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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


TACOS (Template-based Assembly of Complex Structures) is designed to model the structures of protein-protein complexes based on a hierarchical approach of threading refinement simulations. Starting from a pair of sequences, protein complex templates are first identified from the PDB by multi-chain threading algorithms COTH and SPRING. The fragments excised from the threading template alignments are then used to reassemble the complex structure by replica-exchange Monte Carlo simulations based on a composite force field consisting of knowledge-based interface interaction terms and threading template restraints. Final models are selected based on structure clustering by SPICKER and refined into full-atomic models by ModRefiner (More about the server ... ).

The output of the TACOS server include (An example of the TACOS output):

TACOS On-line



TACOS Download



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