3j7a A 1608 3.2 RF01960,RF01959,RF00177 URS000040971D_36329 24913268 0003735 0005840 36329 aaccugguugaucuugccaguagucauaugcuugucucaaagauuaagccaugcaagugaaaguauauauauauauauguagaaacugcgaacggcucauuaaaacaguuauagucuacuugacauuuauaaggauaacuacggaaaagcuguagcuaauacuugcauuauccuuuuggauaaguauuuguuagaaggaauuauaacaaagaaguaacacguaaaguguguaucaaucgaguuucugaccuaucagcuuuugauguuaggguauuggccuaacauggcuaugacggguaacggggaauuagaguucgauuccggagagggagccugagaaauagcuaccacaucuaaggaaggcagcaggcgcguaaauuacccaauucuaaagaagagagguagugacaagaaauaacaaugcaagguuuguauuggaauggugggaauuuaaaaccuucccagaguaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaauuguugcaguuaaaacgcucguaguugaauuucaaagaaucauucuuuuuaaaauccggauuuguuacuuugaguaaauuagaguguucaaagcaaacaguuaaagcauuguguuugaauacuauagcauggaauaacaaaauugaacaagcuaaaauuuuuuguucuuauuuuggcuuaguuacgauuaauaggaguagcuuggggacauucguauucagaugucagaggugaaauucuuagauuuucuggagacgaacaacugcgaaagcauuugucuaaaauacuuccauuaaucaagaacgaaaguuaagggagugaagacgaucagauaccgucguaaucuuaaccauaaacuaugccgacuagguguuggaugaagugcuuccuucaguaccuuaugagaaaucaaagucuuuggguucuggggcgaguauucgcgcaagcgagaaaguuaaaagaauugacggaagggcaccaccaggcguggagcuugcggcuuaauuugacucaacacggggaaacucacuaguuuaagacauuggauggugaugcauggccguuuuuaguucgugaaugauuugucugguuaauuccgauaacgaacgagaucuuaaccugcuaauuagcggcgaguacacuguacuugcugcuucuuagaggaacauugugugucuaacacaaggaaguuuaaggcaacaacaggucugugauguccuuagaugaacuaggcugcacgcgugcuacacugauauauauaacgaguaaaauaugcuugcauacuuuuccuccgccgaaaggcguagguaaucuuuaucaauauauaucgugauggggauagauuauugcaauuauuaaucuugaacgaggaaugccuaguaagcaugauucaucagauugugcugacuacgucccugcccuuuguacacaccgcccgucgcuccuaccgauugaaagauaugaugaauuguuuggacaagaaaaauuuuuucuggaaaaaccguaaauccuaucuuuuaaaggaaggagaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<<<...<......<<<.<<<..<<....<<...<<<<<<..>>>>>>...>>.>>......<<..<.....<<<..<<..<<...<<<<........<<.....<<<<<<.....>>>>>>......>>....<<<<<<....>>>>>>...<<<<<<<.<......>.>>>>>>>.......<<<.....>>>....>>>>..>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>>>.....<<<<<<<<<.>>>>>>>>>......<<<<<<.........>>>>>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<.<....>.>>>>..<<<<<..>>>>><<<<<<.<<.......<<...<.......>.<<<<.......<<<.>>>>>>>...>>......>>.>>..>>>>.....<.<<<.<<.<.<<<.<..........>.>>>.>.>>.>>>..>.>>....<<<<<<..<<..<<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>.>>>>.......<<....>>...>>>>>.>>.>>>.>>>...>>>...>>.>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<<<<<<<<.<<<<..>>>>.>>>>>>>>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<<<....<...>...<<.<<<..<<<<<<<<<....<<<<<<<<<...>>>...<<<......>>>...>>>>>>....<<<<<.<<<..<<<..<<<<<<<<<<<<...>>>>>>>>>>>>..>>>.>>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>>>>>>>...>>.>>>>.>>>.....<<<<<<<<.....<<.<<<.<<<<<..>>>>>.>.>><<<.<<<<....>>>>.>>>....>>.......>>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<.<<<<...<<.<<<<<.>>>.>>.>>...>>>>.>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(((...((.....(((.(((..((....((...((((((()))))))...))[))......(((.......(((..((..((...((((....[...((.....((.(((.....))).))......))....((((((....))))))...(((((((.(......).))))))).....(](((.(..)))))...))))..))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....))).....(((((((((.)))))))))....(.((((((.........))))))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....(((..(....)..)))..(((((())))))((((((.((.......((..((.......)).(((.......(((.))))))....))......)).))..)))).....(..((.(..(.(((.(..........).))).)..).))...).))...(((((((..((..(((((..(((.((((((.....((........))........)))))).))).......((....))...))))).)).))).)))..))))...)).)....((((((...((...((((.........))))...))))))))......{...(((.((.((((((((((.((((())))).))))))))))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((((....(...)...((.(((...(.((((((....(((((((((...)))..(.((......)))...)))))).....((((.(.(..(((..((.(((((((((...))))))))).))..))).).)..(.((((((.....))))))....)..)))).....))).))).....).))))).....)))))))...)).)))).))).(...((((((.......((...(.(((((..))))).)...((..((((....))))..))....)).........))))))......(....(((.((..........)).)))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.(((((.((..(.((.(((((.(((..((.((((...(...((((.))).)...)...)))).))..))).))))).)))..)).)))))..).))...)..)..(((((((((....)))))))))}...... Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit; 18S ribosomal RNA 6okk A 1608 3.3 RF01960,RF01959,RF00177 URS000040971D_36329 24913268 0003735 0005840 36329 aaccugguugaucuugccaguagucauaugcuugucucaaagauuaagccaugcaagugaaaguauauauauauauauguagaaacugcgaacggcucauuaaaacaguuauagucuacuugacauuuauaaggauaacuacggaaaagcuguagcuaauacuugcauuauccuuuuggauaaguauuuguuagaaggaauuauaacaaagaaguaacacguaaaguguguaucaaucgaguuucugaccuaucagcuuuugauguuaggguauuggccuaacauggcuaugacggguaacggggaauuagaguucgauuccggagagggagccugagaaauagcuaccacaucuaaggaaggcagcaggcgcguaaauuacccaauucuaaagaagagagguagugacaagaaauaacaaugcaagguuuguauuggaauggugggaauuuaaaaccuucccagaguaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaauuguugcaguuaaaacgcucguaguugaauuucaaagaaucauucuuuuuaaaauccggauuuguuacuuugaguaaauuagaguguucaaagcaaacaguuaaagcauuguguuugaauacuauagcauggaauaacaaaauugaacaagcuaaaauuuuuuguucuuauuuuggcuuaguuacgauuaauaggaguagcuuggggacauucguauucagaugucagaggugaaauucuuagauuuucuggagacgaacaacugcgaaagcauuugucuaaaauacuuccauuaaucaagaacgaaaguuaagggagugaagacgaucagauaccgucguaaucuuaaccauaaacuaugccgacuagguguuggaugaagugcuuccuucaguaccuuaugagaaaucaaagucuuuggguucuggggcgaguauucgcgcaagcgagaaaguuaaaagaauugacggaagggcaccaccaggcguggagcuugcggcuuaauuugacucaacacggggaaacucacuaguuuaagacauuggauggugaugcauggccguuuuuaguucgugaaugauuugucugguuaauuccgauaacgaacgagaucuuaaccugcuaauuagcggcgaguacacuguacuugcugcuucuuagaggaacauugugugucuaacacaaggaaguuuaaggcaacaacaggucugugauguccuuagaugaacuaggcugcacgcgugcuacacugauauauauaacgaguaaaauaugcuugcauacuuuuccuccgccgaaaggcguagguaaucuuuaucaauauauaucgugauggggauagauuauugcaauuauuaaucuugaacgaggaaugccuaguaagcaugauucaucagauugugcugacuacgucccugcccuuuguacacaccgcccgucgcuccuaccgauugaaagauaugaugaauuguuuggacaagaaaaauuuuuucuggaaaaaccguaaauccuaucuuuuaaaggaaggagaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<<<...<......<<<.<<<..<<....<<...<<<<<<..>>>>>>...>>.>>......<<..<.....<<<..<<..<<...<<<<........<<.....<<<<<<.....>>>>>>......>>....<<<<<<....>>>>>>...<<<<<<<.<......>.>>>>>>>.......<<<.....>>>....>>>>..>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>>>.....<<<<<<<<<.>>>>>>>>>......<<<<<<.........>>>>>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<.<....>.>>>>..<<<<<..>>>>><<<<<<.<<.......<<...<.......>.<<<<.......<<<.>>>>>>>...>>......>>.>>..>>>>.....<.<<<.<<.<.<<<.<..........>.>>>.>.>>.>>>..>.>>....<<<<<<..<<..<<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>.>>>>.......<<....>>...>>>>>.>>.>>>.>>>...>>>...>>.>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<<<<<<<<.<<<<..>>>>.>>>>>>>>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<<<....<...>...<<.<<<..<<<<<<<<<....<<<<<<<<<...>>>...<<<......>>>...>>>>>>....<<<<<.<<<..<<<..<<<<<<<<<<<<...>>>>>>>>>>>>..>>>.>>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>>>>>>>...>>.>>>>.>>>.....<<<<<<<<.....<<.<<<.<<<<<..>>>>>.>.>><<<.<<<<....>>>>.>>>....>>.......>>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<.<<<<...<<.<<<<<.>>>.>>.>>...>>>>.>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(((...((.....(((.(((..((....((...((((((()))))))...))[))......(((.......(((..((..((...((((....[...((.....((.(((.....))).))......))....((((((....))))))...(((((((.(......).))))))).....(](((.(..)))))...))))..))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....))).....(((((((((.)))))))))....(.((((((.........))))))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....(((..(....)..)))..(((((())))))((((((.((.......((..((.......)).(((.......(((.))))))....))......)).))..)))).....(..((.(..(.(((.(..........).))).)..).))...).))...(((((((..((..(((((..(((.((((((.....((........))........)))))).))).......((....))...))))).)).))).)))..))))...)).)....((((((...((...((((.........))))...))))))))......{...(((.((.((((((((((.((((())))).))))))))))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((((....(...)...((.(((...(.((((((....(((((((((...)))..(.((......)))...)))))).....((((.(.(..(((..((.(((((((((...))))))))).))..))).).)..(.((((((.....))))))....)..)))).....))).))).....).))))).....)))))))...)).)))).))).(...((((((.......((...(.(((((..))))).)...((..((((....))))..))....)).........))))))......(....(((.((..........)).)))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.(((((.((..(.((.(((((.(((..((.((((...(...((((.))).)...)...)))).))..))).))))).)))..)).)))))..).))...)..)..(((((((((....)))))))))}...... Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit; 18S ribosomal RNA 8vft 9 1698 3.3 RF01960,RF02542,RF01959,RF00177 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<.<....<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<..<<<.>>>.>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<.[..>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.......].<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<..<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>......>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..(......(((.(((..(.....((....((..........))...))[.)......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(]((((..(((.))).)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).......(.(((...((((.]...))).))))).)...)).).....(((((((((....(...)....)))))).)))....(.((..(...........)..))......)...(((([[......((((.....((..]])).......)))).))))...)))))).)))..[......(.([[...(.(.((...(((..(.....((..((()))..))..(.((((.((()))))))..)..((((((.(.......((..(.........).(((.)))....))......).)))..)))........(.((.((((((.................)))))).)).)....)....(((..((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((.((....)).)))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..(((..((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..))..)))...).))...)..)..(((((((((....)))))))))}........ Translating 80S rabbit ribosome stalled by emetine with eEF2; 18S rRNA