StarFunc result for job id test

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User Input

>input (230 residues)
MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGT
WRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVC
METITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELG
HPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN

Download query sequence and structure.

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:6ohtA	0.224	0.245	6.798E-12	206	0.870	0.971	6ohtA.pdb.gz	Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition.
2	AFDB:Q9JJ46	0.252	0.252	4.452E-11	230	0.809	0.809	Q9JJ46.pdb.gz	EBP_RAT 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase OS=Rattus norvegicus OX=10116 GN=Ebp PE=1 SV=3
3	AFDB:A0A494C0F3	0.208	0.177	3.319E-8	285	0.683	0.551	A0A494C0F3.pdb.gz	A0A494C0F3_HUMAN EXPERA domain-containing protein OS=Homo sapiens OX=9606 PE=3 SV=1
4	AFDB:Q9VCY8	0.756	0.412	2.220E-2	444	0.100	0.052	Q9VCY8.pdb.gz	ADRL_DROME Adiponectin receptor protein OS=Drosophila melanogaster OX=7227 GN=AdipoR PE=1 SV=2
5	AFDB:G3V6I6	0.812	0.519	3.692E-2	375	0.091	0.056	G3V6I6.pdb.gz	G3V6I6_RAT Adiponectin receptor 1 OS=Rattus norvegicus OX=10116 GN=Adipor1 PE=3 SV=1
6	AFDB:A1Z9Q8	0.409	0.239	4.241E-2	504	0.157	0.071	A1Z9Q8.pdb.gz	A1Z9Q8_DROME Diuretic hormone 44 receptor 1 OS=Drosophila melanogaster OX=7227 GN=Dh44-R1 PE=4 SV=1
7	AFDB:Q94177	0.809	0.449	8.488E-2	434	0.087	0.046	Q94177.pdb.gz	ADRL_CAEEL Progestin and adipoQ receptor-like protein 1 OS=Caenorhabditis elegans OX=6239 GN=paqr-1 PE=3 SV=2
8	AFDB:G5ECD9	0.530	0.413	8.890E-2	321	0.117	0.084	G5ECD9.pdb.gz	AEX2_CAEEL G-protein coupled receptor aex-2 OS=Caenorhabditis elegans OX=6239 GN=aex-2 PE=1 SV=1
9	AFDB:Q03419	0.742	0.558	9.752E-2	316	0.100	0.073	Q03419.pdb.gz	IZH1_YEAST ADIPOR-like receptor IZH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=IZH1 PE=1 SV=1
10	AFDB:Q12442	0.793	0.590	1.070E-1	317	0.096	0.069	Q12442.pdb.gz	IZH2_YEAST ADIPOR-like receptor IZH2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=IZH2 PE=1 SV=2
11	AFDB:Q99393	0.526	0.412	1.070E-1	312	0.087	0.064	Q99393.pdb.gz	IZH4_YEAST ADIPOR-like receptor IZH4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=IZH4 PE=1 SV=1
12	PDB:7e9gR	0.511	0.195	2.281E-1	769	0.109	0.033	7e9gR.pdb.gz	Structures of G i -bound metabotropic glutamate receptors mGlu2 and mGlu4.
13	PDB:7d3sR	0.419	0.373	3.793E-1	266	0.165	0.143	7d3sR.pdb.gz	Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.
14	PDB:7td1R	0.531	0.440	3.793E-1	293	0.117	0.092	7td1R.pdb.gz	Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
15	PDB:7td3R	0.441	0.368	5.244E-1	292	0.139	0.110	7td3R.pdb.gz	Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
16	PDB:7e33R	0.437	0.405	6.608E-1	257	0.130	0.117	7e33R.pdb.gz	Structural insights into the lipid and ligand regulation of serotonin receptors.
17	PDB:7epaA	0.493	0.185	6.921E-1	782	0.122	0.036	7epaA.pdb.gz
18	PDB:7wv9R	0.498	0.422	6.921E-1	290	0.122	0.097	7wv9R.pdb.gz	Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.
19	PDB:7yu4A	0.474	0.424	6.921E-1	266	0.087	0.075	7yu4A.pdb.gz	Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.
20	PDB:6vn7R	0.473	0.428	7.592E-1	263	0.126	0.110	6vn7R.pdb.gz	Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A024QYX0	6.64e-171	471	230	1.000	1.000	A0A024QYX0_HUMAN Emopamil binding protein (Fragment) OS=Homo sapiens OX=9606 GN=EBP PE=2 SV=1
2	Q15125	6.64e-171	471	230	1.000	1.000	EBP_HUMAN 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase OS=Homo sapiens OX=9606 GN=EBP PE=1 SV=3
3	Q9JJ46	1.59e-139	392	230	0.809	0.809	EBP_RAT 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase OS=Rattus norvegicus OX=10116 GN=Ebp PE=1 SV=3
4	P70245	8.58e-135	380	230	0.778	0.778	EBP_MOUSE 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase OS=Mus musculus OX=10090 GN=Ebp PE=1 SV=3
5	C9JJ78	9.38e-116	329	160	0.696	1.000	C9JJ78_HUMAN EBP cholestenol delta-isomerase (Fragment) OS=Homo sapiens OX=9606 GN=EBP PE=1 SV=1
6	A0A494C0F3	4.36e-112	324	285	0.678	0.547	A0A494C0F3_HUMAN EXPERA domain-containing protein OS=Homo sapiens OX=9606 PE=3 SV=1
7	C9J719	4.98e-105	301	145	0.630	1.000	C9J719_HUMAN EBP cholestenol delta-isomerase (Fragment) OS=Homo sapiens OX=9606 GN=EBP PE=1 SV=8
8	O48962	2.57e-28	108	223	0.287	0.296	EBP_ARATH Probable 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase OS=Arabidopsis thaliana OX=3702 GN=At1g20050 PE=2 SV=1
9	Q9BY08	4.95e-18	81.3	206	0.230	0.257	EBPL_HUMAN Emopamil-binding protein-like OS=Homo sapiens OX=9606 GN=EBPL PE=1 SV=1
10	P30530	1.3	32.7	894	0.178	0.046	UFO_HUMAN Tyrosine-protein kinase receptor UFO OS=Homo sapiens OX=9606 GN=AXL PE=1 SV=4
11	Q970U6	2.1	31.6	282	0.078	0.064	ARGX_SULTO Glutamate--LysW ligase ArgX OS=Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) OX=273063 GN=argX PE=1 SV=1
12	Q9Y2I8	5.4	30.4	494	0.078	0.036	WDR37_HUMAN WD repeat-containing protein 37 OS=Homo sapiens OX=9606 GN=WDR37 PE=1 SV=2
13	F1R8E2	6.1	30.4	1475	0.083	0.013	F1R8E2_DANRE Protein patched homolog 1 OS=Danio rerio OX=7955 GN=lep PE=3 SV=2
14	P38418	6.7	30.4	896	0.065	0.017	LOX2_ARATH Lipoxygenase 2, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=LOX2 PE=1 SV=1
15	Q94502	6.7	30.4	943	0.061	0.015	GANAB_DICDI Neutral alpha-glucosidase AB OS=Dictyostelium discoideum OX=44689 GN=modA PE=3 SV=1
16	Q86G45	7.4	30.4	2027	0.091	0.010	Q86G45_CAEEL EF-hand domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=unc-2 PE=2 SV=1
17	Q8MPY5	7.7	30.4	1911	0.091	0.011	Q8MPY5_CAEEL EF-hand domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=unc-2 PE=3 SV=2
18	Q944S3	8.2	30.0	429	0.074	0.040	TLP5_ARATH Tubby-like F-box protein 5 OS=Arabidopsis thaliana OX=3702 GN=TULP5 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF05241 EBP	2e-22	91.1	EXPERA (EXPanded EBP superfamily)
2	PF13305 TetR_C_33	5.8e+02	12.6	Tetracyclin repressor-like, C-terminal domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Download graph for PPI

Top PPI partners to 9606.ENSP00000417052

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000264027	0.983	Lathosterol oxidase
2	9606.ENSP00000279263	0.978	Delta(14)-sterol reductase
3	9606.ENSP00000360316	0.961	Delta(24)-sterol reductase
4	9606.ENSP00000359297	0.940	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
5	9606.ENSP00000254521	0.939	3-keto-steroid reductase
6	9606.ENSP00000347717	0.813	7-dehydrocholesterol reductase
7	9606.ENSP00000441417	0.764	Arylsulfatase E
8	9606.ENSP00000463533	0.720	Potassium voltage-gated channel subfamily H member 6
9	9606.ENSP00000356015	0.686	Acetyl-CoA acetyltransferase, cytosolic
10	9606.ENSP00000322229	0.677	Fatty acid desaturase 1
11	9606.ENSP00000322706	0.676	Hydroxymethylglutaryl-CoA synthase, cytoplasmic
12	9606.ENSP00000261507	0.674	Methylsterol monooxygenase 1
13	9606.ENSP00000380837	0.661	Lanosterol synthase
14	9606.ENSP00000339883	0.651	Lamin-B receptor
15	9606.ENSP00000362125	0.629	Protocadherin-19
16	9606.ENSP00000480828	0.624	Squalene synthase
17	9606.ENSP00000003100	0.619	Lanosterol 14-alpha demethylase
18	9606.ENSP00000260363	0.615	Kinesin-like protein KIF23
19	9606.ENSP00000312326	0.607	Membrane primary amine oxidase
20	9606.ENSP00000349078	0.598	Farnesyl pyrophosphate synthase
21	9606.ENSP00000327336	0.576	Biglycan
22	9606.ENSP00000257552	0.555	RNA-binding protein Musashi homolog 1
23	9606.ENSP00000284073	0.555	RNA-binding protein Musashi homolog 2
24	9606.ENSP00000301012	0.552	Diphosphomevalonate decarboxylase
25	9606.ENSP00000265896	0.542	Squalene monooxygenase
26	9606.ENSP00000443551	0.536	Mevalonate kinase
27	9606.ENSP00000256319	0.526	Probable ergosterol biosynthetic protein 28
28	9606.ENSP00000265838	0.525	Acetyl-CoA acetyltransferase, mitochondrial
29	9606.ENSP00000370748	0.524	Isopentenyl-diphosphate Delta-isomerase 1
30	9606.ENSP00000419975	0.519	PEX5-related protein
31	9606.ENSP00000337746	0.518	Inositol-3-phosphate synthase 1
32	9606.ENSP00000255389	0.513	Phosphatidylethanolamine N-methyltransferase
33	9606.ENSP00000282841	0.503	Geranylgeranyl pyrophosphate synthase

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

Download graph for Molecular Function (MF)

GO term	C-score	Name
GO:0016863	1.000	intramolecular oxidoreductase activity, transposing C=C bonds
GO:0042802	0.996	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Download graph for Biological Process (BP)

GO term	C-score	Name
GO:0008203	0.996	cholesterol metabolic process
GO:0008610	0.995	lipid biosynthetic process
GO:0016126	0.988	sterol biosynthetic process
GO:0046165	0.985	alcohol biosynthetic process
GO:1902653	0.984	secondary alcohol biosynthetic process
GO:0048799	0.701	animal organ maturation
GO:0001503	0.674	ossification
GO:0001501	0.647	skeletal system development
GO:0060348	0.641	bone development
GO:0009987	0.458	cellular process
GO:0006695	0.401	cholesterol biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Download graph for Cellular Component (CC)

GO term	C-score	Name
GO:0005783	1.000	endoplasmic reticulum
GO:0016020	0.916	membrane
GO:0005789	0.793	endoplasmic reticulum membrane
GO:0005634	0.319	nucleus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Download sequence-, structure-, PPI-, deep learning-, Pfam family-based function prediction and the final consensus prediction

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:5.3.3.-	1.000	Transposing C=C bonds.

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