1dk1 B 57 2.8 URS000080E305_274 10742169 274 gggcggccuucgggcuagacggugggagaggcuucggcugguccacccgugacgcuc <<<<.<<<....>>>...<<<<<<<<...<<<....>>>..>>>>>.>>>...>>>> ((((.(((....)))..(((((((((...(((....)))..))))).)))..))))) DETAILED VIEW OF A KEY ELEMENT OF THE RIBOSOME ASSEMBLY: CRYSTAL STRUCTURE OF THE S15-RRNA COMPLEX; RRNA FRAGMENT 1duq B 14 2.1 URS000080DE8A_32630 10792052 32630 ccugacgguacagc .............. .............. CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1duq C 12 2.1 URS000080DFAD_32630 10792052 32630 gcugggcgcagg ............ ............ CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1duq D 14 2.1 URS000080DE8A_32630 10792052 32630 ccugacgguacagc .............. .............. CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1duq F 14 2.1 URS000080DE8A_32630 10792052 32630 ccugacgguacagc .............. .............. CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1duq G 12 2.1 URS000080DFAD_32630 10792052 32630 gcugggcgcagg ............ ............ CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1duq H 14 2.1 URS000080DE8A_32630 10792052 32630 ccugacgguacagc .............. .............. CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1jj2 0 2754 2.4 RF02540,RF00002 URS000080DFCD_2238 11483524 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Fully Refined Crystal Structure of the Haloarcula marismortui Large Ribosomal Subunit at 2.4 Angstrom Resolution; 23S RRNA 1jj2 9 122 2.4 RF00001 URS00003592C7_2238 11483524 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Fully Refined Crystal Structure of the Haloarcula marismortui Large Ribosomal Subunit at 2.4 Angstrom Resolution; 5S RRNA 1jtw A 16 NA URS000080E0BC_32630 11724565 32630 gggugcgagagcguca .<<<<<....>>>>>. .(((((....))))). Structure of SL4 RNA from the HIV-1 Packaging Signal; 5'-R(*GP*GP*GP*UP*GP*CP*GP*AP*GP*AP*GP*CP*GP*UP*CP*A)-3' 1k73 A 2754 3.01 RF02540,RF00002 URS000080DFCD_2238 12860128 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit; 23S RRNA 1k73 B 122 3.01 RF00001 URS00003592C7_2238 12860128 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit; 5S RRNA 1k8a A 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 12150912 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Carbomycin A bound to the 50S ribosomal subunit of Haloarcula marismortui; 23S RRNA 1k8a B 122 3.0 RF00001 URS00003592C7_2238 12150912 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal structure of Carbomycin A bound to the 50S ribosomal subunit of Haloarcula marismortui; 5S RRNA 1k9m A 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 12150912 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of tylosin bound to the 50S ribosomal subunit of Haloarcula marismortui; 23S RRNA 1k9m B 122 3.0 RF00001 URS00003592C7_2238 12150912 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal structure of tylosin bound to the 50S ribosomal subunit of Haloarcula marismortui; 5S RRNA 1kc8 A 2754 3.01 RF02540,RF00002 URS000080DFCD_2238 12860128 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal Structure of Blasticidin S Bound to the 50S Ribosomal Subunit; 23S RRNA 1kc8 B 122 3.01 RF00001 URS00003592C7_2238 12860128 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal Structure of Blasticidin S Bound to the 50S Ribosomal Subunit; 5S RRNA 1kd1 A 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 12150912 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal Structure of Spiramycin bound to the 50S Ribosomal Subunit of Haloarcula marismortui; 23S RRNA 1kd1 B 122 3.0 RF00001 URS00003592C7_2238 12150912 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal Structure of Spiramycin bound to the 50S Ribosomal Subunit of Haloarcula marismortui; 5S RRNA 1kqs 0 2754 3.1 RF02540,RF00002 URS000080DFCD_2238 11828326 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The Haloarcula marismortui 50S Complexed with a Pretranslocational Intermediate in Protein Synthesis; 23S RRNA 1kqs 9 122 3.1 RF00001 URS00003592C7_2238 11828326 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The Haloarcula marismortui 50S Complexed with a Pretranslocational Intermediate in Protein Synthesis; 5S RRNA 1l2x A 28 1.25 URS000080DE4C_32630 11904368 32630 ngcgcggcaccguccgcggaacaaacgg ..<<<<<..(((.>>>>>.......))) ..(((((..[[[.))))).......]]] Atomic Resolution Crystal Structure of a Viral RNA Pseudoknot; RNA pseudoknot 1m1k A 2754 3.2 RF02540,RF00002 URS000080DFCD_2238 12150912 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...(((((((((((((.{{)))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of azithromycin bound to the 50S ribosomal subunit of Haloarcula marismortui; 23S RRNA 1m1k B 122 3.2 RF00001 URS00003592C7_2238 12150912 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal structure of azithromycin bound to the 50S ribosomal subunit of Haloarcula marismortui; 5S RRNA 1m90 A 2754 2.8 RF02540,RF00002 URS000080DFCD_2238 12185246 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of CCA-Phe-caproic acid-biotin and sparsomycin bound to the 50S ribosomal subunit; 23S RRNA 1m90 B 122 2.8 RF00001 URS00003592C7_2238 12185246 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal structure of CCA-Phe-caproic acid-biotin and sparsomycin bound to the 50S ribosomal subunit; 5S RRNA 1n8r A 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 12860128 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of large ribosomal subunit in complex with virginiamycin M; 23S ribosomal RNA 1n8r B 122 3.0 RF00001 URS00003592C7_2238 12860128 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Structure of large ribosomal subunit in complex with virginiamycin M; 5S ribosomal RNA 1nji A 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 12860128 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of chloramphenicol bound to the 50S ribosomal subunit; 23S ribosomal RNA 1nji B 122 3.0 RF00001 URS00003592C7_2238 12860128 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Structure of chloramphenicol bound to the 50S ribosomal subunit; 5S ribosomal RNA 1nta A 22 2.9 URS000080DE50_32630 12618190 32630 ggaucgcauuuggacuucugcc ...................... ...................... 2.9 A crystal structure of Streptomycin RNA-aptamer; 5'-R(*GP*GP*AP*UP*CP*GP*CP*AP*UP*UP*UP*GP*GP*AP*CP*UP*UP*CP*UP*GP*CP*C)-3' 1ntb A 22 2.9 URS000080DE50_32630 12618190 32630 ggaucgcauuuggacuucugcc ...................... ...................... 2.9 A crystal structure of Streptomycin RNA-aptamer complex; 5'-R(*GP*GP*AP*UP*CP*GP*CP*AP*UP*UP*UP*GP*GP*AP*CP*UP*UP*CP*UP*GP*CP*C)-3' 1q7y A 2754 3.2 RF02540,RF00002 URS000080DFCD_2238 12185246 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure of CCdAP-Puromycin bound at the Peptidyl transferase center of the 50S ribosomal subunit; 23S ribosomal rna 1q7y B 122 3.2 RF00001 URS00003592C7_2238 12185246 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Crystal Structure of CCdAP-Puromycin bound at the Peptidyl transferase center of the 50S ribosomal subunit; 5S ribosomal RNA 1q81 A 2754 2.95 RF02540,RF00002 URS000080DFCD_2238 12185246 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure of minihelix with 3' puromycin bound to A-site of the 50S ribosomal subunit.; 23S ribosomal rna 1q81 B 122 2.95 RF00001 URS00003592C7_2238 12185246 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Crystal Structure of minihelix with 3' puromycin bound to A-site of the 50S ribosomal subunit.; 5S ribosomal RNA 1q82 A 2754 2.98 RF02540,RF00002 URS000080DFCD_2238 12185246 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure of CC-Puromycin bound to the A-site of the 50S ribosomal subunit; 23S ribosomal rna 1q82 B 122 2.98 RF00001 URS00003592C7_2238 12185246 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Crystal Structure of CC-Puromycin bound to the A-site of the 50S ribosomal subunit; 5S ribosomal RNA 1q86 A 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 12185246 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal structure of CCA-Phe-cap-biotin bound simultaneously at half occupancy to both the A-site and P-site of the the 50S ribosomal Subunit.; 23S ribosomal rna 1q86 B 122 3.0 RF00001 URS00003592C7_2238 12185246 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Crystal structure of CCA-Phe-cap-biotin bound simultaneously at half occupancy to both the A-site and P-site of the the 50S ribosomal Subunit.; 5S ribosomal RNA 1q93 C 27 2.25 URS000080DDB7_32630 14627814 32630 ggugcucaguaggagacgaaccgcacc <<<<<.................>>>>> (((((......(....).....))))) Crystal structure of a mutant of the sarcin/ricin domain from rat 28S rRNA; Sarcin/Ricin 28S rRNA 1qvf 0 2754 3.1 RF02540,RF00002 URS000080DFCD_2238 14561884 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of a deacylated tRNA minihelix bound to the E site of the large ribosomal subunit of Haloarcula marismortui; 23S ribosomal rna 1qvf 9 122 3.1 RF00001 URS00003592C7_2238 14561884 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Structure of a deacylated tRNA minihelix bound to the E site of the large ribosomal subunit of Haloarcula marismortui; 5S ribosomal RNA 1qvg 0 2754 2.9 RF02540,RF00002 URS000080DFCD_2238 14561884 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<....<.<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>>..>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of CCA oligonucleotide bound to the tRNA binding sites of the large ribosomal subunit of Haloarcula marismortui; 23S ribosomal rna 1qvg 9 122 2.9 RF00001 URS00003592C7_2238 14561884 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Structure of CCA oligonucleotide bound to the tRNA binding sites of the large ribosomal subunit of Haloarcula marismortui; 5S ribosomal RNA 1s72 0 2754 2.4 RF02540,RF00002 URS000080DFCD_2238 15184028 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. REFINED CRYSTAL STRUCTURE OF THE HALOARCULA MARISMORTUI LARGE RIBOSOMAL SUBUNIT AT 2.4 ANGSTROM RESOLUTION; 23S ribosomal RNA 1s72 9 122 2.4 RF00001 URS00003592C7_2238 15184028 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... REFINED CRYSTAL STRUCTURE OF THE HALOARCULA MARISMORTUI LARGE RIBOSOMAL SUBUNIT AT 2.4 ANGSTROM RESOLUTION; 5S ribosomal RNA 1vq4 0 2754 2.7 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""DAA"" bound to the large ribosomal subunit of Haloarcula marismortui; 23S ribosomal rna 1vq4 9 122 2.7 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""DAA"" bound to the large ribosomal subunit of Haloarcula marismortui; 5S ribosomal RNA 1vq5 0 2754 2.6 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.((...(((.........)))...))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""RAA"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vq5 9 122 2.6 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""RAA"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vq6 0 2754 2.7 RF02540,RF00002 URS000080DFCD_2238 16306996,16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.((...(((.........)))...)).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...(((((((((((((.{{)))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of c-hpmn and CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vq6 9 122 2.7 RF00001 URS00003592C7_2238 16306996,16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of c-hpmn and CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vq7 0 2754 2.5 RF02540,RF00002 URS000080DFCD_2238 16306996,16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.((...(((.........)))...))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""DCA"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vq7 9 122 2.5 RF00001 URS00003592C7_2238 16306996,16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""DCA"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vq8 0 2754 2.2 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 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The structure of CCDA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vq8 9 122 2.2 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CCDA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vq9 0 2754 2.4 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 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The structure of CCA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vq9 9 122 2.4 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CCA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vqk 0 2754 2.3 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CCDA-PHE-CAP-BIO bound to the a site of the ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vqk 9 122 2.3 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CCDA-PHE-CAP-BIO bound to the a site of the ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vql 0 2754 2.3 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 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..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""DCSN"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vql 9 122 2.3 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""DCSN"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vqm 0 2754 2.3 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""DAN"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vqm 9 122 2.3 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""DAN"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vqn 0 2754 2.4 RF02540,RF00002 URS000080DFCD_2238 16306996,16285925 0003735 0005840 2238 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..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CC-HPMN AND CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vqn 9 122 2.4 RF00001 URS00003592C7_2238 16306996,16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CC-HPMN AND CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vqo 0 2754 2.2 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CCPMN bound to the large ribosomal subunit haloarcula marismortui; 23S ribosomal rna 1vqo 9 122 2.2 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CCPMN bound to the large ribosomal subunit haloarcula marismortui; 5S ribosomal RNA 1vqp 0 2754 2.25 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""RAP"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vqp 9 122 2.25 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""RAP"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1w2b 0 2754 3.5 RF02540,RF00002 URS000080DFCD_2238 15334087 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<..<<<<....>>>>....>>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>>>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..((((.......))))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Trigger Factor ribosome binding domain in complex with 50S; 23S RRNA 1w2b 9 122 3.5 RF00001 URS00003592C7_2238 15334087 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Trigger Factor ribosome binding domain in complex with 50S; 5S RRNA 1xp7 A 23 2.5 URS000080E167_32630 16403527 32630 cuugcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 subtype F genomic RNA Dimerization Initiation Site; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1xpe A 23 1.94 URS000080DD3F_32630 16403527 32630 cuugcugaagcgcgcacggcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 subtype B genomic RNA Dimerization Initiation Site; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3' 1xpe B 23 1.94 URS000080DD3F_32630 16403527 32630 cuugcugaagcgcgcacggcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 subtype B genomic RNA Dimerization Initiation Site; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3' 1xpf A 23 2.3 URS000080E21C_32630 16403527 32630 cuugcugaggugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 subtype A genomic RNA Dimerization Initiation Site; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y3o B 23 2.7 URS000080E167_32630 16403527 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS RNA subtype F- Mn soaked; 5'-R(*CP*UP*(5BU)P*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y6t B 23 2.6 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 Dis(Mal) Duplex Co Hexamine-Soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1yhq 0 2754 2.4 RF02540,RF00002 URS000080E07C_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Azithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S Ribosomal RNA 1yhq 9 122 2.4 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Crystal Structure Of Azithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S Ribosomal RNA 1yi2 0 2754 2.65 RF02540,RF00002 URS000080E07C_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Erythromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S Ribosomal RNA 1yi2 9 122 2.65 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Crystal Structure Of Erythromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S Ribosomal RNA 1yij 0 2754 2.6 RF02540,RF00002 URS000080E07C_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Telithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S Ribosomal RNA 1yij 9 122 2.6 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Crystal Structure Of Telithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S Ribosomal RNA 1yit 0 2754 2.8 RF02540,RF00002 URS000080DF5B_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Virginiamycin M and S Bound To The 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S RIBOSOMAL RNA 1yit 9 122 2.8 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Crystal Structure Of Virginiamycin M and S Bound To The 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S RIBOSOMAL RNA 1yj9 0 2754 2.8 RF02540,RF00002 URS000080DF5B_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of The Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui Containing a three residue deletion in L22; 23S Ribosomal RNA 1yj9 9 122 2.8 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Crystal Structure Of The Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui Containing a three residue deletion in L22; 5S Ribosomal RNA 1yjn 0 2754 3.0 RF02540,RF00002 URS000080E07C_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)......))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Clindamycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S Ribosomal RNA 1yjn 9 122 3.0 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Crystal Structure Of Clindamycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S Ribosomal RNA 1yjw 0 2754 2.9 RF02540,RF00002 URS000080E07C_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Quinupristin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S RIBOSOMAL RNA 1yjw 9 122 2.9 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Crystal Structure Of Quinupristin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S RIBOSOMAL RNA 2b8s B 23 2.76 URS000080E21C_32630 11702070 32630 cuugcugaggugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) Structure of HIV-1(MAL) genomic RNA DIS; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 2gdi X 80 2.05 RF00059 URS000080DDEB_562 16728979 0030976 562 ngacucggggugcccuucugcgugaaggcugagaaauacccguaucaccugaucuggauaaugccagcguagggaaguun <<<<<<<<<..<<.<<<<.....>>>>>>.........>>>>.....<<<...<<<<......>>>>...>>>..>>>>> (((((((((.((((.(((.....))))))......)..)))).....(((...((((......))))...)))..))))) Crystal structure of thiamine pyrophosphate-specific riboswitch in complex with thiamine pyrophosphate; TPP riboswitch 2otj 0 2754 2.9 RF02540,RF00002 URS000080DFCD_2238 17321546 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. 13-deoxytedanolide bound to the large subunit of Haloarcula marismortui; 23S ribosomal RNA 2otj 9 122 2.9 RF00001 URS00003592C7_2238 17321546 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... 13-deoxytedanolide bound to the large subunit of Haloarcula marismortui; 5S ribosomal RNA 2otl 0 2754 2.7 RF02540,RF00002 URS000080DFCD_2238 17321546 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Girodazole bound to the large subunit of Haloarcula marismortui; 23S ribosomal RNA 2otl 9 122 2.7 RF00001 URS00003592C7_2238 17321546 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Girodazole bound to the large subunit of Haloarcula marismortui; 5S ribosomal RNA 2qa4 0 2753 3.0 RF02540,RF00002 URS000080DFCD_2238 17599351 0003735 0005840 2238 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..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<.......>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((.......))).((((((....(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.(((((((.((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)).))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. A more complete structure of the the L7/L12 stalk of the Haloarcula marismortui 50S large ribosomal subunit; 23S RIBOSOMAL RNA 2qa4 9 122 3.0 RF00001 URS00003592C7_2238 17599351 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... A more complete structure of the the L7/L12 stalk of the Haloarcula marismortui 50S large ribosomal subunit; 5S RIBOSOMAL RNA 2qex 0 2754 2.9 RF02540,RF00002 URS000080E276_2238 17664317 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<....<....<<<<<....>>>>>.....>...>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Negamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal Subunit; 23S ribosomal RNA 2qex 9 122 2.9 RF00001 URS00003592C7_2238 17664317 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Negamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal Subunit; 5S ribosomal RNA 2qk9 B 18 2.55 URS000080E35D_32630 17964265 32630 agugcgacaccugauucc .................. .................. Human RNase H catalytic domain mutant D210N in complex with 18-mer RNA/DNA hybrid; 5'-R(*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3' 2r1s A 13 1.4 URS000080DEB6_32630 17940138 32630 gcguungaaacgc ............. ............. Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.4 A (Br1); RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3') 2r1s B 13 1.4 URS000080DEB6_32630 17940138 32630 gcguungaaacgc ............. ............. Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.4 A (Br1); RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3') 2r20 A 13 1.3 URS000080DEB6_32630 17940138 32630 gcguungaaacgc ............. ............. Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.3 A (Br2); RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3') 2r20 B 13 1.3 URS000080DEB6_32630 17940138 32630 gcguungaaacgc ............. ............. Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.3 A (Br2); RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3') 2r21 A 13 1.59 URS000080DEB6_32630 32630 gcguungaaacgc ............. ............. Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.6 A (BrMn); RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3') 2r21 B 13 1.59 URS000080DEB6_32630 32630 gcguungaaacgc ............. ............. Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.6 A (BrMn); RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3') 2r22 A 13 1.4 URS000080DEB6_32630 32630 gcguuugaaacgc ............. ............. Structure of the native RNA tridecamer r(GCGUUUGAAACGC) at 1.5 A (NatMn); RNA (5'-R(*GP*CP*GP*UP*UP*UP*GP*AP*AP*AP*CP*GP*C)-3') 2r22 B 13 1.4 URS000080DEB6_32630 32630 gcguuugaaacgc ............. ............. Structure of the native RNA tridecamer r(GCGUUUGAAACGC) at 1.5 A (NatMn); RNA (5'-R(*GP*CP*GP*UP*UP*UP*GP*AP*AP*AP*CP*GP*C)-3') 2ygh A 95 2.6 RF00162 URS0000BC4670_119072 21893284 0010468 119072 ggcuuaucaagagaggugaagggacuggcccgacgaaacccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccga <<<<<<<<......<<<...<<<...((>>>......>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>.. ((((((((....(.(((...(((.[.[[)))......))))(((..(((....))).)))...(]].](((((....)))))..))))))))).. SAM-I riboswitch with a G2nA mutation in the Kink turn in complex with S-adenosylmethionine; SAM-I RIBOSWITCH 3cc2 0 2754 2.4 RF02540,RF00002 URS000080E102_2238 18455733,15184028,15520287 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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The Refined Crystal Structure of the Haloarcula Marismortui Large Ribosomal Subunit at 2.4 Angstrom Resolution with rrnA Sequence for the 23S rRNA and Genome-derived Sequences for r-Proteins; 23S RIBOSOMAL RNA 3cc2 9 122 2.4 RF00001 URS00000A7E81_2238 18455733,15184028,15520287 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... The Refined Crystal Structure of the Haloarcula Marismortui Large Ribosomal Subunit at 2.4 Angstrom Resolution with rrnA Sequence for the 23S rRNA and Genome-derived Sequences for r-Proteins; 5S RIBOSOMAL RNA 3cc4 0 2754 2.7 RF02540,RF00002 URS000080E102_2238 18455733,12860128 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit; 23S ribosomal RNA 3cc4 9 122 2.7 RF00001 URS00000A7E81_2238 18455733,12860128 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit; 5S ribosomal RNA 3cc7 0 2754 2.7 RF02540,RF00002 URS000080E214_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaauagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2487U; 23S ribosomal RNA 3cc7 9 122 2.7 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2487U; 5S ribosomal RNA 3cce 0 2754 2.75 RF02540,RF00002 URS000080DEE9_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccacgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.....)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535A; 23S RIBOSOMAL RNA 3cce 9 122 2.75 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535A; 5S RIBOSOMAL RNA 3ccj 0 2754 3.3 RF02540,RF00002 URS000080E310_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuacuucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<....<....<<<<<....>>>>>.....>...>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<..[[.>>>>>>....<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>...........>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>......<<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>>......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((.(....).))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.((...(((.........)))...))........(..........)..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)......))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.....)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..((....))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).))......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((....(((...((((((((((}}..)))))...))))).[.)))..)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2534U; 23S RIBOSOMAL RNA 3ccj 9 122 3.3 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2534U; 5S RIBOSOMAL RNA 3ccl 0 2754 2.9 RF02540,RF00002 URS000080DD39_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccccgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535C. Density for Anisomycin is visible but not included in model.; 23S RIBOSOMAL RNA 3ccl 9 122 2.9 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535C. Density for Anisomycin is visible but not included in model.; 5S RIBOSOMAL RNA 3ccm 0 2754 2.55 RF02540,RF00002 URS000080E039_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucguuagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..(...)..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2611U; 23S RIBOSOMAL RNA 3ccm 9 122 2.55 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2611U; 5S RIBOSOMAL RNA 3ccq 0 2754 2.9 RF02540,RF00002 URS000080E20E_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacugagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.....)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488U; 23S RIBOSOMAL RNA 3ccq 9 122 2.9 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488U; 5S RIBOSOMAL RNA 3ccr 0 2754 3.0 RF02540,RF00002 URS000080E07E_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaaccgagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....((..(((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..))).....)).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488C. Density for anisomycin is visible but not included in the model.; 23S RIBOSOMAL RNA 3ccr 9 122 3.0 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488C. Density for anisomycin is visible but not included in the model.; 5S RIBOSOMAL RNA 3ccs 0 2754 2.95 RF02540,RF00002 URS000080E271_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuaggaauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<....<....<<<<<....>>>>>.....>...>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482A; 23S RIBOSOMAL RNA 3ccs 9 122 2.95 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482A; 5S RIBOSOMAL RNA 3ccu 0 2754 2.8 RF02540,RF00002 URS000080E353_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuaggcauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482C; 23S RIBOSOMAL RNA 3ccu 9 122 2.8 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482C; 5S RIBOSOMAL RNA 3ccv 0 2754 2.9 RF02540,RF00002 URS000080DE11_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcuaggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2616A; 23S RIBOSOMAL RNA 3ccv 9 122 2.9 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2616A; 5S RIBOSOMAL RNA 3cd6 0 2754 2.75 RF02540,RF00002 URS000080DE11_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcuaggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-cystal of large Ribosomal Subunit mutant G2616A with CC-Puromycin; 23S RIBOSOMAL RNA 3cd6 9 122 2.75 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-cystal of large Ribosomal Subunit mutant G2616A with CC-Puromycin; 5S RIBOSOMAL RNA 3cma 0 2754 2.8 RF02540,RF00002 URS000080E102_2238 18818369 0003735 0005840 2238 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..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CCA and CCA-Phe-Cap-Bio bound to the large ribosomal subunit of Haloarcula marismortui; 23S RIBOSOMAL RNA 3cma 9 122 2.8 RF00001 URS00000A7E81_2238 18818369 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... The structure of CCA and CCA-Phe-Cap-Bio bound to the large ribosomal subunit of Haloarcula marismortui; 5S RIBOSOMAL RNA 3cme 0 2754 2.95 RF02540,RF00002 URS000080E102_2238 18818369 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...(((((((((((((.{{)))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The Structure of CA and CCA-PHE-CAP-BIO Bound to the Large Ribosomal Subunit of Haloarcula Marismortui; 50S RIBOSOMAL RNA 3cme 9 122 2.95 RF00001 URS00000A7E81_2238 18818369 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... The Structure of CA and CCA-PHE-CAP-BIO Bound to the Large Ribosomal Subunit of Haloarcula Marismortui; 5S RIBOSOMAL RNA 3cpw 0 2754 2.7 RF02540,RF00002 URS000080E267_2238 18494460 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccccgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI; 23S RIBOSOMAL RNA 3cpw 9 122 2.7 RF00001 URS00003592C7_2238 18494460 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI; 5S RIBOSOMAL RNA 3cxc 0 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 18947996 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui; 23S RIBOSOMAL RNA 3cxc 9 122 3.0 RF00001 URS00003592C7_2238 18947996 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui; 5S RIBOSOMAL RNA 3dig X 174 2.8 RF00168 URS000080E0C5_2336 18784651 0009085 2336 ggccgacggaggcgcgcccgagaugaguaggcugucccaucaggggaggaaucggggacggcugaaaggcgagggcgccgaagggugcagaguuccucccgcucugcaugccuggggguauggggaauacccauaccacugucacggaggucucuccguggagagccgucggun <<<<<<<<<....<<<<<<..<.......<<<<<<<<<.....((((((.....>>>>>>>>>......>..>>>>>>...<<<<<<<<<<<<.))))))>>>>>>>>>.>>><<.<<<<<<<<.....>>>>>>>>.>>.<<<<<<<<<..>>>>>>>>>....>>>>>>>>> (((((((((..(.((((((..(.......(((((((((..(..[[[[[[....))))))))))......)..)))))))..((((((((((((.]]]]]]))))))))).)))((.((((((((.....)))))))).)).((((((((....))))))))....))))))))) CRYSTAL STRUCTURE OF THE THERMOTOGA MARITIMA LYSINE RIBOSWITCH BOUND TO S-(2-aminoethyl)-L-cysteine; RNA (174-MER) 3dil A 174 1.9 RF00168 URS000080E0C5_2336 18784651 0009085 2336 ggccgacggaggcgcgcccgagaugaguaggcugucccaucaggggaggaaucggggacggcugaaaggcgagggcgccgaagggugcagaguuccucccgcucugcaugccuggggguauggggaauacccauaccacugucacggaggucucuccguggagagccgucggun <<<<<<<<<....<<<<<<..<.......<<<<<<<<<.....((((((.....>>>>>>>>>......>..>>>>>>...<<<<<<<<<<<<.))))))>>>>>>>>>.>>><<.<<<<<<<<.....>>>>>>>>.>>.<<<<<<<<<..>>>>>>>>>....>>>>>>>>> (((((((((..(.((((((..(.......(((((((((..(..[[[[[[....))))))))))......)..)))))))..((((((((((((.]]]]]]))))))))).)))((.((((((((.....)))))))).)).((((((((....))))))))....))))))))) Crystal structure of the Thermotoga maritima lysine riboswitch bound to lysine; RNA (174-MER) 3dim A 174 2.9 RF00168 URS000080E0C5_2336 18784651 0009085 2336 ggccgacggaggcgcgcccgagaugaguaggcugucccaucaggggaggaaucggggacggcugaaaggcgagggcgccgaagggugcagaguuccucccgcucugcaugccuggggguauggggaauacccauaccacugucacggaggucucuccguggagagccgucggun .<<<<<<<<....<<<<<<..<.......<<<<<<<<<.....((((((.....>>>>>>>>>......>..>>>>>>...<<<<<<<<<<<<.))))))>>>>>>>>>.>>><<.<<<<<<<<.....>>>>>>>>.>>.<<<<<<<<<..>>>>>>>>>....>>>>>>>>. (((((((((..(.((((((..(.......(((((((((..(..[[[[[[....))))))))))......)..)))))))..((((((((((((.]]]]]]))))))))).)))((.((((((((.....)))))))).)).((((((((....))))))))....))))))))) Crystallization of the Thermotoga maritima lysine riboswitch bound to lysine, Cs+ Soak; RNA (174-MER) 3dio X 174 2.4 RF00168 URS000080E0C5_2336 18784651 0009085 2336 ggccgacggaggcgcgcccgagaugaguaggcugucccaucaggggaggaaucggggacggcugaaaggcgagggcgccgaagggugcagaguuccucccgcucugcaugccuggggguauggggaauacccauaccacugucacggaggucucuccguggagagccgucggun <<<<<<<<<....<<<<<<..<.......<<<<<<<<<.....((((((.....>>>>>>>>>......>..>>>>>>...<<<<<<<<<<<<.))))))>>>>>>>>>.>>><<.<<<<<<<<.....>>>>>>>>.>>.<<<<<<<<<..>>>>>>>>>....>>>>>>>>> (((((((((..(.((((((..(.......(((((((((..(..[[[[[[....))))))))))......)..)))))))..((((((((((((.]]]]]]))))))))).)))((.((((((((.....)))))))).)).((((((((....))))))))....))))))))) Crystallization of the Thermotoga maritima lysine riboswitch bound to lysine, IRIDIUM HEXAMINE SOAK; RNA (174-MER) 3diq A 174 2.7 RF00168 URS000080E0C5_2336 18784651 0009085 2336 ggccgacggaggcgcgcccgagaugaguaggcugucccaucaggggaggaaucggggacggcugaaaggcgagggcgccgaagggugcagaguuccucccgcucugcaugccuggggguauggggaauacccauaccacugucacggaggucucuccguggagagccgucggun <<<<<<<<<....<<<<<<..<.......<<<<<<<<<.....((((((.....>>>>>>>>>......>..>>>>>>...<<<<<<<<<<<<.))))))>>>>>>>>>.>>><<.<<<<<<<<.....>>>>>>>>.>>.<<<<<<<<<..>>>>>>>>>....>>>>>>>>> (((((((((..(.((((((..(.......(((((((((..(..[[[[[[....))))))))))......)..)))))))..((((((((((((.]]]]]]))))))))).)))((.((((((((.....)))))))).)).((((((((....))))))))....))))))))) Crystallization of the Thermotoga maritima lysine riboswitch bound to homoarginine; RNA (174-MER) 3dir A 174 2.9 RF00168 URS000080E0C5_2336 18784651 0009085 2336 ngccgacggaggcgcgcccgagaugaguaggcugucccaucaggggaggaaucggggacggcugaaaggcgagggcgccgaagggugcagaguuccucccgcucugcaugccuggggguauggggaauacccauaccacugucacggaggucucuccguggagagccgucggun <<<<<<<<<....<<<<<<..<.......<<<<<<<<<.....((((((.....>>>>>>>>>......>..>>>>>>...<<<<<<<<<<<<.))))))>>>>>>>>>.>>><<.<<<<<<<<.....>>>>>>>>.>>.<<<<<<<<<..>>>>>>>>>....>>>>>>>>> (((((((((..(.((((((..(.......(((((((((..(..[[[[[[....))))))))))......)..)))))))..((((((((((((.]]]]]]))))))))).)))((.((((((((.....)))))))).)).((((((((....))))))))....))))))))) Crystallization of the Thermotoga maritima lysine riboswitch bound to N6-1-iminoethyl-L-Lysine; RNA (174-MER) 3dis A 174 3.1 RF00168 URS000080E0C5_2336 18784651 0009085 2336 ggccgacggaggcgcgcccgagaugaguaggcugucccaucaggggaggaaucggggacggcugaaaggcgagggcgccgaagggugcagaguuccucccgcucugcaugccuggggguauggggaauacccauaccacugucacggaggucucuccguggagagccgucggun <<<<<<<<<....<<<<<<..<.......<<<<<<<<<.....((((((.....>>>>>>>>>......>..>>>>>>...<<<<<<<<<<<<.))))))>>>>>>>>>.>>><<.<<<<<<<<.....>>>>>>>>.>>.<<<<<<<<<..>>>>>>>>>....>>>>>>>>> (((((((((..(.((((((..(.......(((((((((..(..[[[[[[....))))))))))......)..)))))))..((((((((((((.]]]]]]))))))))).)))((.((((((((.....)))))))).)).((((((((....))))))))....))))))))) Crystallization of the Thermotoga maritima lysine riboswitch in free form; RNA (174-MER) 3dix A 174 2.9 RF00168 URS000080E0C5_2336 18784651 0009085 2336 ggccgacggaggcgcgcccgagaugaguaggcugucccaucaggggaggaaucggggacggcugaaaggcgagggcgccgaagggugcagaguuccucccgcucugcaugccuggggguauggggaauacccauaccacugucacggaggucucuccguggagagccgucggun <<<<<<<<<....<<<<<<..<.......<<<<<<<<<.....((((((.....>>>>>>>>>......>..>>>>>>...<<<<<<<<<<<<.))))))>>>>>>>>>.>>><<.<<<<<<<<.....>>>>>>>>.>>.<<<<<<<<<..>>>>>>>>>....>>>>>>>>> (((((((((..(.((((((..(.......(((((((((..(..[[[[[[....))))))))))......)..)))))))..((((((((((((.]]]]]]))))))))).)))((.((((((((.....)))))))).)).((((((((....))))))))....))))))))) Crystallization of the Thermotoga maritima lysine riboswitch bound to lysine, K+ anomalous data; RNA (174-MER) 3diy A 174 2.71 RF00168 URS000080E0C5_2336 18784651 0009085 2336 ngccgacggaggcgcgcccgagaugaguaggcugucccaucaggggaggaaucggggacggcugaaaggcgagggcgccgaagggugcagaguuccucccgcucugcaugccuggggguauggggaauacccauaccacugucacggaggucucuccguggagagccgucggun .<<<<<<<<....<<<<<<..<.......<<<<<<<<<.....((((((.....>>>>>>>>>......>..>>>>>>...<<<<<<<<<<<<.))))))>>>>>>>>>.>>><<.<<<<<<<<.....>>>>>>>>.>>.<<<<<<<<<..>>>>>>>>>....>>>>>>>>. (((((((((..(.((((((..(.......(((((((((..(..[[[[[[....))))))))))......)..)))))))..((((((((((((.]]]]]]))))))))).)))((.((((((((.....)))))))).)).((((((((....))))))))....))))))))) Crystallization of the Thermotoga maritima lysine riboswitch bound to lysine, Mn2+ soak; RNA (174-MER) 3diz A 174 2.85 RF00168 URS000080E0C5_2336 18784651 0009085 2336 ggccgacggaggcgcgcccgagaugaguaggcugucccaucaggggaggaaucggggacggcugaaaggcgagggcgccgaagggugcagaguuccucccgcucugcaugccuggggguauggggaauacccauaccacugucacggaggucucuccguggagagccgucggun <<<<<<<<<....<<<<<<..<.......<<<<<<<<<.....((((((.....>>>>>>>>>......>..>>>>>>...<<<<<<<<<<<<.))))))>>>>>>>>>.>>><<.<<<<<<<<.....>>>>>>>>.>>.<<<<<<<<<..>>>>>>>>>....>>>>>>>>> (((((((((..(.((((((..(.......(((((((((..(..[[[[[[....))))))))))......)..)))))))..((((((((((((.]]]]]]))))))))).)))((.((((((((.....)))))))).)).((((((((....))))))))....))))))))) Crystallization of the Thermotoga maritima lysine riboswitch bound to lysine in the Absence of Mg2+; RNA (174-MER) 3dj0 A 174 2.5 RF00168 URS000080E0C5_2336 18784651 0009085 2336 ggccgacggaggcgcgcccgagaugaguaggcugucccaucaggggaggaaucggggacggcugaaaggcgagggcgccgaagggugcagaguuccucccgcucugcaugccuggggguauggggaauacccauaccacugucacggaggucucuccguggagagccgucggun <<<<<<<<<....<<<<<<..<.......<<<<<<<<<.....((((((.....>>>>>>>>>......>..>>>>>>...<<<<<<<<<<<<.))))))>>>>>>>>>.>>><<.<<<<<<<<.....>>>>>>>>.>>.<<<<<<<<<..>>>>>>>>>....>>>>>>>>> (((((((((..(.((((((..(.......(((((((((..(..[[[[[[....))))))))))......)..)))))))..((((((((((((.]]]]]]))))))))).)))((.((((((((.....)))))))).)).((((((((....))))))))....))))))))) Crystallization of the Thermotoga maritima lysine riboswitch bound to L-4-oxalysine; RNA (174-MER) 3dj2 A 174 2.5 RF00168 URS000080E0C5_2336 18784651 0009085 2336 ggccgacggaggcgcgcccgagaugaguaggcugucccaucaggggaggaaucggggacggcugaaaggcgagggcgccgaagggugcagaguuccucccgcucugcaugccuggggguauggggaauacccauaccacugucacggaggucucuccguggagagccgucggun <<<<<<<<<....<<<<<<..<.......<<<<<<<<<.....((((((.....>>>>>>>>>......>..>>>>>>...<<<<<<<<<<<<.))))))>>>>>>>>>.>>><<.<<<<<<<<.....>>>>>>>>.>>.<<<<<<<<<..>>>>>>>>>....>>>>>>>>> (((((((((..(.((((((..(.......(((((((((..(..[[[[[[....))))))))))......)..)))))))..((((((((((((.]]]]]]))))))))).)))((.((((((((.....)))))))).)).((((((((....))))))))....))))))))) Crystallization of the Thermotoga maritima lysine riboswitch bound to lysine, Tl+ Soak; RNA (174-MER) 3g4s 0 2754 3.2 RF02540,RF00002 URS000080E102_2238 19362093 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<....<....<<<<<....>>>>>.....>...>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<..[[.>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(.(..(((.........)))...))........((........))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)......))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))..(((((((.....)))))))..(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((.(..((((.............))))...)))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Tiamulin bound to the large ribosomal subunit; 23S ribosomal RNA 3g4s 9 122 3.2 RF00001 URS00000A7E81_2238 19362093 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Tiamulin bound to the large ribosomal subunit; 5S ribosomal RNA 3g6e 0 2754 2.7 RF02540,RF00002 URS000080E102_2238 19362093 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit; 23S ribosomal RNA 3g6e 9 122 2.7 RF00001 URS00000A7E81_2238 19362093 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit; 5S ribosomal RNA 3g71 0 2754 2.85 RF02540,RF00002 URS000080E102_2238 19362093 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Bruceantin bound to the large ribosomal subunit; 23S ribosomal RNA 3g71 9 122 2.85 RF00001 URS00000A7E81_2238 19362093 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Bruceantin bound to the large ribosomal subunit; 5S ribosomal RNA 3i55 0 2754 3.11 RF02540,RF00002 URS000080E102_272569 19738021 0003735 0005840 272569 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>>....<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>...........>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((...{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.....)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}...)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit; 23S ribosomal RNA 3i55 9 122 3.11 RF00001 URS00000A7E81_2238 19738021 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit; 5S ribosomal RNA 3i56 0 2754 2.9 RF02540,RF00002 URS000080DF02_272569 19738021 0003735 0005840 272569 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Triacetyloleandomcyin Bound to the Large Ribosomal Subunit; 23S ribosomal RNA 3i56 9 122 2.9 RF00001 URS00000A7E81_2238 19738021 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Triacetyloleandomcyin Bound to the Large Ribosomal Subunit; 5S ribosomal RNA 3nd3 A 16 1.37 URS000080DEAD_32630 21878548 32630 agagaagauuuuuuuu ................ ................ Uhelix 16-mer dsRNA; 5'-R(*AP*GP*AP*GP*AP*AP*GP*AP*UP*UP*UP*UP*UP*UP*UP*U)-3' 3ow2 0 2754 2.7 RF02540,RF00002 URS000080DF99_2238 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..(...)..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure of Enhanced Macrolide Bound to 50S Ribosomal Subunit; 23S RIBOSOMAL RNA 3ow2 9 122 2.7 RF00001 URS00003592C7_2238 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Crystal Structure of Enhanced Macrolide Bound to 50S Ribosomal Subunit; 5S RIBOSOMAL RNA 3pio X 2657 3.2473 RF02540,RF02541 URS000080DEF1_243230 21282615 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccggggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucggaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacugagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacc .<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<............>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<........>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<.>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<.....>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<.....>>>>..>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<.<<<<<<...<<.....>>.>>>>>>..>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<..<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>..>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<.>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. (..(((((......((((((((((.....(((..(...((((.(((......((((((.[......)))......(((((...((......]..))......)))))....)))....(((....)))(((((....)))))(.((....)).)))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((.......(((...(((((......))))).[(...).((......]..))...)))........((((((((..[......)))))))).......(.((].[[[[)).)...)))......)..))))....)..............((....))....)).........((((....)))).............).....)))))))))).....(.((((((((((.......)))))))))).[.(.(........).).((((((....(((.((((((((((..(.(...(((....)))...).)...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((.(((.((((....(((((.)))))....).)))...(((..(.((........)).).)))..).)).)))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((....(.(.(((((....(((...(((.(((.......))).)))..)).)....))))).)..)...))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(........(((...((..((...........))..))........................)))....).)..))))).))..........]]].)....))))))))))...)))))))(..((...(.)...))..)....))))))(.(((((((.........(((((.((....)).)))))......)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[.((((.((...(((...(((....)))...)))...))....(((..........)))..]((((((.((...((...((((....(((((.(((..(((((.((((......{{......))))(((((((.((..((.(.(.((....(.......)..)).)..).))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......)).)))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((...))))))))(...).......(((((((((...(...........)...(((((((.....(((.....))).......))))))).]((((.(((.....((((..((.............(....).............)))))).....))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.........((((.((((((..(((((.(.(.(((((.((((.((((.....))).)))))...((((((........))))))....))))).).)..)))))..(((......[)))((((((..........]))))))(.((...((((((..(.(((((.........)))))...).((.[.[[[)).....))))))...((.....((...{..)).....)).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))........)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).((((.(...(((...(((((((((((.}}.))))))...)))))...)))..)))))....((....((((.............))))....))..))))..]....)))))))..((.))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))..) Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit; RIBOSOMAL 23S RNA 3pip X 2644 3.45 RF02540,RF02541 URS000080DEF1_243230 21282615 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcgacagccaggagguuggcuuagagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucaugugagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccgguugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacuauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucgggucuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacugagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<.<<<<<<<<<......<<<<<<.[...((.>>>.....<<<<<<...<<.))...]..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>..>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<............>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<........>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<..>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<.....>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<.....<<<<<.<<...<<<<......>>>>...>>.......<.<<......>>.>.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<..>>>>..>....>>>>>><<<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<..<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<.<<<<<...<<.....>>.>>>>>.>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.......<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<...>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<.<.<<.......>>..>>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>..>>>>>....<<.<..<<<<<...........>>>>>...>>>..>>>>.......>>>>>>>..<<.>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> (..(((((......((((((((((.....(((..((((((((((((.......(((((.....[[.))).....((((((...((.]]......))......))))))...)).....(((....)))(((((....)))))((((....))))))...((((((.........[.........))))).).........((....))...((((.........]..........))))...(((...((..(((...(((((......)))))[[(...).((......]].))...)))....))..(((((((((.[.....))))))))).......(.((].[[[[)).)...)))......)).)))))).))..............((....))....)).........((((....))))..(......)...).....)))))))))).....(.(((((((((.........))))))))).[.(.(........).).((((((....(((.((((((((((...((...(((....)))...))....((....))....(.......).........)))))))))))))..((.(...((((((.....(((((((((..((((....((((()))))....)[)))...((...(.((........)).)..))....))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...((((.((((((...(((...(((.(((.......))).)))..)).)...)))))).).)))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.((((((.(..{..(((..(((..((..........))..))).....(..............)..)))....).)))))).).))..........]]].)....))))))))))...)))))))(..((......))..)....))))))(.(((((((.........(((((.((....)).)))))......)))))))..).....))))))(......((.....(.((((.......)))).)((((....((((..((..((((((....((.....))..)))))....[.((((..(...(((...(((....)))...)))...)....(((((........))))).]((((((.((..((...((((.....((((.(((..((((...(((.((...{{....))))).(((((((.((..((.(.(((((...((.....)).))))).).))..)))))))))...(((((....))))).....))))...)))..)))).(..).....))))...))......)).)))))))))).))).....((......)).)))).(((((....)))))..))))..((((....(((((((...........(........((((....(....).....)))).((((((((...))))))))(...).......(((((((((.].(...........)....((((((.....(.(.....).)......))))))...((((.(((..((.((((..(.....((...((((......))))...)).....)))))...))))).......(...........((((.........)))).....)....))))...)).))))))).).......))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((...)))))))))...((((((........))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(..(...(((((((.(.(((((.........)))))...).((.[.[[[))....)))))))...((....(((...{..)))....)).(((....))).).]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((.((.(.((((((...((.......))...))))))...)))..).).......(((.((((((..(.(.(((((......)))))...).).(((((.....))))).....)))))..)...))).......((.((((....))).).))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((..(.....(...(((((((((((.}}.))))))...)))))...)....).)))....((....((((.....}.......))))....))..))))..]....)))))))..((.))....(..((((((.......)))))....((((((((.(((.....((((....))))....)))..))))).)))...)..)....)))))..) Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit; RIBOSOMAL 23S RNA 3suh X 101 2.65 RF01831 URS000080DEF0_717961 21873197 0046653 717961 ggacagaguagguaaacgugcguaaagugccugagggacggggaguuguccucaggacgaacaccgaaagguggcgguacguuuaccgcaucucgcuguun ..........<<<<<<<<<<<<<....<<<<<<<<<<...((((....>>>>>>>>.>>..<<<<....>>>>>>>.>>>>>>>>>>...))))....... ..........(((((((((((((......(((((((((..[[[[..).)))))))).....((((....))))))).))))))))))...]]]]....... Crystal structure of THF riboswitch, bound with 5-formyl-THF; Riboswitch 3sux X 101 2.9 RF01831 URS000080DEF0_717961 21873197 0046653 717961 ggacagaguagguaaacgugcguaaagugccugagggacggggaguuguccucaggacgaacaccgaaagguggcgguacguuuaccgcaucucgcuguun ..........<<<<<<<<<<<<<....<<<<<<<<<<...((((....>>>>>>>>.>>..<<<<....>>>>>>>.>>>>>>>>>>...))))....... ..........(((((((((((((......(((((((((..[[[[..).)))))))).....((((....))))))).))))))))))...]]]]....... Crystal structure of THF riboswitch, bound with THF; Riboswitch 3u4m B 80 2.0 RF02541 URS000080E005_274 22868771 0003735 0005840 274 gggaugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuuccc <<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>> ((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))) Crystal structure of ribosomal protein tthl1 in complex with 80nt 23s rna from thermus thermophilus; RNA (80-MER) 3umy B 80 1.9 RF02541 URS000080E005_274 0003735 0005840 274 gggaugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuuccc <<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>> ((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))) Crystal structure of mutant ribosomal protein T217A TthL1 in complex with 80nt 23S RNA from Thermus thermophilus; RNA (80-MER) 3zp8 A 43 1.55 RF00163 URS000080DF75_32630 23711504 3.1.-.- 0004540 32630 ngauguacuaccagcugaugagucccaaauaggacgaaacgcc .....................<<<<......>>>>........ ..............(....).((((......))))........ HIGH-RESOLUTION FULL-LENGTH HAMMERHEAD RIBOZYME; HAMMERHEAD RIBOZYME, ENZYME STRAND 3zp8 B 20 1.55 URS000080DDC4_32630 23711504 32630 ggcguncugguauccaaucc .................... .................... HIGH-RESOLUTION FULL-LENGTH HAMMERHEAD RIBOZYME; HAMMERHEAD RIBOZYME, SUBSTRATE STRAND 437d A 28 1.6 URS000080DE4C_32630 10074948 32630 ngcgcggcaccguccgcggaacaaacgg ..<<<<<..(((.>>>>>.......))) ..(((((..[[[.))))).......]]] CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING; RNA PSEUDOKNOT 4aob A 94 2.95 RF00162 URS000080DF6B_119072 22539525 0010468 119072 ggcuuaucaagagagggcaagagacuggcuugaugacccccggcaaccaaaaauggugccaauuccugcagaggaaacguugaaagaugagcca <<<<<<<<......<<<...<<<...((>>>......>>>.<<<<.<<<....>>>>>>>....))..<<<.<....>.>>>...>>>>>>>>. ((((((((....(.(((...(((.[.[[)))......))))(((..(((....))).)))...(]].](((.(....).)))..))))))))). SAM-I riboswitch containing the T. solenopsae Kt-23 in complex with S- adenosyl methionine; SAM-I RIBOSWITCH 4fax A 392 3.1 RF02001,RF01998 URS000080E12E_182710 23101623 0000373 182710 ggggugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugug {.......<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...(((((([[[[[...........[[[[[......[[[....((((((<<<<..<<<<.....}.>>>>...>>>>.>>>>>>>...))))))....]]]...]]]]]]]]]]...))))))...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<......>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... .....[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((......((....((.((((((((..((((.......))))...)))).]]]]]]]...)))).))....))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((..((((....))))...))))).(((((((((((((....)))..))))))))))... Structure of Oceanobacillus iheyensis group II intron in a ligand-free state in the presence of Na+ and Mg2+; Group IIC intron 4p43 A 21 2.0 URS0000A76342_32630 32630 gcgucucgucgacgaagucgc ..................... ..................... Crystal structure of the bacterial A1408U-mutant ribosomal decoding site (C2 form 2); 5'-R(*UP*UP*GP*CP*GP*UP*CP*UP*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p43 B 23 2.0 URS0000A76342_32630 32630 uugcgucucgucgacgaagucgc ....................... ....................... Crystal structure of the bacterial A1408U-mutant ribosomal decoding site (C2 form 2); 5'-R(*UP*UP*GP*CP*GP*UP*CP*UP*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4r0d A 617 3.676 RF02012,RF00029 URS000080DD74_2885 25252982 0000373 2885 gugcgacaagaaguucaggaagggauugaggugaaaguccuccucccgaaucguucaugggagagucuauccagacuugcguagcgaguaaucgcuaggugagaagcucuggagacaauguaccugcccuucaauuggaggugccagggcuaggcuuuguuccuauggcuagcgaaagcgaauacagguuauaggcgucgugaaaacaaaacucuuucgacauaagggagagguagaugaguuacccuccuuuuuaugggguaacugaacgaucaauaucuaccggcguagacugugagccuaaaggaaacgaaugaaagugucccuuccugggaacuugguaagcccaauagacucccucugggaaaccagaggaggaguaagagcaaucuuacuuaucgucuaguggguaaaagacauaauaggaagcaaaugcuugguuguaacgaucgagauagaaucuguugauuuaagcugaaaggcugcagacuuauuaaauggguguucugcuguauggcguucgcgccuaagcagcagaaugcgugagccgugugcgaugaaagucgcaagcacgguucugauggggggaaaacgagagaucgucuaccuauccaacu ..[[..<<<....<<<<<<<<<<<<<.<<<<.......>>>><<<<<<.(((({{..>>>>>><<<<<.<<<<<<<<<<<.<<<<<<....>>>>>>.>>>>>..]]>>>>>>......<<.<<......<<....>>........>>>>.>>>>>..<<<<<<..<<<<.<<....>>...<<<<<......(<<<<<...............<<<........>>>....<<<<<<.<<<<<<<<<.).......>>>>>>>>>}}.))))....>>>>>>.>>>>>...>>>>>>>>>...>>>.>>>..........>>>>>>>>>>>>>...>>>....<<<<<.<<<<<..<<<<<<<....>>>>>>>..<<<<<<<<....>>>>>>>>...>>>>>.>>>>>........<<<<<....<<.....<<<<<<<.....>>>>>>>...<<<........>>>.<<<<....>>>>>>.....>>>>>.....<<<<<<<<<<<<..<<<<....>>>>...>>>>>>>>>>>>..<<<<<<<<<<<<<<....>>>>>..>>>>>>>>>...<<<.<<<.<.<<<<....>>>>.>.>>>..>>>... ..{{..((((...(((((((((((((.((((.......))))((((((.[[[[[[..))))))(((((.(((((((((((.((((((....)))))).)))))..}}))))))......(..((((.................).))).).)))))..(((((...((((.((....))...(((((......[((((((............(.((...........)).).((((((..(((((((..]........)))))))..]]]]]]....))))))))))))...)))))))))....)).)))..........)))))))))))))..))))....(((((.(((((..(((((((....)))))))..((((((((....))))))))...))))).)))))........(((((....((.....((.((((.....)))).))..[((((...]..)))).((((....)))))).....))))).....((((((((((((..((((....))))...))))))))))))..((.(((((((((((....)))))..)))))).))...(((.(((...(((......)))...)))..)))... Crystal structure of a eukaryotic group II intron lariat; GROUP IIB INTRON LARIAT 4v9f 0 2808 2.404 RF02540,RF00002 URS000080E02E_272569 23695244,10937989 0003735 0005840 272569 acuaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguguccuccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcauucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcggggguuaugacccucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugagacguggucgccgaucggugacugcgacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccgggacagagacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaauggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaaagc ....<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.......<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<...>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<......>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.(((>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<<<<<....>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<<.<<<<<<<<<<<..>>>>>>>>>>>.>>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>.....<<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<))).>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>..... 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The re-refined crystal structure of the Haloarcula marismortui large ribosomal subunit at 2.4 Angstrom resolution: more complete structure of the L7/L12 and L1 stalk, L5 and LX proteins; 23S Ribosomal RNA 4v9f 9 122 2.404 RF00001 URS00000A7E81_272569 23695244,10937989 0003735 0005840 272569 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... The re-refined crystal structure of the Haloarcula marismortui large ribosomal subunit at 2.4 Angstrom resolution: more complete structure of the L7/L12 and L1 stalk, L5 and LX proteins; 5S Ribosomal RNA 4wfa X 2711 3.392 RF02540,RF02541 URS00001450D9_93061 26464510 0003735 0005840 93061 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..<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.......>>>>>>>.>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>.....<<<<<<<<<...<..........<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>.>...>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<.....>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<......>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<........<<<<......>>>>....>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<......<<<...<<<<....<<<<...<<...<...<.<<<...{.{..>>>.>.<....<<<<<.<<<.<<.<..........>.>>.>>>..>>>>>.....>..............>....>>...>>>>.........>>>.>.>>>...>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<....>.>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<..<<.<<<<<<<.<<<...<<...<<<<<..<<.>>...>>>>>...>>...>>>>>>>>..>>>>............<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<.<<<<<<.<<<<.......>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>.>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}.}>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ..((((((......((((((((((.....(((..((((((((.((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((...........))))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((......((.(......).)).......{(((.(((((..............(((.(((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))).)).).....)))))...))))....(((((((...[.......)))))))....}.(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).{.(.(........).).((((((....(((((((.(((((..(((...((.......))...)))...((....))...(((.....)))......))))).)))))))..((.(...((((((.....((((((((((.((((...(((.(...).)))...){)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...(........)...))))))))..)).).....)))).)))))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((.......((..........))...))))).)))).))...........]]].)...))))))))))...)))))))(((((((..)))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((..((..(....((...((((....((((...((...(.............<..............(((...(...((((........))))...)....))).....................)....))...))))(..).....))))..))...)))..))))))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((....((....))....))))))(...).......(((((((((.}.((.........))...(((((((.....(((....))).......))))))).]((((..((.(((((((.(((...((....((((..((.))...))))....))...))))))))..))))............((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..((((((((.(((.((......((((.((((((..(((((.((.((((((.((((.......))))....(...(((((.....)))))..).....)))))).))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.>..))))))..)))))...)))).)))))...(((....((.(.............).))....))).))))..]....)))))))((((...)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with linezolid; 23S rRNA 4xco M 96 2.9 RF00169 URS000080DDBC_2190 26051119,21336278 0006617 0048501 2190 ggcggugggggagcaucuccuguaggggagauguaacccccuuuaccugccgaaccccgccaggcccggaagggagcaacgguaggcaggacgucg <<<<..<<<<<.<<<<<<<<<....>>>>>>>>>..>>>>>....<<<<<<.....<<<...<.<<<....>>>..>..>>>..>>>>>>.>>>>. ((((..(((((.(((((((((....)))))))))..)))))....((((((.....(((.....(((....))).....)))..)))))).)))). Signal-sequence induced conformational changes in the signal recognition particle; RNA 5afi A 2900 2.9 RF02540,RF02541 URS0000A76322_562 25707802 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<..<<<<..>>>>...>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((..((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..(..(..)..)...)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[.....((((((.....(.....((..(((((..(((.....{.(((((.(.......................).....(..(((......)))).)))))...)))..))))).))...........]]].)...)))))).)))...)))))))(((((............)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((....((((.((((((.((.....)))))))).)..)))...[))))...))(..(((........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..(....(.........((.((............((((.(......).))))...................)).)))....)..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 2.9A Structure of E. coli ribosome-EF-TU complex by cs-corrected cryo-EM; 23S ribosomal RNA 5afi B 120 2.9 RF00001 URS00008116C5_562 25707802 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). 2.9A Structure of E. coli ribosome-EF-TU complex by cs-corrected cryo-EM; 5S ribosomal RNA 5axw B 73 2.7 URS000086852A_1280 26317473 1280 ggaaauuaggugcgcuuggcguuuuaguacucuggaaacagaaucuacuaaaacaaggcaaaaugccguguuu ....................<<<<<<<<<.<<<<....>>>>...>>>>>>>>>..<<<.....>>>...... ....................(((((((((.((((....))))...)))))))))..(((.....)))...... Crystal structure of Staphylococcus aureus Cas9 in complex with sgRNA and target DNA (TTGGGT PAM); RNA (73-MER) 5b2o B 94 1.7 RF02747 URS00008FED26_32630 26875867 0010468 32630 gggaaauuaggugcgcuggggguuucaguugcgccgaaaggcgcucuguaaucauuuaaaaguauuuugaacggaccucuguuugacacgucug .....................<<<.<<<..<<<<<....>>>>>.>>>.>>>...<...>...........<<<<<...<<.....>>.>>>>> .....................(((.(((..(((((....))))).))).)))..(.....)..(...)...(((((...(((...))).))))) Crystal structure of Francisella novicida Cas9 in complex with sgRNA and target DNA (TGG PAM); Guide RNA 5b2p B 94 1.7 RF02747 26875867 0010468 32630 gggaaauuaggugcgcuggggguuucaguugcgccgaaaggcgcucuguaaucauuaaaaaguauuuugaacggaccucuguuugacacgucug .....................<<<.<<<..<<<<<....>>>>>.>>>.>>>...<...>...........<<<<<...<<.....>>.>>>>> .....................(((.(((..(((((....))))).))).)))..(.....)..(...)...(((((...(((...))).))))) Crystal structure of Francisella novicida Cas9 in complex with sgRNA and target DNA (TGA PAM); Guide RNA 5b2q B 94 1.7 RF02747 URS00008FED26_32630 26875867 0010468 32630 gggaaauuaggugcgcuggggguuucaguugcgccgaaaggcgcucuguaaucauuuaaaaguauuuugaacggaccucuguuugacacgucug .....................<<<.<<<..<<<<<....>>>>>.>>>.>>>...<...>...........<<<<<...<<.....>>.>>>>> .....................(((.(((..(((((....))))).))).)))..(.....)..(...)...(((((...(((...))).))))) Crystal structure of Francisella novicida Cas9 RHA in complex with sgRNA and target DNA (TGG PAM); Guide RNA 5btm A 43 2.778 URS000086853F_9606 26039897 9606 uauucuaucggcuaaggaugaaagucuaugccgauucuauucu .<<...<<<<<<...<<<<....>>>>..>>>>>>...>>... .((...((((((...((((....))))..))))))...))... Crystal structure of AUUCU repeating RNA that causes spinocerebellar ataxia type 10 (SCA10); RNA (55-mer) 5btm B 43 2.778 URS000086853F_9606 26039897 9606 uauucuaucggcuaaggaugaaagucuaugccgauucuauucu .<<...<<<<<<...<<<<....>>>>..>>>>>>...>>... .((...((((((...((((....))))..))))))...))... Crystal structure of AUUCU repeating RNA that causes spinocerebellar ataxia type 10 (SCA10); RNA (55-mer) 5ccb N 77 2.0 RF00005 URS00008FED2A_9606 26470919 0030533 0006412 9606 ggcccggauagcucagucgguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca .<<<<<<<..<<<<........>>>>.<<<<<.<...>.>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((((((..((((........)))).(((((.(...).))))).....(((((.......))))))))))))..). Crystal structure of human m1A58 methyltransferase in a complex with tRNA3Lys and SAH; tRNA3Lys 5ccx N 77 2.1 RF00005 URS00008FED2A_9606 26470919 0030533 0006412 9606 ggcccggauagcucagucgguagagcaucagacuuuuaaucugaggguccaggguucangucccuguucgggcgcca .<<<<<<<..<<<<........>>>>.<<<<<.<...>.>>>>>.....<<<<<.......>>>>>>>>>>>>.... .(((((((..((((........)))).(((((.(...).))))).....(((((.......)))))))))))).... Structure of the product complex of tRNA m1A58 methyltransferase with tRNA3Lys as substrate; tRNA3Lys 5cd1 M 74 3.6 RF00005 URS00008FED2A_9606 26470919 0030533 0006412 9606 ggcccggauagcucagucgguagagcaucagacuuaaucugaggguccaggguucaagucccuguucgggcgcc .<<<<<<...<<<<........>>>>.<<<<<.....>>>>>.....<<<<<.......>>>>>.>>>>>>... .(((((((..((((........)))).(((((.....))))).....(((((.......))))))))))))... Structure of an asymmetric tetramer of human tRNA m1A58 methyltransferase in a complex with SAH and tRNA3Lys; tRNA3Lys 5cd1 N 76 3.6 RF00005 URS00008FED2A_9606 26470919 0030533 0006412 9606 ggcccggauagcucagucgguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcc .<<<<<<<..<<<<........>>>>.<<<<<.<...>.>>>>>.....<<<<<.......>>>>>>>>>>>>... ((((((((..((((........)))).(((((.(...).))))).....((((.........)))))))))))..) Structure of an asymmetric tetramer of human tRNA m1A58 methyltransferase in a complex with SAH and tRNA3Lys; tRNA3Lys 5czz B 73 2.6 URS000086852A_1280 26317473 1280 ggaaauuaggugcgcuuggcguuuuaguacucuggaaacagaaucuacuaaaacaaggcaaaaugccguguuu ....................<<<<<<<<<.<<<<....>>>>...>>>>>>>>>..<<<.....>>>...... ....................(((((((((.((((....))))...)))))))))..(((.....)))...... Crystal structure of Staphylococcus aureus Cas9 in complex with sgRNA and target DNA (TTGAAT PAM); RNA (73-MER) 5d8h A 74 2.8 RF02540 URS0000A76356_2190 0003735 0005840 2190 gccuaagacagcggggagguuggcuuagaagcagccauccuuuaaagagugcguaacagcucacccgucgaggc <<<.......<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>...>>> (((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...))) CRYSTAL STRUCTURE OF THE BASE OF THE RIBOSOMAL P STALK FROM METHANOCOCCUS JANNASCHII WITH ANTIBIOTIC THIOSTREPTON; 23S ribosomal RNA 5ddp A 61 2.302 RF01739 URS00008FED3F_32046 26655897 0070406 32046 cguugacccaggaaacugggcggaaguaagguccauugcacuccgggccugaagcaacgcg <<<<<.<<<<<....>>>>>........<<<<<<..........>>>>>>....>>>>>.. (((((.(((((....)))))..[.....((((((..........))))))....)))))]. L-glutamine riboswitch bound with L-glutamine; RNA (61-MER) 5ddp B 61 2.302 RF01739 URS00008FED3F_32046 26655897 0070406 32046 cguugacccaggaaacugggcggaaguaagguccauugcacuccgggccugaagcaacgcg <<<<<.<<<<<....>>>>>........<<<<<<..........>>>>>>....>>>>>.. (((((.(((((....)))))..[.....((((((..........))))))....)))))]. L-glutamine riboswitch bound with L-glutamine; RNA (61-MER) 5ddq A 61 2.4 RF01739 URS00008FED3F_32046 26655897 0070406 32046 cguugacccaggaaacugggcggaaguaagguccauugcacuccgggccugaagcaacgcg <<<<<.<<<<<....>>>>>........<<<<<<..........>>>>>>....>>>>>.. (((((.(((((....)))))..[.....((((((..........))))))....)))))]. L-glutamine riboswitch bound with L-glutamine soaked with Mn2+; L-glutamine riboswitch RNA (61-MER) 5ddq B 61 2.4 RF01739 URS00008FED3F_32046 26655897 0070406 32046 cguugacccaggaaacugggcggaaguaagguccauugcacuccgggccugaagcaacgcg <<<<<.<<<<<....>>>>>........<<<<<<..........>>>>>>....>>>>>.. (((((.(((((....)))))..[.....((((((..........))))))....)))))]. L-glutamine riboswitch bound with L-glutamine soaked with Mn2+; L-glutamine riboswitch RNA (61-MER) 5ddr B 61 2.605 RF01739 URS00008FED3F_32046 26655897 0070406 32046 cguugacccaggaaacugggcggaaguaagguccauugcacuccgggccugaagcaacgcg <<<<<.<<<<<....>>>>>........<<<<<<..........>>>>>>....>>>>>.. (((((.(((((....)))))..[.....((((((..........))))))....)))))]. L-glutamine riboswitch bound with L-glutamine soaked with Cs+; L-glutamine riboswitch RNA (61-MER) 5fj1 F 24 2.75 URS0000A76360_2238 27016741 2238 uggggagccgaaaggcgaagaacc .<<...<<<....>>>......>> .((...(((....)))......)) Structure of the standard kink turn HmKt-7 as stem loop in P212121 space group; HMKT-7 5fjc A 94 1.71 RF00162 URS0000A7634F_119072 27016741 0010468 119072 ngcuuaucaagagagggggagugacuggcgcgaagaaccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<...<<....((.>>......>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((....(.(((...(((.[.[[)))......))))(((..(((....))).)))...(]].](((((....)))))..))))))))). SAM-I riboswitch bearing the H. marismortui Kt-7 variant C-2bU; SAM-I RIBOSWITCH 5fk1 A 94 2.5 RF00162 URS0000A76377_119072 27016741 0010468 119072 ggcuuaucaagagagggggagcgacuggcgcgaagauccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<<..<<<...((>>>.....>>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((......(((...(((.[.[[)))......))).(((..(((....))).)))...(]].](((((....)))))..))))))))). SAM-I riboswitch bearing the H. marismortui Kt-7 variant 3bn is UG; SAM-I RIBOSWITCH 5fke A 94 2.8 RF00162 URS0000A7638A_119072 27016741 0010468 119072 ggcuuaucaagagagggugagcgacuggcgcgaagagccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<<..<<<...((>>>.....>>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((....(.((((..(((.[.[[))).....)))))(((..(((....))).)))...(]].](((((....)))))..))))))))). SAM-I riboswitch bearing the H. marismortui Kt-7 variant 3bn is GU; SAM-I RIBOSWITCH 5fkf A 94 2.8 RF00162 URS0000A76399_119072 27016741 0010468 119072 ggcuuaucaagagagggcgagcgacuggcgcgaagauccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<...<<<...((>>>......>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((......(((...(((.[.[[)))......))).(((..(((....))).)))...(]].](((((....)))))..))))))))). SAM-I riboswitch bearing the H. marismortui Kt-7 variant 3bn is UC; SAM-I RIBOSWITCH 5fkg A 94 2.95 RF00162 URS0000A76343_119072 27016741 0010468 119072 ggcuuaucaagagagggggagugacuggcgcgaagacccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<<..<<....((.>>.....>>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((....(.(((...(((.[.[[)))......))))(((..(((....))).)))...(]].](((((....)))))..))))))))). SAM-I riboswitch bearing the H. marismortui Kt-7 variant 3bn is CG; SAM-I RIBOSWITCH 5fkh A 94 2.65 RF00162 URS0000A76344_119072 27016741 0010468 119072 ggcuuaucaagagagggugagcgacuggcgcgaagacccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<...<<<...((>>>......>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((....(.(((...(((.[.[[)))......))))(((..(((....))).)))...(]].](((((....)))))..))))))))). SAM-I riboswitch bearing the H. marismortui Kt-7 variant 3bn is CU; SAM-I RIBOSWITCH 5lr4 C 10 1.8 URS0000BC46A2_9606 28623187 9606 gncggnuggc .......... .......... RNA duplex has central consecutive GA pairs flanked by G-U basepairs with a methyl group on the adenine N6; RNA (5'-R(*GP*(CBV)P*CP*GP*GP*(6MZ)P*UP*GP*GP*C)-3') 5lr4 D 10 1.8 URS0000BC46A2_9606 28623187 9606 gncggnuggc .......... .......... RNA duplex has central consecutive GA pairs flanked by G-U basepairs with a methyl group on the adenine N6; RNA (5'-R(*GP*(CBV)P*CP*GP*GP*(6MZ)P*UP*GP*GP*C)-3') 5lys B 57 2.32 RF00100 URS0000A763A0_9606 28082395 9606 gggaucugucaccccauugaucgccuucgggcugaucuggcuggcuaggcggguccn <<<<<<<<<<.<<<<<..<<<<<<<....>>>.>>>>>>>..>>...>>>>>>>>>> ((((((((((.(((((..(((((((....))).)))))))..))...)))))))))) The crystal structure of 7SK 5'-hairpin - Gold derivative; 7SK RNA 5ndh B 16 1.81 URS0000BC4682_33072 28529131 33072 gnggggacgaccccgc <<<<<<....>>>>>> ((((((....)))))) The structure of the G. violaceus guanidine II riboswitch P2 stem-loop; RNA (5'-R(*GP*(CBV)P*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*GP*C)-3') 5nef A 18 1.91 URS0000BC4678_33072 28529131 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P1 stem-loop with guanidine; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 5nep A 18 1.6 URS0000BC4678_33072 28529131 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P1 stem-loop with methylguanidine; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 5neq A 18 1.69 URS0000BC4678_33072 28529131 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P1 stem-loop with aminoguanidine; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 5nex A 18 1.72 URS0000BC4678_33072 28529131 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P1 stem-loop with agmatine; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 5nom A 18 1.93 URS0000BC4678_33072 28529131 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P1 stem-loop with guanidine; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 5npm B 80 2.7 RF02541 URS000080E005_274 29512642 0003735 0005840 274 gggaugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuuccc <<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>> ((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))) CRYSTAL STRUCTURE OF MUTANT RIBOSOMAL PROTEIN TTHL1 LACKING 8 N-TERMINAL RESIDUES IN COMPLEX WITH 80NT 23S RNA FROM THERMUS THERMOPHILUS; 23S ribosomal RNA 5nwq A 41 1.91 RF01763 URS0000CBFF2B_2021 28988949 0010468 2021 ccggacgaggugcgccguacccggucaggacaagacggngc ((((.......<<<<<<<..))))..........>>>>>>> [[[[.......(((((((.(]]]]....).....))))))) The structure of the thermobifida fusca guanidine III riboswitch with guanidine.; Guanidine III riboswitch 5ny8 A 41 2.04 RF01763 URS0000CBFF2B_2021 28988949 0010468 2021 ccggacgaggugcgccguacccggucaggacaagacggngc ((((.......<<<<<<<..))))..........>>>>>>> [[[[.......(((((((.(]]]]....).....))))))) The structure of the thermobifida fusca guanidine III riboswitch with aminoguanidine; RNA (41-MER) 5nz3 A 41 2.059 RF01763 URS0000CBFF2B_2021 28988949 0010468 2021 cnggacgaggugcgccguacccggucaggacaagacggngc ((((.......<<<<<<<..))))..........>>>>>>> [[[[.......(((((((.(]]]]....).....))))))) The structure of the thermobifida fusca guanidine III riboswitch with methylguanidine; RNA (41-MER) 5nzd A 41 2.007 RF01763 URS0000CBFF2B_2021 28988949 0010468 2021 cnggacgaggugcgccguacccggucaggacaagacggngc ((((.......<<<<<<<..))))..........>>>>>>> [[[[.......(((((((.(]]]]....).....))))))) The structure of the thermobifida fusca guanidine III riboswitch in space group P212121.; guanidine III riboswitch 5xh6 B 40 2.0 URS0000A763A2_1111120 28595896 1111120 aauuucuacucuuguagauggaaauuaggugcgcuuggca ....<<<<<....>>>>>...................... ....(((((....)))))...................... Crystal structure of the Acidaminococcus sp. BV3L6 Cpf1 RVR variant in complex with crRNA and target DNA (TATA PAM); crRNA 5xh7 B 40 2.0 URS0000A763A2_1111120 28595896 1111120 aauuucuacucuuguagauggaaauuaggugcgcuuggca ....<<<<<....>>>>>...................... ....(((((....)))))...................... Crystal structure of the Acidaminococcus sp. BV3L6 Cpf1 RR variant in complex with crRNA and target DNA (TCCA PAM); crRNA 5xus B 40 2.5 URS0000BC4668_32630 28781234 32630 aauuucuacuaaguguagauggaaauuaggugcgcuuggc ....<<<<<.....>>>>>..................... ....(((((.....)))))..................... Crystal structure of Lachnospiraceae bacterium ND2006 Cpf1 in complex with crRNA and target DNA (TTTA PAM); crRNA 5xut B 40 2.4 URS0000BC4668_32630 28781234 32630 aauuucuacuaaguguagauggaaauuaggugcgcuuggc ....<<<<<.....>>>>>..................... ....(((((.....)))))..................... Crystal structure of Lachnospiraceae bacterium ND2006 Cpf1 in complex with crRNA and target DNA (TCTA PAM); crRNA 5xuu B 40 2.5 URS0000BC4668_32630 28781234 32630 aauuucuacuaaguguagauggaaauuaggugcgcuuggc ....<<<<<.....>>>>>..................... ....(((((.....)))))..................... Crystal structure of Lachnospiraceae bacterium ND2006 Cpf1 in complex with crRNA and target DNA (TCCA PAM); crRNA 5xuz B 40 2.4 URS0000BC4668_32630 28781234 32630 aauuucuacuaaguguagauggaaauuaggugcgcuuggc ....<<<<<.....>>>>>..................... ....(((((.....)))))..................... Crystal structure of Lachnospiraceae bacterium ND2006 Cpf1 in complex with crRNA and target DNA (CCCA PAM); crRNA 5xuz F 40 2.4 URS0000BC4668_32630 28781234 32630 aauuucuacuaaguguagauggaaauuaggugcgcuuggc ....<<<<<.....>>>>>..................... ....(((((.....)))))..................... Crystal structure of Lachnospiraceae bacterium ND2006 Cpf1 in complex with crRNA and target DNA (CCCA PAM); crRNA 6chr A 621 3.7 RF02012,RF00029 URS0000E60B9F_2885 30410046 0000373 2885 gugcgacaagaaguucaggaagggauugaggugaaaguccuccucccgaaucguucaugggagagucuauccagacuugcguagcgaguaaucgcuaggugagaagcucuggagacaauguaccugcccuucaauuggaggugccagggcuaggcuuuguuccuauggcuagcgaaagcgaauacagguuauuaggcgucgugaaaacaaaacucuuucgacauaagggagagguagaugaguuacccuccuuuuuaugggguaacugaacgaucaauaucuaccggcguagacugugagccuaaaggaaacgaaugaaagugucccuuccugggaacuugguaagcccaauagacucccucugggaaaccagaggaggaguaagagcaaucuuacuuaucgucuaguggguaaaagacauaauaggaagcaaaugcuugguuguaacgaucgagauagaaucuguugauuuaagcugaaaggcugcagacuuauuaaauggguguucugcuguauggcguucgcgccuaagcagcagaaugcgugagccgugugcgaugaaagucgcaagcacgguucugauggggggaaaacgagagaucgucuaccuauccaacucaa ..[[..<<<....<<<<<<<<<<<<<.<<<<.......>>>><<<<<<...((((..>>>>>><<<<<.<<<<<<<<<<<.<<<<<<....>>>>>>.>>>>>..]]>>>>>>.........<<<<..................>>>>...>>>>>..<<<<<<..<<<<.<<....>>...<<<<<........<<<<<.................<<.......>>......<<<<<..<<<<<<<<.........>>>>>>>>..))))......>>>>>..>>>>>...>>>>>>>>>...>>>.>>>..........>>>>>>>>>>>>>...>>>....<<<<<.<<<<<..<<<<<<<....>>>>>>>..<<<<<<<<....>>>>>>>>...>>>>>.>>>>>........<<<<<....<<.....<<<<<<<.....>>>>>>>...<<<<......>>>>.<<<<....>>>>>>.....>>>>>.....<<<<<<<<<<<<..<<<<....>>>>...>>>>>>>>>>>>..<<<<<<<<<<<<<<....>>>>>..>>>>>>>>>.....<<<<<...<<........>>...>>>.>>........ ..{{..((((...(((((((((((((.((((.......))))(((((....[[[[[..)))))(((((.((((((((((..((((.(....).))))..))))..}}))))))..........((....................))....)))))..((((((..((((.((....))...(((((.......[((((.(...................(..).........((((((..((((((((.].......)))))))).]]]]]......))))))).)))).[.)))))))))...))).)))..........)))))))))))))..))))....(((((.(((((..(.(((((....))))).)..((((((((....))))))))...))))).)))))........(((((....((.....(((((((.....)))))))..[((((...]..)))).((((....)))))).....))))).....((((((((((((..(((......)))...))))))))))))..((((((((((((((....)))))..))))))))).....(..((...((.(....).))...))...).....].. Crystal structure of a group II intron lariat with an intact 3' splice site (pre-2s state); RNA (621-MER) 6cih A 616 3.676 RF02012,RF00029 URS0000E60BD4_2885 30410046 0000373 2885 gugcgacaagaaguucaggaagggauugaggugaaaguccuccucccgaaucguucaugggagagucuauccagacuugcguagcgaguaaucgcuaggugagaagcucuggagacaauguaccugcccuucaauuggaggugccagggcuaggcuuuguuccuauggcuagcgaaagcgaauacagguuauaggcgucgugaaaacaaaacucuuucgacauaagggagagguagaugaguuacccuccuuuuuaugggguaacugaacgaucaauaucuaccggcguagacugugagccuaaaggaaacgaaugaaagugucccuuccugggaacuugguaagcccaauagacucccucugggaaaccagaggaggaguaagagcaaucuuacuuaucgucuaguggguaaaagacauaauaggaagcaaaugcuugguuguaacgaucgagauagaaucuguugauuuaagcugaaaggcugcagacuuauuaaauggguguucugcuguauggcguucgcgccuaagcagcagaaugcgugagccgugugcgaugaaagucgcaagcacgguucugauggggggaaaacgagagaucgucuaccuauccaac ..[[..<<<....<<<<<<<<<<<<<.<<<<.......>>>><<<<<<.(((({{..>>>>>><<<<<.<<<<<<<<<<<.<<<<<<....>>>>>>.>>>>>..]]>>>>>>......<<.<<<....................>>>>>.>>>>>..<<<<<<..<<<<.<<....>>...<<<<<.......<<<<<.............<<<<<.........>>>>>.<<<<<<..<<<<<<<<.........>>>>>>>>.}}.))))....>>>>>.>>>>>>...>>>>>>>>>...>>>.>>>..........>>>>>>>>>>>>>...>>>....<<<<<.<<<<<..<<<<<<<....>>>>>>>..<<<<<<<<....>>>>>>>>...>>>>>.>>>>>........<<<<<<...<<.....<<<<<<<.....>>>>>>>...<<<<......>>>>.<<<<....>>>>>>....>>>>>>.....<<<<<<<<<<<<..<<<<....>>>>...>>>>>>>>>>>>..<<<<<<<<<<<<<<....>>>>>..>>>>>>>>>...<<<<<.<.<.<<<<....>>>>.>.>>..>>>>.. ..{{..((((...(((((((((((((.((((.......))))((((((.[[[[[[..))))))(((((.(((((((((((.(((((......))))).)))))..}}))))))......(..((((.................).))).).)))))...((((...((((.((....))...(((((......[((((((............(((.............))).((((((..((((((((.].......))))))))..]]]]]]....))))))))))))...)))))))))....)).))...........)))))))))))))..))))....(((((.(.(((..(((((((....)))))))...(((((((....)))))))....))).).)))))........(((((....((.....((.((((.....)))).))..[((((...]..)))).((((....)))))).....))))).....((((((((((((..((((....))))...))))))))))))..((((((((((((((....)))))..)))))))))...(((..((...(((......)))...))...))).. Crystal structure of a group II intron lariat in the post-catalytic state; RNA (696-MER) 6dlq A 107 2.8 RF00442 URS0000E60BB3_643648 30120360 0010468 643648 ngaaagugugucuaggguuccgcgugcuucggcacggacugguccaagugacacagacgcauucgugcguuacaccggagggauagaagcccaggcggguagguuun .<<<<.<<<<<<..<<...<<<<<<<<....>>>>>...>>>.>>....>>>>>><<<<<<....>>>>>>...<<<..<<<.......>>>...>>>.....>>>> .((((.((((((..((...((((((((....)))))..).)).))....))))))((((((....)))))).[.(((..(((.......))).].))).....)))) PRPP Riboswitch bound to PRPP, manganese chloride soaked structure; PRPP Riboswitch 6dmc A 102 2.2 URS0000E60BA7_679936 30120360 679936 ngaaguguaccuagggauccaccucgagagaggaaggaccaagcgguacaggccuacuucgguagguuacaccguggggauaaaagacccguggcaaguuun <<<<.<<<<<<..<<..<<<.<<<<....>>>>..>>>>>....>>>>>><<<<<<<....>>>>>>>...<<<<<<<.........>>>>>>>....>>>> ((((.((((((..((...((.((((....))))..)).))....))))))(((((((....)))))))...(((((((.........)))))))....)))) ppGpp Riboswitch bound to ppGpp, native structure; ppGpp Riboswitch 6dmc B 102 2.2 URS0000E60BA7_679936 30120360 679936 ngaaguguaccuagggauccaccucgagagaggaaggaccaagcgguacaggccuacuucgguagguuacaccguggggauaaaagacccguggcaaguuun .<<<.<<<<<<..<<..<<<.<<<<....>>>>..>>>>>....>>>>>><<<<<<<<..>>>>>>>>...<<<<<<<.........>>>>>>>....>>>. ((((.((((((..((...((.((((....))))..)).))....))))))(((((((....)))))))...(((((((.........)))))))....)))) ppGpp Riboswitch bound to ppGpp, native structure; ppGpp Riboswitch 6dmd A 102 2.65 URS0000E60BA7_679936 30120360 679936 ngaaguguaccuagggauccaccucgagagaggaaggaccaagcgguacaggccuacuucgguagguuacaccguggggauaaaagacccguggcaaguuun <<<<.<<<<<<..<<..<<<.<<<<....>>>>..>>>>>....>>>>>><<<<<<<....>>>>>>>...<<<<<<<.........>>>>>>>....>>>> ((((.((((((..((...((.((((....))))..)).))....))))))(((((((....)))))))...(((((((.........)))))))....)))) ppGpp Riboswitch bound to ppGpp, manganese chloride structure; ppGpp Riboswitch 6dmd B 102 2.65 URS0000E60BA7_679936 30120360 679936 ngaaguguaccuagggauccaccucgagagaggaaggaccaagcgguacaggccuacuucgguagguuacaccguggggauaaaagacccguggcaaguuun <<<<.<<<<<<..<<..<<<.<<<<....>>>>..>>>>>....>>>>>><<<<<<<<..>>>>>>>>...<<<<<<<.........>>>>>>>....>>>> ((((.((((((..((...((.((((....))))..)).))....))))))(((((((....)))))))...(((((((.........)))))))....)))) ppGpp Riboswitch bound to ppGpp, manganese chloride structure; ppGpp Riboswitch 6dtd C 37 1.65 URS0000E60B71_28126 30917325 28126 uguugcaucugccuucuuuuugaaagguaaaaacaac .<<<<.....<<<<<<.....>.>>>>>.....>>>> .((((..(.(((((((.....).)))))).)..)))) High-resolution crystal structure of Cas13b from Prevotella buccae; RNA (37-MER) 6e8s A 38 2.35 URS0000E60B64_32630 30992561 32630 gcuacgaaggaaggauugguaugugguauauucguagc <<<<<<<<......................>>>>>>>> ((((((((......................)))))))) Structure of the iMango-III aptamer bound to TO1-Biotin; iMango-III aptamer 6e8s B 38 2.35 URS0000E60B64_32630 30992561 32630 gcuacgaaggaaggauugguaugugguauauucguagc <<<<<<<<......................>>>>>>>> ((((((((......................)))))))) Structure of the iMango-III aptamer bound to TO1-Biotin; iMango-III aptamer 6e8t C 36 2.9 URS0000E60B6C_32630 30992561 32630 guacgaaggaagguuugguaugugguauauucguac <<<<<<<......................>>>>>>> (((((((......................))))))) Structure of the Mango-III (A10U) aptamer bound to TO1-Biotin; RNA (35-MER) 6e8u B 37 1.55 URS0000E60B92_32630 30992561 32630 guacgaaggaagguuugguaugggguaguugucguac <<<<<<.........................>>>>>> ((((((....(..................).)))))) Structure of the Mango-III (A10U) aptamer bound to TO1-Biotin; RNA (37-MER) 6fz0 A 48 2.499 RF01826 URS0000D77952_335992 29931337 0010468,0046500 335992 aggngcauuugaacuguauuguacgccuugcagcaaaaguacuaaaaa <<<<..............[[((((>>>><<<.>>>...)))).]]... [[[[..............((((((]]]]((...))...)))).))... Crystal structure of the metY SAM V riboswitch; metY SAM V (53-MER) 6gyv A 190 2.50004 RF01807 URS000080E1A7_5793 24821772 0008380 5793 cauccgguaucccaagacaaucuucggguuggguugggaaguaucauggcuaaucaccaugaugcaaucggguugaacacuuaauuggguuaaaacggugggggacgaucccguaacauccguccuaacggcgacagacugcacggcccugccucagguguguccaaugaacagucguuccgaaaggaag ...<<<<...<<<<<..<<<<<....>>>>>..>>>>>..<<<<<<<<<...<<<.>>>>>>>>>..>>>>.[[[.<<<<......<<<<<...<<<<..(((...>>>))).......>>>><<....>>.....(((((...>>>>>.<<<<.>>>>>>>>.]]]....))))).<<<<....>>>>. ..{((((...(((((..(((((....)))))..)))))..(((((((((...[[[.)))))))))..)))).(((.((((......(((((}..((((..(((...]]]))).......))))((....)).....[[[[[...))))).((((.)))))))).)))....]]]]].((((....)))). Lariat-capping ribozyme (circular permutation form); Lariat-capping ribozyme 6hc5 A 18 1.413 URS0000BC4678_33072 30609994 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P2 stem-loop with audouine; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 6me0 A 829 3.6 RF02012,RF00029 URS0000EEAD0D_146786 31348888 0000373 146786 uugcgacgcgaaagcuagccagaugauugucccacuagcccaacaagcuagaacgggaccgguuguucccccaaccguagccuagggaggcaugcgugacugguaacggucaggugugaagcccucccgacaauguagcccgaaccgcaagguugaagcugaauccgugaggaggaagcaacuucaccagugucaggugauagggaacuaggcuugaggguauggugagcacaugcgaagugaugucagaagccucgucacagaccaacaggccaaagacacugauaggccugagccaaaacggcaaauggauaggcuacaucgcucgcucgucgguguacggggacgucaauccaucggggcacagucaccaccuaaccccucgugucaucugguuggaacgcgguaagcccguauccucgccuugaacacucaaggcaggcaaaccguaaggaaugcugaugggggugcggguaugggaugcaggagaaagcgaaugccggucuguaauggaccggauagggguugaggagacaauccaacaucaccccgcccgaaagggagcagacuuccugcuggucucucuuugcgagauagccuguagaaccucuugaauggagacaaggcaaauggcaguggaacaaaccacuggugcggucaccaaccaaacggccgugagguaaagaggcugcaagugcguaucgcaaaggcguucgcgccgguuccucuugaaagaggggcuuugagaggccugagccggauguggggaaacucacaaguccgguucuuagggggcggggauggcaguaaugccucccugcuacccggc ..((..<<<.....<<<<<<<<<<<<<.<<<<<.<<.............>>...>>>>><<<<<<.<<<<<>>>>>>.<<<<..<<<<<<<<<<<.<<<<<<....>>>>>>.>>>>>..))>>>>>>......((..<<<.<<<......>>><..<<<...<<<....>>>...>>>..>.<<<<<.<<<<<.>>>>>..>>>.))..>>>><<<<<<...[[[[.<<....>>...(((((.......(((((............<<<<<<...>>>>>.....>>>>>>.<<<.....>>>..(((((..(..<<<<<<<.........>>>>>>>.>>>>>).....))))).)))))...)))))]]]]....>>>>>>.>>>>>>>>>>>>>...>>>....<<<<<<<<<<<<<<<<<<......>>>>>>.<<<<..<<....>>..>>>>...>>>>>>>>>>>>.......<<<<<<....<<.....<<<<<<<.....>>>>>>>...<<<<<...<.........>......>>>>>.<<<....>>>.>>.....>>>>>>.<<<<<<<<.<<<<<<....<<.<<<<<..<<<<<<...<<<.<<<...<<<.....<<<<<<......>>>>>>.>>>.>>>.>>><<..............>>.>>>>>>>>>>>.>>.....>>>>>>.<<<<....>>>><<<<<<<<<....>>>>>>>>>..>>>>>>>>.<<<<<<<<<<<<<<....>>>>>..>>>>>>>>>...<<<<<<<<<<<.<<<<....>>>>>>>>>>>>.>>>... ..{{..((((....((((((((((((..(((((.((.............))...)))))((((((.[[[[[)))))).((((..(((((((((((.((((((....)))))).)))))..}}))))))......((..(((.((.(.....)))(..((....(((....)))....))..)..((((.[[[[[.))))...))).))..))))((((((...((((.((....))...(((((......{((((((...........((((((...]]]]].....)))))).(((.....)))..(((((..((.(((((((.}.......))))))))]]]]]).....)))))))))))...)))))))))....))))))..))))))))))))..))))....((((((((((.(((((((......))))))..((...((....))...))....).))))))))))...(....(((((....((.....(((((((.....)))))))..[(((((...(.........)....].))))).(((....))).)).....)))))..((((((((.((((((....((.(((((..(((((....(((.(((...(((.....((((((......)))))).))).))).)))((...(......)...))..)))))))))).)).....)))))).((((....))))((((((((......))))))))..)))))))).((((((((((((((....)))))..)))))))))...((((((((((..((((....)))).))))))).)))..) Structure of a group II intron retroelement prior to DNA integration; T.el4h RNA 6mec A 818 3.6 RF02012,RF00029 URS0002617737_146786 31348888 0000373 146786 uugcgacgcgaaagcuagccagaugauugucccacuagcccaacaagcuagaacgggaccgguuguucccccaaccguagccuagggaggcaugcgugacugguaacggucaggugugaagcccucccgacaauguagcccgaaccgcaagguugaagcugaauccgugaggaggaagcaacuucaccagugucaggugauagggaacuaggcuugaggguauggugagcacaugcgaagugaugucagaagccucgucacagaccaacaggccaaagacacugauaggccugagccaaaacggcaaauggauaggcuacaucgcucgcucgucgguguacggggacgucaauccaucggggcacagucaccaccuaaccccucgugucaucugguuggaacgcgguaagcccguauccucgccuugaacacucaaggcaggcaugcugaugggggugcggguaugggaugcaggagaaagcgaaugccggucuguaauggaccggauagggguugaggagacaauccaacaucaccccgcccgaaagggagcagacuuccugcuggucucucuuugcgagauagccuguagaaccucuugaauggagacaaggcaaauggcaguggaacaaaccacuggugcggucaccaaccaaacggccgugagguaaagaggcugcaagugcguaucgcaaaggcguucgcgccgguuccucuugaaagaggggcuuugagaggccugagccggauguggggaaacucacaaguccgguucuuagggggcggggauggcaguaaugccucccugcuacccggcg ..((..<<<<....<<<<<<<<<<<<<.<<<<<.<<.............>>...>>>>><<<<<<.<<<<<>>>>>>.<<<<..<<<<<<<<<<<.<<<<<......>>>>>.>>>>>..))>>>>>>......((..<<<.<<<<....>>>><..<<<...<<<....>>>...>>>..>.<<<<<.<<<<<.>>>>>..>>>.))..>>>><<<<<<...[[[[.<<....>>...(((((.......(((((............<<<<<<...>>>>>.....>>>>>>.<<<.....>>>..(((((.....<<<<<<<.........>>>>>>>.>>>>>......))))).)))))...)))))]]]]....>>>>>>.>>>>>>>>>>>>>..>>>>....<<<<<<<<<<<<<<<<<<......>>>>>>.<<....>>...>>>>>>>>>>>>.......<<<<<<<...<<.....<<<<<<<.....>>>>>>>...<<<<<....................>>>>>.<<<....>>>.>>....>>>>>>>.<<<<<<<<.<<<<<<....<<.<<<<<..<<<<<<...<<<.<<<...<<<.....<<<<<<......>>>>>>.>>>.>>>.>>>.<.............>...>>>>>>>>>>>.>>.....>>>>>>.<<<<<..>>>>><<<<<<<<<....>>>>>>>>>..>>>>>>>>.<<<<<<<<<<<<<<....>>>>>..>>>>>>>>>...<<<<<<<<<<<.<<<<....>>>>>>>>>>>>.>>>.... ..{{..((((....((((((((((((..(((((.((.............))...)))))((((((.[[[[[)))))).((((..((((((((.((.((((.(....).)))).)).))..}}))))))......((..(((.((.(.....)))(..(((...(((....)))...)))..)..((.(.[[[[[.).))...))).))..)))).(((((...((((.((....))...(((((......{((((((...........((((((...]]]]].....)))))).(((.....)))..(((((..((.(((((((.}.......))))))))]]]]]).....)))))))))))...)))))))))....)))))...))))))))))))..))))....(((((((.((((((((((......))))))..(....)....)))).)))))))........(((((....((.....((((((.......))))))..[(((((..................].))))).(((....))).)).....)))))..((((((((.((((((....((.(((((..(((((....(((.(((...(((.....((((((......)))))).))).))).)))..(..(......)..)....)))))))))).)).....)))))).((((....))))(((((((((....)))))))))..)))))))).((.(((((((((((....)))))..)))))).))...(((.(((((((.((((....)))))))))).).))).... Structure of a group II intron retroelement after DNA integration; T.el4h RNA 6n2v B 99 2.85 RF00080 URS000197CF63_347 31541094 0030145 347 ngcuuggggaguagccugcuuucggaaacgaaagcgccuguaucaacauacucggcgaaagccguggugcaggaccgaaaggucuggcgagaccaggcc <<<<<<<......<<<.<<<<<<<....>>>>>>>.<<<<<<<<........<<<<....>>>>.>>>>>>>><<<....>>>..>>>....>>>>>>> (((((((......(((.(((((((....))))))).(((((((((.......((((....))))))))))))).((....))...)))....))))))) Manganese riboswitch from Xanthmonas oryzae bound to Mn(II); X. oryzae Mn riboswitch optimized construct 6q8u A 21 1.99 URS0000EEACF7_2238 31234702 2238 cggcgaagnaccggggagccg ..................... ..................... Structure of the standard kink turn HmKt-7 variant A2bm6A bound with AfL7Ae protein; RNA (5'-R(*CP*GP*GP*CP*GP*AP*AP*GP*(6MZ)P*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*CP*G)-3') 6q8u B 21 1.99 URS0000EEACF7_2238 31234702 2238 cggcgaagnaccggggagccg ..................... ..................... Structure of the standard kink turn HmKt-7 variant A2bm6A bound with AfL7Ae protein; RNA (5'-R(*CP*GP*GP*CP*GP*AP*AP*GP*(6MZ)P*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*CP*G)-3') 6t3n A 394 3.22 RF02001,RF01998 URS0001A24B5B_221109 32503992 0000373 221109 guuauugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucaggagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaacggccguauaccgaacgguacguacggucgugug [[[[.....<<<<<...<<<<<<<<<<<...<<<.......>>>..<<<<<...(((((((...>>>>>..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<<<<<<<<...<<<<...]]]].>>>>....>>>.)))))))...>>>>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<......>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... .{{{{.[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[((...(((.((((((((..((((.]}}}}..))))...)))).]]]]]]]...)))).)))...))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((..(((......)))...))))).(((((((((((((....)))..))))))))))... Structure of Oceanobacillus iheyensis group II intron G-mutant (C289G/C358G/G385C) in the presence of Na+, Mg2+ and 5'-exon; Group IIC Intron Ribozyme 6t3s A 393 3.28 RF02001,RF01998 URS0001A24B4F_182710 32503992 0000373 182710 guuauugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucaguagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaacugccguauaccgaacgguacguacgguagugug [[.......<<<<<...<<<<<<<<<<<...<<<.......>>>..<<<<<...(((((((...>>>>>..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<<<<<<<<<..<<<<....]].>>>>...>>>>.)))))))...>>>>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<......>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... .{....[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((...((.((((((((..((((.]..}..))))...)))).]]]]]]]...)))).))...)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((.((((......)))..))))))..((((((((((((....)))..))))))))).... Structure of Oceanobacillus iheyensis group II intron U-mutant (C289U/C358U/G385A) in the presence of Na+, Mg2+ and 5'-exon; Group IIC Intron Ribozyme 6tb7 A 52 2.53 RF03013 URS00021ED92A_204669 32295864 204669 ggcuucaacaaccccguagguugggccgaaaggcagcgaaucuacuggagcc <<<<<<.........<<<<<<<..<<<....>>>....>>>>>>>.>>>>>> (((((((.....[[.((((((((.(((....))).])])))))))))))))) Crystal structure of the ADP-binding domain of the NAD+ riboswitch with Adenosine monophosphate (AMP); RNA 6tf0 A 52 2.1 RF03013 URS00021ED92A_204669 32295864 204669 ggnuucaacaaccccguagguugggccgaaaggcagcgaaucuacuggagcc <<<<<<.........<<<<<<<..<<<....>>>....>>>>>>>.>>>>>> (((((((.....[[.((((((((.(((....))).])])))))))))))))) Crystal structure of the ADP-binding domain of the NAD+ riboswitch with Nicotinamide adenine dinucleotide, reduced (NADH); Chains: A 6tf1 A 52 2.4 RF03013 URS00021ED92A_204669 32295864 204669 ggcuucaacaaccccguagguugggccgaaaggcagcgaaucuacuggagcc <<<<<<.........<<<<<<<..<<<....>>>....>>>>>>>.>>>>>> (((((((.....[[.((((((((.(((....))).])])))))))))))))) Crystal structure of the ADP-binding domain of the NAD+ riboswitch with Adenosine diphosphate (ADP); Chains: A 6tf2 A 52 2.55 RF03013 URS00021ED92A_204669 32295864 204669 ggcuucaacaaccccguagguugggccgaaaggcagcgaaucuacuggagcc <<<<<<.........<<<<<<<..<<<....>>>....>>>>>>>.>>>>>> (((((((.....[[.((((((((.(((....))).])])))))))))))))) Crystal structure of the ADP-binding domain of the NAD+ riboswitch with Adenosine 5-triphosphate (ATP); Chains: A 6tf3 A 52 2.66 RF03013 URS00021ED92A_204669 32295864 204669 ggcuucaacaaccccguagguugggccgaaaggcagcgaaucuacuggagcc <<<<<<.........<<<<<<<..<<<....>>>....>>>>>>>.>>>>>> (((((((.....[[.((((((((.(((....))).])])))))))))))))) Crystal structure of the ADP-binding domain of the NAD+ riboswitch with Cordycepin 5-triphosphate (3-dATP); Chains: A 6tfe A 52 2.3 RF03013 URS00021ED92A_204669 32295864 204669 ggcuucaacaaccccguagguugggccgaaaggcagcgaaucuacuggagcc <<<<<<.........<<<<<<<..<<<....>>>....>>>>>>>.>>>>>> (((((((.....[[.((((((((.(((....))).])])))))))))))))) Crystal structure of the ADP-binding domain of the NAD+ riboswitch with N6-Methyl-adenosine-5'-triphosphate (m6ATP); Chains: A 6tff A 52 2.52 RF03013 URS00021ED92A_204669 32295864 204669 ggcuucaacaaccccguagguugggccgaaaggcagcgaaucuacuggagcc <<<<<<.........<<<<<<<..<<<....>>>....>>>>>>>.>>>>>> (((((((.....[[.((((((((.(((....))).])])))))))))))))) Crystal structure of the ADP-binding domain of the NAD+ riboswitch with Nicotinamide adenine dinucleotide (NAD+); Chains: A 6tfg A 52 2.45 RF03013 URS00021ED92A_204669 32295864 204669 ggcuucaacaaccccguagguugggccgaaaggcagcgaaucuacuggagcc <<<<<<.........<<<<<<<..<<<....>>>....>>>>>>>.>>>>>> (((((((.....[[.((((((((.(((....))).])])))))))))))))) Crystal structure of the ADP-binding domain of the NAD+ riboswitch with Adenosine 3-phosphate 5-phosphosulfate (APPS); Chains: A 6tfh A 52 2.95 RF03013 URS00021ED92A_204669 32295864 204669 ggnuucaacaaccccguagguugggccgaaaggcagcgaaucuacuggagcc <<<<<<.........<<<<<<<..<<<....>>>....>>>>>>>.>>>>>> (((((((.....[[.((((((((.(((....))).])])))))))))))))) Crystal structure of the ADP-binding domain of the NAD+ riboswitch with Nicotinamide adenine dinucleotide, reduced (NADH); soaking with Manganese(II) (Mn2+); Chains: A 6tqb B 19 1.6 URS0001A24B59_10090 32491174 10090 ggaaauuauauuaauuucc <<<<<<<<...>>>>>>>> ((((((((...)))))))) X-ray structure of Roquin ROQ domain in complex with a UCP3 CDE1 SL RNA motif; RNA (5'-R(P*GP*GP*AP*AP*AP*UP*UP*AP*UP*AP*UP*UP*AP*AP*UP*UP*UP*CP*C)-3') 6v39 AN1 2892 3.04 RF02540,RF02541 URS00000BF98D_480119 31964740 0003735 0005840 480119 agucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuuguacagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugaccuuacuuguguaggauaggugggaggcuuugaagcuggaacgcuaguuccaguggagccguccuugaaauaccacccugguaauguugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacua <<<<<<<<......<<<<<<<<<<<....<<<.<<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>>..............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<.........<<<<.........<.........>...............<<........>>...>>>>.....>..>>>>>>>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<.......>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...[[[[...>>>>>>....<<<<...<<<<<.<<<<<<.<<.....>>>>>>>>....>>>>>...>>>>...........<......>.........>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<.<<<<<.............<.................<<........>>........................>....>>>>>.>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>>. (((((((([.....((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((.((((((((..(.(((...(((.(......).)))[[(...).(((.....]])))...)))...)..)))))))).))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((....((.((((...((..((.......))...))...)))).))...)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.......(((((.(.(...(............)...))........((........))..)))))...).)..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))....(((....((((..((.....((.....))....)).....))))..[.)))............................)))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.(((((((.((..((((.(.....(.......[............(..(...........).)..........)........]....).))).).)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((.((.........)).)).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))........((..(.((((((...((.......))...))))))...).))..........(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((((..)])))).(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).))))))))). Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S with P-site tRNA; 23s ribosomal RNA 6v3a AN1 2892 2.82 RF02540,RF02541 URS00000BF98D_480119 31964740 0003735 0005840 480119 agucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuuguacagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugaccuuacuuguguaggauaggugggaggcuuugaagcuggaacgcuaguuccaguggagccguccuugaaauaccacccugguaauguugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacua <<<<<<<<......<<<<<<<<<<<....<<<.<<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>>..............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<.........<<<<...<.....<.........>......>........<<........>>...>>>>.....>..>>>>>>>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<.....>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...[[[[...>>>>>>....<<<<...<<<<<.<<<<<..<<.....>>.>>>>>....>>>>>...>>>>...........<......>.........>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<.<<<<<............<<.....<........<................>.....>...............>>...>>>>>.>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>>. .((((((([.....((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((.((((((((..(.(((...(((.(......).)))[[(...).(((.....]])))...)))...)..)))))))).))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(........).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((....((.((((...((..((.......))...))...)))).))...)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.......{.(((((.(.(...(............)...))........((........))..))))).....)..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((((..((...(.((.....)))...)).....))))..[))))............................)))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.(((((((.((..((((.(.....(.......[............(..(...........).)..........)........]....).))).).)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((.((.........)).)).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..(((((..)])))).(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))).. Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S with E-site tRNA; 23s ribosomal RNA 6v3b AN1 2892 2.91 RF02540,RF02541 URS00000BF98D_480119 31964740 0003735 0005840 480119 agucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuuguacagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugaccuuacuuguguaggauaggugggaggcuuugaagcuggaacgcuaguuccaguggagccguccuugaaauaccacccugguaauguugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacua <<<<<<<<......<<<<<<<<<<<....<<<.<<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>>..............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<.........<<<<...<.....<.........>......>........<<........>>...>>>>.....>..>>>>>>>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<.....>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...[[[[...>>>>>>....<<<<...<<<<<.<<<<<..<<.....>>.>>>>>....>>>>>...>>>>...........<......>.........>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<.<<<<<............<<.................<<........>>........................>>...>>>>>.>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>>. .((((((([.....((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((.((((((((..(.(((...(((.(......).)))[[(...).(((.....]])))...)))...)..)))))))).))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((....((.((((...((..((.......))...))...)))).))...)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.......{.(((((.(.(...(............)...))........(..........)..))))).....)..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((((..((...(.((.....)))...)).....))))..[))))............................)))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.(((((((.((..((((.(.....(.......[............(..(...........).)..........)........]....).))).).)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((.((.........)).)).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..(((((..)])))).(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))).. Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S in Empty state; 23s ribosomal RNA 6v3d AN1 2892 2.95 RF02540,RF02541 URS00000BF98D_480119 31964740 0003735 0005840 480119 agucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuuguacagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugaccuuacuuguguaggauaggugggaggcuuugaagcuggaacgcuaguuccaguggagccguccuugaaauaccacccugguaauguugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacua <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<.........<<<<...<.....<.........>......>........<<........>>...>>>>.....>..>>>>>>>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<.......>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>>....<<<<...<<<<<.<<<<<<.<<.....>>>>>>>>....>>>>>...>>>>...........<......>.........>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<.<<<<<............<<.................<<........>>........................>>...>>>>>.>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>>. (((((((([.....((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((.((((((((..(.(((...(((.(......).)))[[(...).(((.....]])))...)))...)..)))))))).))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(........).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((....((.((((...((..((.......))...))...)))).))...)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.......{.(((((.(.(...(............)...))........((........))..))))).....)..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((((..((...(.((.....)))...)).....))))..[))))............................)))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.(((((((.((..((((.(.....(.......[............(..(...........).)..........)........]....).))).).)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((.((.........)).)).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..(((((..)])))).(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).))))))))). Cryo-EM structure of the Acinetobacter baumannii Ribosome: 50S subunit; 23s ribosomal RNA 6y0y A 27 0.95 URS00021ED99E_32630 32630 ugcuccuaguacgagaggaacggagug .<<<<<...............>>>>>. .(((((.....(....)....))))). Sarcin Ricin Loop, mutant C2666U; RNA (27-MER) 6yl5 A 26 1.7 URS0001A24B6D_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAH; Chains: A,B,C,D,E,F,G,H,I,J,K,L 6yl5 E 26 1.7 URS0001A24B6D_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAH; Chains: A,B,C,D,E,F,G,H,I,J,K,L 6ymk F 26 2.03 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with AMP; Chains: A,C,F,I,M,O 6ysr A 2903 3.1 RF02540,RF02541 URS0000A76322_562 32796827 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..................................<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..................<.<....<.........<..<<......>>..>......>..............>.>.........>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((................))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{.((.((.(....(.............).....).......(((......)))..)).))...)))..)).)).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((..((.((.....))))..))))..))))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(.................(..((........((...(......)...)).....))............)........)..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the P+9 stalled ribosome complex; 23S ribosomal RNA 6yss A 2903 2.6 RF02540,RF02541 URS0000A76322_562 32796827 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..<...<.............>...>.........<..........>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..........>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..................................<..<........>..>................................>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(...........)..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((.(......(.............).............(((......)))..).)))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(..(.................(..((........(((..(......)..))).....))............)........)..).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the P+9 ArfB-ribosome complex in the post-hydrolysis state; 23S ribosomal RNA 6yst A 2903 3.2 RF02540,RF02541 URS0000A76322_562 32796827 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<.........>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<...................................<<<......>>>...>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<........................<.........<..............>......>.........................>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.((((((.((.(((...(((.(......).)))[[......(((.....]])))...)))...)).)))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{.((..(..................................(((......)))..)..))...).)..))))).))...........]]].)...))))))))))...)))))))((((.((((....)))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((.....((((.((..((.((.....))))..)).)..)))...[.)))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....((....(((((..)]))))....))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..((.........((.((..((....))...)).)).........)))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.((..(((((.(((((((.(.(..(................(...(.........((...(......)...))......)............)........)..).).)))))))...(((.((((((.....)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the P+9 ArfB-ribosome complex with P/E hybrid tRNA in the post-hydrolysis state; 23S ribosomal RNA 6ysu A 2903 3.7 RF02540,RF02541 URS0000A76322_562 32796827 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((............<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...............<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<.<<.<.......................>........<<<......>>>..>>.>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<....................<..............<..............>....................>............>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(.((......(((.(((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))).)))...)).)...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.........<..))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((................))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{.((..(.(....(.............).....).......(((......)))..)..))...)))..)).)).))...........]]].)...))))))))))...)))))))((((.((........)).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((.....((((((((.((.((.....)))).)))))..)))...[.)))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((.(((.((.(..(.................(..((.........(..............)......))............)........)..).)).))).))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((.(...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....).)))))(.(((((.....)))))(....((..(((((.......)))))....((((((((........(((((....)))))........))))).))).....))..).))))))))). Structure of the P+0 ArfB-ribosome complex in the post-hydrolysis state; 23S ribosomal RNA 7a0s X 2699 3.22 RF02540,RF02541 URS0002311A26_243230 34417608 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaaccgaaacgcuugcguuucgggguuguaggaccaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcccugaguaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucggaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucugccucagacguaucgggagccgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcugcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacugaagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<.[...((.>>>.....<<<<<<...<<.))...]..>>......>>>>>>...>>>....<<<....>>><<<<......>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<....<<<<<<<<....>>>>>>>>......<<.....<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>...>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<..>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<..<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>...>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....<<.......>>.....>>..........<......>....>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<...>>>>>..>....>>>>>><<<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>.>>>>..>>>>>>>>>...<.>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<.>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>...........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<.<<<<......>>>>.>>>>>>>...<<<<<<.......>>.>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<.<.<<.......>>..>>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<.............>>>>....>>..>>>>.......>>>>>>>..<<..>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((.((((((((......((((((.[...[[.))).....((((((...((.]]...]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))....(((...((((.(........).))))....{.(((....((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)).......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.[..).)))))))))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....((((()))))....)<)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..(((((.((((((...(((...(((.((((......)))).)))..)).)...)))))).).))).)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((.((((.............(.(...(............)...))..........(......)............)))).))))).))..........]]].)....))))))))))...)))))))(..(((((...)))))..)....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..((((((((((...((.....)).)))))).))))..)))))))))...(.)....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((.))))))))(...).......(((((((((.>.(...........)...(((((((.....(((.....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))...........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(....(..(..(.......).)...)...)...((((((.......)).))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....((((.((....))..))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))(.((..))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). 50S Deinococcus radiodurans ribosome bounded with mycinamicin I; RNA (2732-MER) 7a5j A 1492 3.1 RF02541,RF02540 URS000080E357_9606 33243891 0003735 0005840 9606 gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguaccgcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagcaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaacccacagguccuaaacuaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaacaggguu <<<.......<<<<...............................<......>...........<<.....>>.......>>.>>.............<<....>>.................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>..........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>>.......<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>>...<<........>>...........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>...........<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............<<<....>>>................>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>...........<....>..............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.........<<<<.......>>>>. ((.....(..((((...............................(...[..).....(.....((.]...))....)..)).)).............((....))....).............)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((..[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......)))).........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))((((..((((......(.(((((...)))))......(((...((((...............(..)....)))).......))).)...((......)).)))).....))))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))..........................((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((................((....)).................)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....))...........(....).......)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................))).........((((.......)))). Structure of the split human mitoribosomal large subunit with P-and E-site mt-tRNAs; 16S rRNA 7d12 A 20 NA URS00023119FE_9606 33947817 9606 gcagcagcuucggcagcagc <<.<<.<<....>>.>>.>> ((.((.((....)).)).)) NMR solution structures of CAG RNA-DB213 binding complex; RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*CP*UP*UP*CP*GP*GP*CP*AP*GP*CP*AP*GP*C)-3') 7eaf A 94 2.85 RF00162 URS0002311979_119072 33978763 0010468 119072 ggcuuaucaagagagggcgagggacuggcccgacgacccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<...<<<...((>>>......>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((....(.(((...(((.[.[[)))......))))(((..(((....))).)))...(]].](((((....)))))..))))))))). Crystal structure of SAM-I riboswitch with the Actinomyces-1 k-turn; RNA (94-MER) 7edt A 12 1.2 URS0002335907_32630 32630 ggacuccggncc ............ ............ RNA duplex containing CC mispairs; RNA (5'-R(*GP*GP*AP*CP*UP*CP*CP*GP*GP*(5BU)P*CP*C)-3') 7eqj A 76 2.043 RF00005 URS000009F4BF_562 34315814 0030533 0006412 562 gggugauuagcucagcugggagagcaccucccuuacaaggagggggucggcgguucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... crystal structure of E. coli Valine tRNA; RNA (76-MER) 7eqj B 75 2.043 RF00005 URS000009F4BF_562 34315814 0030533 0006412 562 gggugauuagcucagcugggagagcaccucccuuacaaggagggggucggcgguucgaucccgucaucacccacc <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....))))))))))))... crystal structure of E. coli Valine tRNA; RNA (76-MER) 7k16 P 51 2.1 URS00021ED925_161675 33004436 161675 ngcaagguacggcgaaagccguaggggcuugagaacccccccuccccacuc <<...[[<<<<<<....>>>>>><<<<.<.(((.>.>>>>>>.]]...))) {{...((((((((....))))))((((...[[[...))))}}.))...]]] Tamana Bat Virus xrRNA1; RNA (51-MER) 7l0z G 69 2.1 URS0000BC468E_32630 33376189 32630 gggaguacggugagggucggguccaguagguacgccuacuguugaguagagugugggcuccguacuccc <<<<<<<<<<.<.....<...<<<<<<<<<....>>>>>>>..>>.........>..>.>>>>>>>>>> ((((((((((.(.....(...(((((((((....)))))))..)).........)..).)))))))))) Spinach variant bound to DFHBI-1T; RNA (69-MER) 7mjx M 13 1.5 URS00023119EA_820 34526715 820 ggacugaanaucc <<<.......>>> (((.......))) MiaB in the complex with 5'-deoxyadenosine, methionine and RNA; RNA (5'-R(*GP*GP*AP*CP*UP*GP*AP*AP*(MIA)P*AP*UP*CP*C)-3') 7mky A 66 1.31 RF00507 URS0002311984_2697049 34845084 0075523 2697049 cgguguaagugcagcccgucuuacaccgugcggcacagcggaaacgcugaugucguauacagggcu <<<<<<<<<...(((((..>>>>>>>>><<<<<<<<<<<<....>>>>>.>>>>>>>....))))) (((((((((...[[[[[..)))))))))((((((((((((....))))).)))))))....]]]]] SARS-CoV-2 frameshifting pseudoknot RNA; RNA (66-MER) 7ow7 A 3303 2.4 RF02543 URS0002617716_9606 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgggcggaucugaccgucggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggccgaggugggaucccgaggccucucgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucggcaguuuuauccgguaaagcgaaugauuagagguaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacaggaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcaguccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguaccunuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcuagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggagcucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagaguuuuucacugacccggugaggcggggggcgcuucuggcgccaagcgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuugggucgggguuucguacguagcagagcagcgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<.........>>>>.>>>>.....>>>>...<<<<<<<<<.<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>....>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<..<<<<.<<.>>>>>>.>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<..>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>............<<<<<..<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>.>.>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<..>>>>>.>>.....>>>>>......>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<..>>>..<<<<<...<<<..<<<.....>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..........>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<<<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.................>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>>....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<..>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<..>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<..>>>>>>>...<<<<<.....<<<<..................<<<<<<<..>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<..>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<.<.............>..<<.<<<<<<<.<<.....<<<<.<..<<<<..>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((.......))))).))))....))))....((((((((((((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((.(..((((((.(((((.((.))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(((((()))))).......)))).).)))........))))))..)))))))))))............((((((.((((((())))))).((((((.((((.((((((((((..((((((((((((.((((....)))).))))))))))))...))))))).)))...)))))))).))..(((((((..))))).))....)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((())))..(((((...(((..(((.....)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((.....((.....((....(((())))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((..........)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..................)....))...(((((........)))))]]((((.(((((...((((((......))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((())))..)))))).))(...).......(((((((((.].(...........)...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.....(......(((......)))......)..))))..)))))((((()))))........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..)))).)...)))))....)).{..((.((.....]}.)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((())))))))...(((((.....((((..()..............(((((((())))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(...(((......))).....).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...>.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.............))))...))))..)))...).).)).).....((((((..((..((((.(..(((........(((((.(((()))).))))).......)))...(((...(((....((((.(((((((......)))))))))))...)))...)))...........)..))))..)).))))))(((((....(.......).....((.(((((((.((.....(.((.(..((((()))))..))).)....))....)))).))).))..))))).. EIF6-bound large subunit of the human ribosome; 28S rRNA 7ozq F 31 1.91 URS00023119B0_4932 34475498 4932 guacuagauuggucgaaaggcuaauugauga ......<<<<<<<<....>>>>>>>>..... ......((((((((....))))))))..... Crystal structure of archaeal L7Ae bound to eukaryotic kink-loop; RNA 7ozq G 32 1.91 URS00023119B0_4932 34475498 4932 guacuagauuggucgaaaggcuaauugaugac ......<<<<<<<<....>>>>>>>>...... ......((((((((....))))))))...... Crystal structure of archaeal L7Ae bound to eukaryotic kink-loop; RNA 7pjs A 2903 2.35 RF02540,RF02541 URS00021ED929_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<.........>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<.<<<....................................<......>....>>>.>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..........>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<..<<<............<<<................<<<<<....>>>>>.......................>>>...>>>..>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((.((.(.....).))..))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((.(......(.............)..............((......))...).)))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((((......))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((.(...(..............((.(...............(.(......).)......................).))......)...)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S ribosome with tRNAs in the classical pre-translocation state and apramycin (C); 23S ribosomal RNA 7pjs B 120 2.35 RF00001 URS0000049E57_562 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the 70S ribosome with tRNAs in the classical pre-translocation state and apramycin (C); 5S ribosomal RNA 7pjv A 2903 3.1 RF02540,RF02541 URS00021ED929_83333 34635670 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<...........>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<.........<<<<................................................>>>>.....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<.<<<............<<<..............<.<<<<<....>>>>>.>.....................>>>...>>>.>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.<...<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...(((]]]....))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...((..((((...(((.(.........).).))...))))..))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{...(((......(.............)..............((......))...))).....).)..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......(((((((......)))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.((((((...{{{.).))))).((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((....((..............(..(....(.........(..(......)..)......)..............)..).....))....))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP-Pi); 23S ribosomal RNA 7q80 A 14 3.14 URS00023358DC_32630 35301481 32630 ccacugngagcuuc .............. .............. Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine); RNA 1 7q80 C 24 3.14 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine); RNA 3 7qua A 12 1.0 URS000268136B_32630 35687141 32630 cgcgnauuagcg ............ ............ Duplex RNA containing Xanthosine-Cytosine base pairs; RNA (5'-R(*CP*GP*CP*GP*(XAN)P*AP*UP*UP*AP*GP*CP*G)-3') 7szu R 67 2.24 URS00023359D1_32630 35759696 32630 nguaccuaccaaucguagcgugucgaccagcugcgaaacacgcagcuggcacuggcgcuguagguac .<<<<<<<<.......<<<<<...<.<<<<<<<<<.....>>>>>>>>>..>..>>>>>>>>>>>>> .((((((((........((((...(.(((((((((.....)))))))))..)..)))).)))))))) Crystal structure of Pepper RNA aptamer in complex with HBC ligand and Fab BL3-6; RNA aptamer 7zjw S2 1770 2.8 RF01960,RF02542,RF01959,RF00177 URS0002616B7D_9986 35709277 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcggccgcccguccccgccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<...<....>...>>...>>>>[[..(((((.....<<<<<<<<..................<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]]............{{.......{{...[[[.[[.....<........<..>........>.<<...<<<<.<<<<.>>.>>>>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((......>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(....((....(((.....(([...((.....((.(((.....))).))......))......)).((((......................))))((..(((((......{.....{.(..........).....(......)..)))))......)).(]((((.((((......)))))))))...)))...))..).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)........(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..[......(.([[...(.(.((...(.(..(............................((...(((..((((.)).)).))).))..(..(((.(........(..((.......)).(((.......)))....).......).)))....)........(.((.(((((((.......}.....}.))))))).)).)....)....(((..(...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((........(..(((........)))..)......)))))...((.(((...(.((((((.(..((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((.....((((((((((((((((.....)))))))))))).).))).....)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Rabbit 80S ribosome as it decodes the Sec-UGA codon; 18S rRNA 8a3d A 3303 1.67 RF02543 URS00026813B2_9606 36909531 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgggcggaucugaccgucggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggccgaggugggaucccgaggccucucgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucggcaguuuuauccgguaaagcgaaugauuagagguaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacaggaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcaguccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcuagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggagcucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagaguuuuucacugacccggugaggcggggggcgcuucuggcgccaagcgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuugggucgggguuucguacguagcagagcagcgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.....>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<...<<<<.<...>>>>>..>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<..>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>............<<<<<..<<<<<<..>>>>>>.<<<<<<..<<<.<<<<<<<<<<.<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>.>.>>>>>>>.>>>...>>>.>>>>.>>..<<<<<<<..>>>>>.>>.....>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<..>>>..<<<<<...<<<..<<<.....>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..........>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.................>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<..>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<..>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<..>>>>>>>...<<<<<.....<<<<..................<<<<<<<..>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<..>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<..................<<.<<<<<<<.<<.....<<<<....<<<<..>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((.......))))).))))....))))....(((((((....(((((((..({((((......)))))....[[(...).(((....}]])))...).)))))).......)))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((.(..(((((....(((.((.)))))...))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(((((..))))).......)))).).)))........))))))..)))))))))))............((((((.((((((..)))))).(((((...(((.((((((((((..((((((((((((.((((....)))).))))))))))))...))))))).)))...)))..))).))..(((((((..))))).))....)))))).....))).)))))...)))))...)))))))).[((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...(((.).))..(((((...(((..(((.....)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((.....((.....((....(((..)))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((..........)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)............)....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((..)))..)))))).))(...).......(((((((((.].(...........)...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.....(......(((......)))......)..))))..)))))(((....)))........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..)))).)...)))))....)).{..((.((.....]}.)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((..)))))))...(((((.....((((..................(((((((..)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...>.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.............))))...))))..)))...).).)).).....((((((..((..((((.(..(((........(((((.(((..))).))))).......)))...(((...(((....((((.(((((((......)))))))))))...)))...)))...........)..))))..)).))))))(((((....(.......).....((.(((((((.((.....(.((.(..(((....)))..))).)....))....)))).))).))..))))).. Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound; 28S ribosomal RNA 8a3w S1 1663 2.89 RF01960,RF02542,RF01959,RF00177 URS0002915692_347515 0003735 0005840 347515 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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE; SR2_chain_4 8a3w 1 1467 2.89 RF02543 URS00029156BD_347515 0003735 0005840 347515 agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagcggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagagggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggcacgugguuggugcaggaguggcgaaauucaagaaagcaaacccguugcugaauacaaucauggnguauugagccaaagaagguguuagcccauugagccauaaaccugagcgccucaugaacuaagcgnguagcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaanguuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccuugcauuauccugugggaaauccggcggggugcaaugguguuggcgauggaaauggggugcccccacccgucuuganacncggaccaaggagunanacagacgcgcaagggaggagauaugccaguacuucucucguacugaaagggagaugcaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcguuggagugugccngnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaacccagguggaggccuguagcgaugcugncgugcaaaucgcucguaugauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuuccnucaggauagcuggugcuaguagaaguauugugcgguaaagcacuuuaaangugcaaacaaaccggccuuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucucgauacgugaaaaggguguuggugcaccggccccgaaaauggangacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcgagaaaguguagcccuuccgauguagauguggccuggagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcanaunuugguuggcgunncaaagaucuaacggagauauacucaacaugcaacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggaaacugagcacaacguuauaucgunuuguuaggaaagugaaggaacugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcauguggg ......................<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<<......<<.....>>....>>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>.<<<...<<<<<<<<.<<<<<......<<<...<<<<.......>>>>.....<<....>>.....>>>.<<.......((.....>>)).....>>>>>...>>>..>>>>>.>>>..............<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................<<<..<<<<<<.<<<<<......<<<<.<<<<.....<<<<<...<<<<<<<....>>..>>>>>>>>>>.>>>>.>>>>......>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<........>>>..>>>>...<<....>>..<<<<<...>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<<<....<<<..>>.>....>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<........<...........<<<<....<..>....>>>>...........))).>....>>>>.>.........>>>...>>>>>>><<<<.<<<<<.............>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>..............<<<<<<<....................>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>................<....>......>.>>..........<<<<.........>>....>>.>>........... ......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..((((((((......))))).))....))))).(((...((((((((.(((((....({((....((((.......)))).....((....))......)))[[(...)..((....}]])).....)))))...)))..))))).))).........)....(((((((........)))))))......(((((........)))))..)))....................................((....)).............(..((.(....).))............)......................((..((((((.((((((.....((((.((((.....(((.....((((((......)..)))))..))).)))).))))....).)))))))))))..))..(((..........)))((((.(....(((((.(.(((((..(((...((.((......))))...)))...((....))..(((((...)))))...(((((...((.(((((......))))).))....)))))(((((((((.....)))))).)))...))))).).)))))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).).((((((((.....((.(.((((((.....((..))......)))))).....(((.((((.((.....)))))).)))..........)))...))))))).)...((((.((.((.....)).)).))))....(((......)))...((((((....((([[[...(..(..((((....................((((....(..)....))))...........]]]......)))).))........)))....))))))((((.((((((......).....)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....).))))..............(((((((....................)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......))).............................).))....).....((((.........))....)).))........... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE; LSUa_rRNA_chain_1 8a98 1 1579 2.46 RF02543 URS00027E5B01_347515 38722744 0003735 0005840 347515 agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagcggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagagggaacgaacucguugccgaaucgggucuuacaaggccuuaaguuguggcacaaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaagcaaacccguugcugaauacaacccuucaugugaguauugagccaaagaagguguuagcccauugagccauaaaccugagcgccucaugaacaagcgaguagcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagcacuuuggaaagagaguganauagaaccugaagucgugacaaagacaauggaaguaccuccauuucaagagccagaaccagcccuacugcauuauccugucgggggucaaaauccggcgggcaacgaagugcaagagggucuuggugaaaugagcggaguauuugagcuggcacgggcacgcacucuucuccgugaugcuccauguuggcgauggaaauggggugcccccacccgucuugnnacncggaccaaggagunanacagacgcgcaagggaggagauauggccaguacuucucucguacugaaagggagaugcaaaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcguuggagugugccngnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaacccagguggaggccuguagcgaugcugacgugcaaaucgcucguaugauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucccucaggauagcuggugcuaguagaaguauugugcgguaaagcgauacuuuaaangugcaaacaaaccggccuuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucucgauacguaaaggguguugguggccaccggccccgaaaauggangacgcuuaaggccaauuagugaaugcccauuauuccuuugguaagggcggaaacggagaaaguguagcccuuccgauguagauguggccuggagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcanaunuugguuggcgunncaaagaucuaanggagauauacucaacaugcaacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggaaacugagcacaacguuauaucgunuuguuaggaaagugaaguacugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcauguggg ......................<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<<......<<.....>>....>>>>>>...<<<...<<<<<..<.<<<<<......>>>>>..>....>>>>>..........<<<<<<...<<<<<<<<.<<<<<......<<<......<<<<.......>>>>.....<<........>>......>>>.<<.......((.....>>)).....>>>>>...>>>..>>>>>.>>>>>>..........<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................(((..<<<<<<.<<<<<.....<<<<<.<<<<<<<<<...<<<<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>...>>>>>..>>>>........<<<<<.....<<....<<.<..>...>>..>>..>>>>>.....<<<<...>>>>>.....>>>>>>>>>>>..))).<<<<........>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<.........>>>..>>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<<<<...<<<.....>>.>...>>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<<<<......[..((.(........(.........<<<.<<<<<<<..>>>>>>>>>>..........>>>.)....).)).].........>>>...>>>>>>>((((.<<<<<.......>>>>.........>>>>>))))....>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>..............<<<<<<<....................>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>...............<....>......>.>>..........<<<<.........>>....>>.>>........... ......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..((.(((((......)))))..)....)))))...........(((((...((((((((.(((((....({((.......((((.......)))).....((........)).......)))[[(...)..((....}]])).....)))))...)))..))))).)))))......)....(((((((........)))))))......(((((........)))))..)))....................................((....)).............(..((.(....).))............)......................((..((((((.((((((....(((((.((((((((....(((((..((((((((..........)))))))).....)).)))....))))..))))........(((.(.....((...(((.(..)...)).)))..).))).....[[[....)))))...).)))))))))))..))..(((..........)))((((.(....(((((((.(((((..(((...((.((.(..)..))))...)))...((....))..(((((.....)))))...(((((...((.((((((....)))))).))....)))))(((((((((.....)))))).)))...))))).)))))))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).).((((((((.....((.(.((((((....(((.....)).)....)))))).....(((.((((.((.....)))))).)))..........)))...))))))).)...((((.((.((.....)).)).))))....(((......)))...((((((....((([[[...(..(..((.(........(.........(((.(((((((()))))))))))..........]]].)....).)).))........)))....))))))((((.((((((.......]]]...).....)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....).))))..............(((((((....................)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......)))............................).))....).....((((.........))....)).))........... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT; LSUa_rRNA_chain_1 8a98 2 1047 2.46 RF02543 URS00027E5B06_347515 38722744 0003735 0005840 347515 ccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaugcucugguacauagagaaangnaaacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaacacaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaauaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugncnccagucuggcucugugcggcgacauguugcuucacuuaucgaaugaagagaccaaugggauuagcguagucuucgggcuaugcaccgucuagguuccaaccgugcuguaaacugaaccaacgggauccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuuggcggccaagucgcugauccuungaugucggnucuuccuaaccuagcgcgacgcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggagcgguggguaguacuugguacgcucaucacc .......................<<......>>......<<<<<...>>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<<......>>>>....>>.>>>>>..>>>>>....<.........>...........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<..>>>>>>.>>>...<<<<<.....<<<<....<<.....<<<<<<<<<..>>>>>>>>>.>>.....<<<<..>>>>...................<<<...>>>..>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>.........<<<<<..<<<.......>>>..>>>>>..........>>>>..>>>>>>.......<<.<......<......>...>..>>.......<<<<<.<<<<<<..<<<<<<<...>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>......................<.<.......>.>..<.<<<<<<<.<<<<...>>>>>>>>>>>.>. .......................((......))......((((.....))))........(.((.....(((.((.(.((..(....(.......(((((....(.[..).....)))))((.((((((((.((......)).))..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....((....(((........)))....))..))))..)))))..(.............).........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).)))))..)).).........[...(.((......].)).)...(((((((..(((.((......((((.(((((...(((((.(((((((...(((.((((((..)))))).)))...(((((.....((((....((.....(((((.((....)).))))).))..(..((((..))))..)................(((...)))..))))...))))).......)))))))..)))))..(((......[)).)(((.(...........].).)))([((...(((((((.(.((((((..))))))...).((][..[.))....))))))).(.(....(((((....{..)))))...))(((....))).)).].].....((.((..(((.......)))..)).))....)}.....)))..)))))).......(.........(......).......)........((((.((((((..(((((((...))))..)))..((.(.....).))......)))))..)...))).)......((((((....))).))).....))..))).))))))).....................................(.(..(.((.((((...)))))).)..).). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT; LSUb_rRNA_chain_2 8d28 B 33 1.42 URS0002617795_32630 36413497 32630 ggcgauaccagccgaaaggcccuuggcagcgcc <<<<...<<.<<<....>>>....>>...>>>> ((((...((.(((....)))....))...)))) Crystal structure of theophylline aptamer in complex with theophylline; RNA (33-MER) 8d28 A 33 1.42 URS0002617795_32630 36413497 32630 ggcgauaccagccgaaaggcccuuggcagcgcc <<<<...<<.<<<....>>>....>>...>>>> ((((...((.(((....)))....))...)))) Crystal structure of theophylline aptamer in complex with theophylline; RNA (33-MER) 8d2a A 33 2.17 URS0002617795_32630 36413497 32630 ggcgauaccagccgaaaggcccuuggcagcgcc <<<<...<<.<<<....>>>....>>...>>>> ((((...((.(((....)))....))...)))) Crystal structure of theophylline aptamer in complex with TAL3; RNA (33-MER) 8d2a B 33 2.17 URS0002617795_32630 36413497 32630 ggcgauaccagccgaaaggcccuuggcagcgcc <<<<...<<.<<<....>>>....>>...>>>> ((((...((.(((....)))....))...)))) Crystal structure of theophylline aptamer in complex with TAL3; RNA (33-MER) 8d2b A 33 1.44 URS0002617795_32630 36413497 32630 ggcgauaccagccgaaaggcccuuggcagcgcc <<<<...<<.<<<....>>>....>>...>>>> ((((...((.(((....)))....))...)))) Crystal structure of theophylline aptamer in complex with TAL2; RNA (33-MER) 8d2b B 33 1.44 URS0002617795_32630 36413497 32630 ggcgauaccagccgaaaggcccuuggcagcgcc <<<<...<<.<<<....>>>....>>...>>>> ((((...((.(((....)))....))...)))) Crystal structure of theophylline aptamer in complex with TAL2; RNA (33-MER) 8d5l A 33 1.64 URS0002617795_32630 36413497 32630 ggcgauaccagccgaaaggcccuuggcagcgcc <<<<...<<.<<<....>>>....>>...>>>> ((((...((.(((....)))....))...)))) Crystal structure of theophylline aptamer in complex with TAL1; RNA (33-MER) 8d5l B 33 1.64 URS0002617795_32630 36413497 32630 ggcgauaccagccgaaaggcccuuggcagcgcc <<<<...<<.<<<....>>>....>>...>>>> ((((...((.(((....)))....))...)))) Crystal structure of theophylline aptamer in complex with TAL1; RNA (33-MER) 8fru 1 2551 2.49 RF02543 URS0002915677_941442 38242118 0003735 0005840 941442 cgcggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguacgccccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcgggaggagcccgccccgaaggcgcgcuguggggcgcaccgccgcgagggggcccgagggccccgcccgagagggugcaagccccguacggcgggcggcgaguagcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccggcccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccgccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugcccggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucgaaccgccugguagcugguugccuccgaaaugucucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccggcgggagcggggccucgcccgccccccaaacuccgaagggccgcgccgccccgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgauccggacgccgggccagggugcgccgccggggcccgcggaacggcgucggccggucccgacagcagccgaaucggccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcaguagccgcuacuccgcgccccggaggacugagggggagacggguuccgcggcgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaaggggcgugcccgcccgucgaacggggagccggcggagacuccggcaggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggaccgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggggggcccgggggcggaccccgcgcguccccggccgccccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcaggacuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccucgggaaaaggaguggcucugacggccgggucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagugccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuuccgacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgagggccggccagcggggcaagaagacccuuuugagcuugacuccagcccgggccuguggggcgggggccgccgccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggcucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgucggauuguucacccguucaagggaucgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacuggccccggggccagagcacggcgggccaguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggccgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucuaagcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgugccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuccuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcgc ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<....<<.....>>.....>>>>>..[[[...<<<.............>>><<...<<<<<<....<<<<<......>>>>>((......<<<.....))>>>...>>>>>>>>........<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]]..................................<<....>>................<<<....>>>............................<<<<<<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<....>>>..>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<<..<<<<<..<<<<<..>>>>>>>>>>..>>>..>>.>...>>>>>>>.<<<<<<<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((...<<<<<<<........<<<.<<<<<<<<<.................>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<.....<<.....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<<<<..>>>>...>>.>....>>...<<<<<........>>>>>))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<...{{{...>>>>>....<<<<<<...<<<<<<....<<.....>>......>>>>>>...>>>>>>....>>>>>.>>>>>>>..>>>.........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<......>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.........>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))).......(((((.(((((.>>>>>>))))))))))..........]]]]..}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........}}}.))))))..<<<<<..<<<..<<<<<<<<...............>>>>>>>><<<<<...<.<<...<<<<<<<<<<}}}.>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........>>>>>>...>>>..>>>..>>>>>....<<<<<<............................>>>>>>.....<<<<<.......>>>>..<<<<<<<<<<<....<<<<.<..<<...>>..>>>>>...>>>>.>>>>>.>>...>... ........................((((((.....(...[..)......))))).).........((....))...((((....((.]...)).....))))...((((..(((..((...)....))))((...(((((.....(((((......)))))[[(...).(((.....]])))....)))))))...)....(((((((........)))))))...(((((..[[[[[[)))))..)))..................................((....))............(...(((....)))...........)................((((((..))))))[((((........)))).(((((..(.(((((((((((((..((....(((....)))...))...((....))....(......)(((((((((((((....))))))).))))))...)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(((((....)))))((((((((((.(((.(((((((((...(((...(((..(((((..(((((()))))))))))..)))..)).)...))))))).((((((((((.(......)))))))))))...))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(((((((........(((.((((((((((.......(...)...)))))))))))))..........]]]......))))))))))...)))))))(((((....)))))....))))))(.((((((((...((......(((((.((....)).)))))...))))))))))..).....))))).((.....((.....(((((.....)))))..((.....((((..((..(((((((...(.......).)))))).....[(((.((...(((...(((....))).(....((((..)))).).)).)....))...(((((........)))))].((((((((...(((....)))..((((((((((...(((..(((((((((((((((((...{{{...)))))....((((((...((((((...(((.....))).....))))))...))))))....))))).)))))))..)))(...)....))))))))))...)))))))).))).)))..((......)).)))).((((.....))))..))....((((....((((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((..)..)))))).))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..((((((.(...((....(((.(....).)))....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)).{..(((((.....]}.)))))...((((((..(((.((......(((..((((((..(((((.((((((((..((((((((((.....)..)))))))))...((((......)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(.((((.......)))).)...).((][.[[[))....))))))).(.((((((((.....{...)))))))))(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....)}....))))..)).))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((((......))))))..))).(((.(.....).)))....)))))..)...))).).....(((((((....))).))))..>.))..))).))))))..(((((..(((..((((((((.....(....)....))))))))(((((...(.((...((((((((((}}}.)))))..)))))...)).).))))).(((....((((.............))))....)))..)))..)))))(...((((((........(..)................))))))..)..(((((.......))))..(((((((((((....((((.(..((...))..)))))...)))).))))).))...)... 60S subunit of the Giardia lamblia 80S ribosome; 28S rRNA 8h1b C 17 1.55 URS0002681385_93061 36762482 93061 acggacuuugacuccgu <<<<<.......>>>>> (((((.......))))) Crystal structure of MnmM from S. aureus complexed with SAM and tRNA anti-codon stem loop (ASL) (1.55 A); RNA (5'-R(*AP*CP*GP*GP*AP*CP*UP*UP*UP*GP*AP*CP*UP*CP*CP*GP*U)-3') 8i3z A 24 1.67 URS00026813CC_1318 36840714 1318 agagcguugcguccgaaagungcc ........................ ........................ Crystal structure of NAD-II riboswitch (two strands) with NMN at 1.67 angstrom; RNA (5'-R(*AP*GP*AP*GP*CP*GP*UP*UP*GP*CP*GP*UP*CP*CP*GP*AP*AP*AP*GP*UP*(CBV)P*GP*CP*C)-3') 8i3z B 31 1.67 URS00026813C0_1318 36840714 1318 gcgacacggcucuuuaaaaacaaaaggagaa ............................... ............................... Crystal structure of NAD-II riboswitch (two strands) with NMN at 1.67 angstrom; RNA (31-MER) 8k0y A 50 2.28 RF01684 8090 gacgccggugguggcacuccugaggacgggguucaauucccugcgguguc <<<<<<.<<<....>>><<<<.>>>><<<<<.......>>>>>.>>>>>> ((((((((((...[)))((((.))))(((((..]....)))))))))))) Crystal structure of a medaka mascRNA U23G; RNA (56-MER) 8k0y B 50 2.28 RF01684 8090 gacgccgguggggcacuccuggaggacgggguucaauucccugcgguguc <<<<<<.<<<...>>><<<<..>>>><<<<<.......>>>>>.>>>>>> ((((((((((..[)))((((..))))(((((..]....)))))))))))) Crystal structure of a medaka mascRNA U23G; RNA (56-MER) 8k2z A 57 2.4 RF01684 9606 ggugcuggugguuggcacuccugguuuccaggacgggguucaaaucccugcggcguc <<<<<<.<<<.....>>><<<<<<...>>>>>><<<<<.......>>>>>.>>>>>> ((.(((((((....[)))((((((...))))))(((((..]....))))))))).)) Crystal structure of a human mascRNA A2G; RNA (57-MER) 8k30 A 52 2.43 RF01684 8090 gacgccggugguggcacuccuggcaggacgggguucaauucccugcgguguc <<<<<<.<<<....>>><<<<<.>>>>><<<<<.......>>>>>.>>>>>> ((((((((((...[)))(((((.)))))(((((..]....)))))))))))) Crystal structure of a medaka mascRNA U23G; RNA (56-MER) 8k85 A 56 2.95 32630 ggagacggucggguccagucgcaacgauguuggcuguugaguagugugugggcucc ........................................................ ........................................................ Crystal structure of Red Broccoli aptamer with OBI; RNA (56-MER) 8keb A 71 2.2 1409 gauucguauauccuuaaugauaugguuuaagggcaauacauagagaccacaaauuucuuacugcgaauucu <<<<<<<....<<<<<<......((.>>>>>>.......<.<<<<.))......>>>>>...>>>>>>>.. (((((((((..((((((......[[.))))))[....)]..(((((]].....)))))...)))))))).. Crystal structure of 2'-dG-III riboswitch with 2'-dG; RNA (72-MER) 8ked A 71 2.11 1409 gauucguauauccuuaaugauaugguuuaagggcaauacauagagaccacaaauuucuuacugcgaauucu <<<<<<<....<<<<<<......((.>>>>>>.........<<<<.))......>>>>....>>>>>>>.. (((((((((..((((((......[[.))))))[....)]..(((((]].....)))))...)))))))).. Crystal structure of 2'-dG-III riboswitch with guanine; RNA (72-MER) 8om0 A 390 3.61 RF02001,RF01998 URS000080DF32_182710 38898052 0000373 182710 ugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugugg ....<<<<<...<<<<<<<<<<<...<<<.......>>>..<<<<<...(((((((...>>>>>..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<<<<<<<<<..<<<<........>>>>...>>>>.)))))))...>>>>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<......>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>.... ..<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((......(((...((.((((((((..((((........))))...)))).]]]]]]]...)))).))...)))...))))))))))...))))))...)))))))))))....)))))(...((((....))))...).......(((.(....(((.(....).)))...))))....(((((..((((....))))...))))).((((((((((..(....)....)))))))))).... Structure of Oceanobacillus iheyensis group II intron in the presence of Na+, Mg2+ and intronistat B; Domains 1-5 8ova BA 1604 2.47 RF02543 URS00029156E1_5702 37985661 0003735 0005840 5702 agaccugaguguggcaggaccacccgcuaaacuuaagcanauuacucagcggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagagggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggcauagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugcugaacauuacaacccuucaugugnguauugagccaaagaaggugucagcccauuacagccacggagccuacgcgccuccucaagagaguagcacuguuugggaaugcagugucaagccggcagguauuugucugccaagguuaaauauagaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaaguacuuuggaaagagagugacauagaaccugaaaucgugacaacgacaauggaaguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuuccggggcuaacauccggugggucacugugcggguuucgaggucauggggugcgugagugggcggaauaaagggucgguguguuguguucuuccuccuucccuguccgugcgucucgacgcuggcgauggaaauggggugcccccacccgucuugnnacncggaccaaggagunanacagacgcgcaagggaggaguauugugacaacucuuuucucguacugaaagggaggugugauacacccguggcgugcgcaauuuuuugcccaacaccgaccggcccuccgugggcugcgcgcgagugugccunnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaaccccgguggaggccuguagcgaugcugncgugcaaaungcucguacgauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacgucgaaguuucccucaggauagcuggugcuugucaagaaguauugugcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaangugcaaacaacccagccuuaguuauuuuaacaaggcuuuaagaauugaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuugugggcucauunucgauacgugaaaaggguguugguggauauccaccggccccgaaaauggangacgcuuaagccccaugugcgugauugcccauuauuccuuuggugagggcggcuauauggugagaaaguguagcccucccgauguagacguggcgugggggugaggacgaagccgauggcgcgagccucggauggacccgccucuagugcanaunuugguuggcgunncaaagaucuaacggaauauuuuuaaaugcaacguuggauncuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggucacugagcacaacguuacaccgunuuguuaggaaagugaaggugcucugaaaaggggcaacagagaaccugggaugauauuccaaaaagaauugcaugugggac ......................<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<......<<.....>>....>>>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>>........<<........>>......>>>.<<.......((.....>>))......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................<<<..<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<<<<<.......>>>>>.>>>.....>>>>>>....>>>>>>..>>>..............<<<<....<<<<..<<.<.<..<....>..>>.>>..>>>>.>>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<.........>>>.....>>>...<<....>>..<<<<<...>>>>>...<<.<<..<<<<....>>>>...>>.>>..<<<<<<<.....>>>>>>.>.....>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.......<<...<<<<<<....<<<....<<<..<.<<<..>>>.>..>>>..>.>>....>>>>>>...<..<....<<.<......>>>....>..>......>>..>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<<.<<<<........<...........<<<.<<<<<<<<<..>>>>>>>>>>>>..........))).>....>>>>>>...........>>>...>>>>>>><<<<.<<<<<...........>>>>>........>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>..............<<<<<<<..................>>>>>>>....................<<<<<....<<.....>>..>>>>>.....<..........<<.<<<<<......>>>>...............<<<...>>>......>.>>..........<<<<.........>>....>>.>............. ......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..(.((((((......))))).).....))))).(((...((((.((((((((.(...(.((.......((((.......))))........((........)).......)))[[(...)..((.....]]))....)..))))...))))...)))).))).....)....(((((((........)))))))......(((((........)))))..)))....................................((....)).............(..((.(....).))............)......................((..((((((.(((((..((.((((.(((((((((.((((((.....(((.((((.........)))).))).....)))))).....)))))..))).).............(((....((((..((.(.(..(....)..)).))..)))).)))......[[[....))))))....)))))))))))..))..(((..........)))((((.(....((.((((.(((((..(((.(.(((.........)))....))))...((....))..((.((...)).))...((.((..((((....))))...)).))..((((((.(..)..))))).).....))))).)))).))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).).(((((((((......((.(.((((((....(((.....(...(.(((..))).)...)...)).)....))))))...(..(....((.........))....)..).....))).)))))))).)...((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(..((.((((........(...........(((.(((((((((..))))))))))))..........]]].)....)))))))..........)))...)))))))((((.(((((............]]].........)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....).))))..............(((((((..................)))))))....................(((((....((.....))..))))).....(......(...((.(..((......))..................(.....).......).))....).....((((.........))....)).)............. CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; LSUa rRNA 8ova AA 1919 2.47 RF01960,RF02542,RF01959,RF00177 URS0002915680_5702 37985661 0003735 0005840 5702 gaucuggnugauucugcnaguagucaunngcuuguuunaaggacuuagccaugcaugccucagaaucacugcauugcaggaaucugcgcauggcucauuacaucagacguaaucugccgccaaaauuuugcggcgcauuacuggauaacuuggcgaaacgccaagcuaauacaugaaccaaucggacgcucucuuugaugggacguccagcgaaugaaugaaauuagaaccaacgccuccacccggaggcaguaacacucagacguguugacucaauucauuccgugcgaaagccgagcugcucggcgucuacugacgaacaacugcccuaucagccagugauggccguguaguggacugccauggcguugacgggagcgggggauuaggguucgauuccggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugucgaaaaaauacgaugaggcagcgaaaagaaauagagccgaccgugugguuguuuucaaugggggauacucaaacccauucaauaucgaguaacaauuggaggacaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauauuaaugcugungcuguunaaggguucguaguugaacugugggccacguaguguggugccguaccagucccguccaccucgacguguuuugacccacgcccucguggccagauacaagaaacacgggagcaguucgcaugucaugcaugggggcguccgugaauuuacugugaccaaaaagaugcgaccaaagcagucuugccgacuugaauuacaaagcaugggauaacgaagcaucagcccugggguuauguugguuuuagaaguccuugggagauuauggggccgcguuguuucguguggcgcgccgcggcuuccaggaaugaaggaggguaguucgggggagaacguacuggugcgucagaggugaaauucuuagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaagaaccaaaguguggggaucaaagaugauuagagaccauuguaguccacacugcaaaccaugacacccaugaauuggggaacaucauuuuauuuaucaauuuacgugccuacucagcacguuucuuacuucuucacgcgaaagcuuggagguuacagucucagggggnaguacguucgcaanagugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacncaacacggggaacuuuaccagauccggacagggugaggauugacagauggaguguncuuucucgauccccugaauggugnugcauggccgcuuuuggucggugnagugauuuguuugguugauuccgucaacggacgagauccaagcugcccaguaggugccgggauuguccacacaggacagcaguccucgucauccuucuuuuuucaggccccuucucugcgggauuccuugcuuuucgcgcaaggugagauuuugggcaacagcangucngugaugcuccucaauguucugggcgacacgcncacuacaaugucagugagaacaagagcgacgcucccgcuugaucaaaagagcggggaaaccacggaaucacguagacccacuugggaccgaguauugcaauuanuggucgcgcaacgagnaaugucucguaggcgcagcucaucanacugugccgauuacgucccugccauunguacacaccgnccgucguuguuuccgaugnnggugcaauacaggugaucggaccgucaccgaaaguucaccgauauugcuucaauagagnaagcaaaagucguaacaagguagcuguaggugnnccugcagcuggaucauuu 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CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; SSU rRNA 8ova BB 1119 2.47 RF02543 URS00029156D6_5702 37985661 0003735 0005840 5702 cccaacugcagaccguacucaucaccgcaucagguccccaagcaucgaaugcucugguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguaugucgcaaacugauuucugcccagugcucugugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngauucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugacnccagucuggcucugugcggcgacuuacguugcuucacuuaucgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcgccgucuaggcugacgcgugcggaacuacugcgccaaacggggugguucuccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaacagaaaucucacguggaacacaagcguaaaugcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaacaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunguucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuggcuggagauugcgaguaaaagauuauccgcgcaaagcggaggcaguccguuuuuuucugggucugccguuggguggcaugugcuuggcgcu ........................<<......>>......<<<<<...>>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<<<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>...<<<<<.....<<<<....<<<......<<<<<<<......>>>>>>>>>>...<.<..<...>..>>....................<<<.<..>.>>>...>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>.........<<<<<..............<<<<.......>>>>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>...<<<...........>>>..........<..<.<.......>.>.>.... ........................((......))......((((.....))))........(.((.....(((.((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...)))))..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((..(((....((((......))))....))).))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))..)).).........[...(.((......].)).)...(((((((..(((.((......((((.(((((...(((((.(((((((...(((.((((((.().)))))).)))....((((.....(((.....(((......(((((((......))))))))))..(..(...(.)...)..)..................((........))....)))...))))........)))))))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((][....))....))))))).(.(....(((((....{..)))))...))(((....))).))...].....((.((.(............((((.......))))))).))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(((((((.(......).))))..))).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).))))))).......................((((.....))))...((.............))...............(.......)........ CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; LSUb rRNA 8ove AA 1836 2.6 RF01960,RF02542,RF01959,RF00177 URS00029156E8_5702 37985661 0003735 0005840 5702 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CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; SSU rRNA 8ove BA 1579 2.6 RF02543 URS00029156E1_5702 37985661 0003735 0005840 5702 agaccugaguguggcaggaccacccgcuaaacuuaagcanauuacucagcggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagagggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggcauagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugcugaacauacaacccuucaugugnguauugagccaaagaaggugucagcccauuacagccacggagccuacgcgccuccucaagagaguagcacuguuugggaaugcagugucaagccggcagguauuugucugccaagguuaaauauagaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaaguacuuuggaaagagagugacauagaaccugaaaucgugacaacgacaauggaaguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuuccggggcuaacauccgguggguacugugcggguuucgaggucauggggugcgugagugggcggaauaaagggucggugguuguguucuuccuccuucccuguccgugcgucucgacgcuggcgauggaaauggggugcccccacccgucuugnnacncggaccaaggagunanacagacgcgcaagggaggaguauugugacaacuuuucucguacugaaagggaggugugauacacccguggcgugcgcaauuuguguuuuugcccaacaccgaccggcgugggcugcgcgcgagugugccunnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaaccccgguggaggccuguagcgaugcugncgugcaaaungcucguacgauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacgucgaaguuucccucaggauagcuggugcuuguuaagaaguauugugcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaangugcaaacaacccagccuuaguuauaacaaggcuggguaauugaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuugugggcucauunucgauacgugaaaaggguguugguggauauccaccggccccgaaaauggangacgcuuaagccccaugugcgugauugcccauuauuccuuuggugagggcggcuauaugugagaaaguguagcccucccgauguagacguggcgugggggugaggacgaagccgauggcgcgagccucggauggacccgccucuagugcanaunuugguuggcgunncaaagaucuaacggaauauuuuuaaaugcaacguuggauncuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggucacugagcacaacguuacaccgunuuguuaggaaagaaaaggggcaacagagaaccugggaugauauuccaaaaagaauugcauguggg ......................<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<......<<.....>>....>>>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>>.......<<........>>......>>>.<<.......((.....>>))......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................<<<..<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>>>....>>>>>>..>>>..............<<<<....<<<<..<<.<<..<....>..>>.>>..>>>>.>>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<.........>>>...>>>...<<....>>..<<<<<...>>>>>......<...<.<.......>.>....>.....<<<.<<......>>.>>.>.....>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.......<<.<.<<<<<<....<<<....<<<....<<<..>>>....>>>..>.>>....>>>>>>...<<<<<<<<<<.<<<..>>>>>>>>>>>>>.>>>..>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<<.<<<<........<...........<<<.<<<<<<<<<..>>>>>>>>>>>>..........))).>....>>>>>>...........>>>...>>>>>>><<<<.<<<<<..........>>>>>........>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>..............<<<<<<<..................>>>>>>>....................<<<<<....<<.....>>..>>>>>.....<..........<<.<<<<<......>>>>.................>.>>..........<<<<.........>>....>>.>........... ......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..(.((((((......))))).).....))))).(((...((((.(.((((((.(...({((.......((((.......)))).......((........)).......)))[[(...)..((....}]]))....)..))))...)).)...)))).))).....)....(((((((........)))))))......(((((........)))))..)))....................................((....)).............(..((.(....).))............)......................((..((((((.(((((..((.((((.(((((((((.((((((.....(((.((((.........)))).)))....)))))).....)))))..))).).............(((....((((..((.((..(....)..)).))..)))).)))......[[[....))))))....)))))))))))..))..(((..........)))((((.(....((.((((.(((((..(((.(.(((.........)))..))))...((....))..((.((...)).))......(.....(.......)......).....(((.((......)).)).).....))))).)))).))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).).(((((((((......((.(.((((((....(((.....(...(.(((..))).)...)...)).)....))))))...((((((((((.((....)))))))))))).))).)))))))).)...((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(..((.((((........(...........(((.(((((((((..))))))))))))..........]]].)....)))))))..........)))...)))))))((((.(((((...........]]].........)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....).))))..............(((((((..................)))))))....................(((((....((.....))..))))).....(......(...((.(..((......))...................).))....).....((((.........))....)).)........... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; LUS_alpha rRNA 8ove BB 1109 2.6 RF02543 URS00029156B3_5702 37985661 0003735 0005840 5702 caacugcagaccguacucaucaccgcaucagguccccaagcaucgaaugcucugguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguaugucgcaaacugauuucugcccagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngauucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugacnccagucuggcucugugcggcgacuuacguugcuucacuuaucgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcgccgucuaggcugacgcgugcggaacucugcgccaacgggguggaauucuccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaucucacguggaacacaagcguaaaugcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaacaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunguucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuggcuggagauugcgaguaaaagauuauccgcgcaaagcggaggcaguccguuuuuuucugggucugccguuggguggcaugugcuuggcgcu ......................<<......>>......<<<<<...>>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>...<<<<<.....<<<<....<<<......<<<<<<<......>>>>>>>>>>.....<..<...>..>...................<<<.<<..>>.>>>...>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<..>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>.........<<<<<..............<<<<.......>>>>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>...<<<...........>>>..........<..<.<.......>.>.>.... ......................((......))......((((.....))))........(.((.....(((.((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((()))))..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...((....((((......))))....)).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))..)).).........[...(.((......].)).)...(((((((..(((.((......((((.(((((...(((((.(((((((...(((.(((.((....)).))).)))....((((.....(((.....(((......(((((.(......).))))))))..(.....((.)).....)................(((..(..)..)))....)))...))))........)))))))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.(((((())))))...).((][....))....))))))).(.(....(((((....{..)))))...))(((....))).))...].....((.((.(............((.(.......).))))).))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(((((((.(......).))))..))).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).))))))).......................((((.....))))...((.............)).........(...(.(.......).)...).. CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; LSUb rRNA 8ovj 1 1611 2.4 RF02543 38722744 0003735 0005840 347515 cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagcggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagagggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggcacgugugguuggugcaggaguggcgaaauucaagcgaaaagcaaacccguugcugaauacaacccuucaugugnguauugagccaaagaagguguuagcccauugagccauaaaccugagcgccucaugaacaagcgnguagcacuguuugggaaugcagugucaaguggcagguauuugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaanguuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccuacugcauuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaugggucuuggugaaaugagcggaguauuugugcugcgcacggcggccgcacgcacugguuucuucuccgugaugcuccauguuggcgauggaaauggggugcccccacccgucuugnnacncggaccaaggagunanacagacgcgcaagggaggagauaugccaguacuucucucguacugaaagggagaugcaaaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcguuggagugugccngnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaacccagguggaggccuguagcgaugcugncgugcaaaucgcucguaugauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuuccnucaggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauuagaggcgaccuauucucaaacuuuaaangugcaaacaaaccggccuuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucucgauacgugaaaaggguugguggauccaccggccccgaaaauggangacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcggaaacaaaggagaaaguguagcccuuccgauguagauguggccuggagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcanaunuugguuggcgunncaaagaucuaacggagauauacucaacaugcaacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggaaacugagcacaacguuauaucgunuuguuaggaaagugaaggaacugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcauguggg .......................<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<<......<<.....>>....>>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>..<<<<...<<<<<<<<.<<<<<......<<<......<<<<.......>>>>.....<<........>>......>>>.<<.......((.....>>)).....>>>>>...>>>..>>>>>.>>>>............<<<<<<<........>>>>>>>.....<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>......>>>>..>>>>........<<<<<.....<.<<<<.<<.<<<<.>>>>...>>.>.>>>..>..>>>>>.....<<<<...>>>>>>....>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<........>>>..>>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<<<....<<<....<<<..<.<<<...>>>.>..>>>..>.>>....>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<........<...........<<<<<<<<<<..>>>>>>>>>>...........))).>....>>>>.>.........>>>...>>>>>>><<<<.<<<<<..........>>>>.........>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>..............<<<<<<<....................>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>...............<<...>>......>.>>..........<<<<.........>>....>>.>>........... .......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..((((((((......))))).))....)))))...(((...((((((((.(((((....({((.......((((.......)))).....((........)).......)))[[(...)..((....}]])).....)))))...)))..))))).)))........)....(((((((........))))))).....(((((........)))))..)))....................................((....)).............(..((.(....).))............)......................((..((((((.((((((..((.((((.((((((((....((.((..(((((.((..........)).))))).....))..))......))))..))))........(((((.....(.((((..(.((((.))))...)..).)))..)..))))).....[[[[...))))))..).)))))))))))..))..(((..........)))((((.(..(.(((((.(.(((((..(((...((.((......))))...)))...((....))..(((((.....)))))...(((((...((.(((((......))))).))....)))))(((((((((.....)))))).)))...))))).).)))))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).).((((((((.....((.(.(.((((.....((....(((..(.(((...))).)..)))..))......)))).).....(((.((((.((.....)))))).)))..........)))...))))))).)...((((.((.((.....)).)).))))....(((......)))...((((((....((([[[...(..(..((((........(...........(((((((.((..)).)))))))...........]]].)....)))).))........)))....))))))((((.((((((.........]]]]...).....)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....).))))..............(((((((....................)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......))).................(...).......).))....).....((((.........))....)).))........... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN; LSUa_rRNA_chain_1 8ovj S1 1755 2.4 RF01960,RF02542,RF01959,RF00177 38722744 0003735 0005840 347515 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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; SR1_chain_3 8qhu 5 117 2.72 347515 uacgucccucuccaaacgagagaacaugcaugggcuggcaugagcggcugcuuuucggggggcucgcgucccgaggcgcugaaccuugaggccugaaauucaugcucagggacacua ...<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<..<<.....>>...<<..<..>..>>....>>>....>>.....>>>.......>>>>>...>>>>>.... ...(((((((((.......)))).....(((((((.((.....(((...(.....).....(..(())..).....)))....)).....))).......))))....))))).... 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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; 5.8S_rRNA_chain_7 8qhu 2 1190 2.72 RF02543,RF02540,RF02541 0003735 0005840 347515 cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaugcucugguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugacnccagucuggcucugugcggcgacaucugaggguaggguggaagcgcaagcgcaaaugaaauaccaccacucggaacguugcuucacuuaucgaaugaagagaccaauggguugcguagucuucgggcuaugcaccgucuagguuugggagugucccccuguggguacccaaccgugcuguaaacugaaccaacgggaucaguuccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaacagaaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaauaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggacgucgggucguugggccuggcgagcgguggguaguacuugguacgcucaucacc ........................<<......>>......<<<<.....>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<......>>>>....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<......................................>>.>>>..>>>>>>.>>>...<<<<<.....<<<<....<<...<<<<<<<<....>>>>>>>>.>>.....<<<<.<<.....<<.......>>...>>.>>>>...................<<<<<....>>>>>..>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>........<<<<<<..............<<<<.......>>>>.>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>.<<<<<<<<<....>>>>>>>>>.<.<<<<<<<.<<<<...>>>>>>>>>>>.>. ........................((......))......((.(.....).))........(.((.....(((.((.(.((..(....(.......(((((....(.[..).....)))))((.(((((((.(((...))).)..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....((....(((........)))....))..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).)))))..)).).........[..((.((......].)).))..(((((((..(((.((......((((.(((((...(((((.((.((((...((..((((((.(((.((............((....))..................)).)))..))))))..))...(((((......(((....(....((((((((....))))))))..)..(..(((..((.....((..(..).))...))..)))..)................((((......))))..)))....))))).......)))).))..)))))..(((......[)).)(((.(...........].).)))([((...(((.(((.(.((((((.......))))))...).((][..[.))....))).))).(......(((.(.......).)))....)(((....))).)).].].....((.((.(............(((.........)))))).))....)......)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(((((((.(......).))))..))).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).)))))))........................(((.....)))..(((.(((((....))))).))).(.(((((((.((((...))))))))))).). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; LSUb_rRNA_chain_2 8qie 1 1611 2.43 RF02543,RF02540,RF02541 0003735 0005840 347515 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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; LSUa_rRNA_chain_1 8qie 2 1159 2.43 RF02543,RF02540,RF02541 0003735 0005840 347515 ccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaugcucngguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugacnccagucuggcucugugcggcgacaucugaggguaggguggaagcgcaagcgcaaaugaaauaccaccacucggaacguugcuucacuuaucgaaugaagagaccaauggguugcguagucuucgggcuaugcaccgucuagguuugggaguccgucccccuguggguacccaaccgugcuguacugaaccaacgggauccggagucuuguuucgagacacugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaauaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggaggcgagcgguggguaguacaugguacgcucaucacc .......................<<......>>......<<<<<...>>>>>........<<<<....<<<<.<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<......>>>>....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<.............<....>...................>>.>>>..>>>>>>.>>>...<<<<<.....<<<<....<<...<<<<<<<<....>>>>>>>>.>>.....<<<<.<<.......<<.<...>.>>...>>.>>>>.................<<<<.>>>>..>>>>...>>>>>......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>.........<<<<<..............<<<<.......>>>>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>......<.<<<<<<<.<<<<...>>>>>>>>>>>.>. .......................((......))......((.(.....).))........(.((.....(((.((.(.((..(....(........((((....(.[..).....)))).((.(((((((..((...))..)..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....((....(((........)))....))..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).)))))..)).).........[..((.((......].)).))..(((((((..(((.((......((((.(((((...(((((.(((((((...((..((((((..((.((.........(..((....)).............)....)).))...))))))..))...(((((.....((((....(....((((((((....))))))))..)..(..((((.((.......((.(...).))...)).))))..)..............(((...)))..))))...)))))......)))))))..)))))..(((......[)).)(((.(...........].).)))([((...(((((((.(.((((((.))))))...).((][..[.))....))))))).(......(((.(.......).)))....)(((....))).)).].].....((.((.(............(((.........)))))).))....)......)))..))))))............(.((((((...((.......))...))))))...).............((((.((((((..((.((((.(......).))))...))..((.(.....).))......)))))..)...))).)......((((((....))).))).....))..))).)))))))........................(((.....))).......(.(((((((..(((...))).))))))).). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; LSUb_rRNA_chain_2 8qie 4 184 2.43 RF02543,RF02540,RF02541 0003735 0005840 347515 gugggauugugaagggaucucgcagguaucgugagggaaguaugggguaguacgagaggaacucccaugccgunccucuaguuucugggguuugucgaacggcaagugccccgaagccaucgcacggugguucucggcugaacgccucuaagccagaagccaaucccaagaccagaugcccacu <<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...............>>>>>>>><<<<<...<.<<....<<<<<<<<<......>>>>..>>>>>...>>.>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>.......>>>>>>.... (((.(((.........))).))).(((.(((...(((..((((.((......(....).....)).))))(((((...(.((....((((((((.(....).)))..)))))...)).)..)))))...((....((...............))....))....))).....).)).))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; SR2_chain_4 8qie S1 1787 2.43 RF01960,RF02542,RF01959,RF00177 0003735 0005840 347515 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...<<<<..[.((((.>>>><<<<.<<<<<<...<<<...<......<<<.<<<..<<....<<....<<<<.>>>>...>>.>>......<<........<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<<<<<.....>>>>>>......>>..........<<<<<.<<<<...>>>>>>>>>.<<<<<<<<<<.......[.[....................................>>>>>>>>...>>....<<<<<...>>>>>...>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<<....<<<..........>>>..>>>..>....>>>....<<<.<<......>>.>>>.....<<<<............>>>.....>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<<<<...<<<.......<...<<.<..<..>.>.>>...>..................<...............<<<<.......>>>>.............>....<<<<<<<<.......<<...<.......>..<<<....>>>.....>>......>>>>>..>>>...........<<.<<.<<..........].]....>>.>>.>>..............<.<..>.>...............<<<<<..<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.>>>.>.>>.......<<....>>.>>>>>>..>>.>>>.>>....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<<.<<<..<<<<<<<<<<.<.>.>>>>>>>>>>..>>>..<<..))>>.....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<........>>..........<<<<<......<<<<.........<<.<<<........>>>.>>.......>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<<<<...............>>>>..>>>>>>>.....>>>>....<<<<.........>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>>.>>.....<<<.<<<.......<......<<<<<<<........>>>>>>>....>........>>>...>>>......<....<<<..<..........>..>>>.....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<...<.<<..>>.>...>.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[..[[..))))((((.((((((...(((...((.....(((.(((..((....((....((((.))))...))[))......(((.......(((..((..((...((........(((((())))))....(.....(.((((.....)))).)......)...........(((.(.(((.....)))).))).(((((((.((.......{......{...............................)).)))))...))....(((((...)))))......))..))))..))).(.(....(((....(((((.((.......)).))))))))......).)..(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(..(....(.((.]........))..).).).)....)))....(((.((......)).))).....((((............))).....).........((((([[....(.(.((.....((..]])).......)).)))))))..))))))))))..[......((([[...(.((((...(((..(....(.........(..)........)..................(...............((((.......)))).............)....((.(((((.......((..((.......))................))......)))))...))........(..(...(.((.....}......}....)).)...)................(..)......)...)....(.(.(((..((...(((((.((...(((.(((...(..........)......))).)))...)).......((....))..)))))..)).)))..)...))))...))))....((((((....(...((((.........))))...).))))))......{...(((.((..((..((((((((.(.(.).).))))))))..))...((..]])).....))...].))))))).(((......((((....))))....)))...]]..]((((..(.(((((..((..(((((..((.(((((((.......(........)...........(((((.(.....(((......(..((.(.(........).).))....)..)))....((..(....(.((((((....(((.(.(((....)))....((......)).....).))).....((((.((((.....(((.(((.(.((...............)).)..))).))).....))))..(.((((.........))))....)..)))).....))).))).....)..).)).....).)))))...)).))))).)).(...(((((((.......(......((.((((........)))).))....)........))).).)))......(....((...(..........)...)).....)..)..))))).....(((.(((.........))).)))......))...))))).).)).))..(.(..((.(.((((((((..((.(((.(.(.(.(.(((((.(...(.((..)).)...).))))))..).).).))).))..))))))))..).))...)..)..(((((((((....)))))))))}........ CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; SSU_rRNA_chain_S1 8ruk A 388 4.81 RF02001,RF01998 38898052 0000373 182710 ugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugug ....<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...(((((([[[[[...........[[[[[......[[[....((((((<<<<..<<<<.......>>>>...>>>>.>>>>>>>...))))))....]]]...]]]]]]]]]]...))))))...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<......>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... .[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((...((.(((.((((..((((.].....))))...)))).]]]]]]]....))).))...)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((..((((....))))...)))))..((((((((((((....)))..))))))))).... Structure of Oceanobacillus iheyensis group II intron in the presence of Na+, Mg2+, and ARN25850; Domains 1-5 8rxh L1 1677 2.93 RF02543 38722744 0003735 0005840 347515 cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacncagcggaggaaaagaaaacanccgugauucucucagugagcggcgagcgaagagggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggcacaaauaucauugugugguuggugcaggaguggcgaaauucaagcgaaaagcaaacccguugcugaauacaacccuucaugugnguauugagccaaagaagguguuagcccauugagccauaaaccugagcgccucaugaauaagcgnguagcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaanguuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccuacugcauuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaucuugggucuuggugaaaugagcggaguauuugagcugcgcacggcgcgccgcacgcacugguuucuucuccgugaugcuccauguuggcgauggaaauggggugcccccacccgucuuganacncggaccaaggagunanacagacgcgcaagggaggagauaugguugccaguacuucucucguacugaaagggagaugcaaaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcguuggagugugccngnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaacccagguggaggccuguagcgaugcugncgugcaaaucgcucguaugauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuuccnucaggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauuagaggucgaccuauucucaaacuuuaaangugcaaacaaaccgugccuuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucucgauacgugaaaaggguguugguggauacaguuggacccaaccgaauccaccggccccgaaaauggangncgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcggaaacaaauggagaaaguguagcccuuccgauguagauguggccuggagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcanaunuugguuggcgunncaaagaucuaacggagauauacucaacaugcaacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggaaacugagcacaacguuauaucgunuuguuaggaaagugaaggugugucggcggagcuguucgacugugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcauguggga .......................<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<<......<<.....>>....>>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>............<<<<...<<<<<<<<.<<<<<......<<<......<<<<.......>>>>.....<<........>>......>>>.<<.......((.....>>)).....>>>>>...>>>..>>>>>.>>>>............<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>.........>>>>..>>>>........<<<<<.....<<<<<..<<.<<<<..>>>>...>>...>>>.>>..>>>>>.....<<<<...>>>>>>....>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..<<<..<<<.<............>>>>..>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<<....<<<....>>>....>>>..>.>>...>>>>>>>.....<<<.<<<<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<........<...........<<<.<<<<<<<<<<..................>>>>>>>>>>>>>..........))).>....>>>>.>.........>>>...>>>>>>><<<<.<<<<<...........>>>>.........>>>>>>>>>....>>>>>....<<<<<<<<.........<<<..<<<....>>>.>>>.......>>>>>>>>........>>>>>>..............<<<<<<<....................>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>............<..<.<..<<.....<...>....>>..>.>..>...>.>>..........<<<<.........>>....>>.>>............ .......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((.(...(.(..((((((((......))))).))....)).).............((((...((((((((.(((((....(.((.......((((.......)))).....((........)).......)))(((...).{[[.....))]].....)))))...)))..))))).)))).......)....((((.((........)).))))......(((((........)))))...))....................................((....)).............(..((.(....).))............)......................((..(((((..((((((..((.((((.((((.(((....((((...(.((((((..........)))))).)......).))).........)))...))))........(((((.....((((((..(.((.(..).))...)..).))).))..))))).....[[[[...))))))..).))))).)))))..))..(((..........)))(((..(....(((((.(.(((((..(((..(((..(....}.....).)))..)))...((....))..(((((.....)))))...((.((...((.(((((......))))).))....)).))(((((((((.....)))))).)))...))))).).)))))...(.(...((((((.....((((((((((..(((...(.(.(((....))).).)...).))....(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).)...((((((....(.(((....))).).((((((((.....((.(.((((((....(((....(((..(.(((....))).)..)))..)).)....)))))).....(((.(((((.((.....))))))))))..........)))...))))))).)...(((..((.((.....)).))..)))....(((......)))...(((((((...((([[[...(..(..((((........(...........(((.(((((.((((..................)))).))))))))..........]]].)....)))).))........)))...)))))))((((.((((((..........]]]]...).....)))))))))....))))).)(.((((.(((.(......((((..(((....))).))).)...).))).))))..).....)..)))..............(((((((....................)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......))).............(........(..............)........)...).))....).....((((.........))....)).))............ CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; LSUa_rRNA_chain_1 8rxh L2 1155 2.93 RF02543 38722744 0003735 0005840 347515 cccaacugcagancguacucaucaccgcaucagguccccaagcauagaaugcucngguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaaaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagnagacccunuugaguuugncnccagucuggcucugugcgncgacaucugaggcucggaacguugcuucacuuaucgaaugaagagaccaauggguuuagcguagucuucgggcuaugcaccgucuagguuugggaguccccuguggguacccaaccgugcuguaaacugaaccaacgggauugcaguuccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgncaacgcaggnnuccuaaggcgagcucagugggaacagaaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaauaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggacgucgggucguugggccuggcgagcgguggguaguacaugguacgcucaucacc ........................<<......>>......<<<<.....>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<......>>>>....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<.>>.>>>..>>>>>>.>>>...<<<<<.....<<<<....<<.....<<<<<<<<....>>>>>>>>.>>.....<<<<.<<...<<.<..>.>>...>>.>>>>...................<<<<<......>>>>>..>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>.........<<<<<..............<<<<.......>>>>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>.<<<<<<<<<....>>>>>>>>>.<.<<<<<<<.<<<<...>>>>>>>>>>>.>. ........................((......))......((((.....))))........(.((.....(((.((.(.((..(....(.......(((((....(.[..).....)))))((.(((((((..((....))..)..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....((....(((........)))....))..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).)))))..)).).........[..((.((......].)).))..(((((((..(((.((......((((.(((((...(((((.(((((((...((..((((((..(..((.))..)...))))))..))...(((((.....((((....(......((((.(((....))).))))..)..(..((((.((....(.(..).)....)).))))..)................((((((....))))))..))))...))))).......)))))))..)))))..(((......[)).)(((.(...........].).)))([((...(((((((.(.((((((.......))))))...).((][..[.))....))))))).(......(((...........)))....)(((....))).)).].].....((.((.(............((...........))))).))....)......)))..))))))............(.((((((...((.......))...))))))...).............((((.((((((..((.((((.(......).))))...)).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).)))))))........................(((.....)))..(((((((((....))))))))).(.(((((((..(((...))).))))))).). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; LSUb_rRNA_chain_2 8rxh L4 184 2.93 RF02543 38722744 0003735 0005840 347515 gugggauugugaagggaucucgcagguaucgugagggaaguaugggguaguacgagaggaacucccaugccgunccucuaguuucugggguuugucgaacggcaagugccccgaagccaucgcacggugguucucggcugaacgccucuaagccagaagccaaucccaagaccagaugcccacu <<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...............>>>>>>>><<<<<...<.<<....<<<<<<<<<......>>>>..>>>>>...>>.>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>.......>>>>>>.... (((.(((.........))).))).(((.(((...(((..(((((((......(....).....)))))))(((((...(.((....((((((((.(....).)))..)))))...)).)..))))).(.((....((...............))....)).)..))).....).)).))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; SR2_chain_4 8rxh L5 120 2.93 38722744 347515 uuacgucccucuccaaacgagagaacaugcaugggcuggcaugagcggcaugcuucuccgguggggcuccgucccgaggcgcugaaccuugaggccugaaaauucaugcucagggacacu ....<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<.................<<.......>>....>>>....>>.....>>>........>>>>>...>>>>>... ....(((((((((.......)))).....((((.((.((.....(((..............(...(..(.)..)...).)))....)).....)).........))))....)))))... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; SR4_chain_5 8rxh L7 166 2.93 RF00002 38722744 0003735 0005840 347515 aacgugucgcgauggaugacuuggcuuccuauuucguugaagnacgcaguaaagugcgauaagugguaucaauuncagaaucauucaauuaccgaaucuuugaacgcaaacggcgcaugggagaagcucgugucauccccgugcaugccauauucucngugucgaa .........................................<<<<<<<<<....>>>>.....(<<<<......>>.............>>>>.)...>>>....<<.....>><<<<<<<.<..<<....>>..>.>>>>>>>...................... ...........................................((((.[[.....))).....(((((......]].............)))).)...)......((.....))(((((((....((.().))....)))))))...................... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; 5.8S_rRNA_chain_7 8rxh L8 120 2.93 RF00001 38722744 0003735 0005840 347515 gaguacgaccacacuugagugaaaacaccauaucccguccgauuugugaaguuaagcacucacaggcucaguuaguacugaggucagugaugacucgggaacccugagugccguacuccu <<<<<<<......<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>..>>>>>>>.. (((((((.(....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))).))))))).. CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; 5S_rRNA_chain_8 8rxh S1 1844 2.93 RF01960,RF02542,RF01959,RF00177 38722744 0003735 0005840 347515 gaucuggnugauucugcnaguagucaunngcuuguuunaaggacuuagccaugcaugccucagaaucacugcagcaggaaucugcgcauggcucnuuaaaucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacuuggcgaaacgccaagcuaauacaugaaccaaccggguguucuccacgugagacgcccagcgaaugaaugacaguaaaaccaaugccuugcaguaacacccagcaguguugacucaauucauuccgugcgaaagccggcuuguuccggcgucuuuugacgaacaacugcccuaucagcuggugauggccguguaguggacugccauggcguugacgggagcgggggauuaggguucgauuccggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgcnaauugcccaaugucaaaacaaaacgaugaggcngcgaaaagaaauagaguuguuugucauuucaaugggggauauuuaaacccauccaauaucgaguaacaauuggangacaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauauuaaugcugungcuguunaaggguucguaguugaacugugggcugugcagggcccuugcagcccgugaaaaagaaacaagaaacacgggagugggucgcaugucaugcaugccagggggcguccgugauuuuuacugugacuaaagaagcgugacuaaagcagucauuugacuugaauuagaangcaugggauaacaaaggagcagccucuaggcuaccguuucggcuuuuguuguuuuuaaaggucuauuggagauuauggagcuguuucccacggugugacggccucuaggaaugaaggaggguaguucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaagaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccacacugcaaacgaugacacccaugaauuggggauacuuaguaucuuuacgggaauauccucagcacgcacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaanagugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacnnaacacngggaacuuuaccagauccggacaggaugagauugacagauugaguguucuuucucgauucccugaauggngnugcauggccgcuuauggucggugnagugauuuguuuggnugauuccgucaacggacgagauccaagcugcccaguagaauucagaauugcccauaggauagcgcauucggucgaauucuucucugcgggauuccuuuguaauugcacaaggugaaauuuugggcaacagcangucngugaugcuccucaauguucugggcgacacgcnnacuacaaugucagugagaacaagaaaaacgaucgaaccuacuugaucaaaagaguggggaaaccccggaaucacauagacccacuugggaccgaggauugcaauuanuggucgcgcaacgagnaaugucucguaggcgcagcucaucanacugugccgauuacgucccugccauuuguacacaccgncngucguuguuuccgaugauggugcaauacaggugaucggacaggcgcccgaaaguucaccgauauuunuucaauagagnaagcaaaagucguaacaagguagcuguaggggnnccugcagcugggacauuu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<...<......<<<.<<<..<<....<<....<<<<.>>>>...>>.>>......<<..<.....<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<<<<<.....>>>>>>......>>..........<<<<<.<<<<.....>>>>>>>>>.<<<<<<<<<<.....(((((.((((<<...>>.........................>>>>>>>>...>>....<<<<<......>>>>>...>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<.<<<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<<....<<<..........>>>..>>>..>....>>>....<<<.<<.....>>.>>>.....<<<<............>>>.....>.........<<<<<<<........((.....((..>>)).......))...>>>>>..>>>>>>>>>>.........<<<[[.....<<<<...<<<.......<...<<.<..<..>.>.>>...>...................<...............<<<<.......>>>>.............>.....<<<<<<<<.......<<...<.......>..<<<....>>>.....>>......>>>>>..>>>...........<<..<<<<<<.<<<...>>>.....)))).)))))..>>>>>>..>>.......<<<<<<<.<.<<...>>.>...>>>.>>>>............<<<<<..<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<<..<<..<<<<<<<........<<..........>>.>>>>>>>..>>...<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<........>>..........<<<<<.<....<<<<........<<.<<<........>>>.>>.......>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<<<<.................>>>>....>>>>>>>.....>>>>....<<<<.<<......>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>>.>>.....<<<.<<<.......<.....<<..>>..<<<<<<<........>>>>>>>....>........>>>...>>>......<....<<<..<..........>..>>>.....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<...<.<....>.>...>.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... 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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; SSU_rRNA_chain_S1 8rxx L1 1657 2.97 RF02543 38722744 0003735 0005840 347515 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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; LSUa_rRNA_chain_1 8rxx L2 1149 2.97 RF02543 38722744 0003735 0005840 347515 cccaacugcagancguacucaucaccgcaucagguccccaagcauagaaugcucugguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaaaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucuggucaacgugacgagauucaccgacgcgcggguaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugncnccagucuggcucugugcgncgacaucugaggcucggaacguugcuucacuuaucgaaugaagagaccaauggguuuagcguagucuucgggcuaugcaccgucuagguuugggaguccccuguggguacccaaccgugcuguaaacugaaccaacgggaucaguuccggagucuuguuucgagacacugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaacagaaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaauaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggacgucgggucguugggccuggcgagcgguggguaguacaugguacncucaucacc ........................<<......>>......<<<<.....>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<..<<....<<<<......>>>>....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<.>>.>>>..>>>>>>.>>>...<<<<<.....<<<<....<<.....<<<<<<<<....>>>>>>>>.>>.....<<<<.<<...<<.<..>.>>...>>.>>>>...................<<<<<....>>>>>..>>>>...>>>>>......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>........<<<<<<..............<<<<.......>>>>.>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>>..>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>.<<<<<<<<<....>>>>>>>>>.<.<<<<<<<.<<<<...>>>>>>>>>>>.>. ........................((......))......((((.....))))........(.((.....(((.((.(.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((..((....(((........)))....))..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).)))))..)).).........[..((.((......].)).))..(((((((..(((.((......((((.(((((...(((((.(((((((...((..((((((..(..((.))..)...))))))..))...(((((.....((((....((.....((((.(((....))).)))).))..(..((((.((...((.(..).))...)).))))..)................((((((..))))))..))))...)))))......)))))))..)))))..(((......[)).)(((.(...........].).)))([((...(((((((.(.((((((.......))))))...).((][..[.))....))))))).(......(((...........)))....)(((....))).)).].].....((.((.(............((...........))))).))....)......)))..))))))............(.((((((...((.......))...))))))...).............((((.((((((..((.((((.(......).))))...)).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).)))))))........................(((.....)))..(((((((((....))))))))).(.(((((((..(((...))).))))))).). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; LSUb_rRNA_chain_2 8rxx L7 166 2.97 RF00002 38722744 0003735 0005840 347515 aacgugucgcgauggaugacuuggcuuccuauuucguugaagnacgcaguaaagugcgauaagugguaucaauuncagaaucauucaauuaccgaaucuuugaacgcaaacggcgcaugggagaagcucgugucauccccgugcaugccauauucucngugucgaa .........................................<<<<<<<<<....>>>>.....(<<<<......>>.............>>>>.)...>>>....<<.....>><<<<<<<.<..<<....>>..>.>>>>>>>...................... ...........................................((((.[[.....))).....(((((......]].............)))).)...)......((.....))(((((((....((.().))....)))))))...................... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; 5.8S_rRNA_chain_7 8rxx L8 119 2.97 RF00001 38722744 0003735 0005840 347515 gaguacgaccacacuugagugaaaacaccauaucccguccgauuugugaaguuaagcacucacaggcucaguuaguacugaggucagugaugacucgggaacccugagugccguacucc <<<<<<<......<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>..>>>>>>>. (((((((.(....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))).))))))). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; 5S_rRNA_chain_8 8rxx S1 1836 2.97 RF01960,RF02542,RF01959,RF00177 38722744 0003735 0005840 347515 gaucuggnugauucugcnaguagucauangcuuguuunaaggacuuagccaugcaugccucagaaucacugcagcaggaaucugcgcauggcucnuuaaaucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacuuggcgaaacgccaagcuaauacaugaaccaaccggguguucuccacgugagacgcccagcgaaugaaugacaguaaaaccaaugccuugcaguaacacccagcaguguugacucaauucauuccgugcgaaagccggcuuguuccggcgucuuuugacgaacaacugcccuaucagcuggugauggccguguaguggacugccauggcguugacgggagcgggggauuaggguucgauuccggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgcnaauugcccaaugucaaaacaaaacgaugaggcngcgaaaagaaauagaguuguuugucauuucaaugggggauauuuaaacccauccaauaucgaguaacaauuggangacaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauauuaaugcugungcuguunaaggguucguaguugaacugugggcugugcagggcccuugcagcccgugaaaagaaacaagaaacacgggagugggucgcaugucaugcaugccagggggcguccgugauuuuuacugugacuaaagaagcgugacuaaagcagucauuugacuugaauuagaaagcaugggauaacaaaggagcagccucuaggcuaccguuucggcuuuuguuguuuuuaaaggucuauuggagauuauggagcuguuucccacggugugacggccucuaggaaugaaggaggguaguucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaagaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccacacugcaaacgaugacacccaugaauuggggauacuuaguaucuuuacgggaauauccucagcacgcacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaanagugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacnnaacacngggaacuuuaccagauccggacaggaugagauugacagauugaguguucuuucucgauucccugaauggngnugcauggccgcuuauggucggugnagugauuuguuugguugauuccgucaacggacgagauccaagcugcccaguagaauucagaauugcccauaggauagcgcauucggucgaauucuucucugcgggauuccuuuguaauugcacaaggugaaauuuugggcaacagcangucngugaugcuccucaauguucugggcgacacgcnnacuacaaugucagugagaacaagaaaacgaaccuacuugaucaaaagaguggggaaaccccggaaucacauagacccacuugggaccgaggauugcaaunuggucgcgcaacgagnaaugucucguaggcgcagcucaucanacugugccgauuacgucccugccauuuguacacaccgccngucguuguuuccgaugauggugcaauacaggugaucggacaggcgcccgaaaguucaccgauauuunuucaauagagnaagcaaaagucguaacaagguagcuguaggggnnccugcagcugggacauuu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<..........<<<.<<<..<<....<<....<<<<.>>>>...>>.>>......<<........<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<<<<<.....>>>>>>......>>..........<<<<<.<<<<.....>>>>>>>>>.<<<<<<<<<<.....(((((.((((<<...>>.........................>>>>>>>>...>>....<<<<<......>>>>>...>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<<....<<<..........>>>..>>>.......>>>....<<<.<<.....>>.>>>.....<<<<............>>>.....>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<<<<...<<<.......<...<<....<..>...>>...>..................<...............<<<<.......>>>>.............>.....<<<<<<<<.......<<...<.......>..<<<....>>>.....>>......>>>>>..>>>...........<<..<<<<<<.<<.....>>.<...)))).)))))>.>>>>>>..>>.......<<<<<<<.<.<<...>>.>...>>>.>>>>............<<<<<..<<...<<<<<<<<<.<<<<.<<<...<<<......>>>......>>>.>>>.>>>>.......<<....>>.>>>>>>..>>.>>>.>>....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<<..<<..<<<<<<<........<<..........>>.>>>>>>>..>>...<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<........>>..........<<<<<.<....<<<<........<<.<<<........>>>.>>.......>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<<<<.................>>>>....>>>>>>>.....>>>>....<<<<.<<......>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>>.>>.....<<<.<<<<......<........<<<<<<<........>>>>>>>....>.......>>>>...>>>...........<<<..<........>..>>>...........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.....<.<<..>>.>.....>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[..[[..))))((((.((((((...(((...((.....(((.(((..((....((....((((.))))...)){))......(((.......(((..((..((...((........(((((())))))...((.....((((((.....))))))......))..........(((((.(((((..).))))))))).(((((((.((.....[[[[[.[[[[.......................(......).)).)))))...))....((((((..)..)))))......))..))))..))).(((....(((....(((((.((.......)).))))))))......)))..(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...(.((.}........))..))))).)....)))....(((.((.....)).)))...(.((((............))).....)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.((((...(((..(....(.........(..)........)..................(...............((((.......)))).............).....((.(((((.......((..((.......))................))......)))))...))........(..((..((((((.((.....)).....]]]].]]]]]..))))))..)).......(((((((((.((...)).)..)))).)))).)...)....(.(((((..((...(((((.(((..(((.(((...(..........)......))).)))..))).......((....))..)))))..)).))).))...))))...))))....((((((....(...((((.........))))...).))))))......<...(((.((..((..((((((((........(.(......).).))))))))..))...((..}})).....))...}.))))))).(((......((((....))))....)))...]]..]((((..(.(((((..((..(((((..((.(((((((.......(........)...........(((((.(.....(((.....(..((.(.(........).).))....)..)))....((..(....(.((((((....(((.(((((....)))....((......))....)).))).....((((.((((.....(((.((((..((.................))....).))).))).....))))..(.((((.((......))))))....)..)))).....))).))).....)..).)).....).)))))...)).))))).)).(...(((((((.......(........((.((((........)))).))....)........))).).)))......(....((...(........)...)).....)..)..))))).....(((((((.........)))))))......))...))))).).)).))..(.(..((.(.((((((((..(..(((.(.(.(((.(((((.(...(.((..)).)...).)))))).)).).).)))..)..))))))))..).))...)..)..(((((((((....)))))))))>........ CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; SSU_rRNA_chain_S1 8rxx S5 11 2.97 38722744 347515 caccauguuca ........... ........... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; mRNA_chain_S5 8u5r A 36 2.6 32630 gcguacgaaggugaggagaggcgaggaagaguacgc <<<<<<........................>>>>>> ((((((........................)))))) Structure of Mango II variant aptamer bound to T01-6A; Mango II variant 9c6k X 80 2.94 RF00059 39837824 0030976 562 guacucggggugcccuucugcgugaaggcugagaaauacccguaucaccugaucuggauaaugccagcguagggaagugc <<<<<<<<<..<<<.<<<.....>>>>>>.........>>>>.....<<<...<<<<......>>>>...>>>..>>>>> (((((((((.((((.(((.....))))))......)..)))).....(((...((((......))))...)))..))))) Cryo-EM structure of the TPP riboswitch embedded in an RNA scaffold bound to thiamine pyrophosphate; TPP riboswitch embedded in an RNA scaffold bound to thiamine pyrophosphate 9gmo A 3394 2.59 RF02543,RF02540,RF02541 38746087 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgcggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugcccggcggaucuggaccgucccccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagaccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcguccccggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnnacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacacgcaguuuuauccgguaaagcgaaugauuagagguaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggaccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcggcggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggagcucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacguuuuuucacugacccggugaggcgggggcuucuggcgccaagcgcccggccgcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguuccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuugggucgggguuucguacguagcagagcagcgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.....<<<<<.<<..>>>>>>>...>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<..>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>...................<<<<<<.<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<..>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<..>>>>>>..<<<<<...<<<..<<<...[[[.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...............<<<.<<<<<<<<<...<<<....<<<..<.<<<..>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).]]].............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<..>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<....>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<..>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<...............<<<<<<<<<<..>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<..>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>..<<.<<<<<<<.<<.....<<<<....<<<<..>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((.(..((.((((.(...(((((.((())))))))..)))))....))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((.......((((()))))........)))).).)))........))))))..)))))))))))......{............((((((.((((((())))))).((((((.((((.((((((((((((((((((((((((.((((....)))).))))))))))).)))))))))).)))...)))))))).))..((((((((())))))).))....)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...((((((()))))))..(((((...(((..(((...[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...............(((.((((((((.....((.....((....(((..)))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.]]]].]]](...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.((((((((())))))))))).......)....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((.).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.[..).....)))))((.((((((((((()))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....(......((.(....).))......)..))))..)))))(.(.().).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..)))).)...)))))....)).{..((.((.....]}.)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((.(((()))).)))))...(((((.....((((...............((((((((((()))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...a.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.............))))...))))..)))...).).)).).....((((((..((..((((.(..(((........(((((..))))).......)))...(((...(((....((((.(((((((......)))))))))))...)))...)))...........)..))))..)).))))))(((((....(.......).....((.(((((((.((.....(.((.(..((((()))))..))).)....))....)))).))).))..))))).. eIF6-bound pre-60S large ribosomal subunit incorporating mutant uL16; 28S rRNA