3ovb C 35 1.95 URS000080E1A6_32630 21071662 32630 ggaaguagaugguucaaguccauuuacuuccacca <<<<<<<<<<<<.......>>>>>>>>>>>>.... ((((((((((((.......)))))))))))).... How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA; RNA (35-MER) 3ovb D 35 1.95 URS000080E1A6_32630 21071662 32630 ggaaguagaugguucaaguccauuuacuuccacca <<<<<<<<<<<<.......>>>>>>>>>>>>.... ((((((((((((.......)))))))))))).... How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA; RNA (35-MER) 6tf2 A 52 2.55 RF03013 URS00021ED92A_204669 32295864 204669 ggcuucaacaaccccguagguugggccgaaaggcagcgaaucuacuggagcc <<<<<<.........<<<<<<<..<<<....>>>....>>>>>>>.>>>>>> (((((((.....[[.((((((((.(((....))).])])))))))))))))) Crystal structure of the ADP-binding domain of the NAD+ riboswitch with Adenosine 5-triphosphate (ATP); Chains: A 7d7y A 51 2.8 RF03013 URS00021ED902_32630 33170270 32630 gcuucaacaaccccguagguggggacgaaagucagcgcaccuacuggagcc <<<<<.........<<<<<<<..<<<....>>>....>>>>>>>.>>>>>. ((((((.....[[.((((((((.(((....))).])]))))))))))))). Crystal Structure of the Domain1 of NAD+ Riboswitch with adenosine triphosphate (ATP); 18GAAA (52-MER) 7n1p 23 2904 2.33 RF02541 URS0002311982_83333 34234344 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauuaagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..(.(......((((((((....))))))))...).)............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation; 23S rRNA 7n2c 23 2903 2.72 RF02541 URS00004B0F34_83333 34234344 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..((.......))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((..(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((........)))...))))))...)))...))))(..).....))))...))....)))..)))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.....[...(((((..(((......((((((((....))))))))...)))..].........)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2); 23S rRNA 7n2u 23 2902 2.53 RF02541 URS00004B0F34_83333 34234344 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>> ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(.(.((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((.((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))).))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))) Elongating 70S ribosome complex in a hybrid-H1 pre-translocation (PRE-H1) conformation; 23S rRNA 7n2v 23 2904 2.54 RF02541 URS00004B0F34_83333 34234344 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<.<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.....[...(((((..(((......((((((((....))))))))...)))..].........)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...((((.((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)).))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1); 23S rRNA 7n30 23 2901 2.66 RF02541 URS00004B0F34_83333 34234344 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaacc <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<......<<<.........>>>.............<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>> ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(....(((.........))).....)...(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(.(.........(((((..(((.......(((((((....)))))))....)))............)))))).).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))) Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation; 23S rRNA 7n31 23 2904 2.69 RF02541 URS00004B0F34_83333 34234344 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<...........>....>>.....<...<<......>>.>.>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((....................................(......)....)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..((((......))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..((.......((((((((....))))))))....))............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Elongating 70S ribosome complex in a post-translocation (POST) conformation; 23S rRNA 7orj T 17 3.9 URS00023358F9_3052409 35173159 3052409 cuugguaguacacuacu ................. ................. La Crosse virus polymerase at transcription capped RNA cleavage stage; RNA (5'-R(P*CP*UP*UP*GP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3') 7ork T 18 3.1 URS00023358F9_11577 35173159 11577 acuugguaguacacuacu .................. .................. La Crosse virus polymerase in transcription mode with cleaved capped RNA entering the polymerase active site; RNA (5'-R(P*AP*CP*UP*UP*GP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3') 7orn T 18 2.8 URS00023358F9_3052409 35173159 3052409 acuugguaguacacuacu .................. .................. La Crosse virus polymerase at replication initiation stage; RNA (5'-R(P*AP*CP*UP*UP*GP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3') 7otc A 2903 2.9 RF02541 URS00023358D7_469008 35500116 0003735 0005840 469008 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauuggaccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))(...((((...((((((((((((.((.....))))))))))..))))..[))))....)(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.(.((..(.(.(.....[...((((...(.(......(((.((((....)))).)))...).)...].........))))).).)..)).).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli 70S ribosome in complex with elongation factor G and the antibiotic Argyrin B; 23S ribosomal RNA 7uo7 T 34 3.09 URS00026177A0_32630 36725929 32630 cucagcuucuuaggagaaugacguagcaugcuac .................................. .................................. SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state; Template RNA (55-MER) 8peg 7 2903 3.3 RF02541 URS000080E25C_562 38409277 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<............<<..<<<....>>>..>>...................>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((.(((...(((]]]..].))).......))).))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(.(.(((..(.........((.((............((....(....)....))...................)).)))..))).).)..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli paused disome complex (queueing 70S non-rotated closed PRE state); 23S ribosomal RNA 8qyx A2 3706 1.78 RF02543 URS0002F12CA1_9606 39658079 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnnacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccanuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccncggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugaagaaauucaaugaagcgcggnuaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagagacaugagagguguagaauaagugggaggccccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguaauccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<...<<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>..>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<..<....<<....<<<<.<<<...<<....>>.>>>>>>>>>...>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<..<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<......>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<.<...........>..>>>>>>>>>>>.>>>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<...........>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..(((...(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<..<..<.............>..>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..........<..<<.....................>>........................>.....>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))...)))...........................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<......>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<...<..........>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<...............>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<......<...........................................>....>..>>>.>>>>>...<<<<<.....<<<<.....................................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<.<...>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((...((((...(((.((..((((....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))))).)).)))..))))...)))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((.......((((.((......(((((((((((..(((((((..(....((....((((.(((............)))))))))...)..))))...)))))))))))))).......)).))).).......(((((((((((((((((((((((...((..(((....((((......(.(((((....))))).).......))))...)))........))))))..)))))))))))....................((((((.(((((((......))))))).((((((.((((.((((((((((.(((((..((((..................))))..)))).).))))))).)))...))))..)))).))..((((.(.((.......).)).)).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[.[...[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((.....((.....((.....((.....(.............)...)).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.....(.................................(............)..)......)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]...].]].............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((...(...)...))))))).......)....))...(((((........)))))]]((((....(((((...((((((......))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(.((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....(......((((....))))......)..))))..)))))(((.............)))........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..)))).)..))))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.((((..((.(........................................................)))...))))...(((((.....((((.....................................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...a.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).....(((((((.((..((((.(..(((........(((((.(((.(...)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Human 60S ribosomal subunit; 28S rRNA 9fsf 2 1451 2.8 RF01959 URS0003054927_273057 39753558 0003735 0005840 273057 aauccgguugauccngccggacccgaccgcuaucgggguggggcuaagccangggagucguacgcucccgggcaagggagcguggcggacggcugaguaacacguggcuaacnuacccugaggagggagauaaccccgggaaacuggggauaaucucccauaggcgaggaguccuggaacgguuccucgcugaaaggcucaugggcuauuccccgcucaugagcgccucaggauggggcugcggcncaucagguaguuggggggguaagggccccccaagccuauaacggguaggggccgugagagcgggagnccccaguugggcacugagacaagngcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcggaagcgugagggcnccaccccgagugcucccguaagggagcuuuuccccgcucuacaaaggcgggggaauaagcggggggcaagucuggugucagncgccgcgguaaunccagccccgcgaguggungggacucuuacugggccuaaagcgcncguagccngcccgacaagucacuccuuaaagaccccggcucaaccgggggaaugggggugauacugucgggcuagggggcgggagaggccagcgguacucccggaguaggggcgaaauccucagaucucgggangaccaccaguggcgaaagcggcuggcuagaacgcgccngacggugaggggcgaaagccggggcagcaaaagggauuagauaccccuguagucccggcuguaaacaaugcaggcuaggugucacaugggcuuagagcccauguggugccgcagggaagccguuaagccugcngccuggggaguacggucgcaanacugaaacuuaaaggaauuggcgggggagcaccacaaggnguggaaccugcggcucaauungagncaacgccuggaaucuuacuaggggagaccgcaggaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccnucgccagcucgugnugugaaauguccuguuaagucaggcaannagcgagacccccaccacuaguugguauccuggucuccgggccgggaccacacuagugggacugccggcguaagccggaggagggagggggccacggcaggucagcaugccccgaaaccccugggccgcacgcngguuacaauggcagggacagcgggauuccgaccccgaaaggggaagguaaucccuuaaacccugccgcaguugggaucgagggcugaaacucgcccucgugaacgaggaaucccuaguaaccgcagaucaacaaucugcggugaauacgncccugcuccuugcacacaccgncngucgcuccacccgaguaggaccugcaaggggggagaagucguancaagguagnnguaggggnannugcggcuggaucaccucc ..<<<<<<.[.((((>>>>>><<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<<<<<<<(((...>>>>>>>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<<<<<.....)))>>>>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<....>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<<<......<<<.<<<.......>>>.>>>...>>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<...<<..<<<<<<<......>>>>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<...<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<...<<<<.>>>>...>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..(((((((([[[...)))))))))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...((((((((..((......)).)))))))).....((((((((((.....]]])))))))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((....))))))..(.(((((((.......)))))))....).((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((.....((((((((((.(((((((....((........)).......))))))).))).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))........(.(.(((((...((((((......(((.(((.......))).)))...)).))))...((.(((...((((((((....(((((((((....)))..((((......))))..))))))....(((((.(((((((..((..(((.((((....)))).)))))...)))))))..(..(((((....))))).....)..)))))....))).)))...)).)))))....))))).))..)).)))))))).(...(((((((.....(((...((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((((.(((..(.(((.))).)..))).))))..).))...)..)..(((((((((....)))))))))}.......... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-MAP leaderless mRNA with h44 in up position; rRNA 16S 9fsf 4 77 2.8 RF00005 URS0000B21E07_562 39753558 0030533 0006412 562 agcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-MAP leaderless mRNA with h44 in up position; tRNA Met initiator 9n2b 23 2767 2.2 RF02541 URS00004B0F34_83333 40045785,30282032 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagcguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<...............>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.)...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((((((((.((.((.....)))).)))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Impacts of ribosomal RNA sequence variation on gene expression and phenotype: Cryo-EM structure of the rrsB ribosome (BBB-70S); 23S ribosomal RNA (rRNA) from the rrnB operon 9n2c 23 2768 2.4 RF02541 URS00004B0F34_83333 40045785,30282032 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagcguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..()....)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((((((((.((.((.....)))).)))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((()))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Impacts of ribosomal RNA sequence variation on gene expression and phenotype: Cryo-EM structure of the rrsH ribosome (HBB-70S); 23S ribosomal RNA (rRNA) from the rrnB operon 9ypg 13 74 3.0 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... GTPBP1*GCP*Phe-tRNA*ribosome in the GTPase activation-like state, Structure III; Met-tRNA 9ypg 11 74 3.0 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... GTPBP1*GCP*Phe-tRNA*ribosome in the GTPase activation-like state, Structure III; Met-tRNA 9ypo 13 74 3.0 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... GTPBP1*GCP*Phe-tRNA*ribosome in the open state, Structure IIa; Met-tRNA 9ypo 11 74 3.0 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... GTPBP1*GCP*Phe-tRNA*ribosome in the open state, Structure IIa; Met-tRNA 9yps 13 74 3.0 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... GTPBP1*GCP*Phe-tRNA*ribosome in the open state, Structure IIb; Met-tRNA 9yps 11 74 3.0 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... GTPBP1*GCP*Phe-tRNA*ribosome in the open state, Structure IIb; Met-tRNA 9ypt 13 74 3.1 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... GTPBP1*GCP*Phe-tRNA*ribosome in the open state, Structure IIc; Met-tRNA 9ypt 11 74 3.1 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... GTPBP1*GCP*Phe-tRNA*ribosome in the open state, Structure IIc; Met-tRNA 9ypv 13 74 3.0 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... GTPBP1*GCP*Phe-tRNA*ribosome in the open state, Structure IId; Met-tRNA 9ypv 11 74 3.0 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... GTPBP1*GCP*Phe-tRNA*ribosome in the open state, Structure IId; Met-tRNA 9ypw 13 74 2.9 RF00005 41350250,31588918 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... GTPBP1*GDP*Phe-tRNA*ribosome in the post-GTP hydrolysis state, Structure IV; Met-tRNA 9ypw 11 74 2.9 RF00005 41350250,31588918 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... GTPBP1*GDP*Phe-tRNA*ribosome in the post-GTP hydrolysis state, Structure IV; Met-tRNA 9ypy 13 74 3.0 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Ribosome with accommodated A-site tRNA, Structure V; Met-tRNA 9ypy 11 74 3.0 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Ribosome with accommodated A-site tRNA, Structure V; Met-tRNA 9ypz 13 74 2.9 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Vacant ribosome with P-site tRNA, substate 1, Structure Ia; Met-tRNA 9ypz 11 74 2.9 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Vacant ribosome with P-site tRNA, substate 1, Structure Ia; Met-tRNA 9yq0 13 74 2.9 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Vacant ribosome with P-site tRNA, substate 2, Structure Ib; Met-tRNA 9yq0 11 74 2.9 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Vacant ribosome with P-site tRNA, substate 2, Structure Ib; Met-tRNA 9yq1 13 74 2.9 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Vacant ribosome with P-site tRNA, substate 3, Structure Ic; Met-tRNA 9yq1 11 74 2.9 RF00005 41350250 0030533 9606 gcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Vacant ribosome with P-site tRNA, substate 3, Structure Ic; Met-tRNA