3fwo A 2765 3.71 RF02540,RF02541 URS000080DEF1_243230 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuagagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggugggagaaacuggccggucgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<.....<<<<<<..<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..>>>>>>......<<<<.<<<.........>>>.>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<...<.................>.....<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<........>>>>......>>>...<<<..<.<<<......>>>.>.>>>....>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<..<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>...>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<..........<<<<<.<<......<.......>......>>......................>>>>>......>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>>..<.<...<.......>..>.>.......>>>>>><<<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<......<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>>.<...<<.<..<<<..<<<<<<.............>>>>>>.....>>>..>.>>..>.....<<<<......>>>>....>>>>>...>>>...>>>>..........>>....>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<..............<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<....<<<<......>>>>....>...>>>>>>>>..>>>>>.<<<.<.......>.>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<......<............<...........<<>>........>........>......>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<<.....>>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<.<..<<<<.............>>>>...>>>..>>>>.......>>>>>>>..<<....>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((.((((((((.(....(((.((.[...[[[))...]..((((((...((.]]...]..))......))))))...)))...)(((....)))(((((....)))))((((....))))))...((((((.....(......)......))))).).........((....))...((((......((.....)).....))))...(((.....((((((..((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..))))))......((((.((((.......)))).))))......(((((..[[[[)))))..)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).......(((((.((((.......)))).))))).[.(.(........).).((((((....(((.((((((((((.........((....))..........((....))....(......)..........)))))))))))))..((.(...((((((.....((.((.(((..((((....((((........))))....)[)))...((...(.(((......))).)..))....))).)).))..(((.....)))......))))))......).))..((((((....((((......))))(((((((((...((.(.((.((....(((...(((.((((......)))).)))..)).)....)).)).)..))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((.((....(.....((..(((((((..........(((((.(((..(.(.........).)..))).....(...(........).).)))).).....))))))).))..........]]].)..).).))))))))...)))))))....(..((((...))))..)........))))))(.(((((((.((......((((..((....))..))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](.(((((((...((.....((....(((((.(((..(((((..(((.((...{{....)))))....(.((.....((..((.(((....(.....)..))).)).....)).....)).)......(((((....)))))....)))))...)))..)))))(..).....)).....))......))))))).)))))..)).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((...))))))))(...).......((((((.((.].(...........)...(((((((.....(((.....))).......))))))).}((((.(((..((.((((..(((...((...((.(......).))...))...)))))))...)))))(.((((......).))).)........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....).....(((.(....{]..).)))..((((((((.(((..(......((((.((((((..(((((.(.(.((((..(((((.(..(.((((..(....(..(.........(.(()).)......)..))..))).))..).)))))...(((((((......))))))).....)))).).)..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).)})......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((...............))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))..((....))....(((((((((.......)))))....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))))))). The large ribosomal subunit from Deinococcus radiodurans complexed with Methymycin; 23S RIBOSOMAL RNA 5wis 1A 2871 2.703 RF02540,RF02541,RF00002 URS00001698E8_300852 28934499 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..((..(......)....)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 23S ribosomal RNA 5wis 2A 2800 2.703 RF02540,RF02541,RF00002 URS00001698E8_300852 28934499 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((..(((.....((..........))......)))..)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((...((......(((((.((....)).)))))...)).............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 23S ribosomal RNA