5dm7 X 2780 3.0 RF02540,RF02541 URS00008FED45_1299 26464437 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggauaggugggagccugcgaaacuggccuuuuggggucgguggaggcaacggugaaauaccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguuuaucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<<[...((>>>>.....<<<<<<...<<.))...]..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<..<<<<<<....<<...<<<.<<<<......>>>>.>>>..>>.....>>>>>>...>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<<<.....>>>>>>>..>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>....<<<<........>>>>.))<<<<<<<<<...<....<<<<....<<<<..<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>....>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<...<<<......<<<.<<<......>>>.>>>...>>>.............>>>>..>>>>>>>>>>>>>>>>...<<<.<<........>>.>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<<.....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......(.((((((((.....(((..((((((((((((......((((((.[...[[.)))....(((((((...((.]]...]..))......)))))).).)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((...((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..((((((((..[......))))))))......(((((].[[[[)))))..)))......)).)))))).))..............((....))....))......(..((((....))))............)).....)))))))).).....(.(((((((((((.{..).)))))))))).[.(.(........).).((((((....(((.((((((((((...((...(((....)))...))....((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((..(((....(((((......)))))....)[))....(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((.(((...((((.((((((...(((...(((.((((......)))).)))..)).)...)))))).).)))..))).))).))..(((((((.(........).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).........((......))...)))))...)))))))))).))..........]]].)....))))))))))...)))))))...(((((.((...)).))))).......))))))(.(((((((.((.......((((.((....))}))))....)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((....(...((((....(((((.(((..(((((.((((..(...{{....).))))(((((((.((..((((((((((....(.....)..))))))....))))..)))))))))....((((....)))).....)))))...)))..)))))(..).....))))...).......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((...............)))))((((((((...))))))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......)))))))..((((.(((..(((((((..((....((...((((......))))...))....)))))))..)))))..((.(.......).))..........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((.........((((.((((((..(((((.(((.(((((.(((((.(.((((((((.(.........(.(((..(.(...........(........)........).)............))).)).)))))))).).)))))...(((.((........)).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...)..(][..[[).....)))))))...((((..(((...{..)))..)))).(((....))).))].].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))........)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))(.(((.....)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). Crystal structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with hygromycin A; 23S ribosomal RNA 5dox 1A 2872 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 26028538 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<..>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((..)))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((..........)).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution; 23S Ribosomal RNA 5dox 2A 2867 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 26028538 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<.<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<...>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((....................)).........((......))...)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((.......((((((......))))))....)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution; 23S Ribosomal RNA 5doy 1A 2871 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 26028538 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<<......>>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.....(.>>>....>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((....(((.(......).))..)...))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; 23S Ribosomal RNA 5doy 2A 2800 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 26028538 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((((((.....(.(..........)..).....)))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((..))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((.......((((.((....)).))))....)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; 23S Ribosomal RNA 8fc1 1A 2872 2.5 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..<<<...................>>>.........<<......>>....>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...(...........)...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......(((((((......)))))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.50A resolution; 23S Ribosomal RNA 8fc1 2A 2867 2.5 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<.........>....>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.......)))....)).........(........)...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..(.(.((((.(......[..(((((..(((.......((((.((....)).))))....)))..........].)))))).)))).).)..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.50A resolution; 23S Ribosomal RNA 8fc2 1A 2872 2.5 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..<<<...<<.........>>...>>>.........<<......>>....>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.50A resolution; 23S Ribosomal RNA 8fc2 2A 2867 2.5 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.......)))....)).........(........)...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(.((((((.(......[..(((((..(((.......((((.((....)).))))....)))..........].)))))).)))))).).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.50A resolution; 23S Ribosomal RNA 8fc3 1A 2872 2.6 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......((((((........))))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.60A resolution; 23S Ribosomal RNA 8fc3 2A 2867 2.6 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....................>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<.<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((....((.......)).....))......................))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(......[..(((((..(((.......((((.(......).))))....)))..........].)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.60A resolution; 23S Ribosomal RNA 8fc4 1A 2872 2.45 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<...........>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.45A resolution; 23S Ribosomal RNA 8fc4 2A 2867 2.45 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..................>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.........(((.((...(((.......)))....)).........(........)...))).....)))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.45A resolution; 23S Ribosomal RNA 8fc5 1A 2872 2.65 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.65A resolution; 23S Ribosomal RNA 8fc5 2A 2867 2.65 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....................>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.........(((.((...(((.......)))....)).........(........)...))).....).)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..(.((((((.(.........(((((..((........((((.(......).)))).....))............)))))).)))))).)..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(............(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.65A resolution; 23S Ribosomal RNA 8fc6 1A 2872 2.35 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...(...........)...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.35A resolution; 23S Ribosomal RNA 8fc6 2A 2867 2.35 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..................>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.........(((.((...(((.......)))....))......................))).....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..(.((((((.(.........(((((..(((.......((((..........))))....)))............)))))).)))))).)..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.35A resolution; 23S Ribosomal RNA