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by mariaartlle
Fri Dec 09, 2022 11:13 am
Forum: Main Forum
Topic: Take into account pLDDT into TM-score
Replies: 1
Views: 3829

Take into account pLDDT into TM-score

Hi, I am currently superimposing protein structures of different species with TM-Align and using a TM-score threshold to filter. However, I have realized that, since I am using AlphaFold structures, the TM-score is heavily influenced by low pLDDT regions that appear as disordered coils. As I am tryi...