5ndj 13 1508 3.15 RF00177,RF01959,RF01960 URS0000868551_300852 29208708 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<........>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((........))).).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((....(((((((....)))))))...................))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); 16S ribosomal RNA 5ndj 1G 1513 3.15 RF00177,RF01959,RF01960 URS0000868551_300852 29208708 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuug .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<<....>>>...>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((..((((.((....)).))))....((......))...)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....))))))))).............. Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); 16S ribosomal RNA 5ndj 1H 2912 3.15 RF02540,RF02541,RF00002 URS0000868533_300852 29208708 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<.<<<......>>>..>>.>.>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....................>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<.<<..<<<<.....<<<<<<<<....>>>>>>>>..>>>>............>>.>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> .....(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((.((........)).))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((...............)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((...............................(..............).)))))...).)))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........((.......(......(.(...((....))...).)...).................))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))..... Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); 23S ribosomal RNA 5ndj 14 2909 3.15 RF02540,RF02541,RF00002 URS0000868533_300852 29208708 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<.....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<..........>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<.<<........>>..>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<.....................>>.........<........>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<.......<........<<<<<<<..>>>>>>>.....>.................>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>....<.......>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. .....(((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.((((((((......((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))..))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))......(..............).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((.(..........)..)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.((.....{..(((...((...................))..........(........)....)))....)).))))))).))..........]]].)....))))))))))...)))))))((((((.........))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((.(((.(..........(...............(..((((....))))...).....................).).))).))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(...(.......)......(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))..... Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); 23S ribosomal RNA 5ndk 13 1508 2.95 RF00177,RF01959,RF01960 URS0000868551_300852 29208708 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<........>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((........))).).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((....((((((......))))))...................))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; 16S ribosomal RNA 5ndk 1G 1513 2.95 RF00177,RF01959,RF01960 URS0000868551_300852 29208708 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuug .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((...(((.(......).))).....((......))...)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....))))))))).............. Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; 16S ribosomal RNA 5ndw 1 3090 3.7 RF02540,RF02543 URS000061F377_559292 29208708 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccgaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguuugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacuuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<..<<.......>>..>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<..>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.....>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<<...>>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<...>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(..(..........).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......((((..))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((...))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(.).)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 25S ribosomal RNA 5ndw 2 1770 3.7 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29208708 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<<........>>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<<<....<.>.....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>...>.>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<.........>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(.(....).).....(......).)))))).)...).(.((((..((.(....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........((...((..((((....]]]]]]]].))))..))..)).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((.........)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 18S ribosomal RNA 5ndw 3 121 3.7 RF00001 URS000055688D_4932 29208708 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 5S ribosomal RNA 5ndw 4 158 3.7 RF00002 URS00001BF64E_4932 29208708 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5ndw 5 3080 3.7 RF02540,RF02543 URS000061F377_559292 29208708 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccgaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccuguaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcacgcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<......>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<.........>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<....>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<......>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<..>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<..<<<<<<<<..<<<<<<<...>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.((((.((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)).)))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(((...........)))))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......((((..))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((......)))))....))....))...(((((........)))))]]((((..((((..(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((..))))))))))).).))))))).))))(...)....))))))...))....)..)..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((((.........)))).........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((((.(..))))).)....((((.....((((..(((.(......).)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....))))))))......(((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 25S ribosomal RNA 5ndw 6 1736 3.7 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29208708 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucacuggauuuccaacggggccuuuccuucuggcuaacgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<.<..........>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<<.<<<<<.>>>>>.....>>>>.>>>>>>....<<<<<<........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<..>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[[((......)).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((.(................).)).).)....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..(((((.)))))......))).))))))....((((((........))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..((((((((....]]]]]]]].)))))))).))).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.(..(((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)..).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 18S ribosomal RNA 5ndw 7 121 3.7 RF00001 URS000055688D_4932 29208708 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 5S ribosomal RNA