issues with docking result
Posted: Tue Dec 14, 2021 12:06 pm
Hello. I accidentally prepared and docked two files of same ligand. I use Avogadro to optimize both of these ligands files. However, the docking result (on same protein) indicated that both of these ligands had different binding energies and poses.
So I want to ask if it is normal to have different result although it is the same ligand? Or there is actually something wrong with my AutoDock Vina software? Anyone can comment on docking result reproducibility?
Asking for help! Thank you!
So I want to ask if it is normal to have different result although it is the same ligand? Or there is actually something wrong with my AutoDock Vina software? Anyone can comment on docking result reproducibility?
Asking for help! Thank you!