME LD30050p OS=Drosophila melanogaster OX=7227 GN=mura PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF12861 zf-ANAPC11	0.11	23.9	Anaphase-promoting complex subunit 11 RING-H2 finger
2	PF00097 zf-C3HC4	0.016	26.4	Zinc finger, C3HC4 type (RING finger)
3	PF13923 zf-C3HC4_2	0.058	24.5	Zinc finger, C3HC4 type (RING finger)
4	PF13920 zf-C3HC4_3	2.3	19.5	Zinc finger, C3HC4 type (RING finger)
5	PF12678 zf-rbx1	6.5e-05	34.4	RING-H2 zinc finger domain
6	PF17123 zf-RING_11	0.0013	29.7	RING-like zinc finger
7	PF13639 zf-RING_2	1.7e-07	42.8	Ring finger domain
8	PF14634 zf-RING_5	8.9	17.7	zinc-RING finger domain
9	PF13445 zf-RING_UBOX	72	14.9	RING-type zinc-finger

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000371000

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000371070	0.835	Phospholipid-transporting ATPase IB
2	9606.ENSP00000363822	0.779	Androgen receptor
3	9606.ENSP00000370981	0.726	Leucine zipper putative tumor suppressor 1
4	9606.ENSP00000308597	0.722	Deleted in lung and esophageal cancer protein 1
5	9606.ENSP00000357691	0.720	Protein S100-A14
6	9606.ENSP00000378028	0.683	E3 ubiquitin-protein ligase RNF14
7	9606.ENSP00000452871	0.664	Transducin-like enhancer protein 3
8	9606.ENSP00000336740	0.595	LIM domain kinase 1
9	9606.ENSP00000322457	0.559	E3 ubiquitin-protein ligase SIAH2
10	9606.ENSP00000306606	0.551	Alcohol dehydrogenase 1B, beta polypeptide
11	9606.ENSP00000323527	0.532	Muskelin
12	9606.ENSP00000219548	0.524	E3 ubiquitin-protein ligase CHIP
13	9606.ENSP00000240488	0.522	Meiotic nuclear division protein 1 homolog
14	9606.ENSP00000377504	0.514	Zinc finger protein 414
15	9606.ENSP00000282344	0.511	Ubiquitin carboxyl-terminal hydrolase 12
16	9606.ENSP00000275162	0.506	Clavesin-2
17	9606.ENSP00000365961	0.505	F-box only protein 44

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004842	1.000	ubiquitin-protein transferase activity
GO:0061629	0.999	RNA polymerase II-specific DNA-binding transcription factor binding
GO:0050681	0.991	nuclear androgen receptor binding
GO:0061659	0.761	ubiquitin-like protein ligase activity
GO:0061630	0.631	ubiquitin protein ligase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0016567	0.992	protein ubiquitination
GO:0060255	0.990	regulation of macromolecule metabolic process
GO:0031323	0.986	regulation of cellular metabolic process
GO:0080090	0.981	regulation of primary metabolic process
GO:0051171	0.981	regulation of nitrogen compound metabolic process
GO:0048583	0.978	regulation of response to stimulus
GO:0009893	0.976	positive regulation of metabolic process
GO:0009966	0.969	regulation of signal transduction
GO:0010468	0.957	regulation of gene expression
GO:0000209	0.931	protein polyubiquitination
GO:0010604	0.913	positive regulation of macromolecule metabolic process
GO:0048522	0.882	positive regulation of cellular process
GO:0033143	0.880	regulation of intracellular steroid hormone receptor signaling pathway
GO:0051173	0.875	positive regulation of nitrogen compound metabolic process
GO:0019219	0.861	regulation of nucleobase-containing compound metabolic process
GO:0009889	0.857	regulation of biosynthetic process
GO:0009987	0.855	cellular process
GO:0031326	0.841	regulation of cellular biosynthetic process
GO:2001141	0.832	regulation of RNA biosynthetic process
GO:1903506	0.729	regulation of nucleic acid-templated transcription
GO:0031325	0.715	positive regulation of cellular metabolic process
GO:0044237	0.638	cellular metabolic process
GO:0006355	0.597	regulation of DNA-templated transcription
GO:0006508	0.498	proteolysis
GO:0043632	0.473	modification-dependent macromolecule catabolic process
GO:0045935	0.459	positive regulation of nucleobase-containing compound metabolic process
GO:1903508	0.387	positive regulation of nucleic acid-templated transcription
GO:0045893	0.372	positive regulation of DNA-templated transcription
GO:0019941	0.360	modification-dependent protein catabolic process
GO:0006511	0.353	ubiquitin-dependent protein catabolic process
GO:0048519	0.316	negative regulation of biological process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005634	1.000	nucleus
GO:0012505	0.999	endomembrane system
GO:0016020	0.997	membrane
GO:0031975	0.991	envelope
GO:0031967	0.980	organelle envelope
GO:0005737	0.979	cytoplasm
GO:0005635	0.968	nuclear envelope
GO:0031965	0.958	nuclear membrane
GO:0070013	0.948	intracellular organelle lumen
GO:0031981	0.926	nuclear lumen
GO:0005654	0.924	nucleoplasm
GO:0005829	0.905	cytosol
GO:0032991	0.369	protein-containing complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.-.-.-	1.000	Transferases.

[back to server]