6ck4 A 101 3.097 RF00442 URS0000D7794B_583357 29877798 0010468 583357 ugaaaguguaccuaggguuccagccuauguagguguucggaccgagcgguacagguaauaccacaccuuagggacaaaagcccgagaggauagguuucacu <<<<<.<<<<<<..<<..<<<.<<<<<..>>>>>....>>>>>....>>>>>><<<<.>>>>...<<<<.<<<.......>>>..>>>>.....>>>>>.. (((((.((((((..((...((((((((..)))))..).)).))....))))))((((.))))...((((.(((.......)))..)))).....))))).. G96A mutant of the PRPP riboswitch from T. mathranii bound to ppGpp; PRPP riboswitch 6ck4 B 108 3.097 RF00442 URS0000D7794B_583357 29877798 0010468 583357 gugaaaguguaccuaggguuccagccuauuuguagguguucggaccgagcgguacagguauauuauauaccacaccuuagggacaaaagcccgagaggaugguuucac <<<<<<.<<<<<<..<<..<<<.<<<<<....>>>>>....>>>>>....>>>>>><<<<<<<.>>>>>>>...<<<<.<<<.......>>>..>>>>....>>>>>> ((((((.((((((..((...((((((((....)))))..).)).))....))))))(((((((.)))))))...((((.(((.......)))..))))....)))))) G96A mutant of the PRPP riboswitch from T. mathranii bound to ppGpp; PRPP riboswitch 6ck4 C 108 3.097 RF00442 URS0000D7794B_583357 29877798 0010468 583357 gugaaaguguaccuaggguuccagccuauuuguagguguucggaccgagcgguacagguauauuauauaccacaccuuagggacaaaagcccagaggauagguuucac <<<<<<.<<<<<<..<<..<<<.<<<<<<..>>>>>>....>>>>>....>>>>>><<<<<<<.>>>>>>>...<<<<.<<<.......>>>.>>>>.....>>>>>> ((((((.((((((..((...(((((((((..))))))..).)).))....))))))(((((((.)))))))...((((.(((.......))).)))).....)))))) G96A mutant of the PRPP riboswitch from T. mathranii bound to ppGpp; PRPP riboswitch 6ck4 D 101 3.097 RF00442 URS0000D7794B_583357 29877798 0010468 583357 gugaaaguguaccuaggguuccagccuauguagguguucggaccgagcgguacagguaauauaccacaccuuagggacaaaagcccagaggaguuucacgu .<<<<<.<<<<<<..<<..<<<.<<<<<..>>>>>....>>>>>....>>>>>><<<.....>>>...<<<<.<<<.......>>>.>>>>..>>>>>... .((((..((((((..((...((((((((..)))))..).)).))....))))))(((.....)))...((((.(((.......))).))))...))))... G96A mutant of the PRPP riboswitch from T. mathranii bound to ppGpp; PRPP riboswitch 6dmc A 102 2.2 URS0000E60BA7_679936 30120360 679936 ngaaguguaccuagggauccaccucgagagaggaaggaccaagcgguacaggccuacuucgguagguuacaccguggggauaaaagacccguggcaaguuun <<<<.<<<<<<..<<..<<<.<<<<....>>>>..>>>>>....>>>>>><<<<<<<....>>>>>>>...<<<<<<<.........>>>>>>>....>>>> ((((.((((((..((...((.((((....))))..)).))....))))))(((((((....)))))))...(((((((.........)))))))....)))) ppGpp Riboswitch bound to ppGpp, native structure; ppGpp Riboswitch 6dmc B 102 2.2 URS0000E60BA7_679936 30120360 679936 ngaaguguaccuagggauccaccucgagagaggaaggaccaagcgguacaggccuacuucgguagguuacaccguggggauaaaagacccguggcaaguuun .<<<.<<<<<<..<<..<<<.<<<<....>>>>..>>>>>....>>>>>><<<<<<<<..>>>>>>>>...<<<<<<<.........>>>>>>>....>>>. ((((.((((((..((...((.((((....))))..)).))....))))))(((((((....)))))))...(((((((.........)))))))....)))) ppGpp Riboswitch bound to ppGpp, native structure; ppGpp Riboswitch 6dmd A 102 2.65 URS0000E60BA7_679936 30120360 679936 ngaaguguaccuagggauccaccucgagagaggaaggaccaagcgguacaggccuacuucgguagguuacaccguggggauaaaagacccguggcaaguuun <<<<.<<<<<<..<<..<<<.<<<<....>>>>..>>>>>....>>>>>><<<<<<<....>>>>>>>...<<<<<<<.........>>>>>>>....>>>> ((((.((((((..((...((.((((....))))..)).))....))))))(((((((....)))))))...(((((((.........)))))))....)))) ppGpp Riboswitch bound to ppGpp, manganese chloride structure; ppGpp Riboswitch 6dmd B 102 2.65 URS0000E60BA7_679936 30120360 679936 ngaaguguaccuagggauccaccucgagagaggaaggaccaagcgguacaggccuacuucgguagguuacaccguggggauaaaagacccguggcaaguuun <<<<.<<<<<<..<<..<<<.<<<<....>>>>..>>>>>....>>>>>><<<<<<<<..>>>>>>>>...<<<<<<<.........>>>>>>>....>>>> ((((.((((((..((...((.((((....))))..)).))....))))))(((((((....)))))))...(((((((.........)))))))....)))) ppGpp Riboswitch bound to ppGpp, manganese chloride structure; ppGpp Riboswitch 6dme A 102 2.702 URS0000E60BA7_679936 30120360 679936 ngaaguguaccuagggauccaccucgagagaggaaggaccaagcgguacaggccuacuucgguagguuacaccguggggauaaaagacccguggcaaguuun <<<<.<<<<<<..<<..<<<.<<<<....>>>>..>>>>>....>>>>>><<<<<<<<..>>>>>>>>...<<<<<<<.........>>>>>>>....>>>> ((((.((((((..((...((.((((....))))..)).))....))))))(((((((....)))))))...(((((((.........)))))))....)))) ppGpp Riboswitch bound to ppGpp, thallium acetate structure; ppGpp Riboswitch 8fzf A 2899 3.2 RF02541 39030416 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<<.......>>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<<<<..............<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>.....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...(.(.(((.....)))...))...))))..))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((......(........).....).)....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((.((..((....))...)).))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((..(((((...........(...(...(........((..(((....)))..)).....).............)...)..)))).).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an E. coli rotated ribosome complex bound with RF3-ppGpp and p/E-tRNAPhe (Composite state I-C); 23S Ribosomal RNA