1nyi A 16 2.85 URS000080DF69_32630 12948485 32630 guggucugaugaggcc ................ ................ Crosslinked Hammerhead Ribozyme Initial State; 5'-R(P*GP*UP*GP*GP*UP*CP*UP*GP*AP*UP*GP*AP*GP*GP*CP*C)-3' 5l00 A 15 1.25 28058281 32630 nnnnacuuaagucgg ............... ............... Self-complimentary RNA 15mer binding with GMP monomers; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5l00 B 15 1.25 28058281 32630 nnnnacuuaagucgg ............... ............... Self-complimentary RNA 15mer binding with GMP monomers; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5l00 C 15 1.25 28058281 32630 nnnnacuuaagucgg ............... ............... Self-complimentary RNA 15mer binding with GMP monomers; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5l00 D 15 1.25 28058281 32630 nnnnacuuaagucgg ............... ............... Self-complimentary RNA 15mer binding with GMP monomers; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 6cab A 14 2.5 29851379 32630 nnnnacuuaagucg .............. .............. RNA-dGMP complex with Sr ion; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6cab B 14 2.5 29851379 32630 nnnnacuuaagucg .............. .............. RNA-dGMP complex with Sr ion; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6i9r A 1501 3.9 RF02541,RF02540 URS0001A24B39_9606 33910005 0003735 0005840 9606 cuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauaacacaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaancacuuguuccuuaaauagggacnuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgnuguuggaucaggacaucccgauggugcagccgcuauuaaagguucguunguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauacccacacccacccaagaacaggguu <<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>............<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.........>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<...............>>>>>>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<.......>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>..............<<<<.......>>>>. (.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)..........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.....((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))........))..((((((....((((....)))).((.((((((((((.....((........)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(....(((.........)))....)....(..(((......))))..........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.........)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((..(((((..(((((.((((((((...............)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..).))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).)).(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..............((((.......)))). Large subunit of the human mitochondrial ribosome in complex with Virginiamycin M and Quinupristin; 16S rRNA 7pd3 A 1280 3.4 RF02541,RF02540 URS0002311A1E_9606 34609277 0003735 0005840 9606 gcuaaaccuagccccaaacccccaccuuacuaccagacaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguaccgcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagcaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcaccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaccugcauuaaaaauuucgguugnggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguun <<<.......<<<<..................................<......>.....<.....<<.....>>....>..>>.>>.............<<....>>.................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<.<<.....<<......>>.....>>.>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>..........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.......<<<.....<<........<<<<<<......>>>>>>........>>....>>>...<<<<<<.....>>>>>>..........>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......................<<<<.<<<<<<..<<<<<.<<<<<<......>>>>>>>>>>>..<<<.......>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.....................<<.<<<<<<......>>>>>>...>>....... ((.....(..((((..................................(...[..).....(.....((.]...))....)..)).)).............((....))....).............)).........(.(((.......))).{.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((........)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.(((((((.((.....((......)).....)).)))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......)))).........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))((((..((((......(.(((((...)))))......(((...((((...............(..)....)))).......))).)...((......)).)))).....))))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((........((...............((((((......))))))..............))....(((((.......)))))..........)))....)).))))....)..))).))))))).)))).)).....)).[..(((((.....}].))))).......................((((.((((((..(((((.(((((((....))))))))))))..((((.....))))((((((...........))))))..((.....((...(((....[..)))...))....)).........(((....)))......].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)...................((.((((((......))))))...))....... Structure of the human mitoribosomal large subunit in complex with NSUN4.MTERF4.GTPBP7 and MALSU1.L0R8F8.mt-ACP; 16S rRNA 8evr B5 1173 2.87 RF01960,RF02542,RF01959,RF00177 URS0002681484_4932 37595043 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugac ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<......(((.(((.<.<....>.>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<..................>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>......<<<.................................>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))).))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..)))).}.............................................. ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((...(((..).))..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(....(.(...(......).)...).....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((..................)).))))))......((((.............(.....)...........)))).....((((..((.......((..((.......)).(((.....)))....))......))..)..)))..............(.((.(((.....]].]]]].))).)).).........))...(((((((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))).)))..))))...)).)....((((((....(...((((.........))))...).))))))..........(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].............................................. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II; 18S rRNA 8evr A1 3198 2.87 RF02543 URS0002681478_4932 37595043 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((.(.....(...((((((...({((((......)))))[[(...).(((....}]])))....)))))).....)....)......))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((........(..........).........))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..((((((((((....((.(((((((.....(((....(((..(.((((...............)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((.((....((.........))....)).....(...((......)).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((....(...).....)).....))....))...(((((........)))))]]((((..(((((.....((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.(......).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....(((......))).....)).)))))..)))))(.................)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((..((.(((..((..........(..(..(.(...))............)..)..)).)))..))..))))))....((((.....((((..((((........))))...........>....(((((....)))))...))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II; 25S rRNA 8evs B5 1173 2.62 RF01960,RF02542,RF01959,RF00177 URS0002681484_4932 37595043 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugac ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<......(((.{((.<.<....>.>.....<......>.>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<.<<<..................>>>..>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<................>>>.>>>>>>......<<<.................................>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....)).}))).>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}.............................................. ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((...(((..).))..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(....(.....(......).....).....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((..................)).))))))......((((.............(.....)...........)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]].]]]].))).)).)...).....))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))..........(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].............................................. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure II; 18S rRNA 8evs A1 3198 2.62 RF02543 URS0002681472_4932 37595043 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<.<..<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>...>.>>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<.......<<<........>>>........>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<.............>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<<..........>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<............<..........................>...>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<]]].>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((..(((.(.(.(...((((((((...({((((......)))))[[(...).(((....}]])))....))))))))....).).)......))).))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((.......((..........))........))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..((((((((((....((.(((((((.....(((....(((..(.((((...............)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((.((....((.........))....)).....(...((......)).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((((.((...))..)))).....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).....).)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.(......).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....(((......))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((.((.(.((..........(..(..(......)............)..)..))).))..)).)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure II; 25S rRNA 8evt B5 1173 2.2 RF01960,RF02542,RF01959,RF00177 URS0002681484_4932 37595043 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugac ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<.......((.{.................<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<.<<<................>>>..>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>......<<<<...............................>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<........}))..>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}.............................................. ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((.....(..........)....))[))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((........{....................(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((...(.(...(......).)...)....))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((.((.(..............).)).))))))......((((...............................)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((..........}..))).)).)...).....))...(((.(((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))..........(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].].............................................. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES) refined against a composite map; 18S rRNA 8evt A1 3192 2.2 RF02543 URS0002681478_4932 37595043 0003735 0005840 4932 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Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES) refined against a composite map; 25S rRNA 8sx6 A 14 1.45 37920395 32630 nnnnacuuaagucg .............. .............. RNA duplex bound with GMP and AMP monomers; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 8sx6 B 14 1.45 37920395 32630 nnnnacuuaagucg .............. .............. RNA duplex bound with GMP and AMP monomers; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3')