StarFunc result for job id Q9Y6W6

User Input

>input (482 residues)
MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTY
MPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNN
NENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPF
MEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENT
NEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGA
SAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPL
YHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVI
AYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVET
VV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9ESS0	0.813	0.811	8.248E-89	483	0.967	0.965	Q9ESS0.pdb.gz	DUS10_MOUSE Dual specificity protein phosphatase 10 OS=Mus musculus OX=10090 GN=Dusp10 PE=2 SV=2
2	AFDB:Q9VVW5	0.327	0.382	1.266E-30	411	0.220	0.258	Q9VVW5.pdb.gz	DUSK3_DROME Dual specificity protein phosphatase Mpk3 OS=Drosophila melanogaster OX=7227 GN=Mkp3 PE=1 SV=2
3	AFDB:Q91790	0.313	0.394	2.203E-30	369	0.210	0.274	Q91790.pdb.gz	DUS1A_XENLA Dual specificity protein phosphatase 1-A OS=Xenopus laevis OX=8355 GN=dusp1-a PE=1 SV=1
4	AFDB:P28562	0.325	0.409	2.342E-30	367	0.199	0.262	P28562.pdb.gz	DUS1_HUMAN Dual specificity protein phosphatase 1 OS=Homo sapiens OX=9606 GN=DUSP1 PE=1 SV=3
5	AFDB:Q99956	0.304	0.380	1.311E-29	384	0.220	0.276	Q99956.pdb.gz	DUS9_HUMAN Dual specificity protein phosphatase 9 OS=Homo sapiens OX=9606 GN=DUSP9 PE=1 SV=1
6	AFDB:Q7TNL7	0.396	0.417	1.633E-28	452	0.224	0.239	Q7TNL7.pdb.gz	Q7TNL7_MOUSE Dual specificity protein phosphatase OS=Mus musculus OX=10090 GN=Dusp9 PE=1 SV=1
7	AFDB:Q05922	0.302	0.450	8.597E-28	318	0.201	0.305	Q05922.pdb.gz	DUS2_MOUSE Dual specificity protein phosphatase 2 OS=Mus musculus OX=10090 GN=Dusp2 PE=1 SV=2
8	AFDB:Q556Y8	0.280	0.283	1.310E-22	476	0.185	0.187	Q556Y8.pdb.gz	DUSPR_DICDI Probable rhodanese domain-containing dual specificity protein phosphatase OS=Dictyostelium discoideum OX=44689 GN=DDB_G0273199 PE=3 SV=1
9	AFDB:V6CIV8	0.318	0.396	3.099E-22	381	0.180	0.228	V6CIV8.pdb.gz	DUSL_CAEEL Dual specificity protein phosphatase lip-1 OS=Caenorhabditis elegans OX=6239 GN=lip-1 PE=1 SV=1
10	AFDB:Q9Y6J8	0.283	0.431	5.482E-18	313	0.143	0.220	Q9Y6J8.pdb.gz	STYL1_HUMAN Serine/threonine/tyrosine-interacting-like protein 1 OS=Homo sapiens OX=9606 GN=STYXL1 PE=1 SV=1
11	PDB:6d66A	0.290	0.271	8.866E-17	517	0.127	0.118	6d66A.pdb.gz
12	PDB:2wgpA	0.293	0.826	9.764E-16	168	0.102	0.292	2wgpA.pdb.gz
13	PDB:2esbA	0.290	0.846	1.216E-14	162	0.102	0.302	2esbA.pdb.gz
14	PDB:5y15A	0.283	0.895	6.629E-13	148	0.091	0.297	5y15A.pdb.gz
15	PDB:3f81A	0.288	0.751	1.886E-12	179	0.106	0.285	3f81A.pdb.gz	Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.
16	PDB:2gwoC	0.282	0.758	3.843E-11	174	0.098	0.270	2gwoC.pdb.gz
17	PDB:2y96A	0.279	0.740	1.028E-10	175	0.104	0.286	2y96A.pdb.gz
18	PDB:5xjvB	0.281	0.766	1.163E-10	171	0.108	0.304	5xjvB.pdb.gz
19	PDB:2q05A	0.260	0.656	5.606E-9	181	0.075	0.199	2q05A.pdb.gz
20	PDB:4ercA	0.270	0.815	4.539E-8	150	0.054	0.173	4ercA.pdb.gz	New Aspects of the Phosphatase VHZ Revealed by a High-Resolution Structure with Vanadate and Substrate Screening.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	D3ZBG7	0.0	902	482	0.959	0.959	D3ZBG7_RAT Dual specificity phosphatase 10 OS=Rattus norvegicus OX=10116 GN=Dusp10 PE=3 SV=1
2	Q9ESS0	0.0	965	483	0.967	0.965	DUS10_MOUSE Dual specificity protein phosphatase 10 OS=Mus musculus OX=10090 GN=Dusp10 PE=2 SV=2
3	Q9Y6W6	0.0	998	482	1.000	1.000	DUS10_HUMAN Dual specificity protein phosphatase 10 OS=Homo sapiens OX=9606 GN=DUSP10 PE=1 SV=1
4	Q7T2L8	6.79e-53	184	382	0.222	0.280	Q7T2L8_DANRE Dual specificity protein phosphatase OS=Danio rerio OX=7955 GN=mkp3 PE=2 SV=1
5	Q16829	8.68e-53	185	419	0.222	0.255	DUS7_HUMAN Dual specificity protein phosphatase 7 OS=Homo sapiens OX=9606 GN=DUSP7 PE=1 SV=4
6	O09112	6.88e-52	188	663	0.228	0.166	DUS8_MOUSE Dual specificity protein phosphatase 8 OS=Mus musculus OX=10090 GN=Dusp8 PE=2 SV=1
7	Q9DBB1	1.07e-51	181	381	0.247	0.312	DUS6_MOUSE Dual specificity protein phosphatase 6 OS=Mus musculus OX=10090 GN=Dusp6 PE=1 SV=1
8	Q7SZF3	2.52e-51	180	367	0.212	0.278	Q7SZF3_DANRE Dual specificity protein phosphatase OS=Danio rerio OX=7955 GN=zgc:55423 PE=2 SV=1
9	Q64346	6.36e-51	179	381	0.226	0.286	DUS6_RAT Dual specificity protein phosphatase 6 OS=Rattus norvegicus OX=10116 GN=Dusp6 PE=1 SV=1
10	Q9BY84	1.33e-50	184	665	0.224	0.162	DUS16_HUMAN Dual specificity protein phosphatase 16 OS=Homo sapiens OX=9606 GN=DUSP16 PE=1 SV=1
11	Q16828	2.05e-50	178	381	0.224	0.283	DUS6_HUMAN Dual specificity protein phosphatase 6 OS=Homo sapiens OX=9606 GN=DUSP6 PE=1 SV=2
12	D4A3W6	2.60e-50	184	661	0.224	0.163	D4A3W6_RAT Dual specificity phosphatase 16 OS=Rattus norvegicus OX=10116 GN=Dusp16 PE=1 SV=1
13	Q13115	7.48e-50	177	394	0.214	0.261	DUS4_HUMAN Dual specificity protein phosphatase 4 OS=Homo sapiens OX=9606 GN=DUSP4 PE=1 SV=1
14	Q62767	2.30e-49	176	395	0.205	0.251	DUS4_RAT Dual specificity protein phosphatase 4 OS=Rattus norvegicus OX=10116 GN=Dusp4 PE=1 SV=1
15	Q05922	5.69e-46	164	318	0.197	0.299	DUS2_MOUSE Dual specificity protein phosphatase 2 OS=Mus musculus OX=10090 GN=Dusp2 PE=1 SV=2
16	Q05923	1.53e-45	163	314	0.205	0.315	DUS2_HUMAN Dual specificity protein phosphatase 2 OS=Homo sapiens OX=9606 GN=DUSP2 PE=1 SV=1
17	P28562	3.67e-45	163	367	0.199	0.262	DUS1_HUMAN Dual specificity protein phosphatase 1 OS=Homo sapiens OX=9606 GN=DUSP1 PE=1 SV=3
18	Q10038	3.66e-44	166	657	0.220	0.161	VHP1_CAEEL Tyrosine-protein phosphatase vhp-1 OS=Caenorhabditis elegans OX=6239 GN=vhp-1 PE=1 SV=2
19	P28563	1.55e-43	159	367	0.195	0.256	DUS1_MOUSE Dual specificity protein phosphatase 1 OS=Mus musculus OX=10090 GN=Dusp1 PE=1 SV=1
20	Q91790	1.90e-43	159	369	0.214	0.279	DUS1A_XENLA Dual specificity protein phosphatase 1-A OS=Xenopus laevis OX=8355 GN=dusp1-a PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00782 DSPc	9.2e-39	143.7	Dual specificity phosphatase, catalytic domain
2	PF04179 Init_tRNA_PT	9.1	18.0	Rit1 DUSP-like domain
3	PF14566 PTPlike_phytase	0.046	25.3	Inositol hexakisphosphate
4	PF00581 Rhodanese	6.8e-11	54.0	Rhodanese-like domain
5	PF17797 RL	2.9e+02	12.8	RL domain
6	PF00102 Y_phosphatase	2	19.5	Protein-tyrosine phosphatase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000355866

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000229795	0.998	Mitogen-activated protein kinase 14
2	9606.ENSP00000378974	0.985	Mitogen-activated protein kinase 8
3	9606.ENSP00000333685	0.956	Mitogen-activated protein kinase 11
4	9606.ENSP00000215832	0.955	Mitogen-activated protein kinase 1
5	9606.ENSP00000263025	0.954	Mitogen-activated protein kinase 3
6	9606.ENSP00000394560	0.907	Mitogen-activated protein kinase 9
7	9606.ENSP00000211287	0.814	Mitogen-activated protein kinase 13
8	9606.ENSP00000352157	0.814	Mitogen-activated protein kinase 10
9	9606.ENSP00000215659	0.811	Mitogen-activated protein kinase 12
10	9606.ENSP00000450749	0.734	JNK1/MAPK8-associated membrane protein
11	9606.ENSP00000254667	0.690	Receptor-type tyrosine-protein phosphatase epsilon
12	9606.ENSP00000283228	0.689	Receptor-type tyrosine-protein phosphatase R
13	9606.ENSP00000357055	0.638	Astrocytic phosphoprotein PEA-15
14	9606.ENSP00000425040	0.637	Coiled-coil serine rich protein 1
15	9606.ENSP00000326240	0.606	Myoneurin
16	9606.ENSP00000360035	0.594	Protein phosphatase 1 regulatory subunit 3D
17	9606.ENSP00000329033	0.585	Mitochondrial glutamate carrier 2
18	9606.ENSP00000314879	0.569	Hydroperoxide isomerase ALOXE3
19	9606.ENSP00000233154	0.565	Cytoplasmic protein NCK2
20	9606.ENSP00000453293	0.558	Amyloid-beta A4 precursor protein-binding family A member 2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0033549	0.999	MAP kinase phosphatase activity
GO:0005515	0.981	protein binding
GO:0019901	0.520	protein kinase binding
GO:0008138	0.498	protein tyrosine/serine/threonine phosphatase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050794	0.984	regulation of cellular process
GO:0044237	0.981	cellular metabolic process
GO:0060255	0.979	regulation of macromolecule metabolic process
GO:0031323	0.974	regulation of cellular metabolic process
GO:0071704	0.973	organic substance metabolic process
GO:0050896	0.972	response to stimulus
GO:0060284	0.972	regulation of cell development
GO:0080090	0.971	regulation of primary metabolic process
GO:0051171	0.971	regulation of nitrogen compound metabolic process
GO:0044238	0.970	primary metabolic process
GO:0006807	0.959	nitrogen compound metabolic process
GO:0051239	0.954	regulation of multicellular organismal process
GO:0032872	0.941	regulation of stress-activated MAPK cascade
GO:0010033	0.937	response to organic substance
GO:0051172	0.935	negative regulation of nitrogen compound metabolic process
GO:0071901	0.932	negative regulation of protein serine/threonine kinase activity
GO:0070303	0.931	negative regulation of stress-activated protein kinase signaling cascade
GO:1901564	0.930	organonitrogen compound metabolic process
GO:0046328	0.930	regulation of JNK cascade
GO:0043506	0.926	regulation of JUN kinase activity
GO:0032873	0.917	negative regulation of stress-activated MAPK cascade
GO:0043170	0.914	macromolecule metabolic process
GO:0046329	0.908	negative regulation of JNK cascade
GO:0002682	0.902	regulation of immune system process
GO:0006796	0.897	phosphate-containing compound metabolic process
GO:0016311	0.893	dephosphorylation
GO:0036211	0.887	protein modification process
GO:2000026	0.868	regulation of multicellular organismal development
GO:0048518	0.834	positive regulation of biological process
GO:0006470	0.818	protein dephosphorylation
GO:0048522	0.813	positive regulation of cellular process
GO:0051716	0.808	cellular response to stimulus
GO:0043407	0.756	negative regulation of MAP kinase activity
GO:0007165	0.693	signal transduction
GO:0051240	0.646	positive regulation of multicellular organismal process
GO:0045597	0.630	positive regulation of cell differentiation
GO:0051960	0.564	regulation of nervous system development
GO:0051241	0.538	negative regulation of multicellular organismal process
GO:0035556	0.533	intracellular signal transduction
GO:0045596	0.515	negative regulation of cell differentiation
GO:0033554	0.507	cellular response to stress
GO:0000165	0.506	MAPK cascade
GO:0050767	0.501	regulation of neurogenesis
GO:0010721	0.402	negative regulation of cell development
GO:0035335	0.362	peptidyl-tyrosine dephosphorylation
GO:0010720	0.348	positive regulation of cell development
GO:0010468	0.327	regulation of gene expression
GO:0051403	0.308	stress-activated MAPK cascade
GO:0009889	0.306	regulation of biosynthetic process
GO:0010556	0.304	regulation of macromolecule biosynthetic process
GO:0031326	0.302	regulation of cellular biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	1.000	cytosol
GO:0005654	1.000	nucleoplasm
GO:0012505	0.997	endomembrane system
GO:0005794	0.636	Golgi apparatus
GO:0016604	0.621	nuclear body
GO:0016607	0.543	nuclear speck

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.1.3.-	1.000	Phosphoric monoester hydrolases.

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