StarFunc result for job id Q9Y584

User Input

>input (194 residues)
MAAAAPNAGGSAPETAGSAEAPLQYSLLLQYLVGDKRQPRLLEPGSLGGIPSPAKSEEQK
MIEKAMESCAFKAALACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQ
RGMSYAKNFAIVGAMFSCTECLIESYRGTSDWKNSVISGCITGGAIGFRAGLKAGAIGCG
GFAAFSAAIDYYLR

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9CQ85	0.783	0.783	4.702E-22	194	0.954	0.954	Q9CQ85.pdb.gz	TIM22_MOUSE Mitochondrial import inner membrane translocase subunit Tim22 OS=Mus musculus OX=10090 GN=Timm22 PE=1 SV=1
2	PDB:7cgpA	0.620	0.799	1.462E-13	147	0.753	0.993	7cgpA.pdb.gz
3	AFDB:P87146	0.629	0.694	9.887E-9	175	0.320	0.354	P87146.pdb.gz	TIM22_SCHPO Mitochondrial import inner membrane translocase subunit tim22 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=tim22 PE=3 SV=1
4	AFDB:A2RVP7	0.629	0.701	2.668E-8	173	0.314	0.353	A2RVP7.pdb.gz	TI221_ARATH Mitochondrial import inner membrane translocase subunit TIM22-1 OS=Arabidopsis thaliana OX=3702 GN=TIM22-1 PE=1 SV=1
5	AFDB:A0A1D8PI78	0.610	0.641	2.932E-8	184	0.345	0.364	A0A1D8PI78.pdb.gz	TIM22_CANAL Mitochondrial import inner membrane translocase subunit TIM22 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=TIM22 PE=1 SV=1
6	AFDB:Q12328	0.585	0.549	4.548E-7	207	0.299	0.280	Q12328.pdb.gz	TIM22_YEAST Mitochondrial import inner membrane translocase subunit TIM22 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TIM22 PE=1 SV=1
7	AFDB:Q382K7	0.634	0.794	5.067E-6	152	0.196	0.250	Q382K7.pdb.gz	Q382K7_TRYB2 Mitochondrial import inner membrane translocase subunit TIM22 OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.01.4870 PE=3 SV=1
8	PDB:6lo8A	0.541	0.797	3.999E-5	129	0.258	0.388	6lo8A.pdb.gz
9	AFDB:Q9XVQ2	0.445	0.373	4.055E-5	242	0.222	0.178	Q9XVQ2.pdb.gz	Q9XVQ2_CAEEL Mitochondrial import inner membrane translocase subunit TIM23 OS=Caenorhabditis elegans OX=6239 GN=timm-23 PE=1 SV=1
10	AFDB:Q9USM7	0.531	0.497	6.506E-5	210	0.191	0.176	Q9USM7.pdb.gz	TIM23_SCHPO Mitochondrial import inner membrane translocase subunit tim23 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=tim23 PE=3 SV=1
11	AFDB:Q7T2P6	0.502	0.472	1.094E-4	208	0.232	0.216	Q7T2P6.pdb.gz	TIM23_DANRE Mitochondrial import inner membrane translocase subunit Tim23 OS=Danio rerio OX=7955 GN=timm23 PE=2 SV=1
12	AFDB:Q94EH2	0.530	0.492	2.331E-4	210	0.211	0.195	Q94EH2.pdb.gz	TI222_ARATH Chloroplastic import inner membrane translocase subunit TIM22-2 OS=Arabidopsis thaliana OX=3702 GN=TIM22-2 PE=1 SV=1
13	PDB:5xtcV	0.414	0.541	5.997E-3	140	0.160	0.221	5xtcV.pdb.gz	Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.
14	PDB:7psaY	0.420	0.552	8.349E-3	140	0.160	0.221	7psaY.pdb.gz	Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I.
15	PDB:6wlwT	0.229	0.402	1.194	85	0.072	0.165	6wlwT.pdb.gz	Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.
16	PDB:6gciA	0.201	0.149	1.916	292	0.093	0.062	6gciA.pdb.gz	The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier.
17	PDB:4ntaA	0.184	0.227	2.932	147	0.077	0.102	4ntaA.pdb.gz
18	PDB:5kbwB	0.242	0.267	3.074	171	0.077	0.088	5kbwB.pdb.gz	An Aromatic Cap Seals the Substrate Binding Site in an ECF-Type S Subunit for Riboflavin.
19	PDB:7pp4f	0.246	0.294	4.279	142	0.098	0.134	7pp4f.pdb.gz	Mycobacterium RbpA cooperates with the stress-response sigma-B subunit of RNA polymerase in promoter DNA unwinding.
20	PDB:4gbyA	0.203	0.099	4.703	475	0.119	0.048	4gbyA.pdb.gz	Crystal structure of a bacterial homologue of glucose transporters GLUT1-4.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q9Y584	1.62e-140	391	194	1.000	1.000	TIM22_HUMAN Mitochondrial import inner membrane translocase subunit Tim22 OS=Homo sapiens OX=9606 GN=TIMM22 PE=1 SV=2
2	Q9CQ85	6.23e-126	354	194	0.954	0.954	TIM22_MOUSE Mitochondrial import inner membrane translocase subunit Tim22 OS=Mus musculus OX=10090 GN=Timm22 PE=1 SV=1
3	A0A1D8PI78	1.15e-29	109	184	0.361	0.380	TIM22_CANAL Mitochondrial import inner membrane translocase subunit TIM22 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=TIM22 PE=1 SV=1
4	P87146	7.61e-21	86.7	175	0.284	0.314	TIM22_SCHPO Mitochondrial import inner membrane translocase subunit tim22 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=tim22 PE=3 SV=1
5	A2RVP7	8.40e-19	81.3	173	0.206	0.231	TI221_ARATH Mitochondrial import inner membrane translocase subunit TIM22-1 OS=Arabidopsis thaliana OX=3702 GN=TIM22-1 PE=1 SV=1
6	Q12328	2.07e-14	70.5	207	0.309	0.290	TIM22_YEAST Mitochondrial import inner membrane translocase subunit TIM22 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TIM22 PE=1 SV=1
7	Q9Z0V8	2.49e-06	47.8	171	0.170	0.193	TI17A_MOUSE Mitochondrial import inner membrane translocase subunit Tim17-A OS=Mus musculus OX=10090 GN=Timm17a PE=1 SV=1
8	Q382K7	2.90e-06	47.4	152	0.222	0.283	Q382K7_TRYB2 Mitochondrial import inner membrane translocase subunit TIM22 OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.01.4870 PE=3 SV=1
9	Q7PLT4	3.93e-06	47.4	173	0.191	0.214	Q7PLT4_DROME Translocase of the inner mitochondrial membrane 17b, isoform A OS=Drosophila melanogaster OX=7227 GN=Tim17b PE=1 SV=1
10	Q94EH2	5.90e-06	47.4	210	0.201	0.186	TI222_ARATH Chloroplastic import inner membrane translocase subunit TIM22-2 OS=Arabidopsis thaliana OX=3702 GN=TIM22-2 PE=1 SV=1
11	O35092	6.11e-06	46.6	171	0.170	0.193	TI17A_RAT Mitochondrial import inner membrane translocase subunit Tim17-A OS=Rattus norvegicus OX=10116 GN=Timm17a PE=2 SV=1
12	P87130	1.65e-05	45.4	164	0.119	0.140	TIM17_SCHPO Mitochondrial import inner membrane translocase subunit tim17 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=tim17 PE=3 SV=1
13	Q99595	2.52e-05	45.1	171	0.165	0.187	TI17A_HUMAN Mitochondrial import inner membrane translocase subunit Tim17-A OS=Homo sapiens OX=9606 GN=TIMM17A PE=1 SV=1
14	O60830	9.70e-05	43.5	172	0.165	0.186	TI17B_HUMAN Mitochondrial import inner membrane translocase subunit Tim17-B OS=Homo sapiens OX=9606 GN=TIMM17B PE=1 SV=1
15	Q6NKU9	1.76e-04	43.1	214	0.134	0.121	TI223_ARATH Mitochondrial import inner membrane translocase subunit TIM22-3 OS=Arabidopsis thaliana OX=3702 GN=TIM22-3 PE=2 SV=1
16	Q7T2P6	2.08e-04	42.7	208	0.165	0.154	TIM23_DANRE Mitochondrial import inner membrane translocase subunit Tim23 OS=Danio rerio OX=7955 GN=timm23 PE=2 SV=1
17	Q9Z0V7	3.36e-04	42.0	172	0.160	0.180	TI17B_MOUSE Mitochondrial import inner membrane translocase subunit Tim17-B OS=Mus musculus OX=10090 GN=Timm17b PE=1 SV=1
18	P39515	7.33e-04	40.8	158	0.088	0.108	TIM17_YEAST Mitochondrial import inner membrane translocase subunit TIM17 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TIM17 PE=1 SV=1
19	O35093	0.003	39.3	209	0.170	0.158	TIM23_RAT Mitochondrial import inner membrane translocase subunit Tim23 OS=Rattus norvegicus OX=10116 GN=Timm23 PE=2 SV=1
20	Q9LN27	0.014	37.4	218	0.093	0.083	TI171_ARATH Mitochondrial import inner membrane translocase subunit TIM17-1 OS=Arabidopsis thaliana OX=3702 GN=TIM17-1 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF02466 Tim17	4.9e-25	99.5	Tim17/Tim22/Tim23/Pmp24 family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000320236

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000257245	0.999	Mitochondrial import inner membrane translocase subunit Tim10
2	9606.ENSP00000378588	0.999	Mitochondrial import inner membrane translocase subunit Tim9
3	9606.ENSP00000254616	0.997	Mitochondrial import inner membrane translocase subunit Tim10 B
4	9606.ENSP00000347581	0.997	Acylglycerol kinase, mitochondrial
5	9606.ENSP00000270502	0.996	Mitochondrial import inner membrane translocase subunit Tim29
6	9606.ENSP00000410339	0.984	Mitochondrial import receptor subunit TOM40 homolog
7	9606.ENSP00000216034	0.982	Mitochondrial import receptor subunit TOM22 homolog
8	9606.ENSP00000284320	0.976	Mitochondrial import receptor subunit TOM70
9	9606.ENSP00000464522	0.976	Mitochondrial import inner membrane translocase subunit Tim23
10	9606.ENSP00000351214	0.974	Mitochondrial import receptor subunit TOM7 homolog
11	9606.ENSP00000317159	0.960	Cytochrome c1, heme protein, mitochondrial
12	9606.ENSP00000355566	0.952	Mitochondrial import receptor subunit TOM20 homolog
13	9606.ENSP00000297185	0.951	Stress-70 protein, mitochondrial
14	9606.ENSP00000381859	0.944	Mitochondrial import receptor subunit TOM6 homolog
15	9606.ENSP00000438204	0.944	Mitochondrial import receptor subunit TOM5 homolog
16	9606.ENSP00000373620	0.943	60 kDa heat shock protein, mitochondrial
17	9606.ENSP00000356256	0.928	Mitochondrial import inner membrane translocase subunit Tim17-A
18	9606.ENSP00000262030	0.924	ATP synthase subunit beta, mitochondrial
19	9606.ENSP00000216254	0.923	Aconitate hydratase, mitochondrial
20	9606.ENSP00000413908	0.922	Mitochondrial chaperone BCS1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0022857	0.950	transmembrane transporter activity
GO:0008320	0.924	protein transmembrane transporter activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0006626	0.987	protein targeting to mitochondrion
GO:0007007	0.932	inner mitochondrial membrane organization
GO:0051204	0.809	protein insertion into mitochondrial membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	1.000	mitochondrion
GO:0032991	0.987	protein-containing complex
GO:0016020	0.987	membrane
GO:0031090	0.951	organelle membrane
GO:0005740	0.905	mitochondrial envelope
GO:0031966	0.904	mitochondrial membrane
GO:0098796	0.891	membrane protein complex
GO:0098798	0.889	mitochondrial protein-containing complex
GO:0005743	0.889	mitochondrial inner membrane
GO:0070013	0.882	intracellular organelle lumen
GO:0098800	0.764	inner mitochondrial membrane protein complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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