1y27 X 68 2.4 RF00167 URS000080DF8E_1423 15610857 0009113 1423 ngaucauauaaucgcguggauauggcacgcaaguuucuaccgggcaccguaaauguccgacuauggun .<<<<<<<...<.<<<<<.....<<>>>>>.>........<<<<<<>>.....>>>>>>..>>>>>>> .((((((((..(.(((((.....[[))))).)[.....)]((((((]].....))))))..))))))) G-riboswitch-guanine complex; Bacillus subtilis xpt 4ybb DA 2897 2.1 RF02540,RF02541 URS000080E25C_83333 25775265 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((........))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((.(((.(((...(((((......)))))[[(...).(((.....]])))...)))...))).)))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((...((..(............((...((......(.((((((....)))))).)...)).............))...)..))...))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). High-resolution structure of the Escherichia coli ribosome; 23S rRNA 5j5b DA 2897 2.8 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(..........(.((...((......((((((((....))))))))...)).............)).).).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the WT E coli ribosome bound to tetracycline; 23S rRNA 5j7l DA 2897 3.0 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<<<....<<<<<<<<....>>>>>>>>.>>>>>............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(..........(.((...((......((((((((....))))))))...)).............)).).).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S E coli ribosome with the U1052G mutation in the 16S rRNA bound to tetracycline; 23S rRNA 5j88 DA 2897 3.32 RF02540,RF02541 URS00004B0F34_562 27382179 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<.<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>..>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(.........((((....((......((((((((....))))))))...))..............))))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the E coli 70S ribosome with the U1060A mutation in 16S rRNA; 23S rRNA 5j8a DA 2897 3.1 RF02540,RF02541 URS00004B0F34_562 27382179 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(..........(.((...((......((((((((....))))))))...)).............)).).).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline; 23S rRNA 5j91 DA 2897 2.96 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(..........(.((...((......((((((((....))))))))...)).............)).).).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Wild-type 70S E coli ribosome bound to Tigecycline; 23S rRNA 5jc9 DA 2897 3.03 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<.<<<..<<<<<....<<<<<<<<....>>>>>>>>.>>>>>............>>>..>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(.........(((((...((......((((((((....))))))))...)).............)))))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Escherichia coli ribosome with the U1052G mutation in the 16S rRNA; 23S rRNA 6i7v DA 2897 2.9 RF02540,RF02541 URS000080E25C_562 30359641 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<.....>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....................>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<....<<......<<<<<<<<....>>>>>>>>...>>..............>>>.>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((...(............)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((.((.((((.((.....)))))).))...))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((..(((...........((.(....((......(((..............)))...))..............).))..)))..))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Ribosomal protein paralogs bL31 and bL36; 23S ribosomal RNA 6ubu B 67 1.6 RF00167 URS000080DDA1_1423 32414072 0009113 1423 ggacauauaaucgcguggauauggcacgcaaguuucuaccgggcaccguaaauguccgacuaugucc <<<<<<<...<.<<<<<.....<<>>>>>.>........<<<<<<>>.....>>>>>>..>>>>>>> ((((((((..(.(((((.....[[))))).)[.....)]((((((]].....))))))..))))))) 1.60 A resolution structure of the guanine riboswitch bound to guanine; Guanine riboswitch aptamer domain 7q7x B 24 2.8 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (with 1-methyl-adenosine); RNA 2 7q7x C 24 2.8 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (with 1-methyl-adenosine); RNA 3 7q7y B 24 2.9 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (1-benzyl-adenosine derivative); RNA 2 7q7y C 24 2.9 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (1-benzyl-adenosine derivative); RNA 3 7q7z B 24 3.26 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (with 1-benzylamine-adenosine); RNA 2 7q7z C 24 3.26 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (with 1-benzylamine-adenosine); RNA 3 7q7z E 24 3.26 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (with 1-benzylamine-adenosine); RNA 2 7q7z F 24 3.26 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (with 1-benzylamine-adenosine); RNA 3 7q80 B 24 3.14 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine); RNA 2 7q80 C 24 3.14 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine); RNA 3 7q80 E 24 3.14 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine); RNA 2 7q80 F 24 3.14 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine); RNA 3 7q81 B 24 2.85 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, 2'-Selenomethyl-Uridine modified (with 1-methyl-adenosine); RNA 2 7q81 C 24 2.85 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, 2'-Selenomethyl-Uridine modified (with 1-methyl-adenosine); RNA 3 7q82 B 24 2.95 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, Thallium derivative (with 1-methyl-adenosine); RNA 2 7q82 C 24 2.95 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, Thallium derivative (with 1-methyl-adenosine); RNA 3 7v9e A 68 2.3 URS00023358F0_9606 35301479 9606 cgggcugaccgaccccccgaguucgcucggggacaacuagacauacaguaugaaaauacugngcccgc <<<<<.........<<<<<<<<..>>>>>>>>.............<<<<<<....>>>>>>.>>>>>. (((((....((...(((((((....)))))))....)..).....((((((....)))))).))))). Crystal structure of a methyl transferase ribozyme; RNA (68-MER) 8ked A 71 2.11 1409 gauucguauauccuuaaugauaugguuuaagggcaauacauagagaccacaaauuucuuacugcgaauucu <<<<<<<....<<<<<<......((.>>>>>>.........<<<<.))......>>>>....>>>>>>>.. (((((((((..((((((......[[.))))))[....)]..(((((]].....)))))...)))))))).. Crystal structure of 2'-dG-III riboswitch with guanine; RNA (72-MER) 8xzo A 53 1.97 RF02977 38769061 0010468 41312 ngguguguaccguucaacucgucccagcuucgacugggacuacgggagcgccu <<<<<<...<<<<.......<<<<<<<......>>>>>>>.>>>>..>>>>>> ((((((...((((.......((((((((...).))))))).))))..)))))) Crystal structure of folE riboswitch with Guanine; RNA (53-MER)