StarFunc result for job id Q9Y6Y9

User Input

>input (160 residues)
MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGL
LHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFS
FKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q9Y6Y9	1.000	1.000	1.375E-30	160	1.000	1.000	Q9Y6Y9.pdb.gz	LY96_HUMAN Lymphocyte antigen 96 OS=Homo sapiens OX=9606 GN=LY96 PE=1 SV=2
2	PDB:3fxiC	0.853	0.972	4.642E-24	140	0.869	0.993	3fxiC.pdb.gz
3	AFDB:Q9JHF9	0.933	0.933	1.542E-22	160	0.637	0.637	Q9JHF9.pdb.gz	LY96_MOUSE Lymphocyte antigen 96 OS=Mus musculus OX=10090 GN=Ly96 PE=1 SV=1
4	PDB:5ijdC	0.814	0.945	3.023E-18	137	0.556	0.650	5ijdC.pdb.gz	TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
5	AFDB:A0A1D5NZX9	0.753	0.775	9.597E-13	155	0.269	0.277	A0A1D5NZX9.pdb.gz
6	AFDB:A4IFT3	0.763	0.767	6.888E-11	159	0.188	0.189	A4IFT3.pdb.gz	A4IFT3_BOVIN LY86 protein OS=Bos taurus OX=9913 GN=LY86 PE=1 SV=1
7	AFDB:O88188	0.757	0.749	1.095E-10	162	0.169	0.167	O88188.pdb.gz	LY86_MOUSE Lymphocyte antigen 86 OS=Mus musculus OX=10090 GN=Ly86 PE=1 SV=1
8	AFDB:A0A0A8P3N1	0.753	0.729	1.345E-10	166	0.188	0.181	A0A0A8P3N1.pdb.gz	A0A0A8P3N1_DANRE Lymphocyte antigen 86 OS=Danio rerio OX=7955 GN=ly86_tv1 PE=2 SV=1
9	AFDB:O95711	0.743	0.734	4.628E-10	162	0.181	0.179	O95711.pdb.gz	LY86_HUMAN Lymphocyte antigen 86 OS=Homo sapiens OX=9606 GN=LY86 PE=1 SV=1
10	PDB:3t6qC	0.743	0.844	5.120E-10	139	0.156	0.180	3t6qC.pdb.gz	Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
11	PDB:3b2dC	0.727	0.826	1.362E-9	139	0.194	0.223	3b2dC.pdb.gz	Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
12	AFDB:Q9LXQ2	0.522	0.544	8.636E-6	152	0.156	0.164	Q9LXQ2.pdb.gz	Q9LXQ2_ARATH At3g44100 OS=Arabidopsis thaliana OX=3702 GN=F26G5_50 PE=1 SV=1
13	AFDB:Q6FNB1	0.605	0.536	3.844E-5	185	0.131	0.114	Q6FNB1.pdb.gz	NPC2_CANGA Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=NPC2 PE=3 SV=1
14	AFDB:Q12408	0.559	0.525	4.486E-5	173	0.150	0.139	Q12408.pdb.gz	NPC2_YEAST Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=NPC2 PE=1 SV=1
15	PDB:1a9vA	0.391	0.453	2.448E-4	129	0.113	0.140	1a9vA.pdb.gz
16	PDB:2agcA	0.470	0.465	1.090E-3	162	0.138	0.136	2agcA.pdb.gz
17	PDB:5kwyC	0.524	0.607	1.090E-3	133	0.113	0.135	5kwyC.pdb.gz	Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.
18	PDB:2ag2A	0.457	0.449	1.339E-3	164	0.131	0.128	2ag2A.pdb.gz	Crystal Structure Analysis of Phosphatidylcholine-GM2-Activator Product Complexes: Evidence for Hydrolase Activity.
19	PDB:2hkaB	0.501	0.593	3.750E-3	130	0.113	0.138	2hkaB.pdb.gz	Structural Basis of Sterol Binding by NPC2, a Lysosomal Protein Deficient in Niemann-Pick Type C2 Disease
20	PDB:1xo8A	0.352	0.367	7.323E-3	151	0.050	0.053	1xo8A.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q9Y6Y9	4.53e-118	332	160	1.000	1.000	LY96_HUMAN Lymphocyte antigen 96 OS=Homo sapiens OX=9606 GN=LY96 PE=1 SV=2
2	Q9JHF9	5.94e-76	225	160	0.637	0.637	LY96_MOUSE Lymphocyte antigen 96 OS=Mus musculus OX=10090 GN=Ly96 PE=1 SV=1
3	E7F6I2	1.31e-05	45.1	163	0.169	0.166	E7F6I2_DANRE Lymphocyte antigen 86 OS=Danio rerio OX=7955 GN=ly86 PE=4 SV=2
4	O88188	2.30e-05	44.3	162	0.150	0.148	LY86_MOUSE Lymphocyte antigen 86 OS=Mus musculus OX=10090 GN=Ly86 PE=1 SV=1
5	O95711	1.61e-04	42.0	162	0.212	0.210	LY86_HUMAN Lymphocyte antigen 86 OS=Homo sapiens OX=9606 GN=LY86 PE=1 SV=1
6	A4IFT3	4.16e-04	40.8	159	0.150	0.151	A4IFT3_BOVIN LY86 protein OS=Bos taurus OX=9913 GN=LY86 PE=1 SV=1
7	A0A0A8P3N1	0.001	39.7	166	0.169	0.163	A0A0A8P3N1_DANRE Lymphocyte antigen 86 OS=Danio rerio OX=7955 GN=ly86_tv1 PE=2 SV=1
8	Q6UXM1	1.2	31.6	1119	0.113	0.016	LRIG3_HUMAN Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Homo sapiens OX=9606 GN=LRIG3 PE=1 SV=1
9	Q6P1C6	1.3	31.6	1117	0.113	0.016	LRIG3_MOUSE Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Mus musculus OX=10090 GN=Lrig3 PE=1 SV=1
10	Q8BKJ9	4.7	29.6	402	0.156	0.062	SIR7_MOUSE NAD-dependent protein deacetylase sirtuin-7 OS=Mus musculus OX=10090 GN=Sirt7 PE=1 SV=2
11	O22150	5.5	28.9	162	0.075	0.074	SAU36_ARATH Auxin-responsive protein SAUR36 OS=Arabidopsis thaliana OX=3702 GN=SAUR36 PE=2 SV=1
12	P70193	5.8	29.6	1091	0.094	0.014	LRIG1_MOUSE Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Mus musculus OX=10090 GN=Lrig1 PE=1 SV=2
13	Q8C9W3	9.5	28.9	1213	0.069	0.009	ATS2_MOUSE A disintegrin and metalloproteinase with thrombospondin motifs 2 OS=Mus musculus OX=10090 GN=Adamts2 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000284818

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000363089	0.999	Toll-like receptor 4
2	9606.ENSP00000345347	0.998	High mobility group protein B1
3	9606.ENSP00000260010	0.997	Toll-like receptor 2
4	9606.ENSP00000369286	0.994	Lymphocyte antigen 86
5	9606.ENSP00000401399	0.992	Myeloid differentiation primary response protein MyD88
6	9606.ENSP00000304236	0.989	Monocyte differentiation antigen CD14
7	9606.ENSP00000376445	0.984	Toll/interleukin-1 receptor domain-containing adapter protein
8	9606.ENSP00000398632	0.984	CD44 antigen
9	9606.ENSP00000217407	0.981	Lipopolysaccharide-binding protein
10	9606.ENSP00000354932	0.979	Toll-like receptor 1
11	9606.ENSP00000256447	0.977	CD180 antigen
12	9606.ENSP00000358997	0.965	Interleukin-1 receptor-associated kinase 1
13	9606.ENSP00000357727	0.962	Protein S100-A9
14	9606.ENSP00000390651	0.960	Interleukin-1 receptor-associated kinase 4
15	9606.ENSP00000433623	0.960	TNF receptor-associated factor 6
16	9606.ENSP00000357722	0.951	Protein S100-A8
17	9606.ENSP00000314733	0.948	Toll-interacting protein
18	9606.ENSP00000256458	0.942	Interleukin-1 receptor-associated kinase-like 2
19	9606.ENSP00000430684	0.940	Inhibitor of nuclear factor kappa-B kinase subunit beta
20	9606.ENSP00000359424	0.934	Inhibitor of nuclear factor kappa-B kinase subunit alpha

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0038187	1.000	pattern recognition receptor activity
GO:0015026	1.000	coreceptor activity
GO:0001875	0.710	lipopolysaccharide immune receptor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0032103	0.996	positive regulation of response to external stimulus
GO:0002833	0.996	positive regulation of response to biotic stimulus
GO:0042221	0.995	response to chemical
GO:0031349	0.995	positive regulation of defense response
GO:0007165	0.995	signal transduction
GO:0010033	0.991	response to organic substance
GO:0002221	0.990	pattern recognition receptor signaling pathway
GO:0009607	0.989	response to biotic stimulus
GO:0006950	0.988	response to stress
GO:0044419	0.987	biological process involved in interspecies interaction between organisms
GO:0009605	0.987	response to external stimulus
GO:0002237	0.981	response to molecule of bacterial origin
GO:0006952	0.972	defense response
GO:0007166	0.970	cell surface receptor signaling pathway
GO:1901700	0.969	response to oxygen-containing compound
GO:0032496	0.954	response to lipopolysaccharide
GO:0019222	0.831	regulation of metabolic process
GO:0048522	0.824	positive regulation of cellular process
GO:0060255	0.820	regulation of macromolecule metabolic process
GO:0002224	0.815	toll-like receptor signaling pathway
GO:0009595	0.752	detection of biotic stimulus
GO:0009893	0.738	positive regulation of metabolic process
GO:0098581	0.713	detection of external biotic stimulus
GO:0009593	0.644	detection of chemical stimulus
GO:0010468	0.632	regulation of gene expression
GO:0010604	0.631	positive regulation of macromolecule metabolic process
GO:0032490	0.631	detection of molecule of bacterial origin
GO:0023051	0.618	regulation of signaling
GO:0010646	0.618	regulation of cell communication
GO:0009966	0.614	regulation of signal transduction
GO:0006968	0.609	cellular defense response
GO:0051239	0.559	regulation of multicellular organismal process
GO:0070887	0.486	cellular response to chemical stimulus
GO:0001819	0.479	positive regulation of cytokine production
GO:0071310	0.458	cellular response to organic substance
GO:0009967	0.396	positive regulation of signal transduction

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	0.998	plasma membrane
GO:0043235	0.996	receptor complex
GO:0012505	0.996	endomembrane system
GO:0031982	0.995	vesicle
GO:0043231	0.995	intracellular membrane-bounded organelle
GO:0005737	0.994	cytoplasm
GO:0098796	0.994	membrane protein complex
GO:0005576	0.982	extracellular region
GO:0031090	0.932	organelle membrane
GO:0031410	0.921	cytoplasmic vesicle
GO:0098588	0.890	bounding membrane of organelle
GO:0030659	0.867	cytoplasmic vesicle membrane
GO:0005768	0.852	endosome
GO:0046696	0.695	lipopolysaccharide receptor complex
GO:0010008	0.601	endosome membrane
GO:0005829	0.575	cytosol
GO:0005615	0.405	extracellular space
GO:0070013	0.304	intracellular organelle lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]