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COTH Input Query

Posted: Wed Jan 05, 2022 3:10 pm
by dsairam789

I used the COTH server for my protein complex and after observing the output, I realized that one of the monomers was in an inaccurate position after the run. So, I was curious if one can upload the PDB structure of a homolog along with the sequence of the protein complex for COTH ? Secondly, is there any alternative co-threading approach wherein this (manual input of a PDB template) can be carried out ?
Yours Sincerely,

Re: COTH Input Query

Posted: Sat Jan 08, 2022 12:57 am
by xiaogenz
Sorry! The COTH server currently cannot upload templates. You may try to use I-TASSER to build the monomer models, and then input the HDOCK server ( for docking.

Re: COTH Input Query

Posted: Sat Jan 08, 2022 7:07 am
by dsairam789
Thank you for the clarification.